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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2475

FusionGeneSummary for ARHGAP5_NPAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP5_NPAS3
Fusion gene ID: 2475
HgeneTgene
Gene symbol

ARHGAP5

NPAS3

Gene ID

394

64067

Gene nameRho GTPase activating protein 5neuronal PAS domain protein 3
SynonymsGFI2|RhoGAP5|p190-B|p190BRhoGAPMOP6|PASD6|bHLHe12
Cytomap

14q12

14q13.1

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 5growth factor independent 2p100 RasGAP-associated p105 proteinp105 RhoGAPrho-type GTPase-activating protein 5neuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3
Modification date2018052320180523
UniProtAcc

Q13017

Q8IXF0

Ensembl transtripts involved in fusion geneENST00000556611, ENST00000539826, 
ENST00000396582, ENST00000432921, 
ENST00000345122, ENST00000433497, 
ENST00000551492, ENST00000346562, 
ENST00000341321, ENST00000548645, 
ENST00000356141, ENST00000357798, 
ENST00000547068, ENST00000551008, 
ENST00000550662, 
Fusion gene scores* DoF score9 X 4 X 7=2529 X 7 X 6=378
# samples 1010
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP5 [Title/Abstract] AND NPAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8373-01AARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000556611ENST00000551492ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000346562ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000341321ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000548645ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000356141ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000357798ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000547068ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000556611ENST00000551008ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
5CDS-intronENST00000556611ENST00000550662ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000551492ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000346562ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000341321ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000548645ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000356141ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000357798ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000547068ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000539826ENST00000551008ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
5CDS-intronENST00000539826ENST00000550662ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000551492ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000346562ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000341321ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000548645ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000356141ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000357798ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000547068ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000396582ENST00000551008ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-intronENST00000396582ENST00000550662ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000551492ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000346562ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000341321ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000548645ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000356141ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000357798ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000547068ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000432921ENST00000551008ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
5CDS-intronENST00000432921ENST00000550662ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000551492ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000346562ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000341321ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000548645ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000356141ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000357798ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000547068ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
Frame-shiftENST00000345122ENST00000551008ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
5CDS-intronENST00000345122ENST00000550662ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000551492ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000346562ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000341321ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000548645ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000356141ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000357798ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000547068ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-3CDSENST00000433497ENST00000551008ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+
intron-intronENST00000433497ENST00000550662ARHGAP5chr14

32563592

+NPAS3chr14

33836392

+

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FusionProtFeatures for ARHGAP5_NPAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP5

Q13017

NPAS3

Q8IXF0

May play a broad role in neurogenesis. May controlregulatory pathways relevant to schizophrenia and to psychoticillness (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARHGAP5_NPAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARHGAP5_NPAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP5RND3, RND1, RND2, RHOA, PXN, XRCC6, SMURF1, SMURF2, NPM1, ADRB2, UNK, CDH1, PTPRU, IQCF1, PLK1NPAS3ARNT2, TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP5_NPAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP5_NPAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNPAS3C0036341Schizophrenia4PSYGENET
TgeneNPAS3C0005586Bipolar Disorder3PSYGENET
TgeneNPAS3C0033975Psychotic Disorders1PSYGENET
TgeneNPAS3C0041696Unipolar Depression1PSYGENET
TgeneNPAS3C0349204Nonorganic psychosis1PSYGENET
TgeneNPAS3C1269683Major Depressive Disorder1PSYGENET