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Fusion gene ID: 24686 |
FusionGeneSummary for NPEPPS_FAM117A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NPEPPS_FAM117A | Fusion gene ID: 24686 | Hgene | Tgene | Gene symbol | NPEPPS | FAM117A | Gene ID | 9520 | 81558 |
| Gene name | aminopeptidase puromycin sensitive | family with sequence similarity 117 member A | |
| Synonyms | AAP-S|MP100|PSA | - | |
| Cytomap | 17q21.32 | 17q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | puromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100 | protein FAM117AC/EBP-induced protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P55786 | Q9C073 | |
| Ensembl transtripts involved in fusion gene | ENST00000525037, ENST00000530173, ENST00000322157, ENST00000544660, | ENST00000240364, ENST00000513602, ENST00000514018, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 6 X 3 X 4=72 |
| # samples | 10 | 8 | |
| ** MAII score | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/72*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NPEPPS [Title/Abstract] AND FAM117A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NPEPPS | GO:0071456 | cellular response to hypoxia | 21056661 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A04W-01A | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000525037 | ENST00000240364 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 3UTR-5UTR | ENST00000525037 | ENST00000513602 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 3UTR-5UTR | ENST00000525037 | ENST00000514018 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| In-frame | ENST00000530173 | ENST00000240364 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 5CDS-5UTR | ENST00000530173 | ENST00000513602 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 5CDS-5UTR | ENST00000530173 | ENST00000514018 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| In-frame | ENST00000322157 | ENST00000240364 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 5CDS-5UTR | ENST00000322157 | ENST00000513602 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 5CDS-5UTR | ENST00000322157 | ENST00000514018 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| In-frame | ENST00000544660 | ENST00000240364 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 5CDS-5UTR | ENST00000544660 | ENST00000513602 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
| 5CDS-5UTR | ENST00000544660 | ENST00000514018 | NPEPPS | chr17 | 45623359 | + | FAM117A | chr17 | 47810082 | - |
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FusionProtFeatures for NPEPPS_FAM117A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NPEPPS | FAM117A |
| Aminopeptidase with broad substrate specificity forseveral peptides. Involved in proteolytic events essential forcell growth and viability. May act as regulator of neuropeptideactivity. Plays a role in the antigen-processing pathway for MHCclass I molecules. Involved in the N-terminal trimming ofcytotoxic T-cell epitope precursors. Digests the poly-Q peptidesfound in many cellular proteins. Digests tau from normal brainmore efficiently than tau from Alzheimer disease brain.{ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501,ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184,ECO:0000269|PubMed:19917696}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NPEPPS_FAM117A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_498aa MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV MNCADIDIITASYAPEGDEASVPCSVAPEKSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERAS SCAHKRSASWGSTDHRKEISKLKQQLQRTKLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFV KEQGEEELLRILDIPDGHRAPAPPQSGSCDHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDG SPSPVLAFAASPRPNHSYIFKREPPEGCEKVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPG >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_502aa MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQAT NQIVMNCADIDIITASYAPEGDEASVPCSVAPEKSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEG ERASSCAHKRSASWGSTDHRKEISKLKQQLQRTKLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELE EVFVKEQGEEELLRILDIPDGHRAPAPPQSGSCDHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAF LEDGSPSPVLAFAASPRPNHSYIFKREPPEGCEKVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCP >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_458aa MPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEASVPCSVAPEKSVCRPQPLQV RRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERASSCAHKRSASWGSTDHRKEISKLKQQLQRTKLSRSGKEKER GSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFVKEQGEEELLRILDIPDGHRAPAPPQSGSCDHPLLLLEPGN LASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDGSPSPVLAFAASPRPNHSYIFKREPPEGCEKVRVFEEATSP GPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPGSPLPPASPRPPPRKDPEASKASPLPFEPWQRTPPSEEPVL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_1494nt ATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCCTTCATCATATTCCGCAGCCGCTCCTCTCGC CGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGC CTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTG ATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTGGCCCCAGAAAAG TCAGTGTGTAGGCCTCAGCCACTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGCCAGTGGCCACGA GATGCTGATGGGGCCTTCACCTGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGTGAGCGTGCCAGT TCCTGTGCACACAAGCGCTCAGCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTGCAGAGGACGAAG CTGAGCCGCAGTGGGAAAGAGAAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCGTCCCCTCCCAGC TTCCCCTCAGGGTCCCCTGTCTTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAGGAGGTATTTGTG AAGGAGCAGGGAGAAGAGGAGCTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGTGGCAGCTGTGAT CATCCCCTCCTCCTCCTGGAGCCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGCCTGGCCAGTCAT GAGGAACATCGGGGTGCCGCCGAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTTCTTGAAGATGGC AGCCCATCTCCAGTCCTTGCCTTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAAGGCTGTGAGAAA GTGCGTGTGTTTGAAGAAGCCACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTCCATTTCAACCCG ACTGGCTCAGCCTTCTGCCCCGTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCCTCAAACCCGGGA TCTCCCCTTCCCCCGGCCAGCCCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTCGAGCCATGGCAG >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_1506nt ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGC CGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACT AATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTG GCCCCAGAAAAGTCAGTGTGTAGGCCTCAGCCACTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGC CAGTGGCCACGAGATGCTGATGGGGCCTTCACCTGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGT GAGCGTGCCAGTTCCTGTGCACACAAGCGCTCAGCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTG CAGAGGACGAAGCTGAGCCGCAGTGGGAAAGAGAAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCG TCCCCTCCCAGCTTCCCCTCAGGGTCCCCTGTCTTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAG GAGGTATTTGTGAAGGAGCAGGGAGAAGAGGAGCTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGT GGCAGCTGTGATCATCCCCTCCTCCTCCTGGAGCCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGC CTGGCCAGTCATGAGGAACATCGGGGTGCCGCCGAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTT CTTGAAGATGGCAGCCCATCTCCAGTCCTTGCCTTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAA GGCTGTGAGAAAGTGCGTGTGTTTGAAGAAGCCACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTC CATTTCAACCCGACTGGCTCAGCCTTCTGCCCCGTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCC TCAAACCCGGGATCTCCCCTTCCCCCGGCCAGCCCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTC >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_1374nt ATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTC ACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACA GCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCCTCAGCCACTTCAGGTC CGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGCCTTCACCTGCTGCACC AATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAAGCGCTCAGCATCCTGG GGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGGGAAAGAGAAGGAGCGA GGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTCCCCTGTCTTGCGACTC AGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGAAGAGGAGCTGCTGAGG ATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCTCCTGGAGCCTGGCAAC CTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGGTGCCGCCGAGGAGCTG GCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGTCCTTGCCTTTGCTGCC TCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGAAGAAGCCACGTCTCCA GGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTTCTGCCCCGTCAACCTG ATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCCGGCCAGCCCCAGGCCA CCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATCAGAAGAGCCTGTGCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NPEPPS_ENST00000530173_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_2447nt AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCC AGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCCTCAGCCACTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTC AGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGCCTTCACCTGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCC TGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAAGCGCTCAGCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCC AAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGGGAAAGAGAAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTG CGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTCCCCTGTCTTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGG CTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGAAGAGGAGCTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCC CCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCTCCTGGAGCCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCA TCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGGTGCCGCCGAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCT CCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGTCCTTGCCTTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTC AAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGAAGAAGCCACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGT CCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTTCTGCCCCGTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTC ATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCCGGCCAGCCCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAG GCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATCAGAAGAGCCTGTGCTTTTCCAGAGCTCCCTGATGGTCTGAGGGTCC CACCCCTGCCCCACTTTACCATAGAGACCAGTGCCTTGGTGGCAGGTCCCTCCCCAGGTCCCCTGAGATGGGGTATGGAGGGGCCCTTCC CTCTCGGCCTTCGAGCACTTTCTTTCACTTACTGTGTCAAAGCCCTGGGTCCTCTTTTTGATGGGCACCGGCCCCTCTGAACGTGATGGG ACCTGCCTTCTCCACTAGTAGCTGGGCAGCTCACAATTCACACCTGTGTACCTGCCACATCCCTCACTTGGTGGAAAACACCCAGAAGGT CTTGAGTCCCCCACCCCTGGGTGTCAGTCCAAATGACTGTATAGGAGGCCCTTATTTTTGTCACAGAGCAAGCTGGCCATGAACGAAGGA GAGAAGACGCCACAGATTTCCTTCCCTCTCCTCCAGGAGACCATAAGATAGATCCCCCATCCTCTCAGCCCTATTCCCATGCCTCCCTCT CATTGGAGGAGCTGACCAAAGCAGCCCTAACGGGCCATAACACTTGACCAATTCAGCTGCTGGCAGAGGGAGGAAACAAGTGTTTTCCCA AGTGGCATTTTCATCTCGCTTTCACCCTGACTAAAGATTGTCTTAAGTAGCAGCCCAGCCCGCCCAGCCCCAGGTGGGTAGTGGGGAGGA GAGCTGGCATTCCTCCAGGTGGCAAATGGCGACTCTATACTCTCCGCCCGCCCCAGGGCTGGATGGATTAGAAAAATGCCTATTTTTCTT GTATCGATGTAGAGACTCTATTTTCTCCCAAAGACACTATTTTTGCAGCTGTTTGAAGTTTGTATATTTTCCGTACTGCAGAGCTTACAC AAAATTGAAGAATGTTAATGTTCGAGTTTTCTTATCTTGTGTTTAGAGGTTGTTTTTTGCAGATCTTGGTGTTAATAGACCAAATAAATA >In-frame_NPEPPS_ENST00000322157_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_2666nt GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCCTCAGCCA CTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGCCTTCACC TGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAAGCGCTCA GCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGGGAAAGAG AAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTCCCCTGTC TTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGAAGAGGAG CTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCTCCTGGAG CCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGGTGCCGCC GAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGTCCTTGCC TTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGAAGAAGCC ACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTTCTGCCCC GTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCCGGCCAGC CCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATCAGAAGAG CCTGTGCTTTTCCAGAGCTCCCTGATGGTCTGAGGGTCCCACCCCTGCCCCACTTTACCATAGAGACCAGTGCCTTGGTGGCAGGTCCCT CCCCAGGTCCCCTGAGATGGGGTATGGAGGGGCCCTTCCCTCTCGGCCTTCGAGCACTTTCTTTCACTTACTGTGTCAAAGCCCTGGGTC CTCTTTTTGATGGGCACCGGCCCCTCTGAACGTGATGGGACCTGCCTTCTCCACTAGTAGCTGGGCAGCTCACAATTCACACCTGTGTAC CTGCCACATCCCTCACTTGGTGGAAAACACCCAGAAGGTCTTGAGTCCCCCACCCCTGGGTGTCAGTCCAAATGACTGTATAGGAGGCCC TTATTTTTGTCACAGAGCAAGCTGGCCATGAACGAAGGAGAGAAGACGCCACAGATTTCCTTCCCTCTCCTCCAGGAGACCATAAGATAG ATCCCCCATCCTCTCAGCCCTATTCCCATGCCTCCCTCTCATTGGAGGAGCTGACCAAAGCAGCCCTAACGGGCCATAACACTTGACCAA TTCAGCTGCTGGCAGAGGGAGGAAACAAGTGTTTTCCCAAGTGGCATTTTCATCTCGCTTTCACCCTGACTAAAGATTGTCTTAAGTAGC AGCCCAGCCCGCCCAGCCCCAGGTGGGTAGTGGGGAGGAGAGCTGGCATTCCTCCAGGTGGCAAATGGCGACTCTATACTCTCCGCCCGC CCCAGGGCTGGATGGATTAGAAAAATGCCTATTTTTCTTGTATCGATGTAGAGACTCTATTTTCTCCCAAAGACACTATTTTTGCAGCTG TTTGAAGTTTGTATATTTTCCGTACTGCAGAGCTTACACAAAATTGAAGAATGTTAATGTTCGAGTTTTCTTATCTTGTGTTTAGAGGTT >In-frame_NPEPPS_ENST00000544660_chr17_45623359_+_FAM117A_ENST00000240364_chr17_47810082_-_2403nt CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCC TCAGCCACTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGC CTTCACCTGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAA GCGCTCAGCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGG GAAAGAGAAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTC CCCTGTCTTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGA AGAGGAGCTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCT CCTGGAGCCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGG TGCCGCCGAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGT CCTTGCCTTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGA AGAAGCCACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTT CTGCCCCGTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCC GGCCAGCCCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATC AGAAGAGCCTGTGCTTTTCCAGAGCTCCCTGATGGTCTGAGGGTCCCACCCCTGCCCCACTTTACCATAGAGACCAGTGCCTTGGTGGCA GGTCCCTCCCCAGGTCCCCTGAGATGGGGTATGGAGGGGCCCTTCCCTCTCGGCCTTCGAGCACTTTCTTTCACTTACTGTGTCAAAGCC CTGGGTCCTCTTTTTGATGGGCACCGGCCCCTCTGAACGTGATGGGACCTGCCTTCTCCACTAGTAGCTGGGCAGCTCACAATTCACACC TGTGTACCTGCCACATCCCTCACTTGGTGGAAAACACCCAGAAGGTCTTGAGTCCCCCACCCCTGGGTGTCAGTCCAAATGACTGTATAG GAGGCCCTTATTTTTGTCACAGAGCAAGCTGGCCATGAACGAAGGAGAGAAGACGCCACAGATTTCCTTCCCTCTCCTCCAGGAGACCAT AAGATAGATCCCCCATCCTCTCAGCCCTATTCCCATGCCTCCCTCTCATTGGAGGAGCTGACCAAAGCAGCCCTAACGGGCCATAACACT TGACCAATTCAGCTGCTGGCAGAGGGAGGAAACAAGTGTTTTCCCAAGTGGCATTTTCATCTCGCTTTCACCCTGACTAAAGATTGTCTT AAGTAGCAGCCCAGCCCGCCCAGCCCCAGGTGGGTAGTGGGGAGGAGAGCTGGCATTCCTCCAGGTGGCAAATGGCGACTCTATACTCTC CGCCCGCCCCAGGGCTGGATGGATTAGAAAAATGCCTATTTTTCTTGTATCGATGTAGAGACTCTATTTTCTCCCAAAGACACTATTTTT GCAGCTGTTTGAAGTTTGTATATTTTCCGTACTGCAGAGCTTACACAAAATTGAAGAATGTTAATGTTCGAGTTTTCTTATCTTGTGTTT 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FusionGenePPI for NPEPPS_FAM117A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NPEPPS | EIF6, OTUD4, DMWD, CLN3, GBAS, RYK, HDAC5, SIRT7, FBXO25, CUL3, CDK2, UBA6, STRAP, ECT2, CAMKMT, CFTR, FBXO6, CNDP2, NANS, CKB, CSE1L, DAK, FTO, GBP1, LDHB, METAP2, PAK2, PDIA3, RPLP2, PFAS, RPS6KA1, RPS6KA3, SCLY, SLC9A3R1, TGM2, UBFD1, ZNF622, PHKG2, STAU1, CUL7, CCDC8, FAF2, DYNLT1, STXBP1, NTRK1, MED20, FAM204A, ZNF746, LRRC8E, TRIM25, CCND2, BRCA1, CDK20 | FAM117A | DYRK1B, DYRK1A, PICK1, HMBOX1, COBLL1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPEPPS_FAM117A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | NPEPPS | P55786 | DB11638 | Artenimol | Puromycin-sensitive aminopeptidase | small molecule | approved|investigational |
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RelatedDiseases for NPEPPS_FAM117A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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