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Fusion gene ID: 24641 |
FusionGeneSummary for NOTCH2_REG4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOTCH2_REG4 | Fusion gene ID: 24641 | Hgene | Tgene | Gene symbol | NOTCH2 | REG4 | Gene ID | 4853 | 83998 |
| Gene name | notch 2 | regenerating family member 4 | |
| Synonyms | AGS2|HJCYS|hN2 | GISP|REG-IV|RELP | |
| Cytomap | 1p12 | 1p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neurogenic locus notch homolog protein 2Notch homolog 2 | regenerating islet-derived protein 4REG-4REG-like proteingastrointestinal secretory proteinreg IVregenerating gene type IVregenerating islet-derived family, member 4regenerating islet-derived protein IV | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q04721 | Q9BYZ8 | |
| Ensembl transtripts involved in fusion gene | ENST00000256646, ENST00000602566, ENST00000493703, | ENST00000354219, ENST00000256585, ENST00000530654, ENST00000369401, | |
| Fusion gene scores | * DoF score | 9 X 8 X 8=576 | 4 X 4 X 4=64 |
| # samples | 12 | 5 | |
| ** MAII score | log2(12/576*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOTCH2 [Title/Abstract] AND REG4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NOTCH2 | GO:0007050 | cell cycle arrest | 11306509 |
| Hgene | NOTCH2 | GO:0007219 | Notch signaling pathway | 11306509|25985737 |
| Hgene | NOTCH2 | GO:0010629 | negative regulation of gene expression | 11306509 |
| Hgene | NOTCH2 | GO:0045967 | negative regulation of growth rate | 11306509 |
| Hgene | NOTCH2 | GO:0046579 | positive regulation of Ras protein signal transduction | 11306509 |
| Hgene | NOTCH2 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 11306509 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-D3-A5GU-06A | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| TCGA | LD | SKCM | TCGA-GN-A264-06A | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000256646 | ENST00000354219 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| Frame-shift | ENST00000256646 | ENST00000256585 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| Frame-shift | ENST00000256646 | ENST00000530654 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| Frame-shift | ENST00000256646 | ENST00000369401 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000354219 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000256585 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000530654 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000369401 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000354219 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000256585 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000530654 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000369401 | NOTCH2 | chr1 | 120611948 | - | REG4 | chr1 | 120345788 | - |
| In-frame | ENST00000256646 | ENST00000354219 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| In-frame | ENST00000256646 | ENST00000256585 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| In-frame | ENST00000256646 | ENST00000530654 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| In-frame | ENST00000256646 | ENST00000369401 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000354219 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000256585 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000530654 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000602566 | ENST00000369401 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000354219 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000256585 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000530654 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
| intron-3CDS | ENST00000493703 | ENST00000369401 | NOTCH2 | chr1 | 120496166 | - | REG4 | chr1 | 120345788 | - |
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FusionProtFeatures for NOTCH2_REG4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOTCH2 | REG4 |
| Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex withRBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation, proliferation andapoptotic programs (By similarity). Involved in bone remodelingand homeostasis. In collaboration with RELA/p65 enhances NFATc1promoter activity and positively regulates RANKL-inducedosteoclast differentiation (PubMed:29149593). Positively regulatesself-renewal of liver cancer cells (PubMed:25985737).{ECO:0000250|UniProtKB:O35516, ECO:0000269|PubMed:21378985,ECO:0000269|PubMed:21378989, ECO:0000269|PubMed:25985737,ECO:0000269|PubMed:29149593}. | Calcium-independent lectin displaying mannose-bindingspecificity and able to maintain carbohydrate recognition activityin an acidic environment. May be involved in inflammatory andmetaplastic responses of the gastrointestinal epithelium.{ECO:0000269|PubMed:12819006, ECO:0000269|PubMed:20692269}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 105_143 | 788 | 2472 | Domain | EGF-like 3 |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 144_180 | 788 | 2472 | Domain | EGF-like 4 |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 182_219 | 788 | 2472 | Domain | EGF-like 5%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 221_258 | 788 | 2472 | Domain | EGF-like 6 |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 260_296 | 788 | 2472 | Domain | EGF-like 7%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 26_63 | 788 | 2472 | Domain | EGF-like 1 |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 298_336 | 788 | 2472 | Domain | EGF-like 8%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 338_374 | 788 | 2472 | Domain | EGF-like 9%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 375_413 | 788 | 2472 | Domain | EGF-like 10 |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 415_454 | 788 | 2472 | Domain | EGF-like 11%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 456_492 | 788 | 2472 | Domain | EGF-like 12%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 494_530 | 788 | 2472 | Domain | EGF-like 13%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 532_568 | 788 | 2472 | Domain | EGF-like 14%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 570_605 | 788 | 2472 | Domain | EGF-like 15%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 607_643 | 788 | 2472 | Domain | EGF-like 16%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 645_680 | 788 | 2472 | Domain | EGF-like 17%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 64_102 | 788 | 2472 | Domain | EGF-like 2 |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 682_718 | 788 | 2472 | Domain | EGF-like 18%3B calcium-binding |
| Hgene | NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 720_755 | 788 | 2472 | Domain | EGF-like 19 |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000256585 | - | 1 | 6 | 37_155 | 22 | 159 | Domain | C-type lectin |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000354219 | - | 2 | 7 | 37_155 | 22 | 159 | Domain | C-type lectin |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000369401 | - | 1 | 3 | 37_155 | 22 | 135 | Domain | C-type lectin |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000256585 | - | 1 | 6 | 135_137 | 22 | 159 | Region | Note=Carbohydrate-binding |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000256585 | - | 1 | 6 | 98_103 | 22 | 159 | Region | Note=Carbohydrate-binding |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000354219 | - | 2 | 7 | 135_137 | 22 | 159 | Region | Note=Carbohydrate-binding |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000354219 | - | 2 | 7 | 98_103 | 22 | 159 | Region | Note=Carbohydrate-binding |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000369401 | - | 1 | 3 | 135_137 | 22 | 135 | Region | Note=Carbohydrate-binding |
| Tgene | >REG4 | chr1:120496166 | chr1:120345788 | ENST00000369401 | - | 1 | 3 | 98_103 | 22 | 135 | Region | Note=Carbohydrate-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1645_1648 | 788 | 2472 | Compositional bias | Note=Poly-Ala |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1994_1997 | 788 | 2472 | Compositional bias | Note=Poly-Leu |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 2426_2429 | 788 | 2472 | Compositional bias | Note=Poly-Ser |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1025_1061 | 788 | 2472 | Domain | EGF-like 27%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1063_1099 | 788 | 2472 | Domain | EGF-like 28 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1101_1147 | 788 | 2472 | Domain | EGF-like 29 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1149_1185 | 788 | 2472 | Domain | EGF-like 30%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1187_1223 | 788 | 2472 | Domain | EGF-like 31%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1225_1262 | 788 | 2472 | Domain | EGF-like 32%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1264_1302 | 788 | 2472 | Domain | EGF-like 33 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1304_1343 | 788 | 2472 | Domain | EGF-like 34 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1374_1412 | 788 | 2472 | Domain | EGF-like 35 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 757_793 | 788 | 2472 | Domain | EGF-like 20%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 795_831 | 788 | 2472 | Domain | EGF-like 21%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 833_871 | 788 | 2472 | Domain | EGF-like 22 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 873_909 | 788 | 2472 | Domain | EGF-like 23%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 911_947 | 788 | 2472 | Domain | EGF-like 24%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 949_985 | 788 | 2472 | Domain | EGF-like 25%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 987_1023 | 788 | 2472 | Domain | EGF-like 26%3B calcium-binding |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1425_1677 | 788 | 2472 | Region | Note=Negative regulatory region (NRR) |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1425_1465 | 788 | 2472 | Repeat | Note=LNR 1 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1466_1502 | 788 | 2472 | Repeat | Note=LNR 2 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1503_1544 | 788 | 2472 | Repeat | Note=LNR 3 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1827_1871 | 788 | 2472 | Repeat | Note=ANK 1 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1876_1905 | 788 | 2472 | Repeat | Note=ANK 2 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1909_1939 | 788 | 2472 | Repeat | Note=ANK 3 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1943_1972 | 788 | 2472 | Repeat | Note=ANK 4 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1976_2005 | 788 | 2472 | Repeat | Note=ANK 5 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 2009_2038 | 788 | 2472 | Repeat | Note=ANK 6 |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1699_2471 | 788 | 2472 | Topological domain | Cytoplasmic |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 26_1677 | 788 | 2472 | Topological domain | Extracellular |
| Hgene | >NOTCH2 | chr1:120496166 | chr1:120345788 | ENST00000256646 | - | 14 | 34 | 1678_1698 | 788 | 2472 | Transmembrane | Helical |
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FusionGeneSequence for NOTCH2_REG4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000354219_chr1_120345788_-_925aa MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATC RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQ NGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQ CNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKDIIMRPSCAPGWFYHKSNCYGY FRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSS >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000256585_chr1_120345788_-_925aa MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATC RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQ NGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQ CNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKDIIMRPSCAPGWFYHKSNCYGY FRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSS >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000530654_chr1_120345788_-_870aa MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATC RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQ NGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQ CNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKDIIMRPSCAPGWFYHKSNCYGY >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000369401_chr1_120345788_-_901aa MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATC RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQ NGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAG PRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQ CNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQ VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKDIIMRPSCAPGWFYHKSNCYGY FRKLRNWSDAEVRNLLPAWPGLSRAKDQPEPQISFDSGSSVLPGHYEEKPLWLVKWREEGCVFNSFNSVSIAEAGAVCQTLDGLQAHTDT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000354219_chr1_120345788_-_2775nt ATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGAT GGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAA TATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGC CGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACA TGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCT CATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAG ACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCT CAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGT GACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAG AATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGAT GAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGG AGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTC TCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGT GACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCC ATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGA CCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGT CTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTG GATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCG TGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAAC ATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATG GGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAG TGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATG GATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCC TGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAG GTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTT GGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGG TGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGCTCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTAC TTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTACGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAG GAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCCGATATGGATTGGCCTGCACGACCCACAGAAGAGGCAGCAG TGGCAGTGGATTGATGGGGCCATGTATCTGTACAGATCCTGGTCTGGCAAGTCCATGGGTGGGAACAAGCACTGTGCTGAGATGAGCTCC >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000256585_chr1_120345788_-_2775nt ATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGAT GGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAA TATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGC CGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACA TGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCT CATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAG ACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCT CAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGT GACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAG AATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGAT GAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGG AGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTC TCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGT GACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCC ATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGA CCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGT CTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTG GATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCG TGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAAC ATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATG GGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAG TGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATG GATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCC TGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAG GTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTT GGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGG TGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGCTCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTAC TTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTACGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAG GAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCCGATATGGATTGGCCTGCACGACCCACAGAAGAGGCAGCAG TGGCAGTGGATTGATGGGGCCATGTATCTGTACAGATCCTGGTCTGGCAAGTCCATGGGTGGGAACAAGCACTGTGCTGAGATGAGCTCC >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000530654_chr1_120345788_-_2610nt ATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGAT GGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAA TATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGC CGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACA TGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCT CATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAG ACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCT CAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGT GACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAG AATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGAT GAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGG AGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTC TCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGT GACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCC ATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGA CCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGT CTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTG GATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCG TGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAAC ATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATG GGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAG TGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATG GATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCC TGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAG GTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTT GGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGG TGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGCTCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTAC TTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTACGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAG GAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCCGATATGGATTGGCCTGCACGACCCACAGAAGACTTTTTAA >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000369401_chr1_120345788_-_2703nt ATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCTGTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGAT GGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGGCACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAA TATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGGGACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGC CGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCATCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACA TGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTTTACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCT CATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCCTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAG ACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACCTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCT CAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCCTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGT GACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGTGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAG AATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCCCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGAT GAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAACCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGG AGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGTACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTC TCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGATGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGT GACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTACAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCC ATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGATGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGA CCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAATGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGT CTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTG GATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCAGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCG TGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAGTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAAC ATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGTATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATG GGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTGAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAG TGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGATGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATG GATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAGAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCC TGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAG GTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGTCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTT GGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAGAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGG TGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGCTCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTAC TTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGGTAAGAAACTTGCTGCCTGCTTGGCCTGGCCTTTCTAGAGCAAAGGACCAGCCAGAG CCCCAGATCTCATTTGATTCAGGATCAAGTGTCCTTCCTGGGCACTATGAAGAGAAGCCCCTTTGGCTGGTGAAATGGAGAGAAGAGGGT TGTGTGTTCAACTCATTCAATTCTGTAAGCATTGCTGAAGCAGGTGCTGTATGCCAGACCCTAGATGGGCTACAAGCACATACGGATACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000354219_chr1_120345788_-_3595nt AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG CACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGG GACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCA TCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTT TACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTC CTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCAC CTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACC CTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTG TGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCC CCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAA CCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTG TACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGA TGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTA CAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGA TGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAA TGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGA ATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCC AGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCA GTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGG TATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCT GAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGA TGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCA GAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTAT ATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGG TCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCA GAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGC TCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTACTTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTA CGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAGGAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCC GATATGGATTGGCCTGCACGACCCACAGAAGAGGCAGCAGTGGCAGTGGATTGATGGGGCCATGTATCTGTACAGATCCTGGTCTGGCAA GTCCATGGGTGGGAACAAGCACTGTGCTGAGATGAGCTCCAATAACAACTTTTTAACTTGGAGCAGCAACGAATGCAACAAGCGCCAACA CTTCCTGTGCAAGTACCGACCATAGAGCAAGAATCAAGATTCTGCTAACTCCTGCACAGCCCCGTCCTCTTCCTTTCTGCTAGCCTGGCT AAATCTGCTCATTATTTCAGAGGGGAAACCTAGCAAACTAAGAGTGATAAGGGCCCTACTACACTGGCTTTTTTAGGCTTAGAGACAGAA ACTTTAGCATTGGCCCAGTAGTGGCTTCTAGCTCTAAATGTTTGCCCCGCCATCCCTTTCCACAGTATCCTTCTTCCCTCCTCCCCTGTC TCTGGCTGTCTCGAGCAGTCTAGAAGAGTGCATCTCCAGCCTATGAAACAGCTGGGTCTTTGGCCATAAGAAGTAAAGATTTGAAGACAG AAGGAAGAAACTCAGGAGTAAGCTTCTAGACCCCTTCAGCTTCTACACCCTTCTGCCCTCTCTCCATTGCCTGCACCCCACCCCAGCCAC TCAACTCCTGCTTGTTTTTCCTTTGGCCATGGGAAGGTTTACCAGTAGAATCCTTGCTAGGTTGATGTGGGCCATACATTCCTTTAATAA >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000256585_chr1_120345788_-_3529nt AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG CACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGG GACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCA TCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTT TACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTC CTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCAC CTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACC CTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTG TGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCC CCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAA CCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTG TACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGA TGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTA CAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGA TGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAA TGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGA ATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCC AGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCA GTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGG TATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCT GAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGA TGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCA GAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTAT ATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGG TCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCA GAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGC TCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTACTTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTA CGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAGGAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCC GATATGGATTGGCCTGCACGACCCACAGAAGAGGCAGCAGTGGCAGTGGATTGATGGGGCCATGTATCTGTACAGATCCTGGTCTGGCAA GTCCATGGGTGGGAACAAGCACTGTGCTGAGATGAGCTCCAATAACAACTTTTTAACTTGGAGCAGCAACGAATGCAACAAGCGCCAACA CTTCCTGTGCAAGTACCGACCATAGAGCAAGAATCAAGATTCTGCTAACTCCTGCACAGCCCCGTCCTCTTCCTTTCTGCTAGCCTGGCT AAATCTGCTCATTATTTCAGAGGGGAAACCTAGCAAACTAAGAGTGATAAGGGCCCTACTACACTGGCTTTTTTAGGCTTAGAGACAGAA ACTTTAGCATTGGCCCAGTAGTGGCTTCTAGCTCTAAATGTTTGCCCCGCCATCCCTTTCCACAGTATCCTTCTTCCCTCCTCCCCTGTC TCTGGCTGTCTCGAGCAGTCTAGAAGAGTGCATCTCCAGCCTATGAAACAGCTGGGTCTTTGGCCATAAGAAGTAAAGATTTGAAGACAG AAGGAAGAAACTCAGGAGTAAGCTTCTAGACCCCTTCAGCTTCTACACCCTTCTGCCCTCTCTCCATTGCCTGCACCCCACCCCAGCCAC TCAACTCCTGCTTGTTTTTCCTTTGGCCATGGGAAGGTTTACCAGTAGAATCCTTGCTAGGTTGATGTGGGCCATACATTCCTTTAATAA >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000530654_chr1_120345788_-_3094nt AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG CACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGG GACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCA TCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTT TACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTC CTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCAC CTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACC CTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTG TGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCC CCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAA CCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTG TACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGA TGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTA CAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGA TGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAA TGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGA ATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCC AGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCA GTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGG TATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCT GAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGA TGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCA GAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTAT ATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGG TCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCA GAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGC TCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTACTTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTA CGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAGGAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCC GATATGGATTGGCCTGCACGACCCACAGAAGACTTTTTAACTTGGAGCAGCAACGAATGCAACAAGCGCCAACACTTCCTGTGCAAGTAC CGACCATAGAGCAAGAATCAAGATTCTGCTAACTCCTGCACAGCCCCGTCCTCTTCCTTTCTGCTAGCCTGGCTAAATCTGCTCATTATT TCAGAGGGGAAACCTAGCAAACTAAGAGTGATAAGGGCCCTACTACACTGGCTTTTTTAGGCTTAGAGACAGAAACTTTAGCATTGGCCC >In-frame_NOTCH2_ENST00000256646_chr1_120496166_-_REG4_ENST00000369401_chr1_120345788_-_4579nt AAACTTCGGGCGGCGGCTGAGGCGGCGGCCGAGGAGCGGCGGACTCGGGGCGCGGGGAGTCGAGGCATTTGCGCCTGGGCTTCGGAGCGT AGCGCCAGGGCCTGAGCCTTTGAAGCAGGAGGAGGGGAGGAGAGAGTGGGGCTCCTCTATCGGGACCCCCTCCCCATGTGGATCTGCCCA GGCGGCGGCGGCGGCGGCGGAGGAGGAGGCGACCGAGAAGATGCCCGCCCTGCGCCCCGCTCTGCTGTGGGCGCTGCTGGCGCTCTGGCT GTGCTGCGCGGCCCCCGCGCATGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGG CACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGG GACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCA TCCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTT TACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTC CTGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCAC CTGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACC CTCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTG TGAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCC CCCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAA CCGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTG TACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGA TGCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTA CAAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGA TGGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAA TGATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGA ATGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCC AGTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCA GTGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGG TATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCT GAACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGA TGACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCA GAGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTAT ATGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGG TCTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCA GAATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGATATCATCATGAGACCCAGCTGTGC TCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTACTTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGGTAAGAAACTTGCTGCC TGCTTGGCCTGGCCTTTCTAGAGCAAAGGACCAGCCAGAGCCCCAGATCTCATTTGATTCAGGATCAAGTGTCCTTCCTGGGCACTATGA AGAGAAGCCCCTTTGGCTGGTGAAATGGAGAGAAGAGGGTTGTGTGTTCAACTCATTCAATTCTGTAAGCATTGCTGAAGCAGGTGCTGT ATGCCAGACCCTAGATGGGCTACAAGCACATACGGATACATAGGAAAGAGCCCCTACCCTCAGCAAGCTCACTGTCAGTAAAGGAGACAG AAATACATCAATCAAAGGAGGAAGAGAAGATGAGGAATTCACAGAAAGGATAATGGAGTTTCTGTACAAGATTTACCAGAAAGAGAGTGG TGTGTAGACATGCCTGGAGCAGACACCTTGGAGCCGCTGACAGAAGGTGAAGCAGTCCAAGAAAATGTGGAAACTTTTCCGCTGCTCTAC ACAGTCCACAAACCTGTCCATTTTATTTCGTTGAAGCTTTGTCTGAGAGATAACCAAATAGACAGTCAAAGTAAGTTATCTCAGCCACAT ATGGGGAGTGGATGCTGCTGAATTGTGATTAATTGGGGGAGCCATATAGGTACATTTGGCATGATCTGGGCCTATGCGGTCTTACAATCC CTGTATAAAACTAGACAATGAAAAACAGAAAACAAAACAAACAAACAAAAAAACAAGAACGAAGCACCTACCACATGCCAGCTACTGAGG CTATGAAGGTATTCTCCCGCCTTAGAAAGCCCAGGATTAATGCAGGATTGCGACATTTAAACAGAACATTTCCATACAGCATGAGTATAA ATGACTTTCCCAAGTTTACACTGAGAGTAACTGACACAGCAACCCCAGCAAAGTCTGAGCTGAGTCCTGAATAATTGTATAAAAAGGGGA GAGAAACAGAGTGAAGAAAGGGTTTCCCAGACTCTGTCCCAGGAAAGAAAATGAGCTCGTGGAGAGGAATAGACTTTCTCTATGAAAACA GAGGGAACAAAGAGGAAGATGTCTGGGAACCGAGGAGTAATAGAGACCTGAGTTTACATCACTACTCTGCCACTCCCTAGGTACCTCCCT TTACCTGTTTCCCTACTGGAAAGTGGGATAATACTTTTTACCTCATGGACTTGTCAGGAGGATTCATTAAAACGACTCGCATAAAGCCTA TGCCACATGGTAGATGCCAATTCAGGGTCTCAAGAAAGAACAGCCCACAGGATTGACACTGAACCTTAACAAAGTTAACAGGACCAAGGT GCAGAGAGGGTGCTAGGACAGCGAAGCCAAAGAGGACCCCTCAAACCCAACAAGAGCTGTGCGGCTCCCTGATTCCTCGCCAGTGTTGCT ACCGCCCTTGGCTCTTCTTGCATGGCTGGCTCTTGAGACCCCTGGAAGCTGATGGAGGCAACGTGAGAAGCACATGGACATCCGACCTTG AGCTTGAGAGGCAGAGGCCTGAGTTCTAGTTACAGCCCCAGCAGTACCAGTTGTGTGGACTGGGAGGGAGGCTATCACGTACATACTTCA AGCCTCCAAACCTGTTTCCCCTTCTGACACAGGATCTTCTGTGGCTGGTATAGAGTGGGCACTCAATAAATGCTGTCTGGTCGTCTGGCT GGCATGCCTCATGGGCCTGAGAATTGAATAGAATTACAGTGATAGAAGCATGCTGGTATTGTAAGTGGTTTGTAAGTGTGAGGACTAAAT TATTATTAAATAGTAATCACATCTAATCTTGGATAAATTAGTAAAAGCAAGAATGGGAGCAGTAAAAACCTAAGCAACCCGAACTAAAAT |
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FusionGenePPI for NOTCH2_REG4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NOTCH2 | CNTN1, GSK3B, JAG1, DLL1, RBPJ, MAML1, JAG2, CRKL, MYOC, SPEN, NDUFV2, NDUFV1, SEC24C, PCMT1, PSMB1, TJP1, SIN3A, PLAUR, NOTCH1, SMAD1, EGFL7, ANKRD28, LATS2, ASB14, ANKRD44, RABGGTB, ZFP41, EEF2, MLLT4, ATP2A2, CDC42, MSN, RDX, PDIA6, CST6, EPSTI1, FAM84B, IL13RA2, IL24, ITIH5, KLK5, MTA3, PSMC3IP, ST14, TMEM17, FBXL17, CDH1, VASN, LRRIQ1, AGRP | REG4 | ATE1, HTRA1, UBAC1, KLHL26, SIRT3, RNF123 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOTCH2_REG4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOTCH2_REG4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NOTCH2 | C0917715 | Hajdu-Cheney Syndrome | 2 | CTD_human;ORPHANET |
| Hgene | NOTCH2 | C0004114 | Astrocytoma | 1 | CTD_human |
| Hgene | NOTCH2 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Hgene | NOTCH2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | NOTCH2 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | NOTCH2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | NOTCH2 | C0206663 | Neuroectodermal Tumor, Primitive | 1 | CTD_human |
| Hgene | NOTCH2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | NOTCH2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | NOTCH2 | C1857761 | Alagille Syndrome 2 | 1 | ORPHANET;UNIPROT |
| Tgene | REG4 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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