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Fusion gene ID: 2463 |
FusionGeneSummary for ARHGAP44_C17orf78 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP44_C17orf78 | Fusion gene ID: 2463 | Hgene | Tgene | Gene symbol | ARHGAP44 | C17orf78 | Gene ID | 9912 | 284099 |
| Gene name | Rho GTPase activating protein 44 | chromosome 17 open reading frame 78 | |
| Synonyms | NPC-A-10|RICH2 | - | |
| Cytomap | 17p12 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2 | uncharacterized protein C17orf78 | |
| Modification date | 20180523 | 20180406 | |
| UniProtAcc | Q17R89 | Q8N4C9 | |
| Ensembl transtripts involved in fusion gene | ENST00000379672, ENST00000340825, ENST00000262444, ENST00000578087, | ENST00000586700, ENST00000300618, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ARHGAP44 [Title/Abstract] AND C17orf78 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-V1-A8ML-01A | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000379672 | ENST00000586700 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| Frame-shift | ENST00000379672 | ENST00000300618 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| In-frame | ENST00000340825 | ENST00000586700 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| Frame-shift | ENST00000340825 | ENST00000300618 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| In-frame | ENST00000262444 | ENST00000586700 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| Frame-shift | ENST00000262444 | ENST00000300618 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| intron-3CDS | ENST00000578087 | ENST00000586700 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
| intron-3CDS | ENST00000578087 | ENST00000300618 | ARHGAP44 | chr17 | 12862214 | + | C17orf78 | chr17 | 35746181 | + |
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FusionProtFeatures for ARHGAP44_C17orf78 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP44 | C17orf78 |
| GTPase-activating protein (GAP) that stimulates theGTPase activity of Rho-type GTPases. Thereby, controls Rho-typeGTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomalrecycling protein which, in association with SHANK3, is involvedin synaptic plasticity. Promotes GRIA1 exocytosis from recyclingendosomes and spine morphological changes associated to long-termpotentiation. {ECO:0000269|PubMed:11431473}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGAP44 | chr17:12862214 | chr17:35746181 | ENST00000379672 | + | 16 | 21 | 14_249 | 507 | 819 | Domain | BAR |
| Hgene | ARHGAP44 | chr17:12862214 | chr17:35746181 | ENST00000379672 | + | 16 | 21 | 255_445 | 507 | 819 | Domain | Rho-GAP |
| Tgene | >C17orf78 | chr17:12862214 | chr17:35746181 | ENST00000586700 | + | 2 | 5 | 187_207 | 130 | 458 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ARHGAP44 | chr17:12862214 | chr17:35746181 | ENST00000379672 | + | 16 | 21 | 815_818 | 507 | 819 | Motif | PDZ-binding |
| Tgene | C17orf78 | chr17:12862214 | chr17:35746181 | ENST00000300618 | + | 4 | 7 | 187_207 | 211 | 276 | Transmembrane | Helical |
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FusionGeneSequence for ARHGAP44_C17orf78 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ARHGAP44_ENST00000379672_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_537aa MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAF PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE >In-frame_ARHGAP44_ENST00000340825_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_537aa MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAF PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE >In-frame_ARHGAP44_ENST00000262444_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_537aa MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAF PIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ARHGAP44_ENST00000379672_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_1612nt ATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTT CAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCA GAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTT CTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTG ATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGAT TCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGG GAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGAC TATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATC AAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTC CCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAG AAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTAC CTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTT CAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAA TATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACA GAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAG TTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCT GACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGTATCAAT >In-frame_ARHGAP44_ENST00000340825_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_1612nt ATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTT CAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCA GAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTT CTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTG ATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGAT TCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGG GAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGAC TATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATC AAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTC CCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAG AAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTAC CTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTT CAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAA TATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACA GAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAG TTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCT GACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGTATCAAT >In-frame_ARHGAP44_ENST00000262444_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_1612nt ATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTT CAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCA GAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTT CTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTG ATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGAT TCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGG GAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGAC TATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATC AAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTC CCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAG AAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTAC CTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTT CAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAA TATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACA GAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAG TTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCT GACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGTATCAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ARHGAP44_ENST00000379672_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_3000nt GACTGGGAGCAGGCAGCCCGGGCGGAGCGGGCCGGTGCCGAGGACGGCCCCAGGCATTGCTCTGCCCCGGGCATTGCGCGGCGCGCGTGA GGGGGATGCGGCAGGAGGCGGCGCGGCGGGAGGAGTAGGCGGCGGCGCCCTCGGGAGGGAGCTGCGCGCGGGCCAGACGGCGCCCGGAGG CTCCGCAGTGCCGCCGCCGTCGCCCGGGAGGCTCCGCGCGGGAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAG CTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTC ACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATA CATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAG CCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGAT ATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTG ACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCAC CTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTC CGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCC CACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCT TCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATAC TTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTC CTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCAT GCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGC TCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATG CTGGAGTTTTACAAAAAGGATGGTATCAATGCCTAGGAGCCAGGAAGCTGTGCCAATGCCAGTGGTTGTGGAGATGGCAAAAGAAGGGAG GCCAGCCACCTGGGACAGCTGAATCCAAGCCTGACTCTCAGCCCCAGAAGGTTGGACAAGATGCTGCCAATTCATCAAACCCAAAGAAAG CTGCAGAGATCACTGTTATCCACCAGACATACTTCTGAAAAGTTCTGCTCTATCTCAAAGACTGAATGATACTACACAGTCCTCTCCCTA TTAATATGGGCACATTCTTGCCAATTTCACACTTGTATCTTCAGCAGGGACATTACAATCAAACACCAATTCCTGGTTAATGAAGGGAGA GTGTGGGCTTAGCAGAGTTACCCTCATGCCCCTATCTGAGCCACAACCTTCTGTAATTCACTTCATACATCCATCTAAATGGATACCTTT CCATCCCCTCAAACGAGAACAAAAAGTATTCCCTGCAAGCACTATGAATGGACCTTACTACTCTCTTTGACAGAAGACTCAAACACAGCC TCTAAGAAACAAGGCAGCTGTTAGTGTGACATAGCTTCCAGCTCCTCTGTTATCTTCACAGCTGACTTCACACTCACTGGCCCTCAATAG CTTAGAGTGGGACTCCTGATCTCCCTGGTTGACGTTTATAAGGTTTTGTAATTTAGCTTCTGGTACTACATGTATCTATCCACACACTGC TGAAGGGAACTTGACCCTACGCATTCCAAAAGCCTTCCTCATAAGTTATCCCCAAGGGGTTCAGGGACTACAGACCATTAGTACCCAAGT GAAGTCTTCTGACGATCCAGAATTCCTAAGGTGGCTCTGATATTATATCATACTTTAATAGAGAGTTGCATACCTTTTGGACAAAGATTC CAGAGCAAAATAATTATGATAATGCTGTTTCTCACAGGAGAATAGCTATGAGTCAAATCTAACCTGCTTAAATAAGAGTTTGGTGAGAAA GTGAAACCACCTGATCTTGAATCAATGTTGAGGTGAAAAAGGAAATGTCAGGAGGGATAAGACAGGGTGAGGCCCTGCTTCTTTTCCTAA GAGTCTGAAACCATTCCATTTCATTTTGGTGAAATGTGTCTGTTTCTAAGAAATTCTGTTTTCTTAGTTCTCTGGTTAAAAAAAAAAATA >In-frame_ARHGAP44_ENST00000340825_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_3000nt GACTGGGAGCAGGCAGCCCGGGCGGAGCGGGCCGGTGCCGAGGACGGCCCCAGGCATTGCTCTGCCCCGGGCATTGCGCGGCGCGCGTGA GGGGGATGCGGCAGGAGGCGGCGCGGCGGGAGGAGTAGGCGGCGGCGCCCTCGGGAGGGAGCTGCGCGCGGGCCAGACGGCGCCCGGAGG CTCCGCAGTGCCGCCGCCGTCGCCCGGGAGGCTCCGCGCGGGAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAG CTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTC ACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATA CATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAG CCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGAT ATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTG ACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCAC CTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTC CGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCC CACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCT TCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATAC TTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTC CTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCAT GCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGC TCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATG CTGGAGTTTTACAAAAAGGATGGTATCAATGCCTAGGAGCCAGGAAGCTGTGCCAATGCCAGTGGTTGTGGAGATGGCAAAAGAAGGGAG GCCAGCCACCTGGGACAGCTGAATCCAAGCCTGACTCTCAGCCCCAGAAGGTTGGACAAGATGCTGCCAATTCATCAAACCCAAAGAAAG CTGCAGAGATCACTGTTATCCACCAGACATACTTCTGAAAAGTTCTGCTCTATCTCAAAGACTGAATGATACTACACAGTCCTCTCCCTA TTAATATGGGCACATTCTTGCCAATTTCACACTTGTATCTTCAGCAGGGACATTACAATCAAACACCAATTCCTGGTTAATGAAGGGAGA GTGTGGGCTTAGCAGAGTTACCCTCATGCCCCTATCTGAGCCACAACCTTCTGTAATTCACTTCATACATCCATCTAAATGGATACCTTT CCATCCCCTCAAACGAGAACAAAAAGTATTCCCTGCAAGCACTATGAATGGACCTTACTACTCTCTTTGACAGAAGACTCAAACACAGCC TCTAAGAAACAAGGCAGCTGTTAGTGTGACATAGCTTCCAGCTCCTCTGTTATCTTCACAGCTGACTTCACACTCACTGGCCCTCAATAG CTTAGAGTGGGACTCCTGATCTCCCTGGTTGACGTTTATAAGGTTTTGTAATTTAGCTTCTGGTACTACATGTATCTATCCACACACTGC TGAAGGGAACTTGACCCTACGCATTCCAAAAGCCTTCCTCATAAGTTATCCCCAAGGGGTTCAGGGACTACAGACCATTAGTACCCAAGT GAAGTCTTCTGACGATCCAGAATTCCTAAGGTGGCTCTGATATTATATCATACTTTAATAGAGAGTTGCATACCTTTTGGACAAAGATTC CAGAGCAAAATAATTATGATAATGCTGTTTCTCACAGGAGAATAGCTATGAGTCAAATCTAACCTGCTTAAATAAGAGTTTGGTGAGAAA GTGAAACCACCTGATCTTGAATCAATGTTGAGGTGAAAAAGGAAATGTCAGGAGGGATAAGACAGGGTGAGGCCCTGCTTCTTTTCCTAA GAGTCTGAAACCATTCCATTTCATTTTGGTGAAATGTGTCTGTTTCTAAGAAATTCTGTTTTCTTAGTTCTCTGGTTAAAAAAAAAAATA >In-frame_ARHGAP44_ENST00000262444_chr17_12862214_+_C17orf78_ENST00000586700_chr17_35746181_+_2779nt GAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAGCTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCA GTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAA GCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAA GCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGAT GCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCT GTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAAC CAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGA AGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTA CTTTCAAACGCTAATAGAAGTGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACA GGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGC GTGTGTGACCATGCTGCTTGAGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGC GGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTT GCCAGAACCTCTTATGACCTTTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATG GAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGT AAACAAGATGACTCCCAGTAATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGAC CACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTAC TGGCAATTATGGGAGTCCAGTACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCA GCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGTATCAATGCCTAGGAGCC AGGAAGCTGTGCCAATGCCAGTGGTTGTGGAGATGGCAAAAGAAGGGAGGCCAGCCACCTGGGACAGCTGAATCCAAGCCTGACTCTCAG CCCCAGAAGGTTGGACAAGATGCTGCCAATTCATCAAACCCAAAGAAAGCTGCAGAGATCACTGTTATCCACCAGACATACTTCTGAAAA GTTCTGCTCTATCTCAAAGACTGAATGATACTACACAGTCCTCTCCCTATTAATATGGGCACATTCTTGCCAATTTCACACTTGTATCTT CAGCAGGGACATTACAATCAAACACCAATTCCTGGTTAATGAAGGGAGAGTGTGGGCTTAGCAGAGTTACCCTCATGCCCCTATCTGAGC CACAACCTTCTGTAATTCACTTCATACATCCATCTAAATGGATACCTTTCCATCCCCTCAAACGAGAACAAAAAGTATTCCCTGCAAGCA CTATGAATGGACCTTACTACTCTCTTTGACAGAAGACTCAAACACAGCCTCTAAGAAACAAGGCAGCTGTTAGTGTGACATAGCTTCCAG CTCCTCTGTTATCTTCACAGCTGACTTCACACTCACTGGCCCTCAATAGCTTAGAGTGGGACTCCTGATCTCCCTGGTTGACGTTTATAA GGTTTTGTAATTTAGCTTCTGGTACTACATGTATCTATCCACACACTGCTGAAGGGAACTTGACCCTACGCATTCCAAAAGCCTTCCTCA TAAGTTATCCCCAAGGGGTTCAGGGACTACAGACCATTAGTACCCAAGTGAAGTCTTCTGACGATCCAGAATTCCTAAGGTGGCTCTGAT ATTATATCATACTTTAATAGAGAGTTGCATACCTTTTGGACAAAGATTCCAGAGCAAAATAATTATGATAATGCTGTTTCTCACAGGAGA ATAGCTATGAGTCAAATCTAACCTGCTTAAATAAGAGTTTGGTGAGAAAGTGAAACCACCTGATCTTGAATCAATGTTGAGGTGAAAAAG GAAATGTCAGGAGGGATAAGACAGGGTGAGGCCCTGCTTCTTTTCCTAAGAGTCTGAAACCATTCCATTTCATTTTGGTGAAATGTGTCT |
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FusionGenePPI for ARHGAP44_C17orf78 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ARHGAP44 | HN1, CDC42, RAC1, TRIP10, TIPRL, ARHGAP17, FNBP1L, SH3BP1, SH3KBP1, CD2AP, CASP5, PPP3CC, WDTC1, VPS26A, SLC9A3R2 | C17orf78 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ARHGAP44 | chr17:12862214 | chr17:35746181 | ENST00000379672 | + | 16 | 21 | 731_818 | 507 | 819 | BST2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ARHGAP44_C17orf78 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ARHGAP44_C17orf78 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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