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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24824

FusionGeneSummary for NRBP1_NRBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NRBP1_NRBP1
Fusion gene ID: 24824
HgeneTgene
Gene symbol

NRBP1

NRBP1

Gene ID

29959

29959

Gene namenuclear receptor binding protein 1nuclear receptor binding protein 1
SynonymsBCON3|MADM|MUDPNP|NRBPBCON3|MADM|MUDPNP|NRBP
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor-binding proteinmultiple domain putative nuclear proteinmyeloid leukemia factor 1 adaptor moleculenuclear receptor-binding proteinmultiple domain putative nuclear proteinmyeloid leukemia factor 1 adaptor molecule
Modification date2018052720180527
UniProtAcc

Q9UHY1

Q9UHY1

Ensembl transtripts involved in fusion geneENST00000233557, ENST00000379852, 
ENST00000379863, 		ENST00000233557, 
ENST00000379852, ENST00000379863, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 4 X 2=24
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NRBP1 [Title/Abstract] AND NRBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRBP1

GO:0006888

ER to Golgi vesicle-mediated transport

11956649

TgeneNRBP1

GO:0006888

ER to Golgi vesicle-mediated transport

11956649


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU155778NRBP1chr2

27664650

+NRBP1chr2

27656162

+
ChiTaRS3.1AA639598NRBP1chr2

27662675

-NRBP1chr2

27663773

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000233557ENST00000233557NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000233557ENST00000379852NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000233557ENST00000379863NRBP1chr2

27664650

+NRBP1chr2

27656162

+
In-frameENST00000379852ENST00000233557NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000379852ENST00000379852NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000379852ENST00000379863NRBP1chr2

27664650

+NRBP1chr2

27656162

+
In-frameENST00000379863ENST00000233557NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000379863ENST00000379852NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000379863ENST00000379863NRBP1chr2

27664650

+NRBP1chr2

27656162

+
Frame-shiftENST00000233557ENST00000233557NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000233557ENST00000379852NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000233557ENST00000379863NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000379852ENST00000233557NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000379852ENST00000379852NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000379852ENST00000379863NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000379863ENST00000233557NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000379863ENST00000379852NRBP1chr2

27662675

-NRBP1chr2

27663773

-
Frame-shiftENST00000379863ENST00000379863NRBP1chr2

27662675

-NRBP1chr2

27663773

-

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FusionProtFeatures for NRBP1_NRBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NRBP1

Q9UHY1

NRBP1

Q9UHY1

May play a role in subcellular trafficking between theendoplasmic reticulum and Golgi apparatus through interactionswith the Rho-type GTPases. Binding to the NS3 protein of denguevirus type 2 appears to subvert this activity into the alterationof the intracellular membrane structure associated with flaviviralreplication. {ECO:0000269|PubMed:11956649,ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}. May play a role in subcellular trafficking between theendoplasmic reticulum and Golgi apparatus through interactionswith the Rho-type GTPases. Binding to the NS3 protein of denguevirus type 2 appears to subvert this activity into the alterationof the intracellular membrane structure associated with flaviviralreplication. {ECO:0000269|PubMed:11956649,ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NRBP1_NRBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NRBP1_NRBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NRBP1_NRBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NRBP1_NRBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource