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Fusion gene ID: 24805 |
FusionGeneSummary for NR3C2_SPATA17 |
Fusion gene summary |
Fusion gene information | Fusion gene name: NR3C2_SPATA17 | Fusion gene ID: 24805 | Hgene | Tgene | Gene symbol | NR3C2 | SPATA17 | Gene ID | 4306 | 128153 |
Gene name | nuclear receptor subfamily 3 group C member 2 | spermatogenesis associated 17 | |
Synonyms | MCR|MLR|MR|NR3C2VIT | IQCH|MSRG-11|MSRG11 | |
Cytomap | 4q31.23 | 1q41 | |
Type of gene | protein-coding | protein-coding | |
Description | mineralocorticoid receptoraldosterone receptormineralocorticoid receptor 1mineralocorticoid receptor 2mineralocorticoid receptor deltanuclear receptor subfamily 3, group C, member 2 variant 3 | spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P08235 | Q96L03 | |
Ensembl transtripts involved in fusion gene | ENST00000344721, ENST00000355292, ENST00000358102, ENST00000512865, ENST00000511528, ENST00000503313, | ENST00000366933, ENST00000471021, | |
Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 6 X 6 X 6=216 |
# samples | 3 | 6 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NR3C2 [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CHOL | TCGA-W5-AA2T-01A | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000344721 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
5CDS-3UTR | ENST00000344721 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
Frame-shift | ENST00000355292 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
5CDS-3UTR | ENST00000355292 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
Frame-shift | ENST00000358102 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
5CDS-3UTR | ENST00000358102 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
Frame-shift | ENST00000512865 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
5CDS-3UTR | ENST00000512865 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
Frame-shift | ENST00000511528 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
5CDS-3UTR | ENST00000511528 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
intron-3CDS | ENST00000503313 | ENST00000366933 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
intron-3UTR | ENST00000503313 | ENST00000471021 | NR3C2 | chr4 | 149356256 | - | SPATA17 | chr1 | 218036116 | + |
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FusionProtFeatures for NR3C2_SPATA17 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
NR3C2 | SPATA17 |
Receptor for both mineralocorticoids (MC) such asaldosterone and glucocorticoids (GC) such as corticosterone orcortisol. Binds to mineralocorticoid response elements (MRE) andtransactivates target genes. The effect of MC is to increase ionand water transport and thus raise extracellular fluid volume andblood pressure and lower potassium levels.{ECO:0000269|PubMed:3037703}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 603_668 | 585 | 868 | DNA binding | Nuclear receptor |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 726_964 | 585 | 868 | Domain | NR LBD |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 1_602 | 585 | 868 | Region | Note=Modulating |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 669_725 | 585 | 868 | Region | Note=Hinge |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 782_785 | 585 | 868 | Region | Note=Important for coactivator binding |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 603_623 | 585 | 868 | Zinc finger | NR C4-type |
Hgene | >NR3C2 | chr4:149356256 | chr1:218036116 | ENST00000512865 | - | 2 | 8 | 639_663 | 585 | 868 | Zinc finger | NR C4-type |
Tgene | SPATA17 | chr4:149356256 | chr1:218036116 | ENST00000366933 | + | 8 | 11 | 32_61 | 335 | 1879 | Domain | IQ 1 |
Tgene | SPATA17 | chr4:149356256 | chr1:218036116 | ENST00000366933 | + | 8 | 11 | 55_84 | 335 | 1879 | Domain | IQ 2 |
Tgene | SPATA17 | chr4:149356256 | chr1:218036116 | ENST00000366933 | + | 8 | 11 | 91_120 | 335 | 1879 | Domain | IQ 3 |
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FusionGeneSequence for NR3C2_SPATA17 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_NR3C2_ENST00000344721_chr4_149356256_-_SPATA17_ENST00000366933_chr1_218036116_+_612aa METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKT ELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKS SISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPF PFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_NR3C2_ENST00000344721_chr4_149356256_-_SPATA17_ENST00000366933_chr1_218036116_+_1838nt ATGGAGACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGTCAAGTTTCTCAGGCTGTGGAGCGTTCTTCC CTGGGACCTACAGAGAGGACCGATGAGAATAACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACT CAAGGAAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGGCCTGGGATTTTAACATCTGATATTAAAACT GAGCTGGAATCTAAGGAACTTTCAGCAACTGTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAG CAGCAGAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTGGTGAAATTTTACAAAGGAAATGGCCATCGT CCTTCCACTCTAAGTTGTGTGAACACGCCCTTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCGTT GTTAAAAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATGACATCTTCGGTTTGCAGCCCTGCTGGAATC AACTCTGTGTCCTCCACCACAGCCAGCTTTGGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAAT GTTGAAAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCTCTCTCAAGTCCGTTAAGTAGCATGAAATCC TCAATTTCCAGCCCTCCAAGTCACTGCAGTGTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCT GCAAATATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCCACGCTTTCCAGTCCGGCAGCCAGTACTGTG GGATCTATCTGTAGCCCTGTAAACAATGCCTTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCC AGTCCAGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTAGAGAGTGCCATCTCAAATGGTGTGACTGGC CAGCTTAATATTGTCCAGTACATAAAACCAGAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGAT TCTTCATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCTTTTAAAGGGAATCCAACAGTAAACCCGTTT CCATTTATGGATGGCTCGTATTTTTCCTTTATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTT GATGGTAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGATGGGAGCTATTACCCAGAGGCCAGCATCCCTTCC TCTGCTATTGTTGGGGTGAATTCAGGTGGACAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGA GACCAATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGGAAATCACACGGCGACCTGTCGTCTAGAAGA AGTGATGGGTATCCGGTCTTAGAATACATTCCAGAAAATGTATCAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTCAAAGT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_NR3C2_ENST00000344721_chr4_149356256_-_SPATA17_ENST00000366933_chr1_218036116_+_6690nt ATTGCTCTACCCACCGTCAGCAGGGCGACTGCCACTGCCGGGATTATCATCCTCTCCATCCTCACCGCCGATCAGCCAATATTGGACTTG CTGGTGGCGGCGGCAGCAGCGGCGGCGGGAGTCTAGCCGTTCCCCTTCCCCCGCCCCAGCCTCCCCACCATGTCCTAGAAAAGCGATGGA GACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGTCAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGG ACCTACAGAGAGGACCGATGAGAATAACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACTCAAGG AAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGGCCTGGGATTTTAACATCTGATATTAAAACTGAGCT GGAATCTAAGGAACTTTCAGCAACTGTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAGCAGCA GAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTGGTGAAATTTTACAAAGGAAATGGCCATCGTCCTTC CACTCTAAGTTGTGTGAACACGCCCTTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCGTTGTTAA AAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATGACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTC TGTGTCCTCCACCACAGCCAGCTTTGGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAATGTTGA AAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCTCTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAAT TTCCAGCCCTCCAAGTCACTGCAGTGTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCTGCAAA TATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCCACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATC TATCTGTAGCCCTGTAAACAATGCCTTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCCAGTCC AGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTAGAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCT TAATATTGTCCAGTACATAAAACCAGAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGATTCTTC ATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCTTTTAAAGGGAATCCAACAGTAAACCCGTTTCCATT TATGGATGGCTCGTATTTTTCCTTTATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTTGATGG TAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGATGGGAGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGC TATTGTTGGGGTGAATTCAGGTGGACAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGAGACCA ATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGGAAATCACACGGCGACCTGTCGTCTAGAAGAAGTGA TGGGTATCCGGTCTTAGAATACATTCCAGAAAATGTATCAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTCAAAGTATGGA AAATTATATTCAAAAGCTGGACAGATTGTATAAAGGCGTCAGAAGAAGAAACTGAAGCCATCTGCATTTTAAAACTTAACAGTTCTGAAA GGAAAACACAGATGAAGATCCTGTAGGAAATATACTTGCTATGATTCAATAAACTATAAAATTTTGTAGCTCTAGTCATGAATTAATTAT TGTGTGTATGTATTTGAAATCTCTTAGACATATCTTTTCAAACAAATACTTAAACTTGAGTCTGTTACCTCTGAGAATGTCTGTCACAAT CACAGCCCCTGGTGACCAACAGTGCCATAAATGGTTCCCCTGAAATACCCATATTCTGACCCCATCACCCGGGTCACAAATGATGACACC AGTGCTGGGTACCCAAATTAAGGGCGACTAACATGTAAGTAGGATGATGAATGGTTTGAAGTGTAAATTGTGTGAAATAGTTCAGCATGA AAGCTCTGCCCTGAGAAATAATGACTGATTATACCAGTTAGAAACCCTTCAGACTGTTGAACTTGAGACACACAGACACAACAGACACAG ACTAGTGGGTGTGGGAGCAGAAGCATAGGCACTCTCAAATAGAGAAGACATTTGCAAGTCTCTGCTGCCAAGGGAGCAAAGAGATAATCT CGATGCCAGGGCTGTGTCAGATCCTGCATGGCTCTGAACTACAGTTGGTTTCCAAAAAGCTGGGCTTTTGTGAGGTTTCTGTTTTTTATG CGATGCTTAGATTTTCCTGGAATCCTTGGAAGTTAACTCAACATTTGAGGTTCCTATATCCTTTAATCCCATCCCATGTGTATCTTTACA ATAAAACTTCCTGCTAGAGGTATCCTGAGGGAATCTTTGTTTCTTGCATCTGAAGAGAATAACACTAAACTTATTGCATATGATTTGGGG GTTGGATCCAATGATAGCACAGAGGGACAGGAAATGTGATTTATTGACCATAAAAGCTTTAATTTAAAATTGCTGGCCAGCGAAATCCAG ACTCTGGGAAATGTTATAGGCCAAATGATCTGTTTCTTCAACAAATAAATTACAAAACTGAGGGGAAAAAAAGGAACCTATTAAAAAGAC ATTATCTATCAATCACTGTGTGTGTACAGTTTTGAGCTCCTGATTTAAATAAACAAATTGTAAAATAAAAGATCTTTTGAAACAATTGGA AGTTTGAACACTGATTGGATATTGGTGGTATAAAAGAATTATTGGTTTTTTTTAGGTGTCATGGTATTGTTTTGGTTTACAAAGTTATAG ATATAAATGTTGAAATATTTACAGATGCAGTGATATGTTGGCTGGGATTTAATTTGAAAGTCAAAGAAGTGAGTTAAAATACATATACTC CTCCTCTTATAATCGGTTATGTGCCAATAAATCCATTGTAAATTGAAAATATCCTAAGTTGAAAATATTGTAAGTTAAAAATGCATTTAA TACAGCTAACTTACCAGACAGCTTAGCTTAGCCTCACCTACCTTAAATATGCTCAGAACACATACGTTAGCCTATAGTTGGGCAAAATCA TCTAACACAAAGCCTATTTTATAATATTGAACAGCCCATGTAATTTATTGAATATTGTACTAAAAGTGAAAAACTGAATAGTTGTATGCA TACTCAAAGTATGGTTTCTACTGAATGCATTGTAAACCAGAAAGTATCTGAGACAATGTTTTTTTTTTTTTTTTTTTTTTTTTTAATTTC TGAGACAGAGTCTCATTCTGTCACCCAGGTTGGAGTGCAGTGGCATGAACTCAGCTCACTGCAACCTTCACCTCCCAGGCTCAAGCAGTC CTCCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGGGCCAACAAGCCTGGCTAAATATTTTGTACTTTTGGTAGACACGGGTTT TTACCATGTTGTGCAGGCTGGTCTTGAACGCCTGAGCTCAAGTGATCTGCCTGCCTCGGCCTCCCAAAGTACTGGGATTACAGGCATGAG TCACTGAACCCAGCCCTGAGACATGTCTCAATTAGTTTAGAAGTTTATTTGGCCAAGGTTAAGGACATGCCCTTGACACTGCACCTGTCA GTACAGGTCCTGACAACATGTGTCCAAGGTGGTCAAGCTATACAACTTGGTTTTATACATTTTAAGGAGACATAAGACATCAATAAATAC ATGGAAGATGTACATTGGTTCAGTCTGGAAAGGCAGGATGCCTCAAACTTGAAACAAGAGAATGGGGGGTGGGAGGATGTGGGAGATGCT TCCAGGTCATAGTTGGAGTCAAAGACTTTCCAATTGGCAATTGGTTCAAAGAATTTATCTAAAGACCTGGAATCCATAGAAGGCTTTACC TGGATTAAAATAAGGGGACCAAGGTTCTCATGCAGATGAAGCCTCCAGGTGGCAGACTTCAGAGAGCATAGATTGTAAATGTTTCTTATC TGACTTAAAAAGGTGTCAGACTCTTAGTAAATTATCTCCTGGATCAGTGAAAAGATGTGAAAAAAGGTTCTCTACAGAATGTAGATTTTC CCCATAAGAGATAGCTTCGCAGGGCCATTGCAAAATATGTCAAAAATATATATTTTAGGGTAAAATGCCTCAATTTATTTCAAGGCCTGA TATTTGTCATGTGATGCTATACTACAGTCAGGCTGAAACTTGGCATCTTATTGCTATGAAAAATCTTAAGATCTCTATTTTAATGTTAAT GCTGGTCACTGGTGCCTGAATTCCAAAGGGAGGAGGGTATAATGAAGCATGTCCAATTCCCCATGCCCCACCCCCACCCCCACATCCTAT AATGGCCTGAACTAGTTTTTCAGGTTAACTTTGGAATACCCTTGGCCAAGAAGAGGGGTCCATGCAGATGTTTGGAGGGGGGGGTCTTAA AGCTTTATTTTTAGATTACAGCATATTGCTTTTGCACTATCATAAAGTAAAAACATCATAAGTCAAGCCACCATAAATAGCGGACCATCT GTATATCTGAAAGAAGATGAACCAAGACTTGGTTATTGTTAAAGCTGATGATTGGCTGTATGAAGATTTACTATACAATTTTGTGTACTT TTGTAAGTTCTTGGTTGTTTCTAAACTTATAACAAAATAAATAATTGGCCATCTTCATTGGATTGTGAAGCCATTTCCTCCCACATGTTC GTAAAAATGGTAGCCATGGCCCCTGACTGAACCCAGGTATGAATGGCCTTCATTGATTTTGTAGACCCTGACCTTCTCTGTTCTTCCAGA GAAGGTGGTACTCAGATAAAAACTTTGAAGCATTTTATTGTTCAGAATATGACTTTGATCTTCTCATAAGACTCAAGTTTTTGAATGCTT AAGGCTCTTTATCGCTAGTGTATGTAAGTAATATCATTGTCCTTAACCACCATCTGCCTCTCCCCCCAGACACACATAAGTTTATGATAA CTACAGAGGTGTCCAGATGAGTAAAAACTGCCTTTGCATTAAGGTGAGAGAAGACCGAGATGAAATCTTATTAGAAAATATAACTGGGGA AAGCAGTTTGTCTGTTTCTCCTGGAAAACTACTAGACTACATCAACTTATATACTACTTCTTTTCTATATTCTCAATATGAGCCACTTAA GAAAATTAATGAGACTTTATGTTTGACCAAAGCTGGTAATTCCTTGATCTTATTCTCCAAACTTGATTCTGAATGACTACTGACCACTAA AAACACTAAGAGTACCACTGTGGATGTTTAAAAACATACACCCTAAGAGCCTTCAGAATTAGACGCTTCAATTCTTCTGAAATCAAAAGT CACACCAGCTTTGCTGTAGTTAATCAGGTAATACCTTTCTTCTCCACTACTCTCTAATTTCCTTGAGGGCAAATATTGTCTTTCTTGATA AATGCCCTGGACCCAACATCTAACAGAATACCTGGCATAAAGTGAAATCCATCGAATGTGCTAATGATAAATAAAGAAGTTCAAAAAAAT CTTTTAATAGAAGCTATAAAATAGCAGATAAGCTAAGTCATTCTCATAAAACACCATTTGTCATTTGAATGCGTGCATTGTGGCCTGTTA CTTTTAACTAGTCTCACTAATTTATAGTTATATATGATGTAGATCTAGATTGTGATGTACACTAAGTGGGTTGATCCTGAGATCAAGCTA TGATTGCTGCTTGCGTAAAGTGTTCCTTTTGGGAAATAAATAATCTTTCATATCTGTAAACTTTGGTATAATTGGTTATTTATGCAATGT ATTGTTGTGGTTGTCAACTCAAGATTGTATTCTCATCTGGGGACATTATGAATCTTGTTATTTTATCCCCTTTTTTGCTCTGTTTTTTCA CATTTATGGCCTACCTGTTACAGCTGCACGGTATCCATTTTCTGTGCTAAATTCATCTTTAATTTATTATTTTTTTTCAACCTCAGCTTT TAACTTTGCCCTGATTTTCTCTTCCATTTTATTTTCACTTCCATTTTAAGCTGGCTCAAAGCCTTTTAGGAACAATAAGTTACTGAATTA TATGAACCTATTTGAGGTAATGATGATGCCTGGGAAGGAGCAGTATTGCTGGATCAGAATTCACTTTTTCCAAGTTACAGATTTTAATAA ACCACTGTGCAAAGCATTAGGATAAATTTTTATTGAAAATTGAGTGAATGACTGAACAAATCGCTGGGTAATGCTGTTTAGGTTGTTCTA |
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FusionGenePPI for NR3C2_SPATA17 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NR3C2 | TRIM24, NR3C1, PTGES3, PROX1, CAND1, UBE2I, SUMO1, NRIP1, STUB1, FKBP5, FKBP4, PPP5C, DNAJC7, PPID, AIP, HSP90AA1, ACSL1, RXRA, RABAC1, C9orf41, PSMC5, NCOA1, CREBBP, EP300, KAT2B, CAV1, PPP1CA | SPATA17 | KDM1B, KRAS |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NR3C2_SPATA17 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NR3C2 | P08235 | DB00421 | Spironolactone | Mineralocorticoid receptor | small molecule | approved |
Hgene | NR3C2 | P08235 | DB00700 | Eplerenone | Mineralocorticoid receptor | small molecule | approved |
Hgene | NR3C2 | P08235 | DB01395 | Drospirenone | Mineralocorticoid receptor | small molecule | approved |
Hgene | NR3C2 | P08235 | DB00393 | Nimodipine | Mineralocorticoid receptor | small molecule | approved|investigational |
Hgene | NR3C2 | P08235 | DB00624 | Testosterone | Mineralocorticoid receptor | small molecule | approved|investigational |
Hgene | NR3C2 | P08235 | DB00687 | Fludrocortisone | Mineralocorticoid receptor | small molecule | approved|investigational |
Hgene | NR3C2 | P08235 | DB01023 | Felodipine | Mineralocorticoid receptor | small molecule | approved|investigational |
Hgene | NR3C2 | P08235 | DB00396 | Progesterone | Mineralocorticoid receptor | small molecule | approved|vet_approved |
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RelatedDiseases for NR3C2_SPATA17 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NR3C2 | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | NR3C2 | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | NR3C2 | C0041696 | Unipolar Depression | 4 | PSYGENET |
Hgene | NR3C2 | C1269683 | Major Depressive Disorder | 4 | PSYGENET |
Hgene | NR3C2 | C1449842 | Pseudohypoaldosteronism, Type I, Autosomal Dominant | 4 | ORPHANET;UNIPROT |
Hgene | NR3C2 | C1854631 | Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | NR3C2 | C0018801 | Heart failure | 2 | CTD_human |
Hgene | NR3C2 | C0027051 | Myocardial Infarction | 2 | CTD_human |
Hgene | NR3C2 | C0001969 | Alcoholic Intoxication | 1 | PSYGENET |
Hgene | NR3C2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | NR3C2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | NR3C2 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
Hgene | NR3C2 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | NR3C2 | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Hgene | NR3C2 | C0338831 | Manic | 1 | PSYGENET |