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Fusion gene ID: 24648 |
FusionGeneSummary for NOTCH3_DEFB132 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOTCH3_DEFB132 | Fusion gene ID: 24648 | Hgene | Tgene | Gene symbol | NOTCH3 | DEFB132 | Gene ID | 4854 | 400830 |
| Gene name | notch 3 | defensin beta 132 | |
| Synonyms | CADASIL|CADASIL1|CASIL|IMF2|LMNS | BD-32|DEFB-32|DEFB32|HEL-75|KFLL827|UNQ827 | |
| Cytomap | 19p13.12 | 20p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurogenic locus notch homolog protein 3Notch homolog 3 | beta-defensin 132RP5-1103G7.6beta-defensin 32defensin HEL-75defensin, beta 32 | |
| Modification date | 20180527 | 20180329 | |
| UniProtAcc | Q9UM47 | Q7Z7B7 | |
| Ensembl transtripts involved in fusion gene | ENST00000263388, | ENST00000382376, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NOTCH3 [Title/Abstract] AND DEFB132 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DEFB132 | GO:0031640 | killing of cells of other organism | 18343807 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-34-5236-01A | NOTCH3 | chr19 | 15278060 | - | DEFB132 | chr20 | 239718 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263388 | ENST00000382376 | NOTCH3 | chr19 | 15278060 | - | DEFB132 | chr20 | 239718 | + |
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FusionProtFeatures for NOTCH3_DEFB132 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOTCH3 | DEFB132 |
| Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination(PubMed:15350543). Upon ligand activation through the releasednotch intracellular domain (NICD) it forms a transcriptionalactivator complex with RBPJ/RBPSUH and activates genes of theenhancer of split locus. Affects the implementation ofdifferentiation, proliferation and apoptotic programs (Bysimilarity). {ECO:0000250|UniProtKB:Q9R172,ECO:0000269|PubMed:15350543}. | Has antibacterial activity. {ECO:0000305}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1000_1034 | 1787 | 2322 | Domain | EGF-like 26 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1047_1082 | 1787 | 2322 | Domain | EGF-like 27 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1084_1120 | 1787 | 2322 | Domain | EGF-like 28 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1122_1158 | 1787 | 2322 | Domain | EGF-like 29%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1160_1203 | 1787 | 2322 | Domain | EGF-like 30%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 119_156 | 1787 | 2322 | Domain | EGF-like 3 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1205_1244 | 1787 | 2322 | Domain | EGF-like 31 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1246_1287 | 1787 | 2322 | Domain | EGF-like 32 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1289_1325 | 1787 | 2322 | Domain | EGF-like 33 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1335_1373 | 1787 | 2322 | Domain | EGF-like 34 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 158_195 | 1787 | 2322 | Domain | EGF-like 4%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 197_234 | 1787 | 2322 | Domain | EGF-like 5 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 236_272 | 1787 | 2322 | Domain | EGF-like 6%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 274_312 | 1787 | 2322 | Domain | EGF-like 7 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 314_350 | 1787 | 2322 | Domain | EGF-like 8%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 351_389 | 1787 | 2322 | Domain | EGF-like 9 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 391_429 | 1787 | 2322 | Domain | EGF-like 10%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 40_77 | 1787 | 2322 | Domain | EGF-like 1 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 431_467 | 1787 | 2322 | Domain | EGF-like 11%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 469_505 | 1787 | 2322 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 507_543 | 1787 | 2322 | Domain | EGF-like 13%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 545_580 | 1787 | 2322 | Domain | EGF-like 14%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 582_618 | 1787 | 2322 | Domain | EGF-like 15%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 620_655 | 1787 | 2322 | Domain | EGF-like 16%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 657_693 | 1787 | 2322 | Domain | EGF-like 17%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 695_730 | 1787 | 2322 | Domain | EGF-like 18 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 734_770 | 1787 | 2322 | Domain | EGF-like 19 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 771_808 | 1787 | 2322 | Domain | EGF-like 20 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 78_118 | 1787 | 2322 | Domain | EGF-like 2 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 810_847 | 1787 | 2322 | Domain | EGF-like 21%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 849_885 | 1787 | 2322 | Domain | EGF-like 22%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 887_922 | 1787 | 2322 | Domain | EGF-like 23%3B calcium-binding |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 924_960 | 1787 | 2322 | Domain | EGF-like 24 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 962_998 | 1787 | 2322 | Domain | EGF-like 25 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1387_1427 | 1787 | 2322 | Repeat | Note=LNR 1 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1428_1458 | 1787 | 2322 | Repeat | Note=LNR 2 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1467_1505 | 1787 | 2322 | Repeat | Note=LNR 3 |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 40_1643 | 1787 | 2322 | Topological domain | Extracellular |
| Hgene | NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1644_1664 | 1787 | 2322 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1838_1867 | 1787 | 2322 | Repeat | Note=ANK 1 |
| Hgene | >NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1871_1901 | 1787 | 2322 | Repeat | Note=ANK 2 |
| Hgene | >NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1905_1934 | 1787 | 2322 | Repeat | Note=ANK 3 |
| Hgene | >NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1938_1967 | 1787 | 2322 | Repeat | Note=ANK 4 |
| Hgene | >NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1971_2000 | 1787 | 2322 | Repeat | Note=ANK 5 |
| Hgene | >NOTCH3 | chr19:15278060 | chr20:239718 | ENST00000263388 | - | 29 | 33 | 1665_2321 | 1787 | 2322 | Topological domain | Cytoplasmic |
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FusionGeneSequence for NOTCH3_DEFB132 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NOTCH3_ENST00000263388_chr19_15278060_-_DEFB132_ENST00000382376_chr20_239718_+_1864aa MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGR GVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS FRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQF CTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPC HEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRI GQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGT LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCT FGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVC EPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQD VDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGT CTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLE SFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSH CEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPL DSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQ CRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSC RPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNS RCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSAD FLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERL DFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKG ESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPASAGGSKCVSNTP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NOTCH3_ENST00000263388_chr19_15278060_-_DEFB132_ENST00000382376_chr20_239718_+_5592nt ATGGGGCCGGGGGCCCGTGGCCGCCGCCGCCGCCGTCGCCCGATGTCGCCGCCACCGCCACCGCCACCCGTGCGGGCGCTGCCCCTGCTG CTGCTGCTAGCGGGGCCGGGGGCTGCAGCCCCCCCTTGCCTGGACGGAAGCCCGTGTGCAAATGGAGGTCGTTGCACCCAGCTGCCCTCC CGGGAGGCTGCCTGCCTGTGCCCGCCTGGCTGGGTGGGTGAGCGGTGTCAGCTGGAGGACCCCTGTCACTCAGGCCCCTGTGCTGGCCGT GGTGTCTGCCAGAGTTCAGTGGTGGCTGGCACCGCCCGATTCTCATGCCGGTGCCCCCGTGGCTTCCGAGGCCCTGACTGCTCCCTGCCA GATCCCTGCCTCAGCAGCCCTTGTGCCCACGGTGCCCGCTGCTCAGTGGGGCCCGATGGACGCTTCCTCTGCTCCTGCCCACCTGGCTAC CAGGGCCGCAGCTGCCGAAGCGACGTGGATGAGTGCCGGGTGGGTGAGCCCTGCCGCCATGGTGGCACCTGCCTCAACACACCTGGCTCC TTCCGCTGCCAGTGTCCAGCTGGCTACACAGGGCCACTATGTGAGAACCCCGCGGTGCCCTGTGCACCCTCACCATGCCGTAACGGGGGC ACCTGCAGGCAGAGTGGCGACCTCACTTACGACTGTGCCTGTCTTCCTGGGTTTGAGGGTCAGAATTGTGAAGTGAACGTGGACGACTGT CCAGGACACCGATGTCTCAATGGGGGGACATGCGTGGATGGCGTCAACACCTATAACTGCCAGTGCCCTCCTGAGTGGACAGGCCAGTTC TGCACGGAGGACGTGGATGAGTGTCAGCTGCAGCCCAACGCCTGCCACAATGGGGGTACCTGCTTCAACACGCTGGGTGGCCACAGCTGC GTGTGTGTCAATGGCTGGACAGGCGAGAGCTGCAGTCAGAATATCGATGACTGTGCCACAGCCGTGTGCTTCCATGGGGCCACCTGCCAT GACCGCGTGGCTTCTTTCTACTGTGCCTGCCCCATGGGCAAGACTGGCCTCCTGTGTCACCTGGATGACGCCTGTGTCAGCAACCCCTGC CACGAGGATGCTATCTGTGACACAAATCCGGTGAACGGCCGGGCCATTTGCACCTGTCCTCCCGGCTTCACGGGTGGGGCATGTGACCAG GATGTGGACGAGTGCTCTATCGGCGCCAACCCCTGCGAGCACTTGGGCAGGTGCGTGAACACGCAGGGCTCCTTCCTGTGCCAGTGCGGT CGTGGCTACACTGGACCTCGCTGTGAGACCGATGTCAACGAGTGTCTGTCGGGGCCCTGCCGAAACCAGGCCACGTGCCTCGACCGCATA GGCCAGTTCACCTGTATCTGTATGGCAGGCTTCACAGGAACCTATTGCGAGGTGGACATTGACGAGTGTCAGAGTAGCCCCTGTGTCAAC GGTGGGGTCTGCAAGGACCGAGTCAATGGCTTCAGCTGCACCTGCCCCTCGGGCTTCAGCGGCTCCACGTGTCAGCTGGACGTGGACGAA TGCGCCAGCACGCCCTGCAGGAATGGCGCCAAATGCGTGGACCAGCCCGATGGCTACGAGTGCCGCTGTGCCGAGGGCTTTGAGGGCACG CTGTGTGATCGCAACGTGGACGACTGCTCCCCTGACCCATGCCACCATGGTCGCTGCGTGGATGGCATCGCCAGCTTCTCATGTGCCTGT GCTCCTGGCTACACGGGCACACGCTGCGAGAGCCAGGTGGACGAATGCCGCAGCCAGCCCTGCCGCCATGGCGGCAAATGCCTAGACCTG GTGGACAAGTACCTCTGCCGCTGCCCTTCTGGGACCACAGGTGTGAACTGCGAAGTGAACATTGACGACTGTGCCAGCAACCCCTGCACC TTTGGAGTCTGCCGTGATGGCATCAACCGCTACGACTGTGTCTGCCAACCTGGCTTCACAGGGCCCCTTTGTAACGTGGAGATCAATGAG TGTGCTTCCAGCCCATGCGGCGAGGGAGGTTCCTGTGTGGATGGGGAAAATGGCTTCCGCTGCCTCTGCCCGCCTGGCTCCTTGCCCCCA CTCTGCCTCCCCCCGAGCCATCCCTGTGCCCATGAGCCCTGCAGTCACGGCATCTGCTATGATGCACCTGGCGGGTTCCGCTGTGTGTGT GAGCCTGGCTGGAGTGGCCCCCGCTGCAGCCAGAGCCTGGCCCGAGACGCCTGTGAGTCCCAGCCGTGCAGGGCCGGTGGGACATGCAGC AGCGATGGAATGGGTTTCCACTGCACCTGCCCGCCTGGTGTCCAGGGACGTCAGTGTGAACTCCTCTCCCCCTGCACCCCGAACCCCTGT GAGCATGGGGGCCGCTGCGAGTCTGCCCCTGGCCAGCTGCCTGTCTGCTCCTGCCCCCAGGGCTGGCAAGGCCCACGATGCCAGCAGGAT GTGGACGAGTGTGCTGGCCCCGCACCCTGTGGCCCTCATGGTATCTGCACCAACCTGGCAGGGAGTTTCAGCTGCACCTGCCATGGAGGG TACACTGGCCCTTCCTGCGATCAGGACATCAATGACTGTGACCCCAACCCATGCCTGAACGGTGGCTCGTGCCAAGACGGCGTGGGCTCC TTTTCCTGCTCCTGCCTCCCTGGTTTCGCCGGCCCACGATGCGCCCGCGATGTGGATGAGTGCCTGAGCAACCCCTGCGGCCCGGGCACC TGTACCGACCACGTGGCCTCCTTCACCTGCACCTGCCCGCCAGGCTACGGAGGCTTCCACTGCGAACAGGACCTGCCCGACTGCAGCCCC AGCTCCTGCTTCAATGGCGGGACCTGTGTGGACGGCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACAGGAGCCCACTGCCAA CATGAGGCAGACCCCTGCCTCTCGCGGCCCTGCCTACACGGGGGCGTCTGCAGCGCCGCCCACCCTGGCTTCCGCTGCACCTGCCTCGAG AGCTTCACGGGCCCGCAGTGCCAGACGCTGGTGGATTGGTGCAGCCGCCAGCCTTGTCAAAACGGGGGTCGCTGCGTCCAGACTGGGGCC TATTGCCTTTGTCCCCCTGGATGGAGCGGACGCCTCTGTGACATCCGAAGCTTGCCCTGCAGGGAGGCCGCAGCCCAGATCGGGGTGCGG CTGGAGCAGCTGTGTCAGGCGGGTGGGCAGTGTGTGGATGAAGACAGCTCCCACTACTGCGTGTGCCCAGAGGGCCGTACTGGTAGCCAC TGTGAGCAGGAGGTGGACCCCTGCTTGGCCCAGCCCTGCCAGCATGGGGGGACCTGCCGTGGCTATATGGGGGGCTACATGTGTGAGTGT CTTCCTGGCTACAATGGTGATAACTGTGAGGACGACGTGGACGAGTGTGCCTCCCAGCCCTGCCAGCACGGGGGTTCATGCATTGACCTC GTGGCCCGCTATCTCTGCTCCTGTCCCCCAGGAACGCTGGGGGTGCTCTGCGAGATTAATGAGGATGACTGCGGCCCAGGCCCACCGCTG GACTCAGGGCCCCGGTGCCTACACAATGGCACCTGCGTGGACCTGGTGGGTGGTTTCCGCTGCACCTGTCCCCCAGGATACACTGGTTTG CGCTGCGAGGCAGACATCAATGAGTGTCGCTCAGGTGCCTGCCACGCGGCACACACCCGGGACTGCCTGCAGGACCCAGGCGGAGGTTTC CGTTGCCTTTGTCATGCTGGCTTCTCAGGTCCTCGCTGTCAGACTGTCCTGTCTCCCTGCGAGTCCCAGCCATGCCAGCATGGAGGCCAG TGCCGTCCTAGCCCGGGTCCTGGGGGTGGGCTGACCTTCACCTGTCACTGTGCCCAGCCGTTCTGGGGTCCGCGTTGCGAGCGGGTGGCG CGCTCCTGCCGGGAGCTGCAGTGCCCGGTGGGCGTCCCATGCCAGCAGACGCCCCGCGGGCCGCGCTGCGCCTGCCCCCCAGGGTTGTCG GGACCCTCCTGCCGCAGCTTCCCGGGGTCGCCGCCGGGGGCCAGCAACGCCAGCTGCGCGGCCGCCCCCTGTCTCCACGGGGGCTCCTGC CGCCCCGCGCCGCTCGCGCCCTTCTTCCGCTGCGCTTGCGCGCAGGGCTGGACCGGGCCGCGCTGCGAGGCGCCCGCCGCGGCACCCGAG GTCTCGGAGGAGCCGCGGTGCCCGCGCGCCGCCTGCCAGGCCAAGCGCGGGGACCAGCGCTGCGACCGCGAGTGCAACAGCCCAGGCTGC GGCTGGGACGGCGGCGACTGCTCGCTGAGCGTGGGCGACCCCTGGCGGCAATGCGAGGCGCTGCAGTGCTGGCGCCTCTTCAACAACAGC CGCTGCGACCCCGCCTGCAGCTCGCCCGCCTGCCTCTACGACAACTTCGACTGCCACGCCGGTGGCCGCGAGCGCACTTGCAACCCGGTG TACGAGAAGTACTGCGCCGACCACTTTGCCGACGGCCGCTGCGACCAGGGCTGCAACACGGAGGAGTGCGGCTGGGATGGGCTGGATTGT GCCAGCGAGGTGCCGGCCCTGCTGGCCCGCGGCGTGCTGGTGCTCACAGTGCTGCTGCCGCCAGAGGAGCTACTGCGTTCCAGCGCCGAC TTTCTGCAGCGGCTCAGCGCCATCCTGCGCACCTCGCTGCGCTTCCGCCTGGACGCGCACGGCCAGGCCATGGTCTTCCCTTACCACCGG CCTAGTCCTGGCTCCGAACCCCGGGCCCGTCGGGAGCTGGCCCCCGAGGTGATCGGCTCGGTAGTAATGCTGGAGATTGACAACCGGCTC TGCCTGCAGTCGCCTGAGAATGATCACTGCTTCCCCGATGCCCAGAGCGCCGCTGACTACCTGGGAGCGTTGTCAGCGGTGGAGCGCCTG GACTTCCCGTACCCACTGCGGGACGTGCGGGGGGAGCCGCTGGAGCCTCCAGAACCCAGCGTCCCGCTGCTGCCACTGCTAGTGGCGGGC GCTGTCTTGCTGCTGGTCATTCTCGTCCTGGGTGTCATGGTGGCCCGGCGCAAGCGCGAGCACAGCACCCTCTGGTTCCCTGAGGGCTTC TCACTGCACAAGGACGTGGCCTCTGGTCACAAGGGCCGGCGGGAACCCGTGGGCCAGGACGCGCTGGGCATGAAGAACATGGCCAAGGGT GAGAGCCTGATGGGGGAGGTGGCCACAGACTGGATGGACACAGAGTGCCCAGAGGCCAAGCGGCTAAAGGTAGAGGAGCCAGGCATGGGG GCTGAGGAGGCTGTGGATTGCCGTCAGTGGACTCAACACCATCTGGTTGCTGCTGACATCCGCGTGGCACCAGCCATGGCACTGACACCA CCACAGGGCGACGCAGATGCTGATGGCATGGATGTCAATGTGCGTGGCCCAGCCAGTGCAGGTGGGTCAAAATGTGTGAGTAACACCCCA GGATACTGCAGGACATGTTGCCACTGGGGGGAGACAGCATTGTTCATGTGCAACGCTTCCAGAAAATGCTGCATCAGCTACTCCTTCCTG CCGAAGCCTGACCTACCACAGCTCATCGGTAACCACTGGCAATCAAGGAGAAGAAACACACAAAGGAAAGACAAGAAGCAACAAACGACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NOTCH3_ENST00000263388_chr19_15278060_-_DEFB132_ENST00000382376_chr20_239718_+_7458nt GCGGCGCGGAGGCTGGCCCGGGACGCGCCCGGAGCCCAGGGAAGGAGGGAGGAGGGGAGGGTCGCGGCCGGCCGCCATGGGGCCGGGGGC CCGTGGCCGCCGCCGCCGCCGTCGCCCGATGTCGCCGCCACCGCCACCGCCACCCGTGCGGGCGCTGCCCCTGCTGCTGCTGCTAGCGGG GCCGGGGGCTGCAGCCCCCCCTTGCCTGGACGGAAGCCCGTGTGCAAATGGAGGTCGTTGCACCCAGCTGCCCTCCCGGGAGGCTGCCTG CCTGTGCCCGCCTGGCTGGGTGGGTGAGCGGTGTCAGCTGGAGGACCCCTGTCACTCAGGCCCCTGTGCTGGCCGTGGTGTCTGCCAGAG TTCAGTGGTGGCTGGCACCGCCCGATTCTCATGCCGGTGCCCCCGTGGCTTCCGAGGCCCTGACTGCTCCCTGCCAGATCCCTGCCTCAG CAGCCCTTGTGCCCACGGTGCCCGCTGCTCAGTGGGGCCCGATGGACGCTTCCTCTGCTCCTGCCCACCTGGCTACCAGGGCCGCAGCTG CCGAAGCGACGTGGATGAGTGCCGGGTGGGTGAGCCCTGCCGCCATGGTGGCACCTGCCTCAACACACCTGGCTCCTTCCGCTGCCAGTG TCCAGCTGGCTACACAGGGCCACTATGTGAGAACCCCGCGGTGCCCTGTGCACCCTCACCATGCCGTAACGGGGGCACCTGCAGGCAGAG TGGCGACCTCACTTACGACTGTGCCTGTCTTCCTGGGTTTGAGGGTCAGAATTGTGAAGTGAACGTGGACGACTGTCCAGGACACCGATG TCTCAATGGGGGGACATGCGTGGATGGCGTCAACACCTATAACTGCCAGTGCCCTCCTGAGTGGACAGGCCAGTTCTGCACGGAGGACGT GGATGAGTGTCAGCTGCAGCCCAACGCCTGCCACAATGGGGGTACCTGCTTCAACACGCTGGGTGGCCACAGCTGCGTGTGTGTCAATGG CTGGACAGGCGAGAGCTGCAGTCAGAATATCGATGACTGTGCCACAGCCGTGTGCTTCCATGGGGCCACCTGCCATGACCGCGTGGCTTC TTTCTACTGTGCCTGCCCCATGGGCAAGACTGGCCTCCTGTGTCACCTGGATGACGCCTGTGTCAGCAACCCCTGCCACGAGGATGCTAT CTGTGACACAAATCCGGTGAACGGCCGGGCCATTTGCACCTGTCCTCCCGGCTTCACGGGTGGGGCATGTGACCAGGATGTGGACGAGTG CTCTATCGGCGCCAACCCCTGCGAGCACTTGGGCAGGTGCGTGAACACGCAGGGCTCCTTCCTGTGCCAGTGCGGTCGTGGCTACACTGG ACCTCGCTGTGAGACCGATGTCAACGAGTGTCTGTCGGGGCCCTGCCGAAACCAGGCCACGTGCCTCGACCGCATAGGCCAGTTCACCTG TATCTGTATGGCAGGCTTCACAGGAACCTATTGCGAGGTGGACATTGACGAGTGTCAGAGTAGCCCCTGTGTCAACGGTGGGGTCTGCAA GGACCGAGTCAATGGCTTCAGCTGCACCTGCCCCTCGGGCTTCAGCGGCTCCACGTGTCAGCTGGACGTGGACGAATGCGCCAGCACGCC CTGCAGGAATGGCGCCAAATGCGTGGACCAGCCCGATGGCTACGAGTGCCGCTGTGCCGAGGGCTTTGAGGGCACGCTGTGTGATCGCAA CGTGGACGACTGCTCCCCTGACCCATGCCACCATGGTCGCTGCGTGGATGGCATCGCCAGCTTCTCATGTGCCTGTGCTCCTGGCTACAC GGGCACACGCTGCGAGAGCCAGGTGGACGAATGCCGCAGCCAGCCCTGCCGCCATGGCGGCAAATGCCTAGACCTGGTGGACAAGTACCT CTGCCGCTGCCCTTCTGGGACCACAGGTGTGAACTGCGAAGTGAACATTGACGACTGTGCCAGCAACCCCTGCACCTTTGGAGTCTGCCG TGATGGCATCAACCGCTACGACTGTGTCTGCCAACCTGGCTTCACAGGGCCCCTTTGTAACGTGGAGATCAATGAGTGTGCTTCCAGCCC ATGCGGCGAGGGAGGTTCCTGTGTGGATGGGGAAAATGGCTTCCGCTGCCTCTGCCCGCCTGGCTCCTTGCCCCCACTCTGCCTCCCCCC GAGCCATCCCTGTGCCCATGAGCCCTGCAGTCACGGCATCTGCTATGATGCACCTGGCGGGTTCCGCTGTGTGTGTGAGCCTGGCTGGAG TGGCCCCCGCTGCAGCCAGAGCCTGGCCCGAGACGCCTGTGAGTCCCAGCCGTGCAGGGCCGGTGGGACATGCAGCAGCGATGGAATGGG TTTCCACTGCACCTGCCCGCCTGGTGTCCAGGGACGTCAGTGTGAACTCCTCTCCCCCTGCACCCCGAACCCCTGTGAGCATGGGGGCCG CTGCGAGTCTGCCCCTGGCCAGCTGCCTGTCTGCTCCTGCCCCCAGGGCTGGCAAGGCCCACGATGCCAGCAGGATGTGGACGAGTGTGC TGGCCCCGCACCCTGTGGCCCTCATGGTATCTGCACCAACCTGGCAGGGAGTTTCAGCTGCACCTGCCATGGAGGGTACACTGGCCCTTC CTGCGATCAGGACATCAATGACTGTGACCCCAACCCATGCCTGAACGGTGGCTCGTGCCAAGACGGCGTGGGCTCCTTTTCCTGCTCCTG CCTCCCTGGTTTCGCCGGCCCACGATGCGCCCGCGATGTGGATGAGTGCCTGAGCAACCCCTGCGGCCCGGGCACCTGTACCGACCACGT GGCCTCCTTCACCTGCACCTGCCCGCCAGGCTACGGAGGCTTCCACTGCGAACAGGACCTGCCCGACTGCAGCCCCAGCTCCTGCTTCAA TGGCGGGACCTGTGTGGACGGCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACAGGAGCCCACTGCCAACATGAGGCAGACCC CTGCCTCTCGCGGCCCTGCCTACACGGGGGCGTCTGCAGCGCCGCCCACCCTGGCTTCCGCTGCACCTGCCTCGAGAGCTTCACGGGCCC GCAGTGCCAGACGCTGGTGGATTGGTGCAGCCGCCAGCCTTGTCAAAACGGGGGTCGCTGCGTCCAGACTGGGGCCTATTGCCTTTGTCC CCCTGGATGGAGCGGACGCCTCTGTGACATCCGAAGCTTGCCCTGCAGGGAGGCCGCAGCCCAGATCGGGGTGCGGCTGGAGCAGCTGTG TCAGGCGGGTGGGCAGTGTGTGGATGAAGACAGCTCCCACTACTGCGTGTGCCCAGAGGGCCGTACTGGTAGCCACTGTGAGCAGGAGGT GGACCCCTGCTTGGCCCAGCCCTGCCAGCATGGGGGGACCTGCCGTGGCTATATGGGGGGCTACATGTGTGAGTGTCTTCCTGGCTACAA TGGTGATAACTGTGAGGACGACGTGGACGAGTGTGCCTCCCAGCCCTGCCAGCACGGGGGTTCATGCATTGACCTCGTGGCCCGCTATCT CTGCTCCTGTCCCCCAGGAACGCTGGGGGTGCTCTGCGAGATTAATGAGGATGACTGCGGCCCAGGCCCACCGCTGGACTCAGGGCCCCG GTGCCTACACAATGGCACCTGCGTGGACCTGGTGGGTGGTTTCCGCTGCACCTGTCCCCCAGGATACACTGGTTTGCGCTGCGAGGCAGA CATCAATGAGTGTCGCTCAGGTGCCTGCCACGCGGCACACACCCGGGACTGCCTGCAGGACCCAGGCGGAGGTTTCCGTTGCCTTTGTCA TGCTGGCTTCTCAGGTCCTCGCTGTCAGACTGTCCTGTCTCCCTGCGAGTCCCAGCCATGCCAGCATGGAGGCCAGTGCCGTCCTAGCCC GGGTCCTGGGGGTGGGCTGACCTTCACCTGTCACTGTGCCCAGCCGTTCTGGGGTCCGCGTTGCGAGCGGGTGGCGCGCTCCTGCCGGGA GCTGCAGTGCCCGGTGGGCGTCCCATGCCAGCAGACGCCCCGCGGGCCGCGCTGCGCCTGCCCCCCAGGGTTGTCGGGACCCTCCTGCCG CAGCTTCCCGGGGTCGCCGCCGGGGGCCAGCAACGCCAGCTGCGCGGCCGCCCCCTGTCTCCACGGGGGCTCCTGCCGCCCCGCGCCGCT CGCGCCCTTCTTCCGCTGCGCTTGCGCGCAGGGCTGGACCGGGCCGCGCTGCGAGGCGCCCGCCGCGGCACCCGAGGTCTCGGAGGAGCC GCGGTGCCCGCGCGCCGCCTGCCAGGCCAAGCGCGGGGACCAGCGCTGCGACCGCGAGTGCAACAGCCCAGGCTGCGGCTGGGACGGCGG CGACTGCTCGCTGAGCGTGGGCGACCCCTGGCGGCAATGCGAGGCGCTGCAGTGCTGGCGCCTCTTCAACAACAGCCGCTGCGACCCCGC CTGCAGCTCGCCCGCCTGCCTCTACGACAACTTCGACTGCCACGCCGGTGGCCGCGAGCGCACTTGCAACCCGGTGTACGAGAAGTACTG CGCCGACCACTTTGCCGACGGCCGCTGCGACCAGGGCTGCAACACGGAGGAGTGCGGCTGGGATGGGCTGGATTGTGCCAGCGAGGTGCC GGCCCTGCTGGCCCGCGGCGTGCTGGTGCTCACAGTGCTGCTGCCGCCAGAGGAGCTACTGCGTTCCAGCGCCGACTTTCTGCAGCGGCT CAGCGCCATCCTGCGCACCTCGCTGCGCTTCCGCCTGGACGCGCACGGCCAGGCCATGGTCTTCCCTTACCACCGGCCTAGTCCTGGCTC CGAACCCCGGGCCCGTCGGGAGCTGGCCCCCGAGGTGATCGGCTCGGTAGTAATGCTGGAGATTGACAACCGGCTCTGCCTGCAGTCGCC TGAGAATGATCACTGCTTCCCCGATGCCCAGAGCGCCGCTGACTACCTGGGAGCGTTGTCAGCGGTGGAGCGCCTGGACTTCCCGTACCC ACTGCGGGACGTGCGGGGGGAGCCGCTGGAGCCTCCAGAACCCAGCGTCCCGCTGCTGCCACTGCTAGTGGCGGGCGCTGTCTTGCTGCT GGTCATTCTCGTCCTGGGTGTCATGGTGGCCCGGCGCAAGCGCGAGCACAGCACCCTCTGGTTCCCTGAGGGCTTCTCACTGCACAAGGA CGTGGCCTCTGGTCACAAGGGCCGGCGGGAACCCGTGGGCCAGGACGCGCTGGGCATGAAGAACATGGCCAAGGGTGAGAGCCTGATGGG GGAGGTGGCCACAGACTGGATGGACACAGAGTGCCCAGAGGCCAAGCGGCTAAAGGTAGAGGAGCCAGGCATGGGGGCTGAGGAGGCTGT GGATTGCCGTCAGTGGACTCAACACCATCTGGTTGCTGCTGACATCCGCGTGGCACCAGCCATGGCACTGACACCACCACAGGGCGACGC AGATGCTGATGGCATGGATGTCAATGTGCGTGGCCCAGCCAGTGCAGGTGGGTCAAAATGTGTGAGTAACACCCCAGGATACTGCAGGAC ATGTTGCCACTGGGGGGAGACAGCATTGTTCATGTGCAACGCTTCCAGAAAATGCTGCATCAGCTACTCCTTCCTGCCGAAGCCTGACCT ACCACAGCTCATCGGTAACCACTGGCAATCAAGGAGAAGAAACACACAAAGGAAAGACAAGAAGCAACAAACGACCGTAACATCATAATA ACCACTGCTATCGCCTCCACCAACTCAGAGAAATATCATTTCCACAGTTCCAATTCCTCCTACATTGCTGAGTACTAGCCAAGGCTCCTC TTTATGGGGCAGATATCTATAGCCAACCCCAAAACTTCTGTCTTCTATCATTCTGTCATTCATCTAGTAACTAATTTGGAGTTTGTATCT ATCTTACGAGAACAATCATCATGCAGATTCGTCCACAGGGGATCTGTCAGTTTGGGTCCTCCAAATGAAAAATGTCAAGACAGAATTGGA CATGCAAAAGATTGACTGGGAGAACACACCTCTGATGGACAAAGGTGAGACAGAGCAGCCACAGGCAGGGAGAGCCTTCAGACTGCAACG CTGGCCTGATACGTGTCAAAGGAGAGAGGGATAGAGGAGGATTGAATAGAAGGAGACTAAGACTGCAGCTCTAAGAAAGTCTCAGCCAAA CAGATGGGGAGGCCCAAAGCAAGGCTTGCCCCTCAGAGGAGCTCACGCAGGGCAGGAATAGCCAGGTTCTCATATCCCAGGGGTTCAGAC TTTGGCTGAGAACAGCCCCTGGAGAACATGGGGTGACTGCTACCATAGGTCTGGAAGTATGAGGCTGTCCACCAACTATCCCCTTGAAGC AAGTTCTCTTGAAAGGAAATCTAAACAGTGCACCCCCATGGCTGCCACGGAGTATAAGGAGGGAGAGAAAGGAGCTGAAAGTCTAGGTTT GGCCAGCTAGGTAGACTGACTTGTGAGGTATTTATTTATTCATTTGAGTAACAAAGCAGACAGAATACATAGCCACCATTGGTAGTACAC CCCAAAAGCAAGGATGGCATGATGCTGGTGACTCAAACGTGCCTACTCATGGTGTCAAATTGGCATAATCCTCTTGGGAAGCTGTGTGGA AATAAGCACAGAGAAGCAGAACTCTAATTGCTTAATCCACTAAACATTACTTCTGGGAATTGGCTCATCATAAATTATCCAAGAGAAGCA CAAAGTTATGGGCACAAAGGTTTTCCATATAATATTATTTAAAATGCTGAGAAAATGAAAAAATCTAAATGGTGAAATATATACTAATGC CATCTATAAATACAAACAAATAGAATGTTTATAGAATAATGGAACATAATAACATTATTCAAAATTGCATTTATGCTATAGTTGTCAAAA TTGTCTCCTTATATGATACAAAACTCATGAAAATTATGACTTTTTTGTTTGGTTGGAAAGCAGAATTATGCATAAATTTCCTCTTACAGT TCGATGCCCATTAGTTTTATATAACATTTATTTGACACGTACTGACTTCTATCTGAGAAGAACAAACCAAAACACTCAGGCCTAAATAAT TAAAAACGGTCCTAAAAACTAGCAAACCAGATAAGAAAAGATGTTAATGCCCATTCCCTAACTTATGTCTTAGACCAAAATTAATTCTAG ATGGTTTTAAAATGACAGTGTAAAAGTAAAGTATTAAAAGATTGTGTGGTCAAATATTCAATTTAAGAGCAAGGAAATTCTTATAAATAT AACAATAGAGGCAGAACTCATGTAAGAATAAATTGATTAGGTGGTATTAAATATTAAGTTCTTATGTATGTCAAAAGATATCATTTTGAA ATTCATCCATCTTATTGGGTATTGCAGGAGTTCATTCCTTTTTGTTTATAAATACTCTTCCGTCATATGAATAGTATTCATTTGTATACT |
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FusionGenePPI for NOTCH3_DEFB132 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NOTCH3 | SNW1, NOTCH1, DLL1, JAG1, JAG2, MAML1, GSK3B, STRAP, CSNK2B, PSMA1, CBL, PTCRA, FBLN1, EGFL7, MPPED2, GGT6, CBFA2T2, SPTLC2, RET, MYC, SORBS3, WWP2, RBPJ, TNNT2, XKR8, SNX19, CNTD1, WDR25, SCGB3A1, CPNE6, BAG2, SLC39A1, PPIA, C8orf76, C1QL1, TMEM108, NEDD9, RMI2, CRIP2, BTF3L4, TPT1, ANKRD44, TSPAN3, RABGGTB, NEU2, ZFP41, NTRK1, CDH1, HIF1AN, DLK2, ADAM33, ADAM32, DNAJC10, ZNF408, LRRIQ1, MANSC1, DEFA1, IFNGR1, ZNF224, ABCG8, SLC20A1 | DEFB132 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOTCH3_DEFB132 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOTCH3_DEFB132 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NOTCH3 | C0751587 | CADASIL Syndrome | 20 | CTD_human;ORPHANET;UNIPROT |
| Hgene | NOTCH3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | NOTCH3 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | NOTCH3 | C0024121 | Lung Neoplasms | 1 | CTD_human;HPO |
| Hgene | NOTCH3 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | NOTCH3 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
| Hgene | NOTCH3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | NOTCH3 | C3809084 | MYOFIBROMATOSIS, INFANTILE, 2 | 1 | UNIPROT |
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