|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 24772 |
FusionGeneSummary for NQO1_JAG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NQO1_JAG1 | Fusion gene ID: 24772 | Hgene | Tgene | Gene symbol | NQO1 | JAG1 | Gene ID | 1728 | 182 |
| Gene name | NAD(P)H quinone dehydrogenase 1 | jagged 1 | |
| Synonyms | DHQU|DIA4|DTD|NMOR1|NMORI|QR1 | AGS|AGS1|AHD|AWS|CD339|HJ1|JAGL1 | |
| Cytomap | 16q22.1 | 20p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NAD(P)H dehydrogenase [quinone] 1DT-diaphoraseNAD(P)H dehydrogenase, quinone 1NAD(P)H:Quinone acceptor oxidoreductase type 1NAD(P)H:menadione oxidoreductase 1NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone oxireductaseazoreductasediaphorase (NADH/ | protein jagged-1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P15559 | P78504 | |
| Ensembl transtripts involved in fusion gene | ENST00000561500, ENST00000379047, ENST00000320623, ENST00000379046, ENST00000439109, ENST00000564043, | ENST00000254958, ENST00000423891, ENST00000488480, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 3 X 3 X 2=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NQO1 [Title/Abstract] AND JAG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | JAG1 | GO:0001953 | negative regulation of cell-matrix adhesion | 11549580 |
| Tgene | JAG1 | GO:0022408 | negative regulation of cell-cell adhesion | 11549580 |
| Tgene | JAG1 | GO:0030336 | negative regulation of cell migration | 11549580 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-55-6987-01A | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000561500 | ENST00000254958 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000561500 | ENST00000423891 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| 5CDS-intron | ENST00000561500 | ENST00000488480 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000379047 | ENST00000254958 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000379047 | ENST00000423891 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| 5CDS-intron | ENST00000379047 | ENST00000488480 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000320623 | ENST00000254958 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000320623 | ENST00000423891 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| 5CDS-intron | ENST00000320623 | ENST00000488480 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000379046 | ENST00000254958 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000379046 | ENST00000423891 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| 5CDS-intron | ENST00000379046 | ENST00000488480 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000439109 | ENST00000254958 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| In-frame | ENST00000439109 | ENST00000423891 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| 5CDS-intron | ENST00000439109 | ENST00000488480 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| intron-3CDS | ENST00000564043 | ENST00000254958 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| intron-3CDS | ENST00000564043 | ENST00000423891 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
| intron-intron | ENST00000564043 | ENST00000488480 | NQO1 | chr16 | 69760336 | - | JAG1 | chr20 | 10621892 | - |
Top |
FusionProtFeatures for NQO1_JAG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NQO1 | JAG1 |
| The enzyme apparently serves as a quinone reductase inconnection with conjugation reactions of hydroquinons involved indetoxification pathways as well as in biosynthetic processes suchas the vitamin K-dependent gamma-carboxylation of glutamateresidues in prothrombin synthesis. | Ligand for multiple Notch receptors and involved in themediation of Notch signaling. May be involved in cell-fatedecisions during hematopoiesis. Seems to be involved in early andlate stages of mammalian cardiovascular development. Inhibitsmyoblast differentiation (By similarity). Enhances fibroblastgrowth factor-induced angiogenesis (in vitro). {ECO:0000250,ECO:0000269|PubMed:18660822, ECO:0000269|PubMed:9462510}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 1094_1218 | 972 | 1219 | Topological domain | Cytoplasmic |
| Tgene | >JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 1068_1093 | 972 | 1219 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000320623 | - | 1 | 6 | 104_107 | 2 | 275 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000320623 | - | 1 | 6 | 148_151 | 2 | 275 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000320623 | - | 1 | 6 | 18_19 | 2 | 275 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379046 | - | 1 | 5 | 104_107 | 2 | 237 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379046 | - | 1 | 5 | 148_151 | 2 | 237 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379046 | - | 1 | 5 | 18_19 | 2 | 237 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379047 | - | 1 | 5 | 104_107 | 2 | 241 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379047 | - | 1 | 5 | 148_151 | 2 | 241 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379047 | - | 1 | 5 | 18_19 | 2 | 241 | Nucleotide binding | FAD |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000320623 | - | 1 | 6 | 126_128 | 2 | 275 | Region | Note=Substrate binding |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379046 | - | 1 | 5 | 126_128 | 2 | 237 | Region | Note=Substrate binding |
| Hgene | >NQO1 | chr16:69760336 | chr20:10621892 | ENST00000379047 | - | 1 | 5 | 126_128 | 2 | 241 | Region | Note=Substrate binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 185_229 | 972 | 1219 | Domain | DSL |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 230_263 | 972 | 1219 | Domain | EGF-like 1 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 264_294 | 972 | 1219 | Domain | EGF-like 2%3B atypical |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 296_334 | 972 | 1219 | Domain | EGF-like 3 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 336_372 | 972 | 1219 | Domain | EGF-like 4 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 374_410 | 972 | 1219 | Domain | EGF-like 5%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 412_448 | 972 | 1219 | Domain | EGF-like 6%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 450_485 | 972 | 1219 | Domain | EGF-like 7%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 487_523 | 972 | 1219 | Domain | EGF-like 8%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 525_561 | 972 | 1219 | Domain | EGF-like 9 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 586_627 | 972 | 1219 | Domain | EGF-like 10 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 629_665 | 972 | 1219 | Domain | EGF-like 11%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 667_703 | 972 | 1219 | Domain | EGF-like 12%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 705_741 | 972 | 1219 | Domain | EGF-like 13 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 744_780 | 972 | 1219 | Domain | EGF-like 14 |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 782_818 | 972 | 1219 | Domain | EGF-like 15%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 820_856 | 972 | 1219 | Domain | EGF-like 16%3B calcium-binding |
| Tgene | JAG1 | chr16:69760336 | chr20:10621892 | ENST00000254958 | - | 22 | 26 | 34_1067 | 972 | 1219 | Topological domain | Extracellular |
Top |
FusionGeneSequence for NQO1_JAG1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NQO1_ENST00000561500_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000561500_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000379047_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000379047_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000320623_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000320623_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000379046_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000379046_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000439109_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK >In-frame_NQO1_ENST00000439109_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_249aa MVGSYYGAHLQXIEEFEYFEECFRXIFNLHRLRAFPFSEQXNTCGHFCXRYTGXWEPDQGNHXQNNRSCXXTXWKQLADCCRCRSKSSEA ASEEQNRFPCSLAELCLNCGLDLLLGDGLLLVPAEAAEAGQPHTLSLXGQHHQQRAGAAEPDQKPHXETWGQHGPHQGLXEQELQNVXNK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NQO1_ENST00000561500_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000561500_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000379047_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000379047_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000320623_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000320623_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000379046_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000379046_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000439109_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG >In-frame_NQO1_ENST00000439109_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_748nt ATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACAT CGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGA AATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCG GCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTA CTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAA CCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAG GACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGA CAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NQO1_ENST00000561500_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_2629nt GTTCCGGCCAGGGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGC ACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAG CGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATC TTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATT TCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGA AGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGA AACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAG AGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACG GCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCG TATAGCAGACCGCGGGCACTGCCGCCGCTAGGTAGAGTCTGAGGGCTTGTAGTTCTTTAAACTGTCGTGTCATACTCGAGTCTGAGGCCG TTGCTGACTTAGAATCCCTGTGTTAATTTAAGTTTTGACAAGCTGGCTTACACTGGCAATGGTAGTTTCTGTGGTTGGCTGGGAAATCGA GTGCCGCATCTCACAGCTATGCAAAAAGCTAGTCAACAGTACCCTGGTTGTGTGTCCCCTTGCAGCCGACACGGTCTCGGATCAGGCTCC CAGGAGCCTGCCCAGCCCCCTGGTCTTTGAGCTCCCACTTCTGCCAGATGTCCTAATGGTGATGCAGTCTTAGATCATAGTTTTATTTAT ATTTATTGACTCTTGAGTTGTTTTTGTATATTGGTTTTATGATGACGTACAAGTAGTTCTGTATTTGAAAGTGCCTTTGCAGCTCAGAAC CACAGCAACGATCACAAATGACTTTATTATTTATTTTTTTTAATTGTATTTTTGTTGTTGGGGGAGGGGAGACTTTGATGTCAGCAGTTG CTGGTAAAATGAAGAATTTAAAGAAAAAAATGTCAAAAGTAGAACTTTGTATAGTTATGTAAATAATTCTTTTTTATTAATCACTGTGTA TATTTGATTTATTAACTTAATAATCAAGAGCCTTAAAACATCATTCCTTTTTATTTATATGTATGTGTTTAGAATTGAAGGTTTTTGATA GCATTGTAAGCGTATGGCTTTATTTTTTTGAACTCTTCTCATTACTTGTTGCCTATAAGCCAAAATTAAGGTGTTTGAAAATAGTTTATT TTAAAACAATAGGATGGGCTTCTGTGCCCAGAATACTGATGGAATTTTTTTGTACGACGTCAGATGTTTAAAACACCTTCTATAGCATCA CTTAAAACACGTTTTAAGGACTGACTGAGGCAGTTTGAGGATTAGTTTAGAACAGGTTTTTTTGTTTGTTTGTTTTTTGTTTTTCTGCTT TAGACTTGAAAAGAGACAGGCAGGTGATCTGCTGCAGAGCAGTAAGGGAACAAGTTGAGCTATGACTTAACATAGCCAAAATGTGAGTGG TTGAATATGATTAAAAATATCAAATTAATTGTGTGAACTTGGAAGCACACCAATCTTACTTTGTAAATTCTGATTTCTTTTCACCATTCG TACATAATACTGAACCACTTGTAGATTTGATTTTTTTTTTTAATCTACTGCATTTAGGGAGTATTCTAATAAGCTAGTTGAATACTTGAA CCATAAAATGTCCAGTAAGATCACTGTTTAGATTTGCCATAGAGTACACTGCCTGCCTTAAGTGAGGAAATCAAAGTGCTATTACGAAGT TCAAGATCAAAAAGGCTTATAAAACAGAGTAATCTTGTTGGTTCACCATTGAGACCGTGAAGATACTTTGTATTGTCCTATTAGTGTTAT ATGAACATACAAATGCATCTTTGATGTGTTGTTCTTGGCAATAAATTTTGAAAAGTAATATTTATTAAATTTTTTTGTATGAAAACATGG AACAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGT ATAATAGGCTCTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGC TGCTGTGAAGCTGGAACTGCGGGAGCCCCATCTAGGGGAGCCTTGATTCCCTTGTTATTCAACAGCAAGTGTGAATACTGCTTGAATAAA >In-frame_NQO1_ENST00000561500_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_1050nt GTTCCGGCCAGGGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGC ACATTTGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAG CGAACAATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATC TTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATT TCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGA AGCCGGGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGA AACATGGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAG AGGACGACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACG GCACGCCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCG TATAGCAGACCGCGGGCACTGCCGCCGCTAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCT GCTGAGTCTGTTCTGGTAATCGGGGTATAATAGGCTCTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTC >In-frame_NQO1_ENST00000379047_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_2791nt ATCCTCCGCCCAGCACCCCAGGATTCAGGCGTTGGGTCCCGCCCTTGTAGGCTGTCCACCTCAAACGGGCCGGACAGGATATATAAGAGA GAATGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGGGTCGCC CCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGA GGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATG TGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATG GAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGA GCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACAC ACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGG TCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAAC ACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACC CAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCGCGGGCA CTGCCGCCGCTAGGTAGAGTCTGAGGGCTTGTAGTTCTTTAAACTGTCGTGTCATACTCGAGTCTGAGGCCGTTGCTGACTTAGAATCCC TGTGTTAATTTAAGTTTTGACAAGCTGGCTTACACTGGCAATGGTAGTTTCTGTGGTTGGCTGGGAAATCGAGTGCCGCATCTCACAGCT ATGCAAAAAGCTAGTCAACAGTACCCTGGTTGTGTGTCCCCTTGCAGCCGACACGGTCTCGGATCAGGCTCCCAGGAGCCTGCCCAGCCC CCTGGTCTTTGAGCTCCCACTTCTGCCAGATGTCCTAATGGTGATGCAGTCTTAGATCATAGTTTTATTTATATTTATTGACTCTTGAGT TGTTTTTGTATATTGGTTTTATGATGACGTACAAGTAGTTCTGTATTTGAAAGTGCCTTTGCAGCTCAGAACCACAGCAACGATCACAAA TGACTTTATTATTTATTTTTTTTAATTGTATTTTTGTTGTTGGGGGAGGGGAGACTTTGATGTCAGCAGTTGCTGGTAAAATGAAGAATT TAAAGAAAAAAATGTCAAAAGTAGAACTTTGTATAGTTATGTAAATAATTCTTTTTTATTAATCACTGTGTATATTTGATTTATTAACTT AATAATCAAGAGCCTTAAAACATCATTCCTTTTTATTTATATGTATGTGTTTAGAATTGAAGGTTTTTGATAGCATTGTAAGCGTATGGC TTTATTTTTTTGAACTCTTCTCATTACTTGTTGCCTATAAGCCAAAATTAAGGTGTTTGAAAATAGTTTATTTTAAAACAATAGGATGGG CTTCTGTGCCCAGAATACTGATGGAATTTTTTTGTACGACGTCAGATGTTTAAAACACCTTCTATAGCATCACTTAAAACACGTTTTAAG GACTGACTGAGGCAGTTTGAGGATTAGTTTAGAACAGGTTTTTTTGTTTGTTTGTTTTTTGTTTTTCTGCTTTAGACTTGAAAAGAGACA GGCAGGTGATCTGCTGCAGAGCAGTAAGGGAACAAGTTGAGCTATGACTTAACATAGCCAAAATGTGAGTGGTTGAATATGATTAAAAAT ATCAAATTAATTGTGTGAACTTGGAAGCACACCAATCTTACTTTGTAAATTCTGATTTCTTTTCACCATTCGTACATAATACTGAACCAC TTGTAGATTTGATTTTTTTTTTTAATCTACTGCATTTAGGGAGTATTCTAATAAGCTAGTTGAATACTTGAACCATAAAATGTCCAGTAA GATCACTGTTTAGATTTGCCATAGAGTACACTGCCTGCCTTAAGTGAGGAAATCAAAGTGCTATTACGAAGTTCAAGATCAAAAAGGCTT ATAAAACAGAGTAATCTTGTTGGTTCACCATTGAGACCGTGAAGATACTTTGTATTGTCCTATTAGTGTTATATGAACATACAAATGCAT CTTTGATGTGTTGTTCTTGGCAATAAATTTTGAAAAGTAATATTTATTAAATTTTTTTGTATGAAAACATGGAACAGTGTGGCCTCTTCT GAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGTATAATAGGCTCTGCCTGA CAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGCTGCTGTGAAGCTGGAACT GCGGGAGCCCCATCTAGGGGAGCCTTGATTCCCTTGTTATTCAACAGCAAGTGTGAATACTGCTTGAATAAACACCACTGGATTAATGGC >In-frame_NQO1_ENST00000379047_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_1212nt ATCCTCCGCCCAGCACCCCAGGATTCAGGCGTTGGGTCCCGCCCTTGTAGGCTGTCCACCTCAAACGGGCCGGACAGGATATATAAGAGA GAATGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGGGTCGCC CCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGA GGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATG TGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATG GAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGA GCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACAC ACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGG TCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAAC ACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACC CAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCGCGGGCA CTGCCGCCGCTAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTA ATCGGGGTATAATAGGCTCTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGA >In-frame_NQO1_ENST00000320623_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_3074nt TTTCGTGCCAAGGCTAAAAGGGCATGCCCACTTGATCCCTGGACTCTCTTGGGACGACTTCCACCCTGCATCCTCTTGCACCTCAGGGCA CAGTGCGCAGATGGGCTTGCCTTAGCACCCCCAGCCAGATTTTTGAGGCCTCTGTCACACACACCCCTACAATCCCCTCCCCCAGCCCCG AGAGACTTTTCTTGACTTCCACCAGTTGCTCCGGCGGGTGAGAGTGGAGAGGCCCCTCCTTCATCCCCCAGGCTCCCTCCCTTCCTGGAG CTGCAGCCTCAGCATCCTCCGCCCAGCACCCCAGGATTCAGGCGTTGGGTCCCGCCCTTGTAGGCTGTCCACCTCAAACGGGCCGGACAG GATATATAAGAGAGAATGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCC GGCCAGGGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATT TGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAAC AATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTT AGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTT GTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCG GGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACAT GGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGAC GACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACG CCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAG CAGACCGCGGGCACTGCCGCCGCTAGGTAGAGTCTGAGGGCTTGTAGTTCTTTAAACTGTCGTGTCATACTCGAGTCTGAGGCCGTTGCT GACTTAGAATCCCTGTGTTAATTTAAGTTTTGACAAGCTGGCTTACACTGGCAATGGTAGTTTCTGTGGTTGGCTGGGAAATCGAGTGCC GCATCTCACAGCTATGCAAAAAGCTAGTCAACAGTACCCTGGTTGTGTGTCCCCTTGCAGCCGACACGGTCTCGGATCAGGCTCCCAGGA GCCTGCCCAGCCCCCTGGTCTTTGAGCTCCCACTTCTGCCAGATGTCCTAATGGTGATGCAGTCTTAGATCATAGTTTTATTTATATTTA TTGACTCTTGAGTTGTTTTTGTATATTGGTTTTATGATGACGTACAAGTAGTTCTGTATTTGAAAGTGCCTTTGCAGCTCAGAACCACAG CAACGATCACAAATGACTTTATTATTTATTTTTTTTAATTGTATTTTTGTTGTTGGGGGAGGGGAGACTTTGATGTCAGCAGTTGCTGGT AAAATGAAGAATTTAAAGAAAAAAATGTCAAAAGTAGAACTTTGTATAGTTATGTAAATAATTCTTTTTTATTAATCACTGTGTATATTT GATTTATTAACTTAATAATCAAGAGCCTTAAAACATCATTCCTTTTTATTTATATGTATGTGTTTAGAATTGAAGGTTTTTGATAGCATT GTAAGCGTATGGCTTTATTTTTTTGAACTCTTCTCATTACTTGTTGCCTATAAGCCAAAATTAAGGTGTTTGAAAATAGTTTATTTTAAA ACAATAGGATGGGCTTCTGTGCCCAGAATACTGATGGAATTTTTTTGTACGACGTCAGATGTTTAAAACACCTTCTATAGCATCACTTAA AACACGTTTTAAGGACTGACTGAGGCAGTTTGAGGATTAGTTTAGAACAGGTTTTTTTGTTTGTTTGTTTTTTGTTTTTCTGCTTTAGAC TTGAAAAGAGACAGGCAGGTGATCTGCTGCAGAGCAGTAAGGGAACAAGTTGAGCTATGACTTAACATAGCCAAAATGTGAGTGGTTGAA TATGATTAAAAATATCAAATTAATTGTGTGAACTTGGAAGCACACCAATCTTACTTTGTAAATTCTGATTTCTTTTCACCATTCGTACAT AATACTGAACCACTTGTAGATTTGATTTTTTTTTTTAATCTACTGCATTTAGGGAGTATTCTAATAAGCTAGTTGAATACTTGAACCATA AAATGTCCAGTAAGATCACTGTTTAGATTTGCCATAGAGTACACTGCCTGCCTTAAGTGAGGAAATCAAAGTGCTATTACGAAGTTCAAG ATCAAAAAGGCTTATAAAACAGAGTAATCTTGTTGGTTCACCATTGAGACCGTGAAGATACTTTGTATTGTCCTATTAGTGTTATATGAA CATACAAATGCATCTTTGATGTGTTGTTCTTGGCAATAAATTTTGAAAAGTAATATTTATTAAATTTTTTTGTATGAAAACATGGAACAG TGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGTATAAT AGGCTCTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGCTGCTG TGAAGCTGGAACTGCGGGAGCCCCATCTAGGGGAGCCTTGATTCCCTTGTTATTCAACAGCAAGTGTGAATACTGCTTGAATAAACACCA >In-frame_NQO1_ENST00000320623_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_1495nt TTTCGTGCCAAGGCTAAAAGGGCATGCCCACTTGATCCCTGGACTCTCTTGGGACGACTTCCACCCTGCATCCTCTTGCACCTCAGGGCA CAGTGCGCAGATGGGCTTGCCTTAGCACCCCCAGCCAGATTTTTGAGGCCTCTGTCACACACACCCCTACAATCCCCTCCCCCAGCCCCG AGAGACTTTTCTTGACTTCCACCAGTTGCTCCGGCGGGTGAGAGTGGAGAGGCCCCTCCTTCATCCCCCAGGCTCCCTCCCTTCCTGGAG CTGCAGCCTCAGCATCCTCCGCCCAGCACCCCAGGATTCAGGCGTTGGGTCCCGCCCTTGTAGGCTGTCCACCTCAAACGGGCCGGACAG GATATATAAGAGAGAATGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCC GGCCAGGGTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATT TGCAGTGAATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAAC AATGAAATACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTT AGTAAACGTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTT GTTCCCTTGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCG GGCAGCCACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACAT GGGGCCAACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGAC GACATGGACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACG CCGACAAAACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAG CAGACCGCGGGCACTGCCGCCGCTAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGA GTCTGTTCTGGTAATCGGGGTATAATAGGCTCTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTG >In-frame_NQO1_ENST00000379046_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_2707nt AAGAGAGAATGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGG GTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATTTGCAGTG AATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAA TACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTTAGTAAAC GTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCT TGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCC ACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCA ACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACGACATGG ACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAA AACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCG CGGGCACTGCCGCCGCTAGGTAGAGTCTGAGGGCTTGTAGTTCTTTAAACTGTCGTGTCATACTCGAGTCTGAGGCCGTTGCTGACTTAG AATCCCTGTGTTAATTTAAGTTTTGACAAGCTGGCTTACACTGGCAATGGTAGTTTCTGTGGTTGGCTGGGAAATCGAGTGCCGCATCTC ACAGCTATGCAAAAAGCTAGTCAACAGTACCCTGGTTGTGTGTCCCCTTGCAGCCGACACGGTCTCGGATCAGGCTCCCAGGAGCCTGCC CAGCCCCCTGGTCTTTGAGCTCCCACTTCTGCCAGATGTCCTAATGGTGATGCAGTCTTAGATCATAGTTTTATTTATATTTATTGACTC TTGAGTTGTTTTTGTATATTGGTTTTATGATGACGTACAAGTAGTTCTGTATTTGAAAGTGCCTTTGCAGCTCAGAACCACAGCAACGAT CACAAATGACTTTATTATTTATTTTTTTTAATTGTATTTTTGTTGTTGGGGGAGGGGAGACTTTGATGTCAGCAGTTGCTGGTAAAATGA AGAATTTAAAGAAAAAAATGTCAAAAGTAGAACTTTGTATAGTTATGTAAATAATTCTTTTTTATTAATCACTGTGTATATTTGATTTAT TAACTTAATAATCAAGAGCCTTAAAACATCATTCCTTTTTATTTATATGTATGTGTTTAGAATTGAAGGTTTTTGATAGCATTGTAAGCG TATGGCTTTATTTTTTTGAACTCTTCTCATTACTTGTTGCCTATAAGCCAAAATTAAGGTGTTTGAAAATAGTTTATTTTAAAACAATAG GATGGGCTTCTGTGCCCAGAATACTGATGGAATTTTTTTGTACGACGTCAGATGTTTAAAACACCTTCTATAGCATCACTTAAAACACGT TTTAAGGACTGACTGAGGCAGTTTGAGGATTAGTTTAGAACAGGTTTTTTTGTTTGTTTGTTTTTTGTTTTTCTGCTTTAGACTTGAAAA GAGACAGGCAGGTGATCTGCTGCAGAGCAGTAAGGGAACAAGTTGAGCTATGACTTAACATAGCCAAAATGTGAGTGGTTGAATATGATT AAAAATATCAAATTAATTGTGTGAACTTGGAAGCACACCAATCTTACTTTGTAAATTCTGATTTCTTTTCACCATTCGTACATAATACTG AACCACTTGTAGATTTGATTTTTTTTTTTAATCTACTGCATTTAGGGAGTATTCTAATAAGCTAGTTGAATACTTGAACCATAAAATGTC CAGTAAGATCACTGTTTAGATTTGCCATAGAGTACACTGCCTGCCTTAAGTGAGGAAATCAAAGTGCTATTACGAAGTTCAAGATCAAAA AGGCTTATAAAACAGAGTAATCTTGTTGGTTCACCATTGAGACCGTGAAGATACTTTGTATTGTCCTATTAGTGTTATATGAACATACAA ATGCATCTTTGATGTGTTGTTCTTGGCAATAAATTTTGAAAAGTAATATTTATTAAATTTTTTTGTATGAAAACATGGAACAGTGTGGCC TCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGTATAATAGGCTCT GCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGCTGCTGTGAAGCT GGAACTGCGGGAGCCCCATCTAGGGGAGCCTTGATTCCCTTGTTATTCAACAGCAAGTGTGAATACTGCTTGAATAAACACCACTGGATT >In-frame_NQO1_ENST00000379046_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_1128nt AAGAGAGAATGCACCGTGCACTACACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGG GTCGCCCCGGCAACCACGAGCCCAGCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATTTGCAGTG AATTGAGGAATTTGAATATTTTGAAGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAA TACATGTGGCCATTTCTGCTGAAGATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTTAGTAAAC GTGATGGAAACAGCTCGCTGATTGCTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCT TGCTGAGCTCTGTCTTAACTGTGGCTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCC ACACACACTCAGCCTCTGAGGACAACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCA ACACGGTCCCCATCAAGGATTATGAGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACGACATGG ACAAACACCAGCAGAAAGCCCGGTTTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAA AACACCCAAACTGGACAAACAAACAGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCG CGGGCACTGCCGCCGCTAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTT CTGGTAATCGGGGTATAATAGGCTCTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCT >In-frame_NQO1_ENST00000439109_chr16_69760336_-_JAG1_ENST00000254958_chr20_10621892_-_2683nt ACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGGGTCGCCCCGGCAACCACGAGCCCA GCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGA AGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAG ATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTG CTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGG CTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACA ACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATG AGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGT TTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAAC AGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCGCGGGCACTGCCGCCGCTAGGTAGA GTCTGAGGGCTTGTAGTTCTTTAAACTGTCGTGTCATACTCGAGTCTGAGGCCGTTGCTGACTTAGAATCCCTGTGTTAATTTAAGTTTT GACAAGCTGGCTTACACTGGCAATGGTAGTTTCTGTGGTTGGCTGGGAAATCGAGTGCCGCATCTCACAGCTATGCAAAAAGCTAGTCAA CAGTACCCTGGTTGTGTGTCCCCTTGCAGCCGACACGGTCTCGGATCAGGCTCCCAGGAGCCTGCCCAGCCCCCTGGTCTTTGAGCTCCC ACTTCTGCCAGATGTCCTAATGGTGATGCAGTCTTAGATCATAGTTTTATTTATATTTATTGACTCTTGAGTTGTTTTTGTATATTGGTT TTATGATGACGTACAAGTAGTTCTGTATTTGAAAGTGCCTTTGCAGCTCAGAACCACAGCAACGATCACAAATGACTTTATTATTTATTT TTTTTAATTGTATTTTTGTTGTTGGGGGAGGGGAGACTTTGATGTCAGCAGTTGCTGGTAAAATGAAGAATTTAAAGAAAAAAATGTCAA AAGTAGAACTTTGTATAGTTATGTAAATAATTCTTTTTTATTAATCACTGTGTATATTTGATTTATTAACTTAATAATCAAGAGCCTTAA AACATCATTCCTTTTTATTTATATGTATGTGTTTAGAATTGAAGGTTTTTGATAGCATTGTAAGCGTATGGCTTTATTTTTTTGAACTCT TCTCATTACTTGTTGCCTATAAGCCAAAATTAAGGTGTTTGAAAATAGTTTATTTTAAAACAATAGGATGGGCTTCTGTGCCCAGAATAC TGATGGAATTTTTTTGTACGACGTCAGATGTTTAAAACACCTTCTATAGCATCACTTAAAACACGTTTTAAGGACTGACTGAGGCAGTTT GAGGATTAGTTTAGAACAGGTTTTTTTGTTTGTTTGTTTTTTGTTTTTCTGCTTTAGACTTGAAAAGAGACAGGCAGGTGATCTGCTGCA GAGCAGTAAGGGAACAAGTTGAGCTATGACTTAACATAGCCAAAATGTGAGTGGTTGAATATGATTAAAAATATCAAATTAATTGTGTGA ACTTGGAAGCACACCAATCTTACTTTGTAAATTCTGATTTCTTTTCACCATTCGTACATAATACTGAACCACTTGTAGATTTGATTTTTT TTTTTAATCTACTGCATTTAGGGAGTATTCTAATAAGCTAGTTGAATACTTGAACCATAAAATGTCCAGTAAGATCACTGTTTAGATTTG CCATAGAGTACACTGCCTGCCTTAAGTGAGGAAATCAAAGTGCTATTACGAAGTTCAAGATCAAAAAGGCTTATAAAACAGAGTAATCTT GTTGGTTCACCATTGAGACCGTGAAGATACTTTGTATTGTCCTATTAGTGTTATATGAACATACAAATGCATCTTTGATGTGTTGTTCTT GGCAATAAATTTTGAAAAGTAATATTTATTAAATTTTTTTGTATGAAAACATGGAACAGTGTGGCCTCTTCTGAGCTTACGTAGTTCTAC CGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGTATAATAGGCTCTGCCTGACAGAGGGATGGAGGAAGA ACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGCTGCTGTGAAGCTGGAACTGCGGGAGCCCCATCTAGG >In-frame_NQO1_ENST00000439109_chr16_69760336_-_JAG1_ENST00000423891_chr20_10621892_-_1104nt ACACGCGACTCCCACAAGGTTGCAGCCGGAGCCGCCCAGCTCACCGAGAGCCTAGTTCCGGCCAGGGTCGCCCCGGCAACCACGAGCCCA GCCAATCAGCGCCCCGGACTGCACCAGAGCCATGGTCGGGTCTTACTACGGAGCACATTTGCAGTGAATTGAGGAATTTGAATATTTTGA AGAATGTTTCCGCTGAATATTCAATCTACATCGCTTGCGAGCCTTCCCCTTCAGCGAACAATGAAATACATGTGGCCATTTCTGCTGAAG ATATACGGGATGATGGGAACCCGATCAAGGAAATCACTGACAAAATAATCGATCTTGTTAGTAAACGTGATGGAAACAGCTCGCTGATTG CTGCCGTTGCAGAAGTAAGAGTTCAGAGGCGGCCTCTGAAGAACAGAACAGATTTCCTTGTTCCCTTGCTGAGCTCTGTCTTAACTGTGG CTTGGATCTGTTGCTTGGTGACGGCCTTCTACTGGTGCCTGCGGAAGCGGCGGAAGCCGGGCAGCCACACACACTCAGCCTCTGAGGACA ACACCACCAACAACGTGCGGGAGCAGCTGAACCAGATCAAAAACCCCATTGAGAAACATGGGGCCAACACGGTCCCCATCAAGGATTATG AGAACAAGAACTCCAAAATGTCTAAAATAAGGACACACAATTCTGAAGTAGAAGAGGACGACATGGACAAACACCAGCAGAAAGCCCGGT TTGCCAAGCAGCCGGCGTACACGCTGGTAGACAGAGAAGAGAAGCCCCCCAACGGCACGCCGACAAAACACCCAAACTGGACAAACAAAC AGGACAACAGAGACTTGGAAAGTGCCCAGAGCTTAAACCGAATGGAGTACATCGTATAGCAGACCGCGGGCACTGCCGCCGCTAGTGTGG CCTCTTCTGAGCTTACGTAGTTCTACCGGCTTTGCCATGTGCTTCTGCCACCCTGCTGAGTCTGTTCTGGTAATCGGGGTATAATAGGCT CTGCCTGACAGAGGGATGGAGGAAGAACTGAAAGGCTTTTCAACCACAAAACTCATCTGGAGTTCTCAAAGACCTGGGGCTGCTGTGAAG |
Top |
FusionGenePPI for NQO1_JAG1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NQO1 | HSPA4, NQO1, ING1, STUB1, TP53, RPS10P5, LAMB1, POLDIP3, YTHDF1, RPS19, FN1, ITGA4, BAG3, PARP1, NFE2L2, FOS, MOV10, NXF1, NME1, ADK, DAZAP1, FUBP3, GOT1, NDUFS7, TRIM25, UBE2D1 | JAG1 | NOTCH2, NOTCH1, NOTCH3, MLLT4, MIB1, HGS, NEURL1, FBXW7, APBB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NQO1_JAG1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | NQO1 | P15559 | DB00266 | Dicoumarol | NAD(P)H dehydrogenase [quinone] 1 | small molecule | approved |
| Hgene | NQO1 | P15559 | DB00170 | Menadione | NAD(P)H dehydrogenase [quinone] 1 | small molecule | approved|nutraceutical |
Top |
RelatedDiseases for NQO1_JAG1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NQO1 | C0028797 | Occupational Diseases | 4 | CTD_human |
| Hgene | NQO1 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | NQO1 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
| Hgene | NQO1 | C0023895 | Liver diseases | 2 | CTD_human |
| Hgene | NQO1 | C0027659 | Neoplasms, Experimental | 2 | CTD_human |
| Hgene | NQO1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | NQO1 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | NQO1 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | NQO1 | C0008370 | Cholestasis | 1 | CTD_human |
| Hgene | NQO1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | NQO1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | NQO1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | NQO1 | C0019061 | Hemolytic-Uremic Syndrome | 1 | CTD_human |
| Hgene | NQO1 | C0019080 | Hemorrhage | 1 | CTD_human |
| Hgene | NQO1 | C0020456 | Hyperglycemia | 1 | CTD_human |
| Hgene | NQO1 | C0022658 | Kidney Diseases | 1 | CTD_human |
| Hgene | NQO1 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Hgene | NQO1 | C0026764 | Multiple Myeloma | 1 | CTD_human |
| Hgene | NQO1 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | NQO1 | C0030354 | Papilloma | 1 | CTD_human |
| Hgene | NQO1 | C0030567 | Parkinson Disease | 1 | CTD_human |
| Hgene | NQO1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | NQO1 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |
| Hgene | NQO1 | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
| Hgene | NQO1 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | NQO1 | C0853193 | Bipolar I disorder | 1 | PSYGENET |
| Hgene | NQO1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | NQO1 | C1846707 | SPINOCEREBELLAR ATAXIA 17 | 1 | CTD_human |
| Hgene | NQO1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Hgene | NQO1 | C2609414 | Acute kidney injury | 1 | CTD_human |
| Tgene | JAG1 | C1956125 | Alagille Syndrome 1 | 13 | ORPHANET;UNIPROT |
| Tgene | JAG1 | C0015393 | Eye Abnormalities | 3 | CTD_human |
| Tgene | JAG1 | C0085280 | Alagille Syndrome | 3 | CTD_human |
| Tgene | JAG1 | C0039685 | Tetralogy of Fallot | 2 | CTD_human;HPO;ORPHANET;UNIPROT |
| Tgene | JAG1 | C0282631 | Facies | 2 | CTD_human |
| Tgene | JAG1 | C0005940 | Bone Diseases | 1 | CTD_human |
| Tgene | JAG1 | C0010038 | Corneal Opacity | 1 | CTD_human |
| Tgene | JAG1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | JAG1 | C0011053 | Deafness | 1 | CTD_human |
| Tgene | JAG1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | JAG1 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Tgene | JAG1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | JAG1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Tgene | JAG1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | JAG1 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Tgene | JAG1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|