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Fusion gene ID: 24745 |
FusionGeneSummary for NPNT_ST3GAL1 |
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Fusion gene information | Fusion gene name: NPNT_ST3GAL1 | Fusion gene ID: 24745 | Hgene | Tgene | Gene symbol | NPNT | ST3GAL1 | Gene ID | 255743 | 6482 |
Gene name | nephronectin | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | |
Synonyms | EGFL6L|POEM | Gal-NAc6S|SIAT4A|SIATFL|ST3GalA|ST3GalA.1|ST3GalIA|ST3GalIA,1|ST3O | |
Cytomap | 4q24 | 8q24.22 | |
Type of gene | protein-coding | protein-coding | |
Description | nephronectinpreosteoblast EGF-like repeat protein with MAM domain | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferaseSIAT4-AST3GalIalpha 2,3-ST 1beta-galactoside alpha-2,3-sialyltransferase 1sialyltransferase 4A (beta-galactosidase alpha-2,3-sialy | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q6UXI9 | Q11201 | |
Ensembl transtripts involved in fusion gene | ENST00000379987, ENST00000453617, ENST00000427316, ENST00000514622, ENST00000305572, ENST00000506666, ENST00000513430, | ENST00000399640, ENST00000319914, ENST00000521180, ENST00000522652, ENST00000519435, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 8 X 4=256 |
# samples | 3 | 8 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NPNT [Title/Abstract] AND ST3GAL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF329641 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000379987 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000379987 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000379987 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000379987 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000379987 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000453617 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000453617 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000453617 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000453617 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000453617 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000427316 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000427316 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000427316 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000427316 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000427316 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000514622 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000514622 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000514622 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000514622 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000514622 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000305572 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000305572 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000305572 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000305572 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000305572 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000506666 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000506666 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000506666 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000506666 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
5CDS-intron | ENST00000506666 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
intron-intron | ENST00000513430 | ENST00000399640 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
intron-intron | ENST00000513430 | ENST00000319914 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
intron-intron | ENST00000513430 | ENST00000521180 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
intron-intron | ENST00000513430 | ENST00000522652 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
intron-intron | ENST00000513430 | ENST00000519435 | NPNT | chr4 | 106880206 | - | ST3GAL1 | chr8 | 134503048 | - |
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FusionProtFeatures for NPNT_ST3GAL1 |
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Hgene | Tgene |
NPNT | ST3GAL1 |
Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked toThr or Ser and also as a terminal sequence on certaingangliosides. SIAT4A and SIAT4B sialylate the same acceptorsubstrates but exhibit different Km values.{ECO:0000250|UniProtKB:P54751}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NPNT_ST3GAL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NPNT_ST3GAL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPNT_ST3GAL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NPNT_ST3GAL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ST3GAL1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | ST3GAL1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | ST3GAL1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | ST3GAL1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |