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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24744

FusionGeneSummary for NPNT_NPNT

check button Fusion gene summary
Fusion gene informationFusion gene name: NPNT_NPNT
Fusion gene ID: 24744
HgeneTgene
Gene symbol

NPNT

NPNT

Gene ID

255743

255743

Gene namenephronectinnephronectin
SynonymsEGFL6L|POEMEGFL6L|POEM
Cytomap

4q24

4q24

Type of geneprotein-codingprotein-coding
Descriptionnephronectinpreosteoblast EGF-like repeat protein with MAM domainnephronectinpreosteoblast EGF-like repeat protein with MAM domain
Modification date2018052720180527
UniProtAcc

Q6UXI9

Q6UXI9

Ensembl transtripts involved in fusion geneENST00000379987, ENST00000453617, 
ENST00000427316, ENST00000514622, 
ENST00000305572, ENST00000506666, 
ENST00000513430, 		ENST00000379987, 
ENST00000453617, ENST00000427316, 
ENST00000514622, ENST00000305572, 
ENST00000506666, ENST00000513430, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: NPNT [Title/Abstract] AND NPNT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N71523NPNTchr4

106892541

-NPNTchr4

106892564

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000379987ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000379987ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000379987ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000379987ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-3UTRENST00000379987ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000379987ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000379987ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000453617ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000453617ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000453617ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000453617ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000453617ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000453617ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000453617ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000427316ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000427316ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000427316ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000427316ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000427316ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000427316ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000427316ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000514622ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000514622ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000514622ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000514622ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000514622ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000514622ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000514622ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-3UTRENST00000305572ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000305572ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000305572ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000305572ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-3UTRENST00000305572ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000305572ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
3UTR-intronENST00000305572ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000506666ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000506666ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000506666ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000506666ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000506666ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000506666ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000506666ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000513430ENST00000379987NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000513430ENST00000453617NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000513430ENST00000427316NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000513430ENST00000514622NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-3UTRENST00000513430ENST00000305572NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000513430ENST00000506666NPNTchr4

106892541

-NPNTchr4

106892564

+
intron-intronENST00000513430ENST00000513430NPNTchr4

106892541

-NPNTchr4

106892564

+

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FusionProtFeatures for NPNT_NPNT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPNT

Q6UXI9

NPNT

Q6UXI9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPNT_NPNT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NPNT_NPNT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPNT_NPNT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPNT_NPNT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource