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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24840

FusionGeneSummary for NRF1_NRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRF1_NRF1
Fusion gene ID: 24840
HgeneTgene
Gene symbol

NRF1

NRF1

Gene ID

4899

4899

Gene namenuclear respiratory factor 1nuclear respiratory factor 1
SynonymsALPHA-PALALPHA-PAL
Cytomap

7q32.2

7q32.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear respiratory factor 1alpha palindromic-binding proteinnuclear respiratory factor 1alpha palindromic-binding protein
Modification date2018052320180523
UniProtAcc

Q16656

Q16656

Ensembl transtripts involved in fusion geneENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
ENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
Fusion gene scores* DoF score8 X 5 X 4=1604 X 4 X 3=48
# samples 84
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRF1 [Title/Abstract] AND NRF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA503463NRF1chr7

129377095

+NRF1chr7

129377114

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000393232ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393232ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000353868ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000539636ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000311967ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000223190ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393230ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000393231ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000393232NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000353868NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000539636NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000311967NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000223190NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000393230NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000393231NRF1chr7

129377095

+NRF1chr7

129377114

-
intron-intronENST00000477428ENST00000477428NRF1chr7

129377095

+NRF1chr7

129377114

-

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FusionProtFeatures for NRF1_NRF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRF1

Q16656

NRF1

Q16656

Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication. Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRF1_NRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRF1_NRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRF1_NRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRF1_NRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRF1C0006079Bowen's Disease1CTD_human
TgeneNRF1C0006079Bowen's Disease1CTD_human