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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24839

FusionGeneSummary for NRF1_MTMR1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRF1_MTMR1
Fusion gene ID: 24839
HgeneTgene
Gene symbol

NRF1

MTMR1

Gene ID

4899

8776

Gene namenuclear respiratory factor 1myotubularin related protein 1
SynonymsALPHA-PAL-
Cytomap

7q32.2

Xq28

Type of geneprotein-codingprotein-coding
Descriptionnuclear respiratory factor 1alpha palindromic-binding proteinmyotubularin-related protein 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phosphatase
Modification date2018052320180519
UniProtAcc

Q16656

Q13613

Ensembl transtripts involved in fusion geneENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
ENST00000541925, ENST00000542156, 
ENST00000370390, ENST00000451863, 
ENST00000544228, ENST00000445323, 
ENST00000538506, 
Fusion gene scores* DoF score8 X 5 X 4=1605 X 5 X 3=75
# samples 85
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRF1 [Title/Abstract] AND MTMR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTMR1

GO:0046856

phosphatidylinositol dephosphorylation

11733541|27018598

TgeneMTMR1

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-33-4547-01ANRF1chr7

129251665

+MTMR1chrX

149919202

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000393232ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000393232ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000393232ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000393232ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000393232ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000393232ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000393232ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-3CDSENST00000353868ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000353868ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000353868ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000353868ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000353868ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000353868ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000353868ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-3CDSENST00000539636ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000539636ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000539636ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000539636ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000539636ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000539636ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000539636ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-3CDSENST00000311967ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000311967ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000311967ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000311967ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000311967ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000311967ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000311967ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-3CDSENST00000223190ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000223190ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000223190ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000223190ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000223190ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000223190ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
5UTR-intronENST00000223190ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-3CDSENST00000393230ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393230ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393230ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393230ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393230ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393230ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393230ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-3CDSENST00000393231ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393231ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393231ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393231ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393231ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393231ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
intron-intronENST00000393231ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-3CDSENST00000477428ENST00000541925NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-intronENST00000477428ENST00000542156NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-intronENST00000477428ENST00000370390NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-intronENST00000477428ENST00000451863NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-intronENST00000477428ENST00000544228NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-intronENST00000477428ENST00000445323NRF1chr7

129251665

+MTMR1chrX

149919202

+
3UTR-intronENST00000477428ENST00000538506NRF1chr7

129251665

+MTMR1chrX

149919202

+

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FusionProtFeatures for NRF1_MTMR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRF1

Q16656

MTMR1

Q13613

Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication. Lipid phosphatase that has high specificity forphosphatidylinositol 3-phosphate and has no activity withphosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate(PubMed:11733541, PubMed:27018598). Activity withphosphatidylinositol (3,5)-bisphosphate is controversial; it hasbeen shown by PubMed:27018598, while PubMed:11733541 find noactivity with this substrate. {ECO:0000269|PubMed:11733541,ECO:0000269|PubMed:27018598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRF1_MTMR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRF1_MTMR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRF1DYNLL1, MAFF, PPARGC1A, PPRC1, PARP1, CEBPB, CSNK2A1, CSNK2B, FHL2, SP4, TRAF2, POGZ, PLXDC1, FOXJ2, FOXK2, FOXP3, WDR59, DYNLL2MTMR1AURKB, CEP250, TUBGCP3, EFNB2, SKAP1, TRIM10, PSMC2, FBXW11, FOS, SLC4A1AP, MTMR2, SBF1, SBF2, GMNN, RPGR, LIPC, RAB6B, HAVCR2, PIP4K2A, SELE, LRRC4C, TMEM52B, ERBB3, ROR2, PTK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRF1_MTMR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRF1_MTMR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRF1C0006079Bowen's Disease1CTD_human