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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24668

FusionGeneSummary for NPAS3_ARHGAP5

check button Fusion gene summary
Fusion gene informationFusion gene name: NPAS3_ARHGAP5
Fusion gene ID: 24668
HgeneTgene
Gene symbol

NPAS3

ARHGAP5

Gene ID

64067

394

Gene nameneuronal PAS domain protein 3Rho GTPase activating protein 5
SynonymsMOP6|PASD6|bHLHe12GFI2|RhoGAP5|p190-B|p190BRhoGAP
Cytomap

14q13.1

14q12

Type of geneprotein-codingprotein-coding
Descriptionneuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3rho GTPase-activating protein 5growth factor independent 2p100 RasGAP-associated p105 proteinp105 RhoGAPrho-type GTPase-activating protein 5
Modification date2018052320180523
UniProtAcc

Q8IXF0

Q13017

Ensembl transtripts involved in fusion geneENST00000551492, ENST00000346562, 
ENST00000341321, ENST00000548645, 
ENST00000356141, ENST00000357798, 
ENST00000547068, ENST00000551008, 
ENST00000550662, 		ENST00000556611, 
ENST00000539826, ENST00000396582, 
ENST00000432921, ENST00000345122, 
ENST00000433497, 
Fusion gene scores* DoF score4 X 5 X 3=604 X 4 X 3=48
# samples 64
** MAII scorelog2(6/60*10)=0log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPAS3 [Title/Abstract] AND ARHGAP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2113-01ANPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000551492ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
Frame-shiftENST00000551492ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
5CDS-intronENST00000551492ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
5CDS-intronENST00000551492ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
5CDS-intronENST00000551492ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
5CDS-5UTRENST00000551492ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000346562ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000346562ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000346562ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000346562ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000346562ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000346562ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000341321ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000341321ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000341321ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000341321ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000341321ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000341321ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000548645ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000548645ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000548645ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000548645ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000548645ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000548645ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000356141ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000356141ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000356141ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000356141ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000356141ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000356141ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000357798ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000357798ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000357798ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000357798ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000357798ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000357798ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000547068ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000547068ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000547068ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000547068ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000547068ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000547068ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000551008ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000551008ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000551008ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000551008ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000551008ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000551008ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000550662ENST00000556611NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-3CDSENST00000550662ENST00000539826NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000550662ENST00000396582NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000550662ENST00000432921NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-intronENST00000550662ENST00000345122NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+
intron-5UTRENST00000550662ENST00000433497NPAS3chr14

33404209

+ARHGAP5chr14

32586349

+

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FusionProtFeatures for NPAS3_ARHGAP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NPAS3

Q8IXF0

ARHGAP5

Q13017

May play a broad role in neurogenesis. May controlregulatory pathways relevant to schizophrenia and to psychoticillness (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NPAS3_ARHGAP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NPAS3_ARHGAP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NPAS3ARNT2, TP53ARHGAP5RND3, RND1, RND2, RHOA, PXN, XRCC6, SMURF1, SMURF2, NPM1, ADRB2, UNK, CDH1, PTPRU, IQCF1, PLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NPAS3_ARHGAP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NPAS3_ARHGAP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNPAS3C0036341Schizophrenia4PSYGENET
HgeneNPAS3C0005586Bipolar Disorder3PSYGENET
HgeneNPAS3C0033975Psychotic Disorders1PSYGENET
HgeneNPAS3C0041696Unipolar Depression1PSYGENET
HgeneNPAS3C0349204Nonorganic psychosis1PSYGENET
HgeneNPAS3C1269683Major Depressive Disorder1PSYGENET