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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24726

FusionGeneSummary for NPLOC4_CYP4B1

check button Fusion gene summary
Fusion gene informationFusion gene name: NPLOC4_CYP4B1
Fusion gene ID: 24726
HgeneTgene
Gene symbol

NPLOC4

CYP4B1

Gene ID

55666

1580

Gene nameNPL4 homolog, ubiquitin recognition factorcytochrome P450 family 4 subfamily B member 1
SynonymsNPL4CYPIVB1|P-450HP
Cytomap

17q25.3

1p33

Type of geneprotein-codingprotein-coding
Descriptionnuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homologcytochrome P450 4B1cytochrome P450, family 4, subfamily B, polypeptide 1cytochrome P450, subfamily IVB, polypeptide 1cytochrome P450-HPmicrosomal monooxygenase
Modification date2018052320180522
UniProtAcc

Q8TAT6

P13584

Ensembl transtripts involved in fusion geneENST00000331134, ENST00000374747, 
ENST00000539314, ENST00000572760, 
ENST00000573876, ENST00000574344, 
ENST00000546128, ENST00000371923, 
ENST00000271153, ENST00000371919, 
ENST00000452782, 
Fusion gene scores* DoF score11 X 9 X 7=6932 X 2 X 2=8
# samples 132
** MAII scorelog2(13/693*10)=-2.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NPLOC4 [Title/Abstract] AND CYP4B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-BC-A3KG-01ANPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000331134ENST00000546128NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000331134ENST00000371923NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000331134ENST00000271153NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000331134ENST00000371919NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000331134ENST00000452782NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-3UTRENST00000374747ENST00000546128NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000374747ENST00000371923NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000374747ENST00000271153NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000374747ENST00000371919NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5CDS-intronENST00000374747ENST00000452782NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-3UTRENST00000539314ENST00000546128NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000539314ENST00000371923NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000539314ENST00000271153NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000539314ENST00000371919NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000539314ENST00000452782NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-3UTRENST00000572760ENST00000546128NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000572760ENST00000371923NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000572760ENST00000271153NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000572760ENST00000371919NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000572760ENST00000452782NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-3UTRENST00000573876ENST00000546128NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000573876ENST00000371923NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000573876ENST00000271153NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000573876ENST00000371919NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
intron-intronENST00000573876ENST00000452782NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-3UTRENST00000574344ENST00000546128NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000574344ENST00000371923NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000574344ENST00000271153NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000574344ENST00000371919NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+
5UTR-intronENST00000574344ENST00000452782NPLOC4chr17

79580344

-CYP4B1chr1

47230650

+

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FusionProtFeatures for NPLOC4_CYP4B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPLOC4

Q8TAT6

CYP4B1

P13584

The ternary complex containing UFD1, VCP and NPLOC4binds ubiquitinated proteins and is necessary for the export ofmisfolded proteins from the ER to the cytoplasm, where they aredegraded by the proteasome. The NPLOC4-UFD1-VCP complex regulatesspindle disassembly at the end of mitosis and is necessary for theformation of a closed nuclear envelope (By similarity). Acts as anegative regulator of type I interferon production via the complexformed with VCP and UFD1, which binds to DDX58/RIG-I and recruitsRNF125 to promote ubiquitination and degradation of DDX58/RIG-I(PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54,ECO:0000269|PubMed:26471729}. Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It oxidizes a varietyof structurally unrelated compounds, including steroids, fattyacids, and xenobiotics.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPLOC4_CYP4B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NPLOC4_CYP4B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NPLOC4UFD1L, VCP, SVIP, VIMP, USP13, VCPIP1, UBL4A, UBC, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, UBXN8, UBXN11, UBXN10, ASPSCR1, ELAVL1, AMFR, GZMK, SPRTN, UBXN6, HNRNPL, HNRNPR, FLOT1, MRPL19, MRPS9, MTPN, LMNA, ADRB2, NFKBIA, HECW2, ADSL, CBS, DR1, EIF4A3, DNAAF5, METTL1, ARMC9, DPP9, FKBP10, FNTB, LPP, PDLIM5, PKM, RPRD1A, RPRD1B, SURF2, UFM1, PDE12, PLIN3, RAD23B, SAE1, SRP14, SSB, UBA2, UBE3A, UBQLN2, WDR4, CDC25A, BTRC, ZFAND2B, YOD1, RAF1, ENO1, MOV10, NXF1, EZH2, MAP3K1, KCNK16, ETNK2, TMEM62, SLC38A6, CD2AP, NDUFS3, ASNS, CAP1, FUS, GARS, HNRNPK, MTMR12, PTPRF, RRM2, SH3KBP1, UBA1, PICALM, NTRK1, CEP128, DCTN1, MCM2, IFT74, TTC26, ADK, UBAC2, PYCR2, TRIP10, SLC17A2, ATG9A, FAM189B, KDELR1, CYP19A1, KCNC4, TRIM13, ALG10B, FADS3, PSEN2, TRIM25CYP4B1PKLR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPLOC4_CYP4B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPLOC4_CYP4B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCYP4B1C0005695Bladder Neoplasm1CTD_human