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Fusion gene ID: 24833 |
FusionGeneSummary for NRD1_VPS53 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NRD1_VPS53 | Fusion gene ID: 24833 | Hgene | Tgene | Gene symbol | NRD1 | VPS53 | Gene ID | 4898 | 55275 |
| Gene name | nardilysin convertase | VPS53, GARP complex subunit | |
| Synonyms | NRD1|hNRD1|hNRD2 | HCCS1|PCH2E|hVps53L|pp13624 | |
| Cytomap | 1p32.3 | 17p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nardilysinNRD convertasenardilysin (N-arginine dibasic convertase) | vacuolar protein sorting-associated protein 53 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5VIR6 | ||
| Ensembl transtripts involved in fusion gene | ENST00000354831, ENST00000352171, ENST00000485608, ENST00000539524, ENST00000544028, | ENST00000437048, ENST00000574029, ENST00000576149, ENST00000446250, ENST00000291074, ENST00000571805, ENST00000401468, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 5 X 6=240 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/240*10)=-1.77760757866355 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NRD1 [Title/Abstract] AND VPS53 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NRD1 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 18355445 |
| Hgene | NRD1 | GO:0052548 | regulation of endopeptidase activity | 18355445 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-E1-A7YL-01A | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000354831 | ENST00000437048 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-intron | ENST00000354831 | ENST00000574029 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000354831 | ENST00000576149 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000354831 | ENST00000446250 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000354831 | ENST00000291074 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000354831 | ENST00000571805 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000354831 | ENST00000401468 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| In-frame | ENST00000352171 | ENST00000437048 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-intron | ENST00000352171 | ENST00000574029 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000352171 | ENST00000576149 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000352171 | ENST00000446250 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000352171 | ENST00000291074 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000352171 | ENST00000571805 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000352171 | ENST00000401468 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-3CDS | ENST00000485608 | ENST00000437048 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-intron | ENST00000485608 | ENST00000574029 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-5UTR | ENST00000485608 | ENST00000576149 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-5UTR | ENST00000485608 | ENST00000446250 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-5UTR | ENST00000485608 | ENST00000291074 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-5UTR | ENST00000485608 | ENST00000571805 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5UTR-5UTR | ENST00000485608 | ENST00000401468 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| Frame-shift | ENST00000539524 | ENST00000437048 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-intron | ENST00000539524 | ENST00000574029 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000539524 | ENST00000576149 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000539524 | ENST00000446250 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000539524 | ENST00000291074 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000539524 | ENST00000571805 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| 5CDS-5UTR | ENST00000539524 | ENST00000401468 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-3CDS | ENST00000544028 | ENST00000437048 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-intron | ENST00000544028 | ENST00000574029 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-5UTR | ENST00000544028 | ENST00000576149 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-5UTR | ENST00000544028 | ENST00000446250 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-5UTR | ENST00000544028 | ENST00000291074 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-5UTR | ENST00000544028 | ENST00000571805 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
| intron-5UTR | ENST00000544028 | ENST00000401468 | NRD1 | chr1 | 52258049 | - | VPS53 | chr17 | 440416 | - |
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FusionProtFeatures for NRD1_VPS53 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NRD1 | VPS53 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Acts as component of the GARP complex that is involvedin retrograde transport from early and late endosomes to thetrans-Golgi network (TGN). The GARP complex is required for themaintenance of the cycling of mannose 6-phosphate receptorsbetween the TGN and endosomes, this cycling is necessary forproper lysosomal sorting of acid hydrolases such as CTSD(PubMed:15878329, PubMed:18367545). Acts as component of the EARPcomplex that is involved in endocytic recycling. The EARP complexassociates with Rab4-positive endosomes and promotes recycling ofinternalized transferrin receptor (TFRC) to the plasma membrane(PubMed:25799061). {ECO:0000269|PubMed:15878329,ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NRD1 | chr1:52258049 | chr17:440416 | ENST00000352171 | - | 25 | 31 | 142_200 | 941 | 1152 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| Hgene | NRD1 | chr1:52258049 | chr17:440416 | ENST00000352171 | - | 25 | 31 | 144_153 | 941 | 1152 | Compositional bias | Note=Poly-Glu |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | VPS53 | chr1:52258049 | chr17:440416 | ENST00000291074 | - | 15 | 18 | 55_142 | 593 | 671 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | VPS53 | chr1:52258049 | chr17:440416 | ENST00000437048 | - | 16 | 22 | 55_142 | 622 | 833 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | VPS53 | chr1:52258049 | chr17:440416 | ENST00000571805 | - | 16 | 19 | 55_142 | 622 | 700 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for NRD1_VPS53 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NRD1_ENST00000354831_chr1_52258049_-_VPS53_ENST00000437048_chr17_440416_-_1220aa MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARPFPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEG RRGSLSNAGDPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEIEDDDEEGFDDEDEFDD EHDDDLDTEDNELEELEERAEARKKTTEKQQLQSLFLLWSKLTDRLWFKSTYSKMSSTLLVETRNLYGVVGAESRSAPVQHLAGWQAEEQ QGETDTVLSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQ FFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLV VQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGS ILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPV EYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNP DLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYE ADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYARWSMIDKY QALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTV YYQSGTRSLREYTLMELLVMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFANSFIPKFITHLFKCKPISMVGA EQLLLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLLTDCNTETFQKILDMKGLKRSEQ >In-frame_NRD1_ENST00000352171_chr1_52258049_-_VPS53_ENST00000437048_chr17_440416_-_1152aa MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARPFPILAMPGRNKAKSTCSCPDLQPNGQDLGENSRVARLGADESEEEG RRGSLSNAGDPEIVKSPSDPKQYRYIKLQNGLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEIEDDDEEGFDDEDEFDD EHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCE RTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNI DTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQ QHYRVKPLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKR IFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQ YSIEDIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAA NVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILIKPE TLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELP SGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVKFA NSFIPKFITHLFKCKPISMVGAEQLLLDTHSLKMVLLDLPSISSQVVRKAPASYTKIVVKGMTRAEMILKVVMAPHEPLVVFVDNYIKLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NRD1_ENST00000354831_chr1_52258049_-_VPS53_ENST00000437048_chr17_440416_-_3660nt ATGCTGAGGAGAGTCACTGTTGCTGCAGTCTGTGCCACCCGGAGGAAGTTGTGTGAGGCCGGGCGGGAGCTCGCGGCGCTCTGGGGAATC GAAACGCGGGGTCGGTGCGAAGACTCTGCTGCTGCCAGACCCTTTCCTATTCTGGCCATGCCTGGAAGGAACAAGGCGAAGTCTACCTGC AGCTGCCCTGACCTGCAGCCCAATGGACAGGATCTGGGCGAGAACAGCCGGGTTGCCCGTCTAGGAGCGGATGAATCTGAGGAAGAGGGA CGGAGGGGGTCTCTCAGTAATGCTGGGGACCCTGAGATCGTCAAGTCTCCCAGCGACCCCAAGCAATACCGATACATCAAATTACAGAAT GGCTTGCAGGCACTTCTGATTTCAGACCTAAGTAATATGGAAGGTAAAACAGGAAATACAACAGATGATGAAGAAGAAGAGGAGGTGGAG GAAGAAGAAGAAGATGATGATGAAGATTCTGGAGCTGAAATAGAAGATGACGATGAAGAGGGTTTTGATGATGAAGATGAGTTTGATGAT GAACATGATGATGATCTTGATACTGAGGATAATGAATTGGAAGAATTAGAAGAGAGAGCAGAAGCTAGAAAAAAAACTACTGAAAAACAG CAATTGCAGAGCCTGTTTTTGCTGTGGTCAAAGCTGACTGATAGACTGTGGTTTAAGTCAACTTATTCAAAAATGTCTTCAACCCTGCTG GTCGAGACAAGAAATCTTTATGGGGTAGTTGGAGCTGAAAGCAGGTCTGCACCTGTTCAGCATTTGGCAGGATGGCAAGCGGAGGAGCAG CAGGGTGAAACTGACACAGTTCTGTCTGCAGCGGCTCTTTGTGTTGGAGTTGGGAGTTTCGCTGATCCAGATGACCTGCCGGGGCTGGCA CACTTTTTGGAGCACATGGTATTCATGGGTAGTTTGAAATATCCAGATGAGAATGGATTTGATGCCTTCCTGAAGAAGCATGGGGGTAGT GATAATGCCTCAACTGATTGTGAACGCACTGTCTTTCAGTTTGATGTCCAGAGGAAGTACTTCAAGGAAGCTCTTGATAGATGGGCGCAG TTCTTCATCCACCCACTAATGATCAGAGATGCAATTGACCGTGAAGTTGAAGCTGTTGATAGTGAATATCAACTTGCAAGGCCTTCTGAT GCAAACAGAAAGGAAATGTTGTTTGGAAGCCTTGCTAGACCTGGACATCCTATGGGAAAATTTTTTTGGGGAAATGCTGAGACGCTCAAG CATGAGCCAAGAAAGAATAATATTGATACACATGCTAGATTGAGAGAATTCTGGATGCGTTACTACTCTTCTCATTACATGACTTTAGTG GTTCAATCCAAAGAAACACTGGATACTTTGGAAAAGTGGGTGACTGAAATCTTCTCTCAGATACCAAACAATGGGTTACCCAGACCAAAC TTTGGCCATTTAACGGATCCATTTGACACACCAGCATTTAACAAACTTTATAGAGTTGTTCCAATCAGAAAAATTCATGCTCTGACCATC ACATGGGCACTTCCTCCTCAACAGCAACATTACAGGGTGAAGCCACTTCATTATATATCCTGGCTGGTTGGACATGAAGGCAAAGGCAGC ATTCTTTCTTTCCTTAGGAAAAAATGCTGGGCTCTTGCACTGTTTGGTGGAAATGGTGAGACAGGATTTGAGCAAAATTCTACTTATTCA GTGTTCAGCATTTCTATTACATTGACTGATGAGGGTTATGAACATTTTTATGAGGTTGCTTACACTGTCTTTCAGTATTTAAAAATGCTG CAGAAGCTAGGCCCAGAAAAAAGAATTTTTGAAGAGATTCGGAAAATTGAGGATAATGAATTTCATTACCAAGAACAGACAGATCCAGTT GAGTATGTGGAAAACATGTGTGAGAACATGCAGCTGTACCCATTGCAGGACATTCTCACTGGAGATCAGCTTCTTTTTGAATACAAGCCA GAAGTCATTGGTGAAGCCTTGAATCAGCTAGTTCCTCAAAAAGCAAATCTTGTTTTACTGTCTGGTGCTAATGAGGGAAAATGTGACCTC AAGGAGAAATGGTTTGGAACTCAATATAGTATAGAAGATATTGAAAACTCTTGGGCTGAACTGTGGAATAGTAATTTCGAATTAAATCCA GATCTTCATCTTCCAGCTGAAAACAAGTACATAGCCACGGACTTTACGTTGAAGGCTTTCGATTGCCCGGAAACAGAATACCCAGTTAAA ATTGTGAATACTCCACAAGGTTGCCTGTGGTATAAGAAAGACAACAAATTCAAAATCCCCAAAGCATATATACGTTTCCATCTAATTTCA CCGTTGATACAGAAATCTGCAGCAAATGTGGTCCTCTTTGATATCTTTGTCAATATCCTTACGCATAACCTTGCGGAACCAGCTTATGAA GCAGATGTGGCACAGCTGGAGTATAAACTGGTAGCTGGAGAACATGGTTTAATTATTCGAGTGAAAGGATTTAACCACAAACTACCTCTA CTGTTTCAGCTCATTATTGACTACTTAGCTGAGTTCAATTCCACACCAGCTGTCTTTACAATGATAACTGAGCAGTTGAAGAAGACCTAC TTTAACATCCTCATCAAGCCCGAGACTTTGGCCAAAGATGTACGGCTTTTAATCTTGGAATATGCCCGTTGGTCTATGATTGACAAGTAC CAGGCTTTGATGGACGGCCTTTCCCTTGAGTCTCTGCTGAGCTTCGTCAAAGAATTCAAATCCCAGCTCTTTGTGGAGGGCCTGGTACAA GGGAATGTCACAAGCACAGAATCTATGGATTTCCTGAAATATGTTGTTGACAAACTAAACTTCAAGCCTCTGGAGCAGGAGATGCCTGTG CAGTTCCAGGTGGTAGAGCTGCCCAGTGGCCACCATCTATGCAAAGTGAAAGCTCTGAACAAGGGTGATGCCAACTCTGAAGTCACTGTG TACTACCAGTCAGGTACCAGGAGTCTAAGAGAATATACGCTTATGGAGCTGCTTGTGATGCAGTGGCAGAACGTGGAGCACGTTGGTGAC CAGAGCCCCTACGTCACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTC ACTCAGTTCTGCGTTAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCA GAACAGCTGCTGCTGGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCC AGCTACACCAAGATCGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTT GTTGACAACTACATCAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAG AGCAGCATGCTGGAACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACA >In-frame_NRD1_ENST00000352171_chr1_52258049_-_VPS53_ENST00000437048_chr17_440416_-_3456nt ATGCTGAGGAGAGTCACTGTTGCTGCAGTCTGTGCCACCCGGAGGAAGTTGTGTGAGGCCGGGCGGGAGCTCGCGGCGCTCTGGGGAATC GAAACGCGGGGTCGGTGCGAAGACTCTGCTGCTGCCAGACCCTTTCCTATTCTGGCCATGCCTGGAAGGAACAAGGCGAAGTCTACCTGC AGCTGCCCTGACCTGCAGCCCAATGGACAGGATCTGGGCGAGAACAGCCGGGTTGCCCGTCTAGGAGCGGATGAATCTGAGGAAGAGGGA CGGAGGGGGTCTCTCAGTAATGCTGGGGACCCTGAGATCGTCAAGTCTCCCAGCGACCCCAAGCAATACCGATACATCAAATTACAGAAT GGCTTGCAGGCACTTCTGATTTCAGACCTAAGTAATATGGAAGGTAAAACAGGAAATACAACAGATGATGAAGAAGAAGAGGAGGTGGAG GAAGAAGAAGAAGATGATGATGAAGATTCTGGAGCTGAAATAGAAGATGACGATGAAGAGGGTTTTGATGATGAAGATGAGTTTGATGAT GAACATGATGATGATCTTGATACTGAGGATAATGAATTGGAAGAATTAGAAGAGAGAGCAGAAGCTAGAAAAAAAACTACTGAAAAACAG TCTGCAGCGGCTCTTTGTGTTGGAGTTGGGAGTTTCGCTGATCCAGATGACCTGCCGGGGCTGGCACACTTTTTGGAGCACATGGTATTC ATGGGTAGTTTGAAATATCCAGATGAGAATGGATTTGATGCCTTCCTGAAGAAGCATGGGGGTAGTGATAATGCCTCAACTGATTGTGAA CGCACTGTCTTTCAGTTTGATGTCCAGAGGAAGTACTTCAAGGAAGCTCTTGATAGATGGGCGCAGTTCTTCATCCACCCACTAATGATC AGAGATGCAATTGACCGTGAAGTTGAAGCTGTTGATAGTGAATATCAACTTGCAAGGCCTTCTGATGCAAACAGAAAGGAAATGTTGTTT GGAAGCCTTGCTAGACCTGGACATCCTATGGGAAAATTTTTTTGGGGAAATGCTGAGACGCTCAAGCATGAGCCAAGAAAGAATAATATT GATACACATGCTAGATTGAGAGAATTCTGGATGCGTTACTACTCTTCTCATTACATGACTTTAGTGGTTCAATCCAAAGAAACACTGGAT ACTTTGGAAAAGTGGGTGACTGAAATCTTCTCTCAGATACCAAACAATGGGTTACCCAGACCAAACTTTGGCCATTTAACGGATCCATTT GACACACCAGCATTTAACAAACTTTATAGAGTTGTTCCAATCAGAAAAATTCATGCTCTGACCATCACATGGGCACTTCCTCCTCAACAG CAACATTACAGGGTGAAGCCACTTCATTATATATCCTGGCTGGTTGGACATGAAGGCAAAGGCAGCATTCTTTCTTTCCTTAGGAAAAAA TGCTGGGCTCTTGCACTGTTTGGTGGAAATGGTGAGACAGGATTTGAGCAAAATTCTACTTATTCAGTGTTCAGCATTTCTATTACATTG ACTGATGAGGGTTATGAACATTTTTATGAGGTTGCTTACACTGTCTTTCAGTATTTAAAAATGCTGCAGAAGCTAGGCCCAGAAAAAAGA ATTTTTGAAGAGATTCGGAAAATTGAGGATAATGAATTTCATTACCAAGAACAGACAGATCCAGTTGAGTATGTGGAAAACATGTGTGAG AACATGCAGCTGTACCCATTGCAGGACATTCTCACTGGAGATCAGCTTCTTTTTGAATACAAGCCAGAAGTCATTGGTGAAGCCTTGAAT CAGCTAGTTCCTCAAAAAGCAAATCTTGTTTTACTGTCTGGTGCTAATGAGGGAAAATGTGACCTCAAGGAGAAATGGTTTGGAACTCAA TATAGTATAGAAGATATTGAAAACTCTTGGGCTGAACTGTGGAATAGTAATTTCGAATTAAATCCAGATCTTCATCTTCCAGCTGAAAAC AAGTACATAGCCACGGACTTTACGTTGAAGGCTTTCGATTGCCCGGAAACAGAATACCCAGTTAAAATTGTGAATACTCCACAAGGTTGC CTGTGGTATAAGAAAGACAACAAATTCAAAATCCCCAAAGCATATATACGTTTCCATCTAATTTCACCGTTGATACAGAAATCTGCAGCA AATGTGGTCCTCTTTGATATCTTTGTCAATATCCTTACGCATAACCTTGCGGAACCAGCTTATGAAGCAGATGTGGCACAGCTGGAGTAT AAACTGGTAGCTGGAGAACATGGTTTAATTATTCGAGTGAAAGGATTTAACCACAAACTACCTCTACTGTTTCAGCTCATTATTGACTAC TTAGCTGAGTTCAATTCCACACCAGCTGTCTTTACAATGATAACTGAGCAGTTGAAGAAGACCTACTTTAACATCCTCATCAAGCCCGAG ACTTTGGCCAAAGATGTACGGCTTTTAATCTTGGAATATGCCCGTTGGTCTATGATTGACAAGTACCAGGCTTTGATGGACGGCCTTTCC CTTGAGTCTCTGCTGAGCTTCGTCAAAGAATTCAAATCCCAGCTCTTTGTGGAGGGCCTGGTACAAGGGAATGTCACAAGCACAGAATCT ATGGATTTCCTGAAATATGTTGTTGACAAACTAAACTTCAAGCCTCTGGAGCAGGAGATGCCTGTGCAGTTCCAGGTGGTAGAGCTGCCC AGTGGCCACCATCTATGCAAAGTGAAAGCTCTGAACAAGGGTGATGCCAACTCTGAAGTCACTGTGTACTACCAGTCAGGTACCAGGAGT CTAAGAGAATATACGCTTATGGAGCTGCTTGTGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAGAGCCCCTACGTCACCTCTGTC ATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACTCAGTTCTGCGTTAAATTTGCA AACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAACAGCTGCTGCTGGACACCCAC TCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGCTACACCAAGATCGTTGTCAAA GGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTTGACAACTACATCAAACTTCTC ACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGCAGCATGCTGGAACTCCTGCGC CAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCAGAGCAAGAGTCGTCACGCATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NRD1_ENST00000354831_chr1_52258049_-_VPS53_ENST00000437048_chr17_440416_-_14310nt AGTAGCGTCATCGGCGGCCGGGAGGGCGGAGGGACGAGGGAAGTCGGCGAGAGGGAGACTGGGTTGGGGGAGGGGTTCAGGCCTGTTCCC CGCGGCTGCGGCAGCACCAGGGCCGGCCGCCACCGCCTCTAGAACGCGGAGGAGGTGGGTCCTGGGAAGCGGGATGTCCATCGCTCCAGC TTGGTGGTGAATGCTGAGGAGAGTCACTGTTGCTGCAGTCTGTGCCACCCGGAGGAAGTTGTGTGAGGCCGGGCGGGAGCTCGCGGCGCT CTGGGGAATCGAAACGCGGGGTCGGTGCGAAGACTCTGCTGCTGCCAGACCCTTTCCTATTCTGGCCATGCCTGGAAGGAACAAGGCGAA GTCTACCTGCAGCTGCCCTGACCTGCAGCCCAATGGACAGGATCTGGGCGAGAACAGCCGGGTTGCCCGTCTAGGAGCGGATGAATCTGA GGAAGAGGGACGGAGGGGGTCTCTCAGTAATGCTGGGGACCCTGAGATCGTCAAGTCTCCCAGCGACCCCAAGCAATACCGATACATCAA ATTACAGAATGGCTTGCAGGCACTTCTGATTTCAGACCTAAGTAATATGGAAGGTAAAACAGGAAATACAACAGATGATGAAGAAGAAGA GGAGGTGGAGGAAGAAGAAGAAGATGATGATGAAGATTCTGGAGCTGAAATAGAAGATGACGATGAAGAGGGTTTTGATGATGAAGATGA GTTTGATGATGAACATGATGATGATCTTGATACTGAGGATAATGAATTGGAAGAATTAGAAGAGAGAGCAGAAGCTAGAAAAAAAACTAC TGAAAAACAGCAATTGCAGAGCCTGTTTTTGCTGTGGTCAAAGCTGACTGATAGACTGTGGTTTAAGTCAACTTATTCAAAAATGTCTTC AACCCTGCTGGTCGAGACAAGAAATCTTTATGGGGTAGTTGGAGCTGAAAGCAGGTCTGCACCTGTTCAGCATTTGGCAGGATGGCAAGC GGAGGAGCAGCAGGGTGAAACTGACACAGTTCTGTCTGCAGCGGCTCTTTGTGTTGGAGTTGGGAGTTTCGCTGATCCAGATGACCTGCC GGGGCTGGCACACTTTTTGGAGCACATGGTATTCATGGGTAGTTTGAAATATCCAGATGAGAATGGATTTGATGCCTTCCTGAAGAAGCA TGGGGGTAGTGATAATGCCTCAACTGATTGTGAACGCACTGTCTTTCAGTTTGATGTCCAGAGGAAGTACTTCAAGGAAGCTCTTGATAG ATGGGCGCAGTTCTTCATCCACCCACTAATGATCAGAGATGCAATTGACCGTGAAGTTGAAGCTGTTGATAGTGAATATCAACTTGCAAG GCCTTCTGATGCAAACAGAAAGGAAATGTTGTTTGGAAGCCTTGCTAGACCTGGACATCCTATGGGAAAATTTTTTTGGGGAAATGCTGA GACGCTCAAGCATGAGCCAAGAAAGAATAATATTGATACACATGCTAGATTGAGAGAATTCTGGATGCGTTACTACTCTTCTCATTACAT GACTTTAGTGGTTCAATCCAAAGAAACACTGGATACTTTGGAAAAGTGGGTGACTGAAATCTTCTCTCAGATACCAAACAATGGGTTACC CAGACCAAACTTTGGCCATTTAACGGATCCATTTGACACACCAGCATTTAACAAACTTTATAGAGTTGTTCCAATCAGAAAAATTCATGC TCTGACCATCACATGGGCACTTCCTCCTCAACAGCAACATTACAGGGTGAAGCCACTTCATTATATATCCTGGCTGGTTGGACATGAAGG CAAAGGCAGCATTCTTTCTTTCCTTAGGAAAAAATGCTGGGCTCTTGCACTGTTTGGTGGAAATGGTGAGACAGGATTTGAGCAAAATTC TACTTATTCAGTGTTCAGCATTTCTATTACATTGACTGATGAGGGTTATGAACATTTTTATGAGGTTGCTTACACTGTCTTTCAGTATTT AAAAATGCTGCAGAAGCTAGGCCCAGAAAAAAGAATTTTTGAAGAGATTCGGAAAATTGAGGATAATGAATTTCATTACCAAGAACAGAC AGATCCAGTTGAGTATGTGGAAAACATGTGTGAGAACATGCAGCTGTACCCATTGCAGGACATTCTCACTGGAGATCAGCTTCTTTTTGA ATACAAGCCAGAAGTCATTGGTGAAGCCTTGAATCAGCTAGTTCCTCAAAAAGCAAATCTTGTTTTACTGTCTGGTGCTAATGAGGGAAA ATGTGACCTCAAGGAGAAATGGTTTGGAACTCAATATAGTATAGAAGATATTGAAAACTCTTGGGCTGAACTGTGGAATAGTAATTTCGA ATTAAATCCAGATCTTCATCTTCCAGCTGAAAACAAGTACATAGCCACGGACTTTACGTTGAAGGCTTTCGATTGCCCGGAAACAGAATA CCCAGTTAAAATTGTGAATACTCCACAAGGTTGCCTGTGGTATAAGAAAGACAACAAATTCAAAATCCCCAAAGCATATATACGTTTCCA TCTAATTTCACCGTTGATACAGAAATCTGCAGCAAATGTGGTCCTCTTTGATATCTTTGTCAATATCCTTACGCATAACCTTGCGGAACC AGCTTATGAAGCAGATGTGGCACAGCTGGAGTATAAACTGGTAGCTGGAGAACATGGTTTAATTATTCGAGTGAAAGGATTTAACCACAA ACTACCTCTACTGTTTCAGCTCATTATTGACTACTTAGCTGAGTTCAATTCCACACCAGCTGTCTTTACAATGATAACTGAGCAGTTGAA GAAGACCTACTTTAACATCCTCATCAAGCCCGAGACTTTGGCCAAAGATGTACGGCTTTTAATCTTGGAATATGCCCGTTGGTCTATGAT TGACAAGTACCAGGCTTTGATGGACGGCCTTTCCCTTGAGTCTCTGCTGAGCTTCGTCAAAGAATTCAAATCCCAGCTCTTTGTGGAGGG CCTGGTACAAGGGAATGTCACAAGCACAGAATCTATGGATTTCCTGAAATATGTTGTTGACAAACTAAACTTCAAGCCTCTGGAGCAGGA GATGCCTGTGCAGTTCCAGGTGGTAGAGCTGCCCAGTGGCCACCATCTATGCAAAGTGAAAGCTCTGAACAAGGGTGATGCCAACTCTGA AGTCACTGTGTACTACCAGTCAGGTACCAGGAGTCTAAGAGAATATACGCTTATGGAGCTGCTTGTGATGCAGTGGCAGAACGTGGAGCA CGTTGGTGACCAGAGCCCCTACGTCACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACG CAAGTACTTCACTCAGTTCTGCGTTAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCAT GGTGGGAGCAGAACAGCTGCTGCTGGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAA GGCACCCGCCAGCTACACCAAGATCGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTT GGTGGTGTTTGTTGACAACTACATCAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAG GAGTGAGCAGAGCAGCATGCTGGAACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGAC GGCGCCAACACCAGAGCAAGAGTCGTCACGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTG CTCCTGGCTGGAGACCCTCAGCGCCCGTTCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAAC TTCCTGGGACATGTGGGTTGTTACTGAGTCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTC TAAGAGGGCGATTTAGGTGATCTCTGGTTCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTC CCCATGGCAGTCACACCCTCTTGACACGTGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTG TCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGA GTATCGGATTACAGGCGTGAGCCACCGAGCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAAC CAGGAAGTTCACTTGGAAGACGTTTCCTAGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTT CTGCCCACTCACCTTCAGGTCCACAGCACTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTG TTATGAGAAGGAGTCTGGGGTTCTGGATGCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCT GCCCGCCCCCCCCGCCCTTCCTGTCCACCGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGC ATCCAGAGAATGGCAGCATATCAAGCCGTTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACA GGCAAACCGCTGCTGTTGCTGCCTGCTTTTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGG AGACCAAGGCAGGAGGATCACTTGAGTCCAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGT GTGGTGGCATGCACCTGTAGTCCCAACTGCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAAC CTGGCAAAACCAAAAATACAAAAAATTGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCA CCTGAGGTCAGGAATTCGAGACCAGCCTGCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCG AGTGCCTGTAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACC ACTGCACTCCAGCCTGGGTGACAGAGCAAGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTA ACAGCCGTACAGTAGGAATAAGGTTTGGAAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCT GTGCCCCTGCCCTCTCTGCCAGGCTTTCTCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCT TGCTAGCTGGTTTGACTCTCACGCATCAAGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTT CAGTTGAGGTCTATTAGGAAAAGATTCCAAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCC CACCCCAGCCCATGGAGTTGCTATGGTTAAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCA GTTCAGCCGTCTGTCCTCAACCCAGGAGAGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGA TCACCACTTCTCTTTTTGGTTCATTGTTGAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACA GTTGGTGGTCACAGCCAGGGAAGTTGCTGTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCT GTTAAATGTCTCCTTGATGGGGACTCAGTACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTT AAAATCTACAGATGCCGGCCGGGCGCCGTGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGA AATTGAGACCATCCTTGCCAATATGGTGAAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAG CTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGG CGACAGAGTGAGACTCTATCTCAAAACAAACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAG GTTTAAAAGTTCCATAGGTAGTTATAACGTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCA CGCATTTTCATACATGTCTATTTTTCTGACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTC TACTGATAACAGCTTTCATTTTAAACTTGTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGG CGGATCACATGAGGTCACGAGTTTGAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAA AGCAGGCAGGTGGCGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTG AGCCGAGGTCCCGCCACTGCACTCCAGCCTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGC CCAGGATTGGGCTCTCTCCATACTGATGAGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTC AAAAATAACGTATCAAAGGGGCACCCTAGGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGAT TGCTTGAGCCCAGGACTTCAAGACAAGCCTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACT GGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGT CTTTACTAAAAATACAAAATTAGCCAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAA CCCAGGAGGCAGAGGCTGCAGTGAGCCGAGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGT AAAAGGAGTACCTGTGGATGAAAGCAGCAGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCA TTTTCTGTAGCCCCTTTAAAAACCAAAAAACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGA GTTCACTCTGCTCTTACTGAGGGGACTTGTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATG AAACAGGAGCCGCAATGGACAAGGTGTTCTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAG AACAAAGAGCCAGTACCCAGGGCTCTGCCCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGA CAGGACTGAGAGCAGACAAGCTGAGACCAGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAG GGTATGACACCAACCCTTCCTGAATTGCCATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCAC AGCTGGAAATGGGGTTCCTTCTCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAA CCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAAT AACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGA ATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCG GAATAACCTGCTGGAAATGGGGTTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACT CGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCA CTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAG CACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAG AGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGA AGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAG GAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCT AGGAAGAGCACTCAGAACAACCTGCCTGCTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATA AAATAGAGCTCCAATGGGCAATTTAAGCAAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTT ATATATTAAATAAAAATTCCCAGTCCTGTTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAA ATTTCCTTAAAATAAAGGGATTGCTTCTTTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACA AAATACTGCAGTTAATTAAAGCATTACTGGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAA AGAAGTAGCAAGTCCGTGACCCTGGCCGCTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAA TGTGGCCGACTGAGCCCAGTCCTGACCTGCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAAC CCTACTTGCCCTGTGAATTTCTATCCTGTGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAA GTGATTTCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTG TCCTTTAGTGATTTCTCTCCTGCACGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAA GTCCTGTGTCCTTTCAACAGGGGAAAACTGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAAC AGCTCCCCACTTTACTAGGGAAGCCAAGGGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAG CTCCTTCCTTCTCACCTATGTGAACAGGAGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAA AGCAGCCTGGGATTGGAAGCATCCACAGAAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATC CCCTGAGCATCCATTTTCAATATTGGTGAGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGC TCTGCCATAAGGCAGTGTGAAGTGTGTTCGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGG ATGAGTGGTGACAAATCCTGCGGCCGTGTGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGT AATATCAAGCTTACACGAGAGTTTTAAAAGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCT GCAGACACTGAGAAGAGAGCTTCCTCCCTCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGA ATTGCGAGGGTTGCCAAAGCCTCCCTTCCAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAA ATTCTTGCCTGCCTTTCTTTTTCTTTTTTTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAA AAAACTAAGCAAGATTAACTTGGGACAGGCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCA AAGATGTTTAGACTTTTCCCAAGGCCAGCTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGT TGACTCAGAGAACCTGGGGCAATATGAGATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGA GGGTTCTGGGAGCTTCTGCTCAGTCATCAAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAAT TAAGAACAGCTTCTCAACAAACTTCCCTCTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTG AAATGGTGGCAAGAAACCCCAGCTCCCTTCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATT CCACAGGGTTCTTCACAAAATCAAGCACTGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAA ATGCTATATAAAGAAAACATCTGTTTACACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAG TTTACACACAGAGCCCCCCACAACCTCATACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCAC AGCCTCATACCCATGCCTGTCACATCTTTGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGA GGGTGCTGAGGGGAGTGGAGGTCAGTTGGGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAG GTCATGAGAGGGCCTGGGCAATTCAGTGCTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGA TACATTATCTCATCGGATGAAATTCCTGCTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCC AAGGATATGTGCCTAGTGAGGGGTGAGCCAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGT CAGCCAGGATTTCATATGGGACTAGTAAGGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACT AGTGAGGGGCGAGCCAGGATTCGATATGTGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGA TATGTGACTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCC AGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAG GGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTG ACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATT TGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGG GGTTAGCCAGTCAGGATTTGATATGTGGCTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATA CGTGACAAGTGAGGGGTGAGCCAGGATTCAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAG GATGCGATACGTGACCAGTGAGGGGCGAGCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGA GTGAGCCAGGATTTGATATGTGGCTACTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGAC TAGTCAGGGGGTCAGCCAGGATTCGATACGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTT GACATGTGACTAGTGAGGGGTGAGCCAGGATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAG CCAGGATTTGATATGTGGCTAGTAAGGGGTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACT AGTAAGGGGGTGAGGCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTT GATATGTGACTAGTGAGGGGTGAGCCAGGATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACAT CCATGCCTTTTGTACTTCACCAGCAGTTTTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATT TTATGAATACATTTTATGAGTTCAAATATTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAA CCAAGGTTATGGATGAAAATGTGTGTGTATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAG AATTTTCAAATAGTATCCATTTTGTTTTGTTTTAAACAGCTCTTCTTGCAATGGTAGAGGCTCTTCAATTAAACAGAGATGGTAACAGGC >In-frame_NRD1_ENST00000352171_chr1_52258049_-_VPS53_ENST00000437048_chr17_440416_-_14106nt AGTAGCGTCATCGGCGGCCGGGAGGGCGGAGGGACGAGGGAAGTCGGCGAGAGGGAGACTGGGTTGGGGGAGGGGTTCAGGCCTGTTCCC CGCGGCTGCGGCAGCACCAGGGCCGGCCGCCACCGCCTCTAGAACGCGGAGGAGGTGGGTCCTGGGAAGCGGGATGTCCATCGCTCCAGC TTGGTGGTGAATGCTGAGGAGAGTCACTGTTGCTGCAGTCTGTGCCACCCGGAGGAAGTTGTGTGAGGCCGGGCGGGAGCTCGCGGCGCT CTGGGGAATCGAAACGCGGGGTCGGTGCGAAGACTCTGCTGCTGCCAGACCCTTTCCTATTCTGGCCATGCCTGGAAGGAACAAGGCGAA GTCTACCTGCAGCTGCCCTGACCTGCAGCCCAATGGACAGGATCTGGGCGAGAACAGCCGGGTTGCCCGTCTAGGAGCGGATGAATCTGA GGAAGAGGGACGGAGGGGGTCTCTCAGTAATGCTGGGGACCCTGAGATCGTCAAGTCTCCCAGCGACCCCAAGCAATACCGATACATCAA ATTACAGAATGGCTTGCAGGCACTTCTGATTTCAGACCTAAGTAATATGGAAGGTAAAACAGGAAATACAACAGATGATGAAGAAGAAGA GGAGGTGGAGGAAGAAGAAGAAGATGATGATGAAGATTCTGGAGCTGAAATAGAAGATGACGATGAAGAGGGTTTTGATGATGAAGATGA GTTTGATGATGAACATGATGATGATCTTGATACTGAGGATAATGAATTGGAAGAATTAGAAGAGAGAGCAGAAGCTAGAAAAAAAACTAC TGAAAAACAGTCTGCAGCGGCTCTTTGTGTTGGAGTTGGGAGTTTCGCTGATCCAGATGACCTGCCGGGGCTGGCACACTTTTTGGAGCA CATGGTATTCATGGGTAGTTTGAAATATCCAGATGAGAATGGATTTGATGCCTTCCTGAAGAAGCATGGGGGTAGTGATAATGCCTCAAC TGATTGTGAACGCACTGTCTTTCAGTTTGATGTCCAGAGGAAGTACTTCAAGGAAGCTCTTGATAGATGGGCGCAGTTCTTCATCCACCC ACTAATGATCAGAGATGCAATTGACCGTGAAGTTGAAGCTGTTGATAGTGAATATCAACTTGCAAGGCCTTCTGATGCAAACAGAAAGGA AATGTTGTTTGGAAGCCTTGCTAGACCTGGACATCCTATGGGAAAATTTTTTTGGGGAAATGCTGAGACGCTCAAGCATGAGCCAAGAAA GAATAATATTGATACACATGCTAGATTGAGAGAATTCTGGATGCGTTACTACTCTTCTCATTACATGACTTTAGTGGTTCAATCCAAAGA AACACTGGATACTTTGGAAAAGTGGGTGACTGAAATCTTCTCTCAGATACCAAACAATGGGTTACCCAGACCAAACTTTGGCCATTTAAC GGATCCATTTGACACACCAGCATTTAACAAACTTTATAGAGTTGTTCCAATCAGAAAAATTCATGCTCTGACCATCACATGGGCACTTCC TCCTCAACAGCAACATTACAGGGTGAAGCCACTTCATTATATATCCTGGCTGGTTGGACATGAAGGCAAAGGCAGCATTCTTTCTTTCCT TAGGAAAAAATGCTGGGCTCTTGCACTGTTTGGTGGAAATGGTGAGACAGGATTTGAGCAAAATTCTACTTATTCAGTGTTCAGCATTTC TATTACATTGACTGATGAGGGTTATGAACATTTTTATGAGGTTGCTTACACTGTCTTTCAGTATTTAAAAATGCTGCAGAAGCTAGGCCC AGAAAAAAGAATTTTTGAAGAGATTCGGAAAATTGAGGATAATGAATTTCATTACCAAGAACAGACAGATCCAGTTGAGTATGTGGAAAA CATGTGTGAGAACATGCAGCTGTACCCATTGCAGGACATTCTCACTGGAGATCAGCTTCTTTTTGAATACAAGCCAGAAGTCATTGGTGA AGCCTTGAATCAGCTAGTTCCTCAAAAAGCAAATCTTGTTTTACTGTCTGGTGCTAATGAGGGAAAATGTGACCTCAAGGAGAAATGGTT TGGAACTCAATATAGTATAGAAGATATTGAAAACTCTTGGGCTGAACTGTGGAATAGTAATTTCGAATTAAATCCAGATCTTCATCTTCC AGCTGAAAACAAGTACATAGCCACGGACTTTACGTTGAAGGCTTTCGATTGCCCGGAAACAGAATACCCAGTTAAAATTGTGAATACTCC ACAAGGTTGCCTGTGGTATAAGAAAGACAACAAATTCAAAATCCCCAAAGCATATATACGTTTCCATCTAATTTCACCGTTGATACAGAA ATCTGCAGCAAATGTGGTCCTCTTTGATATCTTTGTCAATATCCTTACGCATAACCTTGCGGAACCAGCTTATGAAGCAGATGTGGCACA GCTGGAGTATAAACTGGTAGCTGGAGAACATGGTTTAATTATTCGAGTGAAAGGATTTAACCACAAACTACCTCTACTGTTTCAGCTCAT TATTGACTACTTAGCTGAGTTCAATTCCACACCAGCTGTCTTTACAATGATAACTGAGCAGTTGAAGAAGACCTACTTTAACATCCTCAT CAAGCCCGAGACTTTGGCCAAAGATGTACGGCTTTTAATCTTGGAATATGCCCGTTGGTCTATGATTGACAAGTACCAGGCTTTGATGGA CGGCCTTTCCCTTGAGTCTCTGCTGAGCTTCGTCAAAGAATTCAAATCCCAGCTCTTTGTGGAGGGCCTGGTACAAGGGAATGTCACAAG CACAGAATCTATGGATTTCCTGAAATATGTTGTTGACAAACTAAACTTCAAGCCTCTGGAGCAGGAGATGCCTGTGCAGTTCCAGGTGGT AGAGCTGCCCAGTGGCCACCATCTATGCAAAGTGAAAGCTCTGAACAAGGGTGATGCCAACTCTGAAGTCACTGTGTACTACCAGTCAGG TACCAGGAGTCTAAGAGAATATACGCTTATGGAGCTGCTTGTGATGCAGTGGCAGAACGTGGAGCACGTTGGTGACCAGAGCCCCTACGT CACCTCTGTCATTCTGCACATCAAGCAGAACGTCCCCATCATCCGTGACAACCTGGCTTCCACACGCAAGTACTTCACTCAGTTCTGCGT TAAATTTGCAAACTCCTTCATTCCCAAATTCATCACCCACCTCTTCAAGTGCAAGCCAATTAGCATGGTGGGAGCAGAACAGCTGCTGCT GGACACCCACTCGCTGAAGATGGTCCTGCTCGATCTCCCCTCCATCAGCTCGCAGGTGGTGAGGAAGGCACCCGCCAGCTACACCAAGAT CGTTGTCAAAGGCATGACCCGGGCTGAGATGATCCTCAAGGTAGTGATGGCCCCTCATGAACCGTTGGTGGTGTTTGTTGACAACTACAT CAAACTTCTCACAGACTGCAACACAGAAACCTTTCAGAAGATACTGGACATGAAGGGGCTGAAGAGGAGTGAGCAGAGCAGCATGCTGGA ACTCCTGCGCCAGCGGCTCCCCGCACCGCCCTCGGGGGCAGAAAGCTCCGGCTCACTGTCCCTGACGGCGCCAACACCAGAGCAAGAGTC GTCACGCATCCGCAAGCTCGAGAAACTCATTAAAAAGAGACTGTAGCAGCAGCAAGGGGCCCTTTGCTCCTGGCTGGAGACCCTCAGCGC CCGTTCCCCAGAAGCCCCCAACCTCTCCTGTGCTCCCCGGCACTCTCACATCGTCGGTCTTCAAACTTCCTGGGACATGTGGGTTGTTAC TGAGTCTCTCCCATGCCCTGTCTTACTTCCTGCCCTAATCGGAGACGCTGAGTAAGGGCTGGGCTCTAAGAGGGCGATTTAGGTGATCTC TGGTTCGTGAAGCAGAGGCAGCAGTGGAGGATAGGTCCCTGAGCTGCCCTTGACTCATGTAGCCTCCCCATGGCAGTCACACCCTCTTGA CACGTGGGCCCCACCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGC GTGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTATCGGATTACAGGCGTGAGCCA CCGAGCCCAGCCCCTTCCTCCATTTCTTTACTCCCACCCTGCTCCTGGTTTCTAGGGAAGGGAAACCAGGAAGTTCACTTGGAAGACGTT TCCTAGGTTTTCTCATCAGATGAAGCCATGGGAACGCCCAGGAAGTCCATACTCTCAAACCCCTTTCTGCCCACTCACCTTCAGGTCCAC AGCACTTTCCAGCGTCATCTGAAATAGCAAAGGTGATGTGCAGCATCCCAGTGATGTGTTCCTGTGTTATGAGAAGGAGTCTGGGGTTCT GGATGCCTCAGGAACAGAATATGGACCTTAAAGACCAGGCTGAGAGCCTGGCCTGGCACGCAGCCTGCCCGCCCCCCCCGCCCTTCCTGT CCACCGCGGGCTCTCTGCAGCAGGGCTTGCCGAAGAGACTGCTCCCGACCTCTCATGTCATCCTGCATCCAGAGAATGGCAGCATATCAA GCCGTTAACCCTGATTCACTCGGTTCCCTTGAAACCAGGCCTCAGTTAACCATGACCACAGCTACAGGCAAACCGCTGCTGTTGCTGCCT GCTTTTGCTGAAGAATGATATCTTGCCAGGCACGGCGGCTCATGCCTGTAGTCGCAACACTTTGGGAGACCAAGGCAGGAGGATCACTTG AGTCCAGGAGTTTGAGACCAGCCTGGGCAACATACAGATGTCTACAAAAATAAAAATTTGCAAGGTGTGGTGGCATGCACCTGTAGTCCC AACTGCTAGGGAGGCTGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCAGTCTGGGCAACCTGGCAAAACCAAAAATACAAAAA ATTGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAATTCGAGACCA GCCTGCCCAACATGGCGAAACCCTGTCTCAACTAAAAATAAAAAAAATTAGCCGGGTGTCATGGCGAGTGCCTGTAATCCCAGCTACTGG GGAGGCTGAGGCAGGAGAATCACTTAAACCCGGGAGGTGGAGGCTGCAGTGAGCCAAGATTTCACCACTGCACTCCAGCCTGGGTGACAG AGCAAGACCCCTTCTCAAAAAGTTTTCAGGATAGAGGAAATTTCCTTAAAATCCATAAAACTTGTAACAGCCGTACAGTAGGAATAAGGT TTGGAAATCTGCCTGGAAACCTGATTTCCTCATCCCCACCTTGTTTCCCAACATAACCACTGCTCTGTGCCCCTGCCCTCTCTGCCAGGC TTTCTCCCCGATGCCGTCCAGCTCTGATCCTGAGTGTCATTTCTTCATCGGCTTCCAGGCTGTCCTTGCTAGCTGGTTTGACTCTCACGC ATCAAGCGTCTCAAATTTGAGAATGCGGAGGAGAAAAGAAGTGTTGCGAGAAGGAGATGCGGCCTTCAGTTGAGGTCTATTAGGAAAAGA TTCCAAATAAGACAAGGGCGGGGGGCGGCAGTCGGGAGAGCCCCCAGGAAGCCCTGTAGATGCCCCCACCCCAGCCCATGGAGTTGCTAT GGTTAAGCAGCCTGAGCCGTACAGTTGAAAAGGGGCGGTGGGGCCCATCTCCAAATAGCACAGCCAGTTCAGCCGTCTGTCCTCAACCCA GGAGAGCTGGGAAAGCCAGTGGACTCCTGCACCTGGTTCTTGTCACTCCTGGCGTTTGTGTACAGATCACCACTTCTCTTTTTGGTTCAT TGTTGAGGAGTCGTTTTCCGGACGGCTCCATCACAGCATTGAGCTATCAAGCTGCTGTTTTCCACAGTTGGTGGTCACAGCCAGGGAAGT TGCTGTCTTGATTTGTTACATTGTCAGTAATCCCCAAGGAACCAATGGATGTCAGTAGGAGTTTCTGTTAAATGTCTCCTTGATGGGGAC TCAGTACTGTGTAGAGACGCTGTGTTTCTCTTCTGGGGGTGTGCATCAGAACCACTGGGGCCTTTTAAAATCTACAGATGCCGGCCGGGC GCCGTGGCTCACGCCTGGAATCCCAGCACTTGGGGAGGCTGAGGCGGGCGGATCACAAGCGCAGGAAATTGAGACCATCCTTGCCAATAT GGTGAAACCCCATCTCTACAAAAAATACAAAAATTACCGGGGTGTGGTGGCGTGCACACCTCCCAGCTACTTGGGAGGCTGAGGCAGGAG AATCGCTTGAACCCGGGAGGCAAAGATTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCGACAGAGTGAGACTCTATCTCAA AACAAACAAAAAAACAGATGCCCGGAGATTTTGAGTCAGTAAGTTTGGATGGGGCCTGGCATACAGGTTTAAAAGTTCCATAGGTAGTTA TAACGTTTACACCTTGTTAAGAACCACTGCAACAGAGAGATTTGCTTTATGGAAGGGCTCCTGCCACGCATTTTCATACATGTCTATTTT TCTGACTCTAAGCTAAAAGTGCGCCGACACTACACTTGAGCTGGTGCCAACGTGGTGAAGATTCTCTACTGATAACAGCTTTCATTTTAA ACTTGTGTTGGGTCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACATGAGGTCACGAGTTT GAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATACAAAAAAAAAAAAAAAAAAAGCAGGCAGGTGGCGGGTGCCTGT AATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCAGTTGAATCCGGGAGGCGGAGGTTGCAGTGAGCCGAGGTCCCGCCACTGCACTC CAGCCTGGGAGACAGAGTGAGACTCAGTTAAAAAAAAAAGACTTTTGGTGGTGGTGGGGACCATGCCCAGGATTGGGCTCTCTCCATACT GATGAGGATTCTTCTTGTTTTGATGACCAACCCCCAAGCAGAAGCTTTATTTATTAACATCACTTCAAAAATAACGTATCAAAGGGGCAC CCTAGGCCGGGTACTGTGGCATCACACCTGTAATGCCAGTGCTTTGAGAGGCTGAGGTGGGAAGATTGCTTGAGCCCAGGACTTCAAGAC AAGCCTGGGCAACAGAGTGAGACCCCATCTCTATTAAAAAATAGGCCGGGCATGGTGGCTCACACTGGTAATCCCAGCACTTTGGGAGGC CGAGGCAGGTGGATCATGTGAGGTCAGGAGTTCGAGACCAGCCTGGCCGACATGGTGAAACCCTGTCTTTACTAAAAATACAAAATTAGC CAGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCAGGAGGATCGCTTGAACCCAGGAGGCAGAGGCTGCAGTGA GCCGAGATCATGCCATTGCACTCCTGCCTGGGTGACGGAGCAAGACTCTCTAAAAAATAATAAGGTAAAAGGAGTACCTGTGGATGAAAG CAGCAGCTAACAGCTCTGTGATTCAGCTAGACCTAGATATTGTGCCCATTCCTTCCCCTCAGTCCATTTTCTGTAGCCCCTTTAAAAACC AAAAAACAACTTTGAAGTCACTTTGGGTTTAAAATAAATAGTGGTAATTTGTATAATCAATAAAGAGTTCACTCTGCTCTTACTGAGGGG ACTTGTCTGAAAGCTGGCTTAGCGGTGTCCAGGCCAGAGAACATCCTGTGTGGACTCTTAACAATGAAACAGGAGCCGCAATGGACAAGG TGTTCTGATCTCCAAACCCAGCTCAGGGATTGAAGCTAACTACCGCCACTCCTTCCTCTCTCGAAGAACAAAGAGCCAGTACCCAGGGCT CTGCCCACCCCCGAGAAGGGGTGCCTGATTTCTTATGTCTAGGGTGGCTCCTCTGTGCAGATCAGACAGGACTGAGAGCAGACAAGCTGA GACCAGCATGACCAGTACAGGGCACGCAGAGCGTGGGGGCAGGTCCGAGGCTGCTGCTCGATGCAGGGTATGACACCAACCCTTCCTGAA TTGCCATCGGATGAGGAGACCTGGTTCCCTGTTGAAAGAATGCCAGGGGAAATGCTGCATGTGCACAGCTGGAAATGGGGTTCCTTCTCT AGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGG CTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTTGGCTAGGAAGAGCACTCAGAATAACCTGCTGGAAATGGGATTCCTT ACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTACCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCC TTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGGTT CCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGA TTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGG GATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAAT GGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAA ATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGG AAATGGGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGAGATTCCTTCCCTAGGAAGAGCACTCGGAATAACCTGCT GGAAATGGGATTCCTTCGCTAGGAAGAGCACTCGGAATAACCTGCTGGAAATGGGATTCCTTCGCTAGGAAGAGCACTCAGAACAACCTG CCTGCTTGAGGGTGACAGCAAGTGTCTCACACTTCTCGTCTACTCCAAGTCAGATTCCTAAAAATAAAATAGAGCTCCAATGGGCAATTT AAGCAAAAGCCTTAGAAACATGGACACCTGAAATGCTGGCCTACATGAAGGGTACGATGACATTTTATATATTAAATAAAAATTCCCAGT CCTGTTTTAGTATTCATCAGAATAGCCTCTTGGACCCTCGAAGTTCTACACCTTTGGGAGATATAAATTTCCTTAAAATAAAGGGATTGC TTCTTTGTGTAAATAGCTTTCATTTTCTCCATCTGGAAGTGATTTCTGCCTGCATGTTGGAGCACAAAATACTGCAGTTAATTAAAGCAT TACTGGATGTCATTTGCTAGAATGTATTTCCTTACTGCTGACAGAAAACAGAACAGACTCTAGGAAAGAAGTAGCAAGTCCGTGACCCTG GCCGCTCCTGGTGGCTGCCCTTCTCCCTTCCCTGACAGTCTAAGGAAGCAACGCGTGGGAGCAGAATGTGGCCGACTGAGCCCAGTCCTG ACCTGCCCAGTTGCAGTGGAGCCTGTCTGTAATGTTGTGTAAAGTGTTTTGCTTCTGACTTGGAACCCTACTTGCCCTGTGAATTTCTAT CCTGTGAACCTTCCCTTCTCTGTCCTTACCGTTCCCATCACAGCCTGCTCTTCCAGTGACGGCCAAGTGATTTCTCTCCTGCACGCATGA GTCCATCCTGTTTCCTTAGTAGCTGGATGGACGTTTTGCCATGAAAACTCTTTGGGAAGTCTTGTGTCCTTTAGTGATTTCTCTCCTGCA CGCATGAGTCCATCCTGTTTCCTTAGTAGCTGGTTGGACGTTTTTGCCATGAAAACTCTTCGGGAAGTCCTGTGTCCTTTCAACAGGGGA AAACTGGCTGCGGCCCTTCCATTAGGCTCCAGGATCATTACCTCGTTTCCATTCTTTCTTTTCAACAGCTCCCCACTTTACTAGGGAAGC CAAGGGATCAACCTAATGAGAAAAGAACCTTCCCTGTAGCCCACCTGGAAGGGCATTGCCTGCCAGCTCCTTCCTTCTCACCTATGTGAA CAGGAGGGAAGATGCCGGCGATCCATGGATCTGTGGGACATGAAGGACGTGTCCATCAGAAATGAAAGCAGCCTGGGATTGGAAGCATCC ACAGAAGACTTGATCTGCAGGTCTTGATTTGGACCTGGCACTTTGACACCAGGCGAGTCACTGATCCCCTGAGCATCCATTTTCAATATT GGTGAGAGGGGATTATAATGAATATTGGCTGTGAAGGTCACACAAGACCGGGCTATATGCACTTGCTCTGCCATAAGGCAGTGTGAAGTG TGTTCGTGATCACTTGTGGGCGGGAGCCTGTGGCTGTCTTGCCTGGACTGGCTTTTTTAAACATGGATGAGTGGTGACAAATCCTGCGGC CGTGTGCAGGCTACATCCGCAGCGAGCTCCGCATATCTGGTCTTTGCCTTTTTAGGTCATGACTGTAATATCAAGCTTACACGAGAGTTT TAAAAGACTGAGCAGTATCCCCTTCCCCTGGCAGCTGCTGCTTCCGTAGCATTTAGGGATAAACCTGCAGACACTGAGAAGAGAGCTTCC TCCCTCCTGGGGCTGGTGGCGAGGCTGCCTGTTGTGGAAAATAGGGCATGTCTCCTGTGAATGCGAATTGCGAGGGTTGCCAAAGCCTCC CTTCCAAGAAACTTGCTTAGGTGTCTGGTGTCCACAGACCAGACTCTTCTCCCGACAGGGACAAAAATTCTTGCCTGCCTTTCTTTTTCT TTTTTTTCCTTTTACTTATTCTTGCCTTTTTTCTTCTTCTTCTTCTTTAGGTATGATGCCCCCCAAAAAACTAAGCAAGATTAACTTGGG ACAGGCAGTTCTAACTGGGAAGCCTGAGCTCACAGGCTGTTTGGATTACTTTCCAATTGTGTTTCAAAGATGTTTAGACTTTTCCCAAGG CCAGCTGAATCCTTATAATCAGCCCAAAAGTTCCTTTCTGTTTCTGTCTGTCCCCTTTGAGGGTGTTGACTCAGAGAACCTGGGGCAATA TGAGATGTTAAAATAAAAATAGCGTCCAACGTCCCGCCTCCTGGGAATGCTGCTCACTTCATCCGAGGGTTCTGGGAGCTTCTGCTCAGT CATCAAATGGAATTTGCACAATTGTCTTGCCTCCTGTTTTGGGTAATTTTTCAACAAGTGAGAAATTAAGAACAGCTTCTCAACAAACTT CCCTCTACTTCCAGGGCCAAGAAAAGTATTTGCAGTGTGGGCTGCAGCTTTCAGGGGTCTCAGGTGAAATGGTGGCAAGAAACCCCAGCT CCCTTCATGTGTTTGCCTTGCGCTGATGGAAAAGGAAGGCACTTCTCAGCTGCCAGAGACCACATTCCACAGGGTTCTTCACAAAATCAA GCACTGCAGTGGACCAACTGGAGCAGCCACTGGAGGGCTTTAGAAGGCAAATGGAATACATATCAAATGCTATATAAAGAAAACATCTGT TTACACAGAGTCCCCCACAGCCTCATACCTACACCCAATATCAAATGCTGTATAAAGAAACATCAGTTTACACACAGAGCCCCCCACAAC CTCATACCCACACCGAATATCAAATGCTATACAAAGAAACATCAGTTTACACACAGAGTCCCCCACAGCCTCATACCCATGCCTGTCACA TCTTTGCACAGCCCTAAAGGATCCAGAGCTTTGGATCAGCAGCTGGCTAGCTCGGAGGCCAGAGGAGGGTGCTGAGGGGAGTGGAGGTCA GTTGGGGTAGCCCTGGGCCCTGGCTGCACAGTCCAGCTGCTGTGTGGCCTGCATGTGGTATCTTAGGTCATGAGAGGGCCTGGGCAATTC AGTGCTATCTGTACATGTTGGTGGGGTGGGAAGGAAAAGGTAACTGTGTATTTACTGTGTCCTGGATACATTATCTCATCGGATGAAATT CCTGCTAAGTTAAGCTCCGTTTAGTGGACGGGACTTGGAGGCTCAAAGAGGGTAAGTGACAGGCCCAAGGATATGTGCCTAGTGAGGGGT GAGCCAGGATTCGATGTGTGACTAGTAAGGGGTCAGCCAGGATTCAATATGTGACTAGTAAGGGGTCAGCCAGGATTTCATATGGGACTA GTAAGGGGTCGGCCAGGATTTGATACGTGACTAGCAAGGGGACAAGCCAGGATTTGATATGTGACTAGTGAGGGGCGAGCCAGGATTCGA TATGTGACTAGTAAGGGGTCAGCCAAGATTTGATATGTGACTAGTGAGGGGCGAGACAGGATTTGATATGTGACTAGTGAGGGGCGAGCC AGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAG GGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTG ACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATT TGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGAGCCAGGATTTGATATGTGACTGGTGAGGGGCGA GCCAGGATTTGATATGTGACTGGTGAGGGGTGGAGCCAGTCAGGATTTGATATGTGGTTAGTGAGGGGTTAGCCAGTCAGGATTTGATAT GTGGCTAGTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGCCAGGATTCAATACGTGACAAGTGAGGGGTGAGCCAG GATTCAATACGTGACCAGTGAGGGGCGAGCCAGGATTCGATACGTGACCAGTGAGGGGCGAGCCAGGATGCGATACGTGACCAGTGAGGG GCGAGCCAGGATTCCATACGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTGAGTAGTGAGGAGTGAGCCAGGATTTGATATGTGGC TACTGAGGGGCGAGCCAGGATTTGATATGTGACTAGTAAGGGGTCAGCCAGGATTTGATACGTGACTAGTCAGGGGGTCAGCCAGGATTC GATACGTGACTAGTAAGGGGTCAGCCAGGATTTGATATGTGACTAGTGAGGGGTGAGCCAGGATTTGACATGTGACTAGTGAGGGGTGAG CCAGGATTCAATATGTGACTAGTGAGGGGTGAGCCAGGATTCGATATGTACCTAGTGAGGGGTCAGCCAGGATTTGATATGTGGCTAGTA AGGGGTGAGCCAGCCAGGATTTGATATGTGACTAGTGACGAGTGAGCCAGGATTTGATATGTGACTAGTAAGGGGGTGAGGCAGGATTTG ATATGTGACTAGTAAGGGGGTGAGGCAGGATTTGATATGTGACTGGTGAGGGGTGAGACAGGATTTGATATGTGACTAGTGAGGGGTGAG CCAGGATTTGCTATGTGACTAGTAAGGGGGCGAGCCAGGATTTGGCTCCAGCCTTCATTCCAACATCCATGCCTTTTGTACTTCACCAGC AGTTTTCAAATTTATGGGACAAAATTTTACATTGGATTCCCTCTATACAAAATAGATAAAAGTATTTTATGAATACATTTTATGAGTTCA AATATTTTTCAGAAGAAATCAGTAAAAGCATTGAAAACTATTCCAGCAAATAGGAAGCACTTTAAACCAAGGTTATGGATGAAAATGTGT GTGTATCAACCCCAGTTTACTTCTGGGTTGCACAGAATAGAGAAATCTTGATTTAATCCAGCTAAGAATTTTCAAATAGTATCCATTTTG 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FusionGenePPI for NRD1_VPS53 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NRD1 | HBEGF, BTRC, FBXW11, UIMC1, HIST2H3C, MAD1L1, COBLL1, NCOR1, UACA, IQGAP1, HDAC3, NCOR2, TBL1X, NRD1, MOB1A, STK3, MOB2, HSPB1, PNKP, DNAJC7, ELAC2, P3H1, SETSIP, MSH2, NSUN2, PDIA6, PFDN5, PPP1R12A, PPP2CA, PPP2R2A, PPP3CA, PUS1, XPO5, YARS, PFDN1, TSN, MOV10, NXF1, FMR1NB, ZNF707, LUC7L, SEPT1, KPNA3, NTRK1, ATM, LGALS3BP, PDGFRA, ERP44, PCDHB15, KIF7, CHCHD2, ATP5A1, APOOL, COQ7, COQ6, WBSCR16, LYRM4, C6orf203, CHCHD1, NME4, OCIAD1, ACP6, ADCK2, TRUB2, DHRS4, CISD3, OPA3, BOLA3, NLGN3, AURKAIP1, TMEM184A, DEF8, BATF3, METTL25, CDRT15, CLK3 | VPS53 | VPS52, VPS51, EXOC2, VPS53, VPS54, STX6, VAMP4, THOC2, THOC1, USP7, TXNDC9, VCP, SNAP29, BSG, PSMD7, CCDC132, DTNBP1, TSSC1, C10orf76, PTAR1, RAB1A, CCDC40, EXOC1, EXOC6, SYCE3, PRAF2, CEP170, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, GIT2, RPRD1A, ARNTL, MAX, RABGEF1, NUF2, THAP11, KDM1A, RABEP1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NRD1_VPS53 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NRD1_VPS53 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | VPS53 | C4014488 | PONTOCEREBELLAR HYPOPLASIA, TYPE 2E | 1 | UNIPROT |
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