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Fusion gene ID: 24769 |
FusionGeneSummary for NPY_FOXP1 |
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Fusion gene information | Fusion gene name: NPY_FOXP1 | Fusion gene ID: 24769 | Hgene | Tgene | Gene symbol | NPY | FOXP1 | Gene ID | 4852 | 27086 |
Gene name | neuropeptide Y | forkhead box P1 | |
Synonyms | PYY4 | 12CC4|HSPC215|MFH|QRF1|hFKH1B | |
Cytomap | 7p15.3 | 3p13 | |
Type of gene | protein-coding | protein-coding | |
Description | pro-neuropeptide Yprepro-neuropeptide Y | forkhead box protein P1fork head-related protein like Bglutamine-rich factor 1mac-1-regulated forkhead | |
Modification date | 20180527 | 20180522 | |
UniProtAcc | P01303 | Q9H334 | |
Ensembl transtripts involved in fusion gene | ENST00000242152, ENST00000407573, ENST00000405982, | ENST00000318789, ENST00000475937, ENST00000493089, ENST00000484350, ENST00000318779, ENST00000491238, ENST00000498215, ENST00000468577, ENST00000472382, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 37 X 16 X 17=10064 |
# samples | 3 | 40 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(40/10064*10)=-4.65306001710456 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NPY [Title/Abstract] AND FOXP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FOXP1 | GO:0002903 | negative regulation of B cell apoptotic process | 25267198 |
Tgene | FOXP1 | GO:0030316 | osteoclast differentiation | 18799727 |
Tgene | FOXP1 | GO:0032496 | response to lipopolysaccharide | 18799727 |
Tgene | FOXP1 | GO:0032680 | regulation of tumor necrosis factor production | 18799727 |
Tgene | FOXP1 | GO:0035926 | chemokine (C-C motif) ligand 2 secretion | 18799727 |
Tgene | FOXP1 | GO:0036035 | osteoclast development | 18799727 |
Tgene | FOXP1 | GO:0042116 | macrophage activation | 18799727 |
Tgene | FOXP1 | GO:0042117 | monocyte activation | 18799727 |
Tgene | FOXP1 | GO:0045655 | regulation of monocyte differentiation | 15286807 |
Tgene | FOXP1 | GO:0045892 | negative regulation of transcription, DNA-templated | 20950788 |
Tgene | FOXP1 | GO:0050706 | regulation of interleukin-1 beta secretion | 18799727 |
Tgene | FOXP1 | GO:0050727 | regulation of inflammatory response | 18799727 |
Tgene | FOXP1 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 18640093 |
Tgene | FOXP1 | GO:1900424 | regulation of defense response to bacterium | 18799727 |
Tgene | FOXP1 | GO:1901256 | regulation of macrophage colony-stimulating factor production | 18799727 |
Tgene | FOXP1 | GO:2001182 | regulation of interleukin-12 secretion | 18799727 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-G9-6354-01A | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000242152 | ENST00000318789 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-3UTR | ENST00000242152 | ENST00000475937 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000493089 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000484350 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000318779 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000491238 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000498215 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000468577 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
5CDS-intron | ENST00000242152 | ENST00000472382 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-3UTR | ENST00000407573 | ENST00000318789 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-3UTR | ENST00000407573 | ENST00000475937 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000493089 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000484350 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000318779 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000491238 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000498215 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000468577 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000407573 | ENST00000472382 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-3UTR | ENST00000405982 | ENST00000318789 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-3UTR | ENST00000405982 | ENST00000475937 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000493089 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000484350 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000318779 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000491238 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000498215 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000468577 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
intron-intron | ENST00000405982 | ENST00000472382 | NPY | chr7 | 24331484 | + | FOXP1 | chr3 | 71007472 | - |
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FusionProtFeatures for NPY_FOXP1 |
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Hgene | Tgene |
NPY | FOXP1 |
NPY is implicated in the control of feeding and insecretion of gonadotrophin-release hormone. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NPY_FOXP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NPY_FOXP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NPY | PMCH, NPY1R, MEP1A, NR1H2, BAG6, ATP12A, UBQLN1 | FOXP1 | CTBP1, FOXP1, FOXP2, FOXP4, GATAD2B, MTA1, NCOR2, ELAVL1, MYC, IL3RA, CCDC183, UNK, RCC1, HOXD13, QSER1, SATB1, SATB2, CTBP2, MYH10, LIG3, C10orf2, CUX1, VRK3, XRCC1, CHD1L, RPA2, BLM, MRE11A, MYL12B, TBP, TP53, TTF2, ZBTB10, MYL9, RPA3, TFCP2, TOP2A, UBP1, FOXP3, AURKA, SNRNP70 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPY_FOXP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NPY_FOXP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NPY | C0011581 | Depressive disorder | 7 | CTD_human;PSYGENET |
Hgene | NPY | C0001973 | Alcoholic Intoxication, Chronic | 6 | CTD_human;PSYGENET |
Hgene | NPY | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | NPY | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | NPY | C0525045 | Mood Disorders | 5 | PSYGENET |
Hgene | NPY | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | NPY | C0003123 | Anorexia | 3 | CTD_human |
Hgene | NPY | C0036572 | Seizures | 3 | CTD_human |
Hgene | NPY | C0014544 | Epilepsy | 2 | CTD_human |
Hgene | NPY | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | NPY | C0085762 | Alcohol abuse | 2 | PSYGENET |
Hgene | NPY | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Hgene | NPY | C0003469 | Anxiety Disorders | 1 | CTD_human |
Hgene | NPY | C0004096 | Asthma | 1 | CTD_human |
Hgene | NPY | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
Hgene | NPY | C0007785 | Cerebral Infarction | 1 | CTD_human |
Hgene | NPY | C0008677 | Bronchitis, Chronic | 1 | CTD_human |
Hgene | NPY | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
Hgene | NPY | C0020564 | Hypertrophy | 1 | CTD_human |
Hgene | NPY | C0025261 | Memory Disorders | 1 | CTD_human |
Hgene | NPY | C0026837 | Muscle Rigidity | 1 | CTD_human |
Hgene | NPY | C0027429 | Nasal obstruction present finding | 1 | CTD_human |
Hgene | NPY | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | NPY | C0035455 | Rhinitis | 1 | CTD_human |
Hgene | NPY | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
Hgene | NPY | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Hgene | NPY | C0085159 | Seasonal Affective Disorder | 1 | PSYGENET |
Hgene | NPY | C0236664 | Alcohol-Related Disorders | 1 | PSYGENET |
Hgene | NPY | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Hgene | NPY | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | NPY | C0424295 | Hyperactive behavior | 1 | CTD_human |
Hgene | NPY | C0600427 | Cocaine Dependence | 1 | PSYGENET |
Hgene | NPY | C1262477 | Weight decreased | 1 | CTD_human |
Hgene | NPY | C2362914 | clinical depression | 1 | PSYGENET |
Tgene | FOXP1 | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
Tgene | FOXP1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | FOXP1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Tgene | FOXP1 | C0042900 | Vitiligo | 1 | CTD_human |
Tgene | FOXP1 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
Tgene | FOXP1 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Tgene | FOXP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | FOXP1 | C4013764 | MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND WITH OR WITHOUT AUTISTIC FEATURES | 1 | CTD_human;ORPHANET;UNIPROT |