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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24805

FusionGeneSummary for NR3C2_SPATA17

check button Fusion gene summary
Fusion gene informationFusion gene name: NR3C2_SPATA17
Fusion gene ID: 24805
HgeneTgene
Gene symbol

NR3C2

SPATA17

Gene ID

4306

128153

Gene namenuclear receptor subfamily 3 group C member 2spermatogenesis associated 17
SynonymsMCR|MLR|MR|NR3C2VITIQCH|MSRG-11|MSRG11
Cytomap

4q31.23

1q41

Type of geneprotein-codingprotein-coding
Descriptionmineralocorticoid receptoraldosterone receptormineralocorticoid receptor 1mineralocorticoid receptor 2mineralocorticoid receptor deltanuclear receptor subfamily 3, group C, member 2 variant 3spermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11
Modification date2018051920180519
UniProtAcc

P08235

Q96L03

Ensembl transtripts involved in fusion geneENST00000344721, ENST00000355292, 
ENST00000358102, ENST00000512865, 
ENST00000511528, ENST00000503313, 
ENST00000366933, ENST00000471021, 
Fusion gene scores* DoF score2 X 3 X 2=126 X 6 X 6=216
# samples 36
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NR3C2 [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCHOLTCGA-W5-AA2T-01ANR3C2chr4

149356256

-SPATA17chr1

218036116

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344721ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000344721ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000355292ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000355292ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000358102ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000358102ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000512865ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000512865ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
Frame-shiftENST00000511528ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
5CDS-3UTRENST00000511528ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+
intron-3CDSENST00000503313ENST00000366933NR3C2chr4

149356256

-SPATA17chr1

218036116

+
intron-3UTRENST00000503313ENST00000471021NR3C2chr4

149356256

-SPATA17chr1

218036116

+

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FusionProtFeatures for NR3C2_SPATA17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NR3C2

P08235

SPATA17

Q96L03

Receptor for both mineralocorticoids (MC) such asaldosterone and glucocorticoids (GC) such as corticosterone orcortisol. Binds to mineralocorticoid response elements (MRE) andtransactivates target genes. The effect of MC is to increase ionand water transport and thus raise extracellular fluid volume andblood pressure and lower potassium levels.{ECO:0000269|PubMed:3037703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28603_668585868DNA bindingNuclear receptor
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28726_964585868DomainNR LBD
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-281_602585868RegionNote=Modulating
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28669_725585868RegionNote=Hinge
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28782_785585868RegionNote=Important for coactivator binding
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28603_623585868Zinc fingerNR C4-type
HgeneNR3C2chr4:149356256chr1:218036116ENST00000512865-28639_663585868Zinc fingerNR C4-type
TgeneSPATA17chr4:149356256chr1:218036116ENST00000366933+81132_613351879DomainIQ 1
TgeneSPATA17chr4:149356256chr1:218036116ENST00000366933+81155_843351879DomainIQ 2
TgeneSPATA17chr4:149356256chr1:218036116ENST00000366933+81191_1203351879DomainIQ 3


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FusionGeneSequence for NR3C2_SPATA17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NR3C2_ENST00000344721_chr4_149356256_-_SPATA17_ENST00000366933_chr1_218036116_+_612aa
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKT
ELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNVENRGSRSHSPAHASNVGSPLSSPLSSMKS
SISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPF
PFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NR3C2_ENST00000344721_chr4_149356256_-_SPATA17_ENST00000366933_chr1_218036116_+_1838nt
ATGGAGACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGTCAAGTTTCTCAGGCTGTGGAGCGTTCTTCC
CTGGGACCTACAGAGAGGACCGATGAGAATAACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACT
CAAGGAAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGGCCTGGGATTTTAACATCTGATATTAAAACT
GAGCTGGAATCTAAGGAACTTTCAGCAACTGTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAG
CAGCAGAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTGGTGAAATTTTACAAAGGAAATGGCCATCGT
CCTTCCACTCTAAGTTGTGTGAACACGCCCTTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCGTT
GTTAAAAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATGACATCTTCGGTTTGCAGCCCTGCTGGAATC
AACTCTGTGTCCTCCACCACAGCCAGCTTTGGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAAT
GTTGAAAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCTCTCTCAAGTCCGTTAAGTAGCATGAAATCC
TCAATTTCCAGCCCTCCAAGTCACTGCAGTGTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCT
GCAAATATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCCACGCTTTCCAGTCCGGCAGCCAGTACTGTG
GGATCTATCTGTAGCCCTGTAAACAATGCCTTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCC
AGTCCAGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTAGAGAGTGCCATCTCAAATGGTGTGACTGGC
CAGCTTAATATTGTCCAGTACATAAAACCAGAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGAT
TCTTCATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCTTTTAAAGGGAATCCAACAGTAAACCCGTTT
CCATTTATGGATGGCTCGTATTTTTCCTTTATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTT
GATGGTAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGATGGGAGCTATTACCCAGAGGCCAGCATCCCTTCC
TCTGCTATTGTTGGGGTGAATTCAGGTGGACAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGA
GACCAATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGGAAATCACACGGCGACCTGTCGTCTAGAAGA
AGTGATGGGTATCCGGTCTTAGAATACATTCCAGAAAATGTATCAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTCAAAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_NR3C2_ENST00000344721_chr4_149356256_-_SPATA17_ENST00000366933_chr1_218036116_+_6690nt
ATTGCTCTACCCACCGTCAGCAGGGCGACTGCCACTGCCGGGATTATCATCCTCTCCATCCTCACCGCCGATCAGCCAATATTGGACTTG
CTGGTGGCGGCGGCAGCAGCGGCGGCGGGAGTCTAGCCGTTCCCCTTCCCCCGCCCCAGCCTCCCCACCATGTCCTAGAAAAGCGATGGA
GACCAAAGGCTACCACAGTCTCCCTGAAGGTCTAGATATGGAAAGACGGTGGGGTCAAGTTTCTCAGGCTGTGGAGCGTTCTTCCCTGGG
ACCTACAGAGAGGACCGATGAGAATAACTACATGGAGATTGTCAACGTAAGCTGTGTTTCCGGTGCTATTCCAAACAACAGTACTCAAGG
AAGCAGCAAAGAAAAACAAGAACTACTCCCTTGCCTTCAGCAAGACAATAATCGGCCTGGGATTTTAACATCTGATATTAAAACTGAGCT
GGAATCTAAGGAACTTTCAGCAACTGTAGCTGAGTCCATGGGTTTATATATGGATTCTGTAAGAGATGCTGACTATTCCTATGAGCAGCA
GAACCAACAAGGAAGCATGAGTCCAGCTAAGATTTATCAGAATGTTGAACAGCTGGTGAAATTTTACAAAGGAAATGGCCATCGTCCTTC
CACTCTAAGTTGTGTGAACACGCCCTTGAGATCATTTATGTCTGACTCTGGGAGCTCCGTGAATGGTGGCGTCATGCGCGCCGTTGTTAA
AAGCCCTATCATGTGTCATGAGAAAAGCCCGTCTGTTTGCAGCCCTCTGAACATGACATCTTCGGTTTGCAGCCCTGCTGGAATCAACTC
TGTGTCCTCCACCACAGCCAGCTTTGGCAGTTTTCCAGTGCACAGCCCAATCACCCAGGGAACTCCTCTGACATGCTCCCCTAATGTTGA
AAATCGAGGCTCCAGGTCGCACAGCCCTGCACATGCTAGCAATGTGGGCTCTCCTCTCTCAAGTCCGTTAAGTAGCATGAAATCCTCAAT
TTCCAGCCCTCCAAGTCACTGCAGTGTAAAATCTCCAGTCTCCAGTCCCAATAATGTCACTCTGAGATCCTCTGTGTCTAGCCCTGCAAA
TATTAACAACTCAAGGTGCTCTGTTTCCAGCCCTTCGAACACTAATAACAGATCCACGCTTTCCAGTCCGGCAGCCAGTACTGTGGGATC
TATCTGTAGCCCTGTAAACAATGCCTTCAGCTACACTGCTTCTGGCACCTCTGCTGGATCCAGTACATTGCGGGATGTGGTTCCCAGTCC
AGACACGCAGGAGAAAGGTGCTCAAGAGGTCCCTTTTCCTAAGACTGAGGAAGTAGAGAGTGCCATCTCAAATGGTGTGACTGGCCAGCT
TAATATTGTCCAGTACATAAAACCAGAACCAGATGGAGCTTTTAGCAGCTCATGTCTAGGAGGAAATAGCAAAATAAATTCGGATTCTTC
ATTCTCAGTACCAATAAAGCAAGAATCAACCAAGCATTCATGTTCAGGCACCTCTTTTAAAGGGAATCCAACAGTAAACCCGTTTCCATT
TATGGATGGCTCGTATTTTTCCTTTATGGATGATAAAGACTATTATTCCCTATCAGGAATTTTAGGACCACCTGTGCCCGGCTTTGATGG
TAACTGTGAAGGCAGCGGATTCCCAGTGGGTATTAAACAAGAACCAGATGATGGGAGCTATTACCCAGAGGCCAGCATCCCTTCCTCTGC
TATTGTTGGGGTGAATTCAGGTGGACAGTCCTTCCACTACAGGATTGGTGCTCAAGGTACAATATCTTTATCACGATCGGCTAGAGACCA
ATCTTTCCAACACCTGAGTTCCTTTCCTCCTGTCAATACTTTAGTGGAGTCATGGAAATCACACGGCGACCTGTCGTCTAGAAGAAGTGA
TGGGTATCCGGTCTTAGAATACATTCCAGAAAATGTATCAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTCAAAGTATGGA
AAATTATATTCAAAAGCTGGACAGATTGTATAAAGGCGTCAGAAGAAGAAACTGAAGCCATCTGCATTTTAAAACTTAACAGTTCTGAAA
GGAAAACACAGATGAAGATCCTGTAGGAAATATACTTGCTATGATTCAATAAACTATAAAATTTTGTAGCTCTAGTCATGAATTAATTAT
TGTGTGTATGTATTTGAAATCTCTTAGACATATCTTTTCAAACAAATACTTAAACTTGAGTCTGTTACCTCTGAGAATGTCTGTCACAAT
CACAGCCCCTGGTGACCAACAGTGCCATAAATGGTTCCCCTGAAATACCCATATTCTGACCCCATCACCCGGGTCACAAATGATGACACC
AGTGCTGGGTACCCAAATTAAGGGCGACTAACATGTAAGTAGGATGATGAATGGTTTGAAGTGTAAATTGTGTGAAATAGTTCAGCATGA
AAGCTCTGCCCTGAGAAATAATGACTGATTATACCAGTTAGAAACCCTTCAGACTGTTGAACTTGAGACACACAGACACAACAGACACAG
ACTAGTGGGTGTGGGAGCAGAAGCATAGGCACTCTCAAATAGAGAAGACATTTGCAAGTCTCTGCTGCCAAGGGAGCAAAGAGATAATCT
CGATGCCAGGGCTGTGTCAGATCCTGCATGGCTCTGAACTACAGTTGGTTTCCAAAAAGCTGGGCTTTTGTGAGGTTTCTGTTTTTTATG
CGATGCTTAGATTTTCCTGGAATCCTTGGAAGTTAACTCAACATTTGAGGTTCCTATATCCTTTAATCCCATCCCATGTGTATCTTTACA
ATAAAACTTCCTGCTAGAGGTATCCTGAGGGAATCTTTGTTTCTTGCATCTGAAGAGAATAACACTAAACTTATTGCATATGATTTGGGG
GTTGGATCCAATGATAGCACAGAGGGACAGGAAATGTGATTTATTGACCATAAAAGCTTTAATTTAAAATTGCTGGCCAGCGAAATCCAG
ACTCTGGGAAATGTTATAGGCCAAATGATCTGTTTCTTCAACAAATAAATTACAAAACTGAGGGGAAAAAAAGGAACCTATTAAAAAGAC
ATTATCTATCAATCACTGTGTGTGTACAGTTTTGAGCTCCTGATTTAAATAAACAAATTGTAAAATAAAAGATCTTTTGAAACAATTGGA
AGTTTGAACACTGATTGGATATTGGTGGTATAAAAGAATTATTGGTTTTTTTTAGGTGTCATGGTATTGTTTTGGTTTACAAAGTTATAG
ATATAAATGTTGAAATATTTACAGATGCAGTGATATGTTGGCTGGGATTTAATTTGAAAGTCAAAGAAGTGAGTTAAAATACATATACTC
CTCCTCTTATAATCGGTTATGTGCCAATAAATCCATTGTAAATTGAAAATATCCTAAGTTGAAAATATTGTAAGTTAAAAATGCATTTAA
TACAGCTAACTTACCAGACAGCTTAGCTTAGCCTCACCTACCTTAAATATGCTCAGAACACATACGTTAGCCTATAGTTGGGCAAAATCA
TCTAACACAAAGCCTATTTTATAATATTGAACAGCCCATGTAATTTATTGAATATTGTACTAAAAGTGAAAAACTGAATAGTTGTATGCA
TACTCAAAGTATGGTTTCTACTGAATGCATTGTAAACCAGAAAGTATCTGAGACAATGTTTTTTTTTTTTTTTTTTTTTTTTTTAATTTC
TGAGACAGAGTCTCATTCTGTCACCCAGGTTGGAGTGCAGTGGCATGAACTCAGCTCACTGCAACCTTCACCTCCCAGGCTCAAGCAGTC
CTCCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGGGCCAACAAGCCTGGCTAAATATTTTGTACTTTTGGTAGACACGGGTTT
TTACCATGTTGTGCAGGCTGGTCTTGAACGCCTGAGCTCAAGTGATCTGCCTGCCTCGGCCTCCCAAAGTACTGGGATTACAGGCATGAG
TCACTGAACCCAGCCCTGAGACATGTCTCAATTAGTTTAGAAGTTTATTTGGCCAAGGTTAAGGACATGCCCTTGACACTGCACCTGTCA
GTACAGGTCCTGACAACATGTGTCCAAGGTGGTCAAGCTATACAACTTGGTTTTATACATTTTAAGGAGACATAAGACATCAATAAATAC
ATGGAAGATGTACATTGGTTCAGTCTGGAAAGGCAGGATGCCTCAAACTTGAAACAAGAGAATGGGGGGTGGGAGGATGTGGGAGATGCT
TCCAGGTCATAGTTGGAGTCAAAGACTTTCCAATTGGCAATTGGTTCAAAGAATTTATCTAAAGACCTGGAATCCATAGAAGGCTTTACC
TGGATTAAAATAAGGGGACCAAGGTTCTCATGCAGATGAAGCCTCCAGGTGGCAGACTTCAGAGAGCATAGATTGTAAATGTTTCTTATC
TGACTTAAAAAGGTGTCAGACTCTTAGTAAATTATCTCCTGGATCAGTGAAAAGATGTGAAAAAAGGTTCTCTACAGAATGTAGATTTTC
CCCATAAGAGATAGCTTCGCAGGGCCATTGCAAAATATGTCAAAAATATATATTTTAGGGTAAAATGCCTCAATTTATTTCAAGGCCTGA
TATTTGTCATGTGATGCTATACTACAGTCAGGCTGAAACTTGGCATCTTATTGCTATGAAAAATCTTAAGATCTCTATTTTAATGTTAAT
GCTGGTCACTGGTGCCTGAATTCCAAAGGGAGGAGGGTATAATGAAGCATGTCCAATTCCCCATGCCCCACCCCCACCCCCACATCCTAT
AATGGCCTGAACTAGTTTTTCAGGTTAACTTTGGAATACCCTTGGCCAAGAAGAGGGGTCCATGCAGATGTTTGGAGGGGGGGGTCTTAA
AGCTTTATTTTTAGATTACAGCATATTGCTTTTGCACTATCATAAAGTAAAAACATCATAAGTCAAGCCACCATAAATAGCGGACCATCT
GTATATCTGAAAGAAGATGAACCAAGACTTGGTTATTGTTAAAGCTGATGATTGGCTGTATGAAGATTTACTATACAATTTTGTGTACTT
TTGTAAGTTCTTGGTTGTTTCTAAACTTATAACAAAATAAATAATTGGCCATCTTCATTGGATTGTGAAGCCATTTCCTCCCACATGTTC
GTAAAAATGGTAGCCATGGCCCCTGACTGAACCCAGGTATGAATGGCCTTCATTGATTTTGTAGACCCTGACCTTCTCTGTTCTTCCAGA
GAAGGTGGTACTCAGATAAAAACTTTGAAGCATTTTATTGTTCAGAATATGACTTTGATCTTCTCATAAGACTCAAGTTTTTGAATGCTT
AAGGCTCTTTATCGCTAGTGTATGTAAGTAATATCATTGTCCTTAACCACCATCTGCCTCTCCCCCCAGACACACATAAGTTTATGATAA
CTACAGAGGTGTCCAGATGAGTAAAAACTGCCTTTGCATTAAGGTGAGAGAAGACCGAGATGAAATCTTATTAGAAAATATAACTGGGGA
AAGCAGTTTGTCTGTTTCTCCTGGAAAACTACTAGACTACATCAACTTATATACTACTTCTTTTCTATATTCTCAATATGAGCCACTTAA
GAAAATTAATGAGACTTTATGTTTGACCAAAGCTGGTAATTCCTTGATCTTATTCTCCAAACTTGATTCTGAATGACTACTGACCACTAA
AAACACTAAGAGTACCACTGTGGATGTTTAAAAACATACACCCTAAGAGCCTTCAGAATTAGACGCTTCAATTCTTCTGAAATCAAAAGT
CACACCAGCTTTGCTGTAGTTAATCAGGTAATACCTTTCTTCTCCACTACTCTCTAATTTCCTTGAGGGCAAATATTGTCTTTCTTGATA
AATGCCCTGGACCCAACATCTAACAGAATACCTGGCATAAAGTGAAATCCATCGAATGTGCTAATGATAAATAAAGAAGTTCAAAAAAAT
CTTTTAATAGAAGCTATAAAATAGCAGATAAGCTAAGTCATTCTCATAAAACACCATTTGTCATTTGAATGCGTGCATTGTGGCCTGTTA
CTTTTAACTAGTCTCACTAATTTATAGTTATATATGATGTAGATCTAGATTGTGATGTACACTAAGTGGGTTGATCCTGAGATCAAGCTA
TGATTGCTGCTTGCGTAAAGTGTTCCTTTTGGGAAATAAATAATCTTTCATATCTGTAAACTTTGGTATAATTGGTTATTTATGCAATGT
ATTGTTGTGGTTGTCAACTCAAGATTGTATTCTCATCTGGGGACATTATGAATCTTGTTATTTTATCCCCTTTTTTGCTCTGTTTTTTCA
CATTTATGGCCTACCTGTTACAGCTGCACGGTATCCATTTTCTGTGCTAAATTCATCTTTAATTTATTATTTTTTTTCAACCTCAGCTTT
TAACTTTGCCCTGATTTTCTCTTCCATTTTATTTTCACTTCCATTTTAAGCTGGCTCAAAGCCTTTTAGGAACAATAAGTTACTGAATTA
TATGAACCTATTTGAGGTAATGATGATGCCTGGGAAGGAGCAGTATTGCTGGATCAGAATTCACTTTTTCCAAGTTACAGATTTTAATAA
ACCACTGTGCAAAGCATTAGGATAAATTTTTATTGAAAATTGAGTGAATGACTGAACAAATCGCTGGGTAATGCTGTTTAGGTTGTTCTA


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FusionGenePPI for NR3C2_SPATA17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NR3C2TRIM24, NR3C1, PTGES3, PROX1, CAND1, UBE2I, SUMO1, NRIP1, STUB1, FKBP5, FKBP4, PPP5C, DNAJC7, PPID, AIP, HSP90AA1, ACSL1, RXRA, RABAC1, C9orf41, PSMC5, NCOA1, CREBBP, EP300, KAT2B, CAV1, PPP1CASPATA17KDM1B, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NR3C2_SPATA17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNR3C2P08235DB00421SpironolactoneMineralocorticoid receptorsmall moleculeapproved
HgeneNR3C2P08235DB00700EplerenoneMineralocorticoid receptorsmall moleculeapproved
HgeneNR3C2P08235DB01395DrospirenoneMineralocorticoid receptorsmall moleculeapproved
HgeneNR3C2P08235DB00393NimodipineMineralocorticoid receptorsmall moleculeapproved|investigational
HgeneNR3C2P08235DB00624TestosteroneMineralocorticoid receptorsmall moleculeapproved|investigational
HgeneNR3C2P08235DB00687FludrocortisoneMineralocorticoid receptorsmall moleculeapproved|investigational
HgeneNR3C2P08235DB01023FelodipineMineralocorticoid receptorsmall moleculeapproved|investigational
HgeneNR3C2P08235DB00396ProgesteroneMineralocorticoid receptorsmall moleculeapproved|vet_approved

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RelatedDiseases for NR3C2_SPATA17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNR3C2C0011570Mental Depression5PSYGENET
HgeneNR3C2C0011581Depressive disorder5PSYGENET
HgeneNR3C2C0041696Unipolar Depression4PSYGENET
HgeneNR3C2C1269683Major Depressive Disorder4PSYGENET
HgeneNR3C2C1449842Pseudohypoaldosteronism, Type I, Autosomal Dominant4ORPHANET;UNIPROT
HgeneNR3C2C1854631Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in Pregnancy3CTD_human;ORPHANET;UNIPROT
HgeneNR3C2C0018801Heart failure2CTD_human
HgeneNR3C2C0027051Myocardial Infarction2CTD_human
HgeneNR3C2C0001969Alcoholic Intoxication1PSYGENET
HgeneNR3C2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNR3C2C0005586Bipolar Disorder1PSYGENET
HgeneNR3C2C0007193Cardiomyopathy, Dilated1CTD_human
HgeneNR3C2C0014175Endometriosis1CTD_human
HgeneNR3C2C0242698Ventricular Dysfunction, Left1CTD_human
HgeneNR3C2C0338831Manic1PSYGENET