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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 24657

FusionGeneSummary for NOV_ENPP2

check button Fusion gene summary
Fusion gene informationFusion gene name: NOV_ENPP2
Fusion gene ID: 24657
HgeneTgene
Gene symbol

NOV

ENPP2

Gene ID

6134

5168

Gene nameribosomal protein L10ectonucleotide pyrophosphatase/phosphodiesterase 2
SynonymsAUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QMATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2
Cytomap

Xq28

8q24.12

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QMectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase D
Modification date2018052320180519
UniProtAcc

P48745

Q13822

Ensembl transtripts involved in fusion geneENST00000259526, ENST00000259486, 
ENST00000427067, ENST00000522167, 
ENST00000522826, ENST00000075322, 
ENST00000518109, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 3=108
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOV [Title/Abstract] AND ENPP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneENPP2

GO:0009395

phospholipid catabolic process

15280042

TgeneENPP2

GO:0030334

regulation of cell migration

1733949

TgeneENPP2

GO:0034638

phosphatidylcholine catabolic process

21240271

TgeneENPP2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

18054784


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-JY-A6FD-01ANOVchr8

120431585

+ENPP2chr8

120606100

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000259526ENST00000259486NOVchr8

120431585

+ENPP2chr8

120606100

-
In-frameENST00000259526ENST00000427067NOVchr8

120431585

+ENPP2chr8

120606100

-
5CDS-intronENST00000259526ENST00000522167NOVchr8

120431585

+ENPP2chr8

120606100

-
5CDS-intronENST00000259526ENST00000522826NOVchr8

120431585

+ENPP2chr8

120606100

-
5CDS-intronENST00000259526ENST00000075322NOVchr8

120431585

+ENPP2chr8

120606100

-
5CDS-intronENST00000259526ENST00000518109NOVchr8

120431585

+ENPP2chr8

120606100

-

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FusionProtFeatures for NOV_ENPP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOV

P48745

ENPP2

Q13822

Immediate-early protein playing a role in variouscellular processes including proliferation, adhesion, migration,differentiation and survival (PubMed:15181016, PubMed:15611078,PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts bybinding to integrins or membrane receptors such as NOTCH1(PubMed:12695522, PubMed:21344378, PubMed:15611078). Essentialregulator of hematopoietic stem and progenitor cell function(PubMed:17463287). Inhibits myogenic differentiation through theactivation of Notch-signaling pathway (PubMed:12050162). Inhibitsvascular smooth muscle cells proliferation by increasingexpression of cell-cycle regulators such as CDKN2B or CDKN1Aindependently of TGFB1 signaling (PubMed:20139355). Ligand ofintegrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly uponendothelial cells to stimulate pro-angiogenic activities andinduces angiogenesis. In endothelial cells, supports celladhesion, induces directed cell migration (chemotaxis) andpromotes cell survival (PubMed:12695522). Plays also a role incutaneous wound healing acting as integrin receptor ligand.Supports skin fibroblast adhesion through ITGA5:ITGB1 andITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5.Seems to enhance bFGF-induced DNA synthesis in fibroblasts(PubMed:15611078). Involved in bone regeneration as a negativeregulator (By similarity). Enhances the articular chondrocyticphenotype, whereas it repressed the one representing endochondralossification (PubMed:21871891). Impairs pancreatic beta-cellfunction, inhibits beta-cell proliferation and insulin secretion(By similarity). Plays a role as negative regulator of endothelialpro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to thecontrol and coordination of inflammatory processes inatherosclerosis (By similarity). Attenuates inflammatory painthrough regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2expression. Inhibits MMP9 expression through ITGB1 engagement(PubMed:21871891). {ECO:0000250|UniProtKB:Q64299,ECO:0000269|PubMed:12050162, ECO:0000269|PubMed:12695522,ECO:0000269|PubMed:15181016, ECO:0000269|PubMed:15611078,ECO:0000269|PubMed:17463287, ECO:0000269|PubMed:20139355,ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:21344378,ECO:0000269|PubMed:21871891}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOVchr8:120431585chr8:120606100ENST00000259526+45108_174259358DomainVWFC
HgeneNOVchr8:120431585chr8:120606100ENST00000259526+45205_250259358DomainTSP type-1
HgeneNOVchr8:120431585chr8:120606100ENST00000259526+4532_105259358DomainIGFBP N-terminal
TgeneENPP2chr8:120431585chr8:120606100ENST00000075322-1025830_851324864RegionRequired for secretion
TgeneENPP2chr8:120431585chr8:120606100ENST00000259486-1126830_851376916RegionRequired for secretion
TgeneENPP2chr8:120431585chr8:120606100ENST00000522826-1026830_851324889RegionRequired for secretion

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOVchr8:120431585chr8:120606100ENST00000259526+45264_338259358DomainCTCK
TgeneENPP2chr8:120431585chr8:120606100ENST00000075322-102555_98324864DomainSMB 1
TgeneENPP2chr8:120431585chr8:120606100ENST00000075322-102599_143324864DomainSMB 2
TgeneENPP2chr8:120431585chr8:120606100ENST00000259486-112655_98376916DomainSMB 1
TgeneENPP2chr8:120431585chr8:120606100ENST00000259486-112699_143376916DomainSMB 2
TgeneENPP2chr8:120431585chr8:120606100ENST00000522826-102655_98324889DomainSMB 1
TgeneENPP2chr8:120431585chr8:120606100ENST00000522826-102699_143324889DomainSMB 2
TgeneENPP2chr8:120431585chr8:120606100ENST00000075322-1025127_129324864MotifCell attachment site
TgeneENPP2chr8:120431585chr8:120606100ENST00000259486-1126127_129376916MotifCell attachment site
TgeneENPP2chr8:120431585chr8:120606100ENST00000522826-1026127_129324889MotifCell attachment site
TgeneENPP2chr8:120431585chr8:120606100ENST00000075322-1025211_214324864RegionSubstrate binding
TgeneENPP2chr8:120431585chr8:120606100ENST00000075322-1025244_255324864RegionSubstrate binding
TgeneENPP2chr8:120431585chr8:120606100ENST00000259486-1126211_214376916RegionSubstrate binding
TgeneENPP2chr8:120431585chr8:120606100ENST00000259486-1126244_255376916RegionSubstrate binding
TgeneENPP2chr8:120431585chr8:120606100ENST00000522826-1026211_214324889RegionSubstrate binding
TgeneENPP2chr8:120431585chr8:120606100ENST00000522826-1026244_255324889RegionSubstrate binding


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FusionGeneSequence for NOV_ENPP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NOV_ENST00000259526_chr8_120431585_+_ENPP2_ENST00000259486_chr8_120606100_-_799aa
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCD
RSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDS
LGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKMTNPLREIDKI
VGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYL
KQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCD
LLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYGRPAVL
YRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYD
AFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKC

>In-frame_NOV_ENST00000259526_chr8_120431585_+_ENPP2_ENST00000427067_chr8_120606100_-_824aa
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCD
RSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDS
LGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKMTNPLREIDKI
VGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYL
KQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCD
LLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEAETRKFRGSRNE
NKENINGNFEPRKERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAY
KNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGS
SIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEIL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NOV_ENST00000259526_chr8_120431585_+_ENPP2_ENST00000259486_chr8_120606100_-_2397nt
ATGCAGAGTGTGCAGAGCACGAGCTTTTGTCTCCGAAAGCAGTGCCTTTGCCTGACCTTCCTGCTTCTCCATCTCCTGGGACAGGTCGCT
GCGACTCAGCGCTGCCCTCCCCAGTGCCCGGGCCGGTGCCCTGCGACGCCGCCGACCTGCGCCCCCGGGGTGCGCGCGGTGCTGGACGGC
TGCTCATGCTGTCTGGTGTGTGCCCGCCAGCGTGGCGAGAGCTGCTCAGATCTGGAGCCATGCGACGAGAGCAGTGGCCTCTACTGTGAT
CGCAGCGCGGACCCCAGCAACCAGACTGGCATCTGCACGGCGGTAGAGGGAGATAACTGTGTGTTCGATGGGGTCATCTACCGCAGTGGA
GAGAAATTTCAGCCAAGCTGCAAATTCCAGTGCACCTGCAGAGATGGGCAGATTGGCTGTGTGCCCCGCTGTCAGCTGGATGTGCTACTG
CCTGAGCCTAACTGCCCAGCTCCAAGAAAAGTTGAGGTGCCTGGAGAGTGCTGTGAAAAGTGGATCTGTGGCCCAGATGAGGAGGATTCA
CTGGGAGGCCTTACCCTTGCAGCTTACAGGCCAGAAGCCACCCTAGGAGTAGAAGTCTCTGACTCAAGTGTCAACTGCATTGAACAGACC
ACAGAGTGGACAGCATGCTCCAAGAGCTGTGGTATGGGGTTCTCCACCCGGGTCACCAATAGGAACCGTCAATGTGAGATGCTGAAACAG
ACTCGGCTCTGCATGGTGCGGCCCTGTGAACAAGAGCCAGAGCAGCCAACAGATAAGATGACAAATCCTCTGAGGGAAATCGACAAAATT
GTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTC
ACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCC
AAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTG
AAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCA
AGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAG
ACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGAT
CTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCA
GAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCA
AAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGAGACACCTCCTCTATGGGCGACCTGCAGTGCTT
TATCGGACTAGATATGATATCTTATATCACACTGACTTTGAAAGTGGTTATAGTGAAATATTCCTAATGCCACTCTGGACATCATATACT
GTTTCCAAACAGGCTGAGGTTTCCAGCGTTCCTGACCATCTGACCAGTTGCGTCCGGCCTGATGTCCGTGTTTCTCCGAGTTTCAGTCAG
AACTGTTTGGCCTACAAAAATGATAAGCAGATGTCCTACGGATTCCTCTTTCCTCCTTATCTGAGCTCTTCACCAGAGGCTAAATATGAT
GCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCTTTCAAACGGGTCTGGAATTATTTCCAAAGGGTATTGGTGAAGAAATATGCT
TCGGAAAGAAATGGAGTTAACGTGATAAGTGGACCAATCTTCGACTATGACTATGATGGCTTACATGACACAGAAGACAAAATAAAACAG
TACGTGGAAGGCAGTTCCATTCCTGTTCCAACTCACTACTACAGCATCATCACCAGCTGTCTGGATTTCACTCAGCCTGCCGACAAGTGT
GACGGCCCTCTCTCTGTGTCCTCCTTCATCCTGCCTCACCGGCCTGACAACGAGGAGAGCTGCAATAGCTCAGAGGACGAATCAAAATGG
GTAGAAGAACTCATGAAGATGCACACAGCTAGGGTGCGTGACATTGAACATCTCACCAGCCTGGACTTCTTCCGAAAGACCAGCCGCAGC

>In-frame_NOV_ENST00000259526_chr8_120431585_+_ENPP2_ENST00000427067_chr8_120606100_-_2472nt
ATGCAGAGTGTGCAGAGCACGAGCTTTTGTCTCCGAAAGCAGTGCCTTTGCCTGACCTTCCTGCTTCTCCATCTCCTGGGACAGGTCGCT
GCGACTCAGCGCTGCCCTCCCCAGTGCCCGGGCCGGTGCCCTGCGACGCCGCCGACCTGCGCCCCCGGGGTGCGCGCGGTGCTGGACGGC
TGCTCATGCTGTCTGGTGTGTGCCCGCCAGCGTGGCGAGAGCTGCTCAGATCTGGAGCCATGCGACGAGAGCAGTGGCCTCTACTGTGAT
CGCAGCGCGGACCCCAGCAACCAGACTGGCATCTGCACGGCGGTAGAGGGAGATAACTGTGTGTTCGATGGGGTCATCTACCGCAGTGGA
GAGAAATTTCAGCCAAGCTGCAAATTCCAGTGCACCTGCAGAGATGGGCAGATTGGCTGTGTGCCCCGCTGTCAGCTGGATGTGCTACTG
CCTGAGCCTAACTGCCCAGCTCCAAGAAAAGTTGAGGTGCCTGGAGAGTGCTGTGAAAAGTGGATCTGTGGCCCAGATGAGGAGGATTCA
CTGGGAGGCCTTACCCTTGCAGCTTACAGGCCAGAAGCCACCCTAGGAGTAGAAGTCTCTGACTCAAGTGTCAACTGCATTGAACAGACC
ACAGAGTGGACAGCATGCTCCAAGAGCTGTGGTATGGGGTTCTCCACCCGGGTCACCAATAGGAACCGTCAATGTGAGATGCTGAAACAG
ACTCGGCTCTGCATGGTGCGGCCCTGTGAACAAGAGCCAGAGCAGCCAACAGATAAGATGACAAATCCTCTGAGGGAAATCGACAAAATT
GTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTC
ACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCC
AAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTG
AAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCA
AGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAG
ACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGAT
CTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCA
GAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCA
AAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGCTGAAACCAGGAAATTCAGAGGCAGCAGAAATGAA
AACAAGGAAAACATTAATGGAAATTTTGAACCTAGAAAAGAGAGACACCTCCTCTATGGGCGACCTGCAGTGCTTTATCGGACTAGATAT
GATATCTTATATCACACTGACTTTGAAAGTGGTTATAGTGAAATATTCCTAATGCCACTCTGGACATCATATACTGTTTCCAAACAGGCT
GAGGTTTCCAGCGTTCCTGACCATCTGACCAGTTGCGTCCGGCCTGATGTCCGTGTTTCTCCGAGTTTCAGTCAGAACTGTTTGGCCTAC
AAAAATGATAAGCAGATGTCCTACGGATTCCTCTTTCCTCCTTATCTGAGCTCTTCACCAGAGGCTAAATATGATGCATTCCTTGTAACC
AATATGGTTCCAATGTATCCTGCTTTCAAACGGGTCTGGAATTATTTCCAAAGGGTATTGGTGAAGAAATATGCTTCGGAAAGAAATGGA
GTTAACGTGATAAGTGGACCAATCTTCGACTATGACTATGATGGCTTACATGACACAGAAGACAAAATAAAACAGTACGTGGAAGGCAGT
TCCATTCCTGTTCCAACTCACTACTACAGCATCATCACCAGCTGTCTGGATTTCACTCAGCCTGCCGACAAGTGTGACGGCCCTCTCTCT
GTGTCCTCCTTCATCCTGCCTCACCGGCCTGACAACGAGGAGAGCTGCAATAGCTCAGAGGACGAATCAAAATGGGTAGAAGAACTCATG
AAGATGCACACAGCTAGGGTGCGTGACATTGAACATCTCACCAGCCTGGACTTCTTCCGAAAGACCAGCCGCAGCTACCCAGAAATCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NOV_ENST00000259526_chr8_120431585_+_ENPP2_ENST00000259486_chr8_120606100_-_3059nt
ACAGCCAATTGCCATGGCAACCCCGGGGTTCGTTCCACTTCCCCACCCAGCCGATCTCCCCCCTCCTCCCTGCACTGCAGCCAACCGGCT
TGTGCGCGTCCCAGGAGCGCGCTATAAAACCTGTGCTGGGCGTGATCGGCAAGCACCGGACCAGGGGGAAGGCGAGCAGTGCCAATCTAC
AGCGAAGAAAGTCTCGTTTGGTAAAAGCGAGAGGGGAAAGCCTGAGCATGCAGAGTGTGCAGAGCACGAGCTTTTGTCTCCGAAAGCAGT
GCCTTTGCCTGACCTTCCTGCTTCTCCATCTCCTGGGACAGGTCGCTGCGACTCAGCGCTGCCCTCCCCAGTGCCCGGGCCGGTGCCCTG
CGACGCCGCCGACCTGCGCCCCCGGGGTGCGCGCGGTGCTGGACGGCTGCTCATGCTGTCTGGTGTGTGCCCGCCAGCGTGGCGAGAGCT
GCTCAGATCTGGAGCCATGCGACGAGAGCAGTGGCCTCTACTGTGATCGCAGCGCGGACCCCAGCAACCAGACTGGCATCTGCACGGCGG
TAGAGGGAGATAACTGTGTGTTCGATGGGGTCATCTACCGCAGTGGAGAGAAATTTCAGCCAAGCTGCAAATTCCAGTGCACCTGCAGAG
ATGGGCAGATTGGCTGTGTGCCCCGCTGTCAGCTGGATGTGCTACTGCCTGAGCCTAACTGCCCAGCTCCAAGAAAAGTTGAGGTGCCTG
GAGAGTGCTGTGAAAAGTGGATCTGTGGCCCAGATGAGGAGGATTCACTGGGAGGCCTTACCCTTGCAGCTTACAGGCCAGAAGCCACCC
TAGGAGTAGAAGTCTCTGACTCAAGTGTCAACTGCATTGAACAGACCACAGAGTGGACAGCATGCTCCAAGAGCTGTGGTATGGGGTTCT
CCACCCGGGTCACCAATAGGAACCGTCAATGTGAGATGCTGAAACAGACTCGGCTCTGCATGGTGCGGCCCTGTGAACAAGAGCCAGAGC
AGCCAACAGATAAGATGACAAATCCTCTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATC
GGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATG
TGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTG
CCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAA
GAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCT
TTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTA
AAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAA
GTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTC
AGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAG
GGTCTACAGAAGAGAGACACCTCCTCTATGGGCGACCTGCAGTGCTTTATCGGACTAGATATGATATCTTATATCACACTGACTTTGAAA
GTGGTTATAGTGAAATATTCCTAATGCCACTCTGGACATCATATACTGTTTCCAAACAGGCTGAGGTTTCCAGCGTTCCTGACCATCTGA
CCAGTTGCGTCCGGCCTGATGTCCGTGTTTCTCCGAGTTTCAGTCAGAACTGTTTGGCCTACAAAAATGATAAGCAGATGTCCTACGGAT
TCCTCTTTCCTCCTTATCTGAGCTCTTCACCAGAGGCTAAATATGATGCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCTTTCA
AACGGGTCTGGAATTATTTCCAAAGGGTATTGGTGAAGAAATATGCTTCGGAAAGAAATGGAGTTAACGTGATAAGTGGACCAATCTTCG
ACTATGACTATGATGGCTTACATGACACAGAAGACAAAATAAAACAGTACGTGGAAGGCAGTTCCATTCCTGTTCCAACTCACTACTACA
GCATCATCACCAGCTGTCTGGATTTCACTCAGCCTGCCGACAAGTGTGACGGCCCTCTCTCTGTGTCCTCCTTCATCCTGCCTCACCGGC
CTGACAACGAGGAGAGCTGCAATAGCTCAGAGGACGAATCAAAATGGGTAGAAGAACTCATGAAGATGCACACAGCTAGGGTGCGTGACA
TTGAACATCTCACCAGCCTGGACTTCTTCCGAAAGACCAGCCGCAGCTACCCAGAAATCCTGACACTCAAGACATACCTGCATACATATG
AGAGCGAGATTTAACTTTCTGAGCATCTGCAGTACAGTCTTATCAACTGGTTGTATATTTTTATATTGTTTTTGTATTTATTAATTTGAA
ACCAGGACATTAAAAATGTTAGTATTTTAATCCTGTACCAAATCTGACATATTATGCCTGAATGACTCCACTGTTTTTCTCTAATGCTTG
ATTTAGGTAGCCTTGTGTTCTGAGTAGAGCTTGTAATAAATACTGCAGCTTGAGTTTTTAGTGGAAGCTTCTAAATGGTGCTGCAGATTT
GATATTTGCATTGAGGAAATATTAATTTTCCAATGCACAGTTGCCACATTTAGTCCTGTACTGTATGGAAACACTGATTTTGTAAAGTTG

>In-frame_NOV_ENST00000259526_chr8_120431585_+_ENPP2_ENST00000427067_chr8_120606100_-_3134nt
ACAGCCAATTGCCATGGCAACCCCGGGGTTCGTTCCACTTCCCCACCCAGCCGATCTCCCCCCTCCTCCCTGCACTGCAGCCAACCGGCT
TGTGCGCGTCCCAGGAGCGCGCTATAAAACCTGTGCTGGGCGTGATCGGCAAGCACCGGACCAGGGGGAAGGCGAGCAGTGCCAATCTAC
AGCGAAGAAAGTCTCGTTTGGTAAAAGCGAGAGGGGAAAGCCTGAGCATGCAGAGTGTGCAGAGCACGAGCTTTTGTCTCCGAAAGCAGT
GCCTTTGCCTGACCTTCCTGCTTCTCCATCTCCTGGGACAGGTCGCTGCGACTCAGCGCTGCCCTCCCCAGTGCCCGGGCCGGTGCCCTG
CGACGCCGCCGACCTGCGCCCCCGGGGTGCGCGCGGTGCTGGACGGCTGCTCATGCTGTCTGGTGTGTGCCCGCCAGCGTGGCGAGAGCT
GCTCAGATCTGGAGCCATGCGACGAGAGCAGTGGCCTCTACTGTGATCGCAGCGCGGACCCCAGCAACCAGACTGGCATCTGCACGGCGG
TAGAGGGAGATAACTGTGTGTTCGATGGGGTCATCTACCGCAGTGGAGAGAAATTTCAGCCAAGCTGCAAATTCCAGTGCACCTGCAGAG
ATGGGCAGATTGGCTGTGTGCCCCGCTGTCAGCTGGATGTGCTACTGCCTGAGCCTAACTGCCCAGCTCCAAGAAAAGTTGAGGTGCCTG
GAGAGTGCTGTGAAAAGTGGATCTGTGGCCCAGATGAGGAGGATTCACTGGGAGGCCTTACCCTTGCAGCTTACAGGCCAGAAGCCACCC
TAGGAGTAGAAGTCTCTGACTCAAGTGTCAACTGCATTGAACAGACCACAGAGTGGACAGCATGCTCCAAGAGCTGTGGTATGGGGTTCT
CCACCCGGGTCACCAATAGGAACCGTCAATGTGAGATGCTGAAACAGACTCGGCTCTGCATGGTGCGGCCCTGTGAACAAGAGCCAGAGC
AGCCAACAGATAAGATGACAAATCCTCTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATC
GGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATG
TGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTG
CCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAA
GAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCT
TTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTA
AAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAA
GTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTC
AGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAG
GGTCTACAGAAGCTGAAACCAGGAAATTCAGAGGCAGCAGAAATGAAAACAAGGAAAACATTAATGGAAATTTTGAACCTAGAAAAGAGA
GACACCTCCTCTATGGGCGACCTGCAGTGCTTTATCGGACTAGATATGATATCTTATATCACACTGACTTTGAAAGTGGTTATAGTGAAA
TATTCCTAATGCCACTCTGGACATCATATACTGTTTCCAAACAGGCTGAGGTTTCCAGCGTTCCTGACCATCTGACCAGTTGCGTCCGGC
CTGATGTCCGTGTTTCTCCGAGTTTCAGTCAGAACTGTTTGGCCTACAAAAATGATAAGCAGATGTCCTACGGATTCCTCTTTCCTCCTT
ATCTGAGCTCTTCACCAGAGGCTAAATATGATGCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCTTTCAAACGGGTCTGGAATT
ATTTCCAAAGGGTATTGGTGAAGAAATATGCTTCGGAAAGAAATGGAGTTAACGTGATAAGTGGACCAATCTTCGACTATGACTATGATG
GCTTACATGACACAGAAGACAAAATAAAACAGTACGTGGAAGGCAGTTCCATTCCTGTTCCAACTCACTACTACAGCATCATCACCAGCT
GTCTGGATTTCACTCAGCCTGCCGACAAGTGTGACGGCCCTCTCTCTGTGTCCTCCTTCATCCTGCCTCACCGGCCTGACAACGAGGAGA
GCTGCAATAGCTCAGAGGACGAATCAAAATGGGTAGAAGAACTCATGAAGATGCACACAGCTAGGGTGCGTGACATTGAACATCTCACCA
GCCTGGACTTCTTCCGAAAGACCAGCCGCAGCTACCCAGAAATCCTGACACTCAAGACATACCTGCATACATATGAGAGCGAGATTTAAC
TTTCTGAGCATCTGCAGTACAGTCTTATCAACTGGTTGTATATTTTTATATTGTTTTTGTATTTATTAATTTGAAACCAGGACATTAAAA
ATGTTAGTATTTTAATCCTGTACCAAATCTGACATATTATGCCTGAATGACTCCACTGTTTTTCTCTAATGCTTGATTTAGGTAGCCTTG
TGTTCTGAGTAGAGCTTGTAATAAATACTGCAGCTTGAGTTTTTAGTGGAAGCTTCTAAATGGTGCTGCAGATTTGATATTTGCATTGAG
GAAATATTAATTTTCCAATGCACAGTTGCCACATTTAGTCCTGTACTGTATGGAAACACTGATTTTGTAAAGTTGCCTTTATTTGCTGTT


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FusionGenePPI for NOV_ENPP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOVPOLR2L, ITGAV, FN1, IGF1, IGF2, INS, NOTCH1, FBLN1, CDK2, CDKN1A, ADSL, NFKB1, RELA, FBXO21, S100A4ENPP2ITGB4, LPAR1, HSPB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOV_ENPP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNOVP48745DB00071Insulin PorkProtein NOV homologbiotechapproved
HgeneNOVP48745DB00030Insulin HumanProtein NOV homologbiotechapproved|investigational

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RelatedDiseases for NOV_ENPP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneENPP2C0005612Birth Weight1CTD_human
TgeneENPP2C0019158Hepatitis1CTD_human
TgeneENPP2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneENPP2C0027627Neoplasm Metastasis1CTD_human
TgeneENPP2C0040136Thyroid Neoplasm1CTD_human