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Fusion gene ID: 24671 |
FusionGeneSummary for NPAT_OAF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NPAT_OAF | Fusion gene ID: 24671 | Hgene | Tgene | Gene symbol | NPAT | OAF | Gene ID | 4863 | 220323 |
| Gene name | nuclear protein, coactivator of histone transcription | out at first homolog | |
| Synonyms | E14|E14/NPAT|p220 | NS5ATP13TP2 | |
| Cytomap | 11q22.3 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein NPATnuclear protein of the ATM locusnuclear protein of the ataxia telangiectasia mutated locusnuclear protein, ataxia-telangiectasia locusnuclear protein, co-activator of histone transcription | out at first protein homologHCV NS5A-transactivated protein 13 target protein 2OAF homolog | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q14207 | Q86UD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000278612, ENST00000610253, | ENST00000328965, ENST00000531220, ENST00000534735, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 3 X 5=75 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NPAT [Title/Abstract] AND OAF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NPAT | GO:0045893 | positive regulation of transcription, DNA-templated | 18850719 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-QQ-A5VA-01A | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000278612 | ENST00000328965 | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
| 5CDS-intron | ENST00000278612 | ENST00000531220 | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
| 5CDS-intron | ENST00000278612 | ENST00000534735 | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
| 5UTR-3CDS | ENST00000610253 | ENST00000328965 | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
| 5UTR-intron | ENST00000610253 | ENST00000531220 | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
| 5UTR-intron | ENST00000610253 | ENST00000534735 | NPAT | chr11 | 108093227 | - | OAF | chr11 | 120096370 | + |
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FusionProtFeatures for NPAT_OAF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NPAT | OAF |
| Required for progression through the G1 and S phases ofthe cell cycle and for S phase entry. Activates transcription ofthe histone H2A, histone H2B, histone H3 and histone H4 genes inconjunction with MIZF. Also positively regulates the ATM, MIZF andPRKDC promoters. Transcriptional activation may be accomplished atleast in part by the recruitment of the NuA4 histoneacetyltransferase (HAT) complex to target gene promoters.{ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387,ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424,ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403,ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025,ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457,ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892,ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 3_35 | 12 | 1428 | Domain | LisH |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 1039_1054 | 12 | 1428 | Region | Note=Required for acceleration of G1 phase |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 1228_1252 | 12 | 1428 | Region | Note=Required for acceleration of G1 phase |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 1325_1349 | 12 | 1428 | Region | Note=Required for acceleration of G1 phase |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 262_338 | 12 | 1428 | Region | Note=Mediates transcriptional activation |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 629_653 | 12 | 1428 | Region | Note=Required for acceleration of G1 phase |
| Hgene | >NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 828_853 | 12 | 1428 | Region | Note=Required for acceleration of G1 phase |
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FusionGeneSequence for NPAT_OAF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NPAT_ENST00000278612_chr11_108093227_-_OAF_ENST00000328965_chr11_120096370_+_209aa MLLPSDVARLVLGCEGLPGPDPGGAGEGAESVPGPLLCHPAAAQXDHPQXGHGQAPAEKSPGSAAGGGGSGSGASAHGCRCQLQPGGPAE PPSPQRVCRGRGCHLHPPGGCPVLAGARCGQFCVRGSAQGLRAGGAASLQAGGGPREALRLPLWPEPGLVPLHAQVLPQPRPAHALQVWH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NPAT_ENST00000278612_chr11_108093227_-_OAF_ENST00000328965_chr11_120096370_+_628nt ATGTTGTTACCCTCGGACGTAGCCCGGCTTGTATTGGGATGTGAAGGTCTTCCGGGCCCTGATCCTGGGGGAGCTGGAGAAGGGGCAGAG TCAGTTCCAGGCCCTCTGCTTTGTCACCCAGCTGCAGCACAATGAGATCATCCCCAGTGAGGCCATGGCCAAGCTCCGGCAGAAAAATCC CCGGGCAGTGCGGCAGGCGGAGGAGGTTCGGGGTCTGGAGCATCTGCACATGGATGTCGCTGTCAACTTCAGCCAGGGGGCCCTGCTGAG CCCCCATCTCCACAACGTGTGTGCCGAGGCCGTGGATGCCATCTACACCCGCCAGGAGGATGTCCGGTTCTGGCTGGAGCAAGGTGTGGA CAGTTCTGTGTTCGAGGCTCTGCCCAAGGCCTCAGAGCAGGCGGAGCTGCCTCGCTGCAGGCAGGTGGGGGACCACGGGAAGCCCTGCGT CTGCCGCTATGGCCTGAGCCTGGCCTGGTACCCCTGCATGCTCAAGTACTGCCACAGCCGCGACCGGCCCACGCCCTACAAGTGTGGCAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NPAT_ENST00000278612_chr11_108093227_-_OAF_ENST00000328965_chr11_120096370_+_1924nt GTTCAGTGCCGCCACTGGAACCAGGAGATGCGGCGCAGGAGCTGTCGCTGTGTTTGCTTTAACCTGAGTCTTGTTCCTTATTGTGGTTCC TGCTGTGGTTTTGATCATGTTGTTACCCTCGGACGTAGCCCGGCTTGTATTGGGATGTGAAGGTCTTCCGGGCCCTGATCCTGGGGGAGC TGGAGAAGGGGCAGAGTCAGTTCCAGGCCCTCTGCTTTGTCACCCAGCTGCAGCACAATGAGATCATCCCCAGTGAGGCCATGGCCAAGC TCCGGCAGAAAAATCCCCGGGCAGTGCGGCAGGCGGAGGAGGTTCGGGGTCTGGAGCATCTGCACATGGATGTCGCTGTCAACTTCAGCC AGGGGGCCCTGCTGAGCCCCCATCTCCACAACGTGTGTGCCGAGGCCGTGGATGCCATCTACACCCGCCAGGAGGATGTCCGGTTCTGGC TGGAGCAAGGTGTGGACAGTTCTGTGTTCGAGGCTCTGCCCAAGGCCTCAGAGCAGGCGGAGCTGCCTCGCTGCAGGCAGGTGGGGGACC ACGGGAAGCCCTGCGTCTGCCGCTATGGCCTGAGCCTGGCCTGGTACCCCTGCATGCTCAAGTACTGCCACAGCCGCGACCGGCCCACGC CCTACAAGTGTGGCATCCGCAGCTGCCAGAAGAGCTACAGCTTCGACTTCTACGTGCCCCAGAGGCAGCTGTGTCTCTGGGATGAGGATC CCTACCCAGGCTAGGGTGGGAGCAACCTGGCGGGTGGCTGCTCTGGGCCCACTGCTCTTCACCAGCCACTAGAGGGGGTGGCAACCCCCA CCTGAGGCCTTATTTCCCTCCCTCCCCACTCCCCTGGCCCTAGAGCCTGGGCCCCTCTGGCCCCATCTCACATGACTGTGAAGGGGGTGT GGCATGGCAGGGGGTCTCATGAAGGCACCCCCATTCCCACCCTGTGCCTTCCTTGCGGGCAGAGAGGGAGAGAAGGGCTCCCCAGATCTA CACCCCTCCCTCCTGCATCTCCCCTGGAGTGTTCACTTGCAAGCTGCCAAAACATGATGGCCTCTGGTTGTTCTGTTGAACTCCTTGAAC GTTTAGACCCTAAAAGGAGTCTATACCTGGACACCCACCTCCCCAGACACAACTCCCTTCCCCATGCACACATCTGGAAGGAGCTGGCCC CTCAGTCCCTTCCTACTCCCCAACAAGGGGCTCACTATCCCCAAAGAAGGAGCTGTTGGGGACCCACGACGCAGCCCCTGTACTGGATTA CAGCATATTCTCATCTCTGGCCCCGAGGCTGCCTGTGGGGCGAGTGGAGACCTCCCATCACTGAGACAGATCACAGACCACGAGTGCCTT TCCCGGACCTGGACGTTGCCTCCAGAGCAGGCACCAGCTCTTTCCCTCTCTACACAGAAATATTTTTGTAAGGTTCTGGGGCAGGGAGGG AGCATGAAGTACGAGGAAAACTTGAATTCCAGATTTTTAGTGCAAAGTATTTATCATTTCTACCAGAAATAAACGTTTTAAGTTTTTACT TGACTAATGAGACCCAGAGTTTGGAGAAAACTTTTGGCCAATGCTGCCACCTGATGTCAGAAAGTGTCCCCACACCCTAGCAGTGGCCTA TCTTGGAACAAGAACTTCGAAAGCACCTACTGTGTGCTCAGCCATTTGAGGAAGGAAGGAGGAGAAGGAAGATGTTACTAGGGAAGGATG AGATAAAACTTCTGCACCCAAGACAATGAGACAGACATAGCTGCAACCGTAGTAAGCCAGTCAGAAATAGCCAGCGCGAAGGCAAGAGAT GGGGTGGAGATTGGAACCCCGCTTCAGATCTGGGCTCGGCTACTTACCTGCTGTGCAGCCATGGGTCAAGTTGCTTGACCTCTCTGTGCC |
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FusionGenePPI for NPAT_OAF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NPAT | POU2F1, GAPDH, STIP1, TRRAP, RAD21, HINFP, CCNE1, CREBBP, CDK2, CCNA1, SREBF2, HCCS, ZNF219, ASB8, RBBP7, UNK, S100A4, AP4M1, RNF41, LTN1, GAR1, GATAD1, ASB7, CRAMP1L, HIST1H4A, H2AFX, VPS39 | OAF | TM2D3, FCGR3B, HLA-DQB2, TRAC, CEACAM21, ST3GAL4, FIGF, ATP1B4, SIAE, NAAA, BOC, DKKL1, PLA2G10, ARL4C, SFTA2, ST8SIA4, CFB, CCL22, LYPD4, EPHA7, F9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NPAT | chr11:108093227 | chr11:120096370 | ENST00000278612 | - | 1 | 18 | 1_318 | 12 | 1428 | MIZF |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NPAT_OAF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NPAT_OAF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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