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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24745

FusionGeneSummary for NPNT_ST3GAL1

check button Fusion gene summary
Fusion gene informationFusion gene name: NPNT_ST3GAL1
Fusion gene ID: 24745
HgeneTgene
Gene symbol

NPNT

ST3GAL1

Gene ID

255743

6482

Gene namenephronectinST3 beta-galactoside alpha-2,3-sialyltransferase 1
SynonymsEGFL6L|POEMGal-NAc6S|SIAT4A|SIATFL|ST3GalA|ST3GalA.1|ST3GalIA|ST3GalIA,1|ST3O
Cytomap

4q24

8q24.22

Type of geneprotein-codingprotein-coding
Descriptionnephronectinpreosteoblast EGF-like repeat protein with MAM domainCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferaseSIAT4-AST3GalIalpha 2,3-ST 1beta-galactoside alpha-2,3-sialyltransferase 1sialyltransferase 4A (beta-galactosidase alpha-2,3-sialy
Modification date2018052720180523
UniProtAcc

Q6UXI9

Q11201

Ensembl transtripts involved in fusion geneENST00000379987, ENST00000453617, 
ENST00000427316, ENST00000514622, 
ENST00000305572, ENST00000506666, 
ENST00000513430, 
ENST00000399640, 
ENST00000319914, ENST00000521180, 
ENST00000522652, ENST00000519435, 
Fusion gene scores* DoF score3 X 3 X 2=188 X 8 X 4=256
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPNT [Title/Abstract] AND ST3GAL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF329641NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379987ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000379987ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000379987ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000379987ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000379987ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000453617ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000453617ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000453617ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000453617ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000453617ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000427316ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000427316ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000427316ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000427316ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000427316ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000514622ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000514622ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000514622ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000514622ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000514622ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000305572ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000305572ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000305572ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000305572ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000305572ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000506666ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000506666ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000506666ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000506666ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
5CDS-intronENST00000506666ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
intron-intronENST00000513430ENST00000399640NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
intron-intronENST00000513430ENST00000319914NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
intron-intronENST00000513430ENST00000521180NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
intron-intronENST00000513430ENST00000522652NPNTchr4

106880206

-ST3GAL1chr8

134503048

-
intron-intronENST00000513430ENST00000519435NPNTchr4

106880206

-ST3GAL1chr8

134503048

-

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FusionProtFeatures for NPNT_ST3GAL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPNT

Q6UXI9

ST3GAL1

Q11201

Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked toThr or Ser and also as a terminal sequence on certaingangliosides. SIAT4A and SIAT4B sialylate the same acceptorsubstrates but exhibit different Km values.{ECO:0000250|UniProtKB:P54751}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPNT_ST3GAL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NPNT_ST3GAL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPNT_ST3GAL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPNT_ST3GAL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneST3GAL1C0005586Bipolar Disorder1PSYGENET
TgeneST3GAL1C0033975Psychotic Disorders1PSYGENET
TgeneST3GAL1C0036341Schizophrenia1PSYGENET
TgeneST3GAL1C0349204Nonorganic psychosis1PSYGENET