FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24836

FusionGeneSummary for NRF1_ADAD2

check button Fusion gene summary
Fusion gene informationFusion gene name: NRF1_ADAD2
Fusion gene ID: 24836
HgeneTgene
Gene symbol

NRF1

ADAD2

Gene ID

4899

161931

Gene namenuclear respiratory factor 1adenosine deaminase domain containing 2
SynonymsALPHA-PALTENRL
Cytomap

7q32.2

16q24.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear respiratory factor 1alpha palindromic-binding proteinadenosine deaminase domain-containing protein 2
Modification date2018052320180523
UniProtAcc

Q16656

Q8NCV1

Ensembl transtripts involved in fusion geneENST00000393232, ENST00000353868, 
ENST00000539636, ENST00000311967, 
ENST00000223190, ENST00000393230, 
ENST00000393231, ENST00000477428, 
ENST00000268624, ENST00000315906, 
ENST00000567413, 
Fusion gene scores* DoF score8 X 5 X 4=1602 X 1 X 2=4
# samples 82
** MAII scorelog2(8/160*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: NRF1 [Title/Abstract] AND ADAD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-NC-A5HJ-01ANRF1chr7

129251665

+ADAD2chr16

84228048

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000393232ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000393232ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-intronENST00000393232ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000353868ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000353868ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-intronENST00000353868ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000539636ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000539636ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-intronENST00000539636ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000311967ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000311967ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-intronENST00000311967ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000223190ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-3CDSENST00000223190ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
5UTR-intronENST00000223190ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
intron-3CDSENST00000393230ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
intron-3CDSENST00000393230ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
intron-intronENST00000393230ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
intron-3CDSENST00000393231ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
intron-3CDSENST00000393231ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
intron-intronENST00000393231ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+
3UTR-3CDSENST00000477428ENST00000268624NRF1chr7

129251665

+ADAD2chr16

84228048

+
3UTR-3CDSENST00000477428ENST00000315906NRF1chr7

129251665

+ADAD2chr16

84228048

+
3UTR-intronENST00000477428ENST00000567413NRF1chr7

129251665

+ADAD2chr16

84228048

+

Top

FusionProtFeatures for NRF1_ADAD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRF1

Q16656

ADAD2

Q8NCV1

Transcription factor that activates the expression ofthe EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulationof key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required forrespiration, heme biosynthesis, and mitochondrial DNAtranscription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NRF1_ADAD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for NRF1_ADAD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NRF1DYNLL1, MAFF, PPARGC1A, PPRC1, PARP1, CEBPB, CSNK2A1, CSNK2B, FHL2, SP4, TRAF2, POGZ, PLXDC1, FOXJ2, FOXK2, FOXP3, WDR59, DYNLL2ADAD2APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NRF1_ADAD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NRF1_ADAD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRF1C0006079Bowen's Disease1CTD_human