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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24838

FusionGeneSummary for NRF1_MLXIPL

check button Fusion gene summary
Fusion gene informationFusion gene name: NRF1_MLXIPL
Fusion gene ID: 24838
HgeneTgene
Gene symbol

NRF1

MLXIPL

Gene ID

4899

51085

Gene namenuclear respiratory factor 1MLX interacting protein like
SynonymsALPHA-PALCHREBP|MIO|MLX|MONDOB|WBSCR14|WS-bHLH|bHLHd14
Cytomap

7q32.2

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionnuclear respiratory factor 1alpha palindromic-binding proteincarbohydrate-responsive element-binding proteinMlx interactorWS basic-helix-loop-helix leucine zipper proteinWilliams Beuren syndrome chromosome region 14Williams-Beuren syndrome chromosome region 14 protein 1Williams-Beuren syndrome chromosome regio
Modification date2018052320180523
UniProtAcc

Q16656

Q9NP71

Ensembl transtripts involved in fusion geneENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
ENST00000414749, ENST00000429400, 
ENST00000395189, ENST00000313375, 
ENST00000354613, ENST00000434326, 
Fusion gene scores* DoF score8 X 5 X 4=1603 X 3 X 4=36
# samples 84
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRF1 [Title/Abstract] AND MLXIPL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-KK-A7B4-01ANRF1chr7

129251665

+MLXIPLchr7

73030507

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000393232ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000393232ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000393232ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000393232ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000393232ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000393232ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000353868ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000353868ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000353868ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000353868ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000353868ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000353868ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000539636ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000539636ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000539636ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000539636ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000539636ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000539636ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000311967ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000311967ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000311967ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000311967ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000311967ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000311967ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000223190ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000223190ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000223190ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000223190ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000223190ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
5UTR-3CDSENST00000223190ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393230ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393230ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393230ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393230ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393230ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393230ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393231ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393231ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393231ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393231ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393231ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
intron-3CDSENST00000393231ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-
3UTR-3CDSENST00000477428ENST00000414749NRF1chr7

129251665

+MLXIPLchr7

73030507

-
3UTR-3CDSENST00000477428ENST00000429400NRF1chr7

129251665

+MLXIPLchr7

73030507

-
3UTR-3CDSENST00000477428ENST00000395189NRF1chr7

129251665

+MLXIPLchr7

73030507

-
3UTR-3CDSENST00000477428ENST00000313375NRF1chr7

129251665

+MLXIPLchr7

73030507

-
3UTR-3CDSENST00000477428ENST00000354613NRF1chr7

129251665

+MLXIPLchr7

73030507

-
3UTR-3CDSENST00000477428ENST00000434326NRF1chr7

129251665

+MLXIPLchr7

73030507

-

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FusionProtFeatures for NRF1_MLXIPL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRF1

Q16656

MLXIPL

Q9NP71

Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRF1_MLXIPL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRF1_MLXIPL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRF1DYNLL1, MAFF, PPARGC1A, PPRC1, PARP1, CEBPB, CSNK2A1, CSNK2B, FHL2, SP4, TRAF2, POGZ, PLXDC1, FOXJ2, FOXK2, FOXP3, WDR59, DYNLL2MLXIPLMLX, GRB2, MTOR, EVC2, XPO1, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRF1_MLXIPL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRF1_MLXIPL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRF1C0006079Bowen's Disease1CTD_human
TgeneMLXIPLC0022661Kidney Failure, Chronic1CTD_human
TgeneMLXIPLC2239176Liver carcinoma1CTD_human