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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24771

FusionGeneSummary for NQO1_DYRK1A

check button Fusion gene summary
Fusion gene informationFusion gene name: NQO1_DYRK1A
Fusion gene ID: 24771
HgeneTgene
Gene symbol

NQO1

DYRK1A

Gene ID

1728

1859

Gene nameNAD(P)H quinone dehydrogenase 1dual specificity tyrosine phosphorylation regulated kinase 1A
SynonymsDHQU|DIA4|DTD|NMOR1|NMORI|QR1DYRK|DYRK1|HP86|MNB|MNBH|MRD7
Cytomap

16q22.1

21q22.13

Type of geneprotein-codingprotein-coding
DescriptionNAD(P)H dehydrogenase [quinone] 1DT-diaphoraseNAD(P)H dehydrogenase, quinone 1NAD(P)H:Quinone acceptor oxidoreductase type 1NAD(P)H:menadione oxidoreductase 1NAD(P)H:quinone oxidoreductase 1NAD(P)H:quinone oxireductaseazoreductasediaphorase (NADH/dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs
Modification date2018052320180522
UniProtAcc

P15559

Q13627

Ensembl transtripts involved in fusion geneENST00000561500, ENST00000379047, 
ENST00000320623, ENST00000379046, 
ENST00000439109, ENST00000564043, 
ENST00000462274, ENST00000338785, 
ENST00000451934, ENST00000321219, 
ENST00000339659, ENST00000398960, 
ENST00000398956, ENST00000455387, 
Fusion gene scores* DoF score6 X 5 X 3=903 X 3 X 2=18
# samples 73
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NQO1 [Title/Abstract] AND DYRK1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

TgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

TgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM983726NQO1chr16

69744922

+DYRK1Achr21

38887379

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000561500ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000561500ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000561500ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000561500ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379047ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379047ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379047ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000320623ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000320623ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000320623ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379046ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000379046ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000379046ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000439109ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000439109ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000439109ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000462274NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000564043ENST00000338785NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000451934NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000321219NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-3UTRENST00000564043ENST00000339659NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000398960NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000398956NQO1chr16

69744922

+DYRK1Achr21

38887379

+
intron-intronENST00000564043ENST00000455387NQO1chr16

69744922

+DYRK1Achr21

38887379

+

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FusionProtFeatures for NQO1_DYRK1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NQO1

P15559

DYRK1A

Q13627

The enzyme apparently serves as a quinone reductase inconnection with conjugation reactions of hydroquinons involved indetoxification pathways as well as in biosynthetic processes suchas the vitamin K-dependent gamma-carboxylation of glutamateresidues in prothrombin synthesis. Dual-specificity kinase which possesses bothserine/threonine and tyrosine kinase activities. May play a rolein a signaling pathway regulating nuclear functions of cellproliferation. Modulates alternative splicing by phosphorylatingthe splice factor SRSF6 (By similarity). Exhibits a substratepreference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates theapoptotic process. Promotes cell survival upon genotoxic stressthrough phosphorylation of SIRT1. This in turn inhibits TP53activity and apoptosis (By similarity).{ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20,ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067,ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NQO1_DYRK1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NQO1_DYRK1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NQO1_DYRK1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNQO1P15559DB00266DicoumarolNAD(P)H dehydrogenase [quinone] 1small moleculeapproved
HgeneNQO1P15559DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1small moleculeapproved|nutraceutical

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RelatedDiseases for NQO1_DYRK1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNQO1C0028797Occupational Diseases4CTD_human
HgeneNQO1C0036341Schizophrenia3PSYGENET
HgeneNQO1C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneNQO1C0023895Liver diseases2CTD_human
HgeneNQO1C0027659Neoplasms, Experimental2CTD_human
HgeneNQO1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneNQO1C0004096Asthma1CTD_human
HgeneNQO1C0005695Bladder Neoplasm1CTD_human
HgeneNQO1C0008370Cholestasis1CTD_human
HgeneNQO1C0009404Colorectal Neoplasms1CTD_human
HgeneNQO1C0011616Contact Dermatitis1CTD_human
HgeneNQO1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneNQO1C0019061Hemolytic-Uremic Syndrome1CTD_human
HgeneNQO1C0019080Hemorrhage1CTD_human
HgeneNQO1C0020456Hyperglycemia1CTD_human
HgeneNQO1C0022658Kidney Diseases1CTD_human
HgeneNQO1C0023470Myeloid Leukemia1CTD_human
HgeneNQO1C0026764Multiple Myeloma1CTD_human
HgeneNQO1C0028754Obesity1CTD_human
HgeneNQO1C0030354Papilloma1CTD_human
HgeneNQO1C0030567Parkinson Disease1CTD_human
HgeneNQO1C0033578Prostatic Neoplasms1CTD_human
HgeneNQO1C0235032Neurotoxicity Syndromes1CTD_human
HgeneNQO1C0236663Alcohol withdrawal syndrome1PSYGENET
HgeneNQO1C0525045Mood Disorders1PSYGENET
HgeneNQO1C0853193Bipolar I disorder1PSYGENET
HgeneNQO1C1458155Mammary Neoplasms1CTD_human
HgeneNQO1C1846707SPINOCEREBELLAR ATAXIA 171CTD_human
HgeneNQO1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneNQO1C2609414Acute kidney injury1CTD_human