FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 24629

FusionGeneSummary for NOTCH1_TMEM117

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH1_TMEM117
Fusion gene ID: 24629
HgeneTgene
Gene symbol

NOTCH1

TMEM117

Gene ID

4851

84216

Gene namenotch 1transmembrane protein 117
SynonymsAOS5|AOVD1|TAN1|hN1-
Cytomap

9q34.3

12q12

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatedtranslocation-associated notch protein TAN-1transmembrane protein 117
Modification date2018052720180329
UniProtAcc

P46531

Q9H0C3

Ensembl transtripts involved in fusion geneENST00000277541, ENST00000491649, 
ENST00000551577, ENST00000266534, 
ENST00000536799, ENST00000546978, 
Fusion gene scores* DoF score11 X 9 X 10=9906 X 5 X 3=90
# samples 126
** MAII scorelog2(12/990*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH1 [Title/Abstract] AND TMEM117 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH1

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH1

GO:0007219

Notch signaling pathway

11306509

HgeneNOTCH1

GO:0008284

positive regulation of cell proliferation

17849174

HgeneNOTCH1

GO:0008285

negative regulation of cell proliferation

11306509|20616313

HgeneNOTCH1

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH1

GO:0010812

negative regulation of cell-substrate adhesion

16501043

HgeneNOTCH1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

20616313

HgeneNOTCH1

GO:0045944

positive regulation of transcription by RNA polymerase II

20616313

HgeneNOTCH1

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH1

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH1

GO:0071372

cellular response to follicle-stimulating hormone stimulus

20613903

HgeneNOTCH1

GO:0090051

negative regulation of cell migration involved in sprouting angiogenesis

20616313

HgeneNOTCH1

GO:2001027

negative regulation of endothelial cell chemotaxis

20616313


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-67-3774-01ANOTCH1chr9

139407473

-TMEM117chr12

44338013

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000277541ENST00000551577NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
In-frameENST00000277541ENST00000266534NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
Frame-shiftENST00000277541ENST00000536799NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
5CDS-intronENST00000277541ENST00000546978NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
intron-3CDSENST00000491649ENST00000551577NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
intron-3CDSENST00000491649ENST00000266534NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
intron-3CDSENST00000491649ENST00000536799NOTCH1chr9

139407473

-TMEM117chr12

44338013

+
intron-intronENST00000491649ENST00000546978NOTCH1chr9

139407473

-TMEM117chr12

44338013

+

Top

FusionProtFeatures for NOTCH1_TMEM117


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH1

P46531

TMEM117

Q9H0C3

Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex withRBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation, proliferation andapoptotic programs. Involved in angiogenesis; negatively regulatesendothelial cell proliferation and migration and angiogenicsprouting. Involved in the maturation of both CD4+ and CD8+ cellsin the thymus. Important for follicular differentiation andpossibly cell fate selection within the follicle. Duringcerebellar development, functions as a receptor for neuronal DNERand is involved in the differentiation of Bergmann glia. Repressesneuronal and myogenic differentiation. May play an essential rolein postimplantation development, probably in some aspect of cellspecification and/or differentiation. May be involved in mesodermdevelopment, somite formation and neurogenesis. May enhance HIF1Afunction by sequestering HIF1AN away from HIF1A. Required for theTHBS4 function in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury. Involved indetermination of left/right symmetry by modulating the balancebetween motile and immotile (sensory) cilia at the left-rightorganiser (LRO). {ECO:0000269|PubMed:20616313}. Involved in endoplasmic reticulum (ER) stress-inducedcell death pathway. {ECO:0000269|PubMed:28285135}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534102_1398222556DomainEGF-like 3
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534140_1768222556DomainEGF-like 4
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534178_2168222556DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-153420_588222556DomainEGF-like 1
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534218_2558222556DomainEGF-like 6
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534257_2938222556DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534295_3338222556DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534335_3718222556DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534372_4108222556DomainEGF-like 10
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534412_4508222556DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534452_4888222556DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534490_5268222556DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534528_5648222556DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534566_6018222556DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-153459_998222556DomainEGF-like 2
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534603_6398222556DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534641_6768222556DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534678_7148222556DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534716_7518222556DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534753_7898222556DomainEGF-like 20
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18132_15492515Topological domainExtracellular
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18176_19892515Topological domainCytoplasmic
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18220_23992515Topological domainExtracellular
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18261_29592515Topological domainCytoplasmic
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18317_39492515Topological domainExtracellular
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18416_51492515Topological domainCytoplasmic
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18111_13192515TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18155_17592515TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18199_21992515TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18240_26092515TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18296_31692515TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+18395_41592515TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341575_15788222556Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341661_16648222556Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341728_17318222556Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341740_17438222556Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341901_19048222556Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342259_22628222556Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342403_24068222556Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342410_24178222556Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342521_25248222556Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341021_10578222556DomainEGF-like 27
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341059_10958222556DomainEGF-like 28
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341097_11438222556DomainEGF-like 29
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341145_11818222556DomainEGF-like 30
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341183_12198222556DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341221_12658222556DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341267_13058222556DomainEGF-like 33
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341307_13468222556DomainEGF-like 34
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341348_13848222556DomainEGF-like 35
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341387_14268222556DomainEGF-like 36
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534791_8278222556DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534829_8678222556DomainEGF-like 22
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534869_9058222556DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534907_9438222556DomainEGF-like 24
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534945_9818222556DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534983_10198222556DomainEGF-like 26
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341947_19558222556RegionHIF1AN-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342014_20228222556RegionHIF1AN-binding
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341449_14898222556RepeatNote=LNR 1
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341490_15318222556RepeatNote=LNR 2
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341532_15718222556RepeatNote=LNR 3
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341928_19608222556RepeatNote=ANK 1
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341961_19948222556RepeatNote=ANK 2
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341995_20278222556RepeatNote=ANK 3
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342028_20608222556RepeatNote=ANK 4
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342061_20948222556RepeatNote=ANK 5
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15342095_21228222556RepeatNote=ANK 6
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341757_25558222556Topological domainCytoplasmic
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-153419_17358222556Topological domainExtracellular
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-15341736_17568222556TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+181_1592515Topological domainCytoplasmic
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+1837_6592515Topological domainExtracellular
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+1887_11092515Topological domainCytoplasmic
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+1816_3692515TransmembraneHelical
TgeneTMEM117chr9:139407473chr12:44338013ENST00000266534+1866_8692515TransmembraneHelical


Top

FusionGeneSequence for NOTCH1_TMEM117


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NOTCH1_ENST00000277541_chr9_139407473_-_TMEM117_ENST00000551577_chr12_44338013_+_999aa
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWM
VTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQANGL

>In-frame_NOTCH1_ENST00000277541_chr9_139407473_-_TMEM117_ENST00000266534_chr12_44338013_+_1245aa
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCA
LGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVN
ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG
ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCE
CPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCE
IDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG
AKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCL
KGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNEC
NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDV
AGYKCNCLLPYTGQLLRLKMFREDHGSWMTMFFSTILFLFIFSHIYNTILLMDGNMGAYIITDYMGIRNESFMKLAAVGTWMGDFVTAWM
VTDMMLQDKPYPDWGKSARAFWKKGNVRITLFWTVLFTLTSVVVLVITTDWISWDKLNRGFLPSDEVSRAFLASFILVFDLLIVMQDWEF
PHFMGDVDVNLPGLHTPHMQFKIPFFQKIFKEEYRIHITGKWFNYGIIFLVLILDLNMWKNQIFYKPHEYGQYIGPGQKIYTVKDSESLK
DLNRTKLSWEWRSNHTNPRTNKTYVEGDMFLHSRFIGASLDVKCLAFVPSLIAFVWFGFFIWFFGRFLKNEPRMENQDKTYTRMKRKSPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NOTCH1_ENST00000277541_chr9_139407473_-_TMEM117_ENST00000551577_chr12_44338013_+_2997nt
ATGCCGCCGCTCCTGGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACC
TGCCTGAATGGCGGGAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCC
AACCCGTGCCTCAGCACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCC
CTGGGCTTCTCTGGGCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTC
ACGCTGACGGAGTACAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCC
AACGGTGGCCAGTGCCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAAC
GAGTGTGGCCAGAAGCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCAC
ACTGGCCCCAACTGCGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACC
CACGAGTGTGCCTGCCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGT
GCCTGTGTGGACGGCGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAG
CTGATGCCAAATGCCTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAG
GACTGCAGCGAGAACATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAG
TGTCCCCATGGCCGCACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAAC
CCTGTCAATGGCAAGGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCC
AACCCCTGCGAGCATGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAG
ATCGACGTCAACGAGTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCC
GGCTACGAGGGTGTGCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAAT
GAGTTCCAGTGCGAGTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGT
GCCAAGTGCCTGGACGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGC
GACCCCGACCCCTGCCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGC
GAGACCAACATCAACGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTG
AAGGGGACCACAGGACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGAT
GGCTACGAGTGTGCCTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGG
GGCACCTGCGAGGACGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGC
AACAGCAACCCCTGCGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGT
GACATCAACAACAATGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGG
GAGGGCTTCAGCGGTCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTT
GCCGGGTACAAGTGCAACTGCCTGCTGCCCTACACAGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTGGATGACA
ATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGCATATATC
ATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGCTTGGATG
GTCACTGATATGATGCTTCAGGACAAACCCTATCCTGACTGGGGAAAATCAGCAAGAGCTTTCTGGAAGAAAGGAAATGTTAGGATCACT
TTATTCTGGACAGTTCTTTTTACTCTGACGTCTGTGGTTGTACTTGTGATTACAACGGACTGGATCAGCTGGGACAAGCTGAATCGGGGA
TTTTTGCCCAGTGATGAAGTTTCCAGAGCATTCCTTGCTTCTTTTATCTTGGTCTTTGACCTTCTTATTGTGATGCAGGCAAATGGTTTA

>In-frame_NOTCH1_ENST00000277541_chr9_139407473_-_TMEM117_ENST00000266534_chr12_44338013_+_3735nt
ATGCCGCCGCTCCTGGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACC
TGCCTGAATGGCGGGAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCC
AACCCGTGCCTCAGCACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCC
CTGGGCTTCTCTGGGCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTC
ACGCTGACGGAGTACAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCC
AACGGTGGCCAGTGCCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAAC
GAGTGTGGCCAGAAGCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCAC
ACTGGCCCCAACTGCGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACC
CACGAGTGTGCCTGCCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGT
GCCTGTGTGGACGGCGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAG
CTGATGCCAAATGCCTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAG
GACTGCAGCGAGAACATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAG
TGTCCCCATGGCCGCACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAAC
CCTGTCAATGGCAAGGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCC
AACCCCTGCGAGCATGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAG
ATCGACGTCAACGAGTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCC
GGCTACGAGGGTGTGCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAAT
GAGTTCCAGTGCGAGTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGT
GCCAAGTGCCTGGACGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGC
GACCCCGACCCCTGCCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGC
GAGACCAACATCAACGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTG
AAGGGGACCACAGGACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGAT
GGCTACGAGTGTGCCTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGG
GGCACCTGCGAGGACGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGC
AACAGCAACCCCTGCGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGT
GACATCAACAACAATGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGG
GAGGGCTTCAGCGGTCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTT
GCCGGGTACAAGTGCAACTGCCTGCTGCCCTACACAGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTGGATGACA
ATGTTCTTCAGCACAATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGCATATATC
ATTACAGACTATATGGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGCTTGGATG
GTCACTGATATGATGCTTCAGGACAAACCCTATCCTGACTGGGGAAAATCAGCAAGAGCTTTCTGGAAGAAAGGAAATGTTAGGATCACT
TTATTCTGGACAGTTCTTTTTACTCTGACGTCTGTGGTTGTACTTGTGATTACAACGGACTGGATCAGCTGGGACAAGCTGAATCGGGGA
TTTTTGCCCAGTGATGAAGTTTCCAGAGCATTCCTTGCTTCTTTTATCTTGGTCTTTGACCTTCTTATTGTGATGCAGGACTGGGAATTC
CCACATTTCATGGGAGATGTTGATGTAAATCTCCCTGGTTTGCACACCCCTCACATGCAGTTCAAGATTCCTTTCTTCCAGAAAATCTTC
AAGGAGGAATATCGTATTCACATAACAGGCAAATGGTTTAACTATGGAATTATCTTCCTCGTCTTGATTTTGGATCTTAATATGTGGAAG
AACCAAATATTTTATAAACCTCATGAATATGGGCAATATATCGGCCCGGGGCAGAAGATATATACAGTGAAAGACTCAGAAAGTTTAAAA
GATTTGAACAGAACCAAGCTATCCTGGGAATGGAGGTCCAATCACACTAACCCTCGGACTAATAAAACATATGTTGAGGGAGACATGTTC
TTACACAGCAGGTTCATAGGAGCCAGTCTTGATGTCAAGTGTCTGGCCTTTGTTCCAAGCCTGATAGCCTTTGTGTGGTTTGGATTCTTT
ATTTGGTTCTTTGGACGATTTTTGAAAAATGAGCCACGCATGGAGAATCAAGACAAAACTTACACTCGCATGAAAAGAAAATCTCCATCA
GAACATAGCAAAGACATGGGAATCACTCGAGAAAACACCCAGGCTTCAGTAGAAGACCCCTTGAATGACCCTTCTTTGGTTTGCATCAGG
TCTGACTTCAATGAGATCGTCTACAAGTCTTCCCACCTAACCTCGGAAAACTTGAGCTCACAGTTGAACGAATCTACTAGTGCAACAGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_NOTCH1_ENST00000277541_chr9_139407473_-_TMEM117_ENST00000551577_chr12_44338013_+_4767nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTGGATGACAATGTTCTTCAGCAC
AATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGCATATATCATTACAGACTATAT
GGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGCTTGGATGGTCACTGATATGAT
GCTTCAGGACAAACCCTATCCTGACTGGGGAAAATCAGCAAGAGCTTTCTGGAAGAAAGGAAATGTTAGGATCACTTTATTCTGGACAGT
TCTTTTTACTCTGACGTCTGTGGTTGTACTTGTGATTACAACGGACTGGATCAGCTGGGACAAGCTGAATCGGGGATTTTTGCCCAGTGA
TGAAGTTTCCAGAGCATTCCTTGCTTCTTTTATCTTGGTCTTTGACCTTCTTATTGTGATGCAGGCAAATGGTTTAACTATGGAATTATC
TTCCTCGTCTTGATTTTGGATCTTAATATGTGGAAGAACCAAATATTTTATAAACCTCATGAATATGGGCAATATATCGGCCCGGGGCAG
AAGATATATACAGTGAAAGACTCAGAAAGTTTAAAAGATTTGAACAGAACCAAGCTATCCTGGGAATGGAGGTCCAATCACACTAACCCT
CGGACTAATAAAACATATGTTGAGGGAGACATGTTCTTACACAGCAGGTTCATAGGAGCCAGTCTTGATGTCAAGTGTCTGGCCTTTGTT
CCAAGCCTGATAGCCTTTGTGTGGTTTGGATTCTTTATTTGGTTCTTTGGACGATTTTTGAAAAATGAGCCACGCATGGAGAATCAAGAC
AAAACTTACACTCGCATGAAAAGAAAATCTCCATCAGAACATAGCAAAGACATGGGAATCACTCGAGAAAACACCCAGGCTTCAGTAGAA
GACCCCTTGAATGACCCTTCTTTGGTTTGCATCAGGTCTGACTTCAATGAGATCGTCTACAAGTCTTCCCACCTAACCTCGGAAAACTTG
AGCTCACAGTTGAACGAATCTACTAGTGCAACAGAAGCTGATCAAGACCCAACGACTTCTAAAAGTACACCTACGAACTAGACTCGGAGA
TAGACTTGGAGATAACACAAAAAGCAACCTTGAGTGTAACTTTAAAAATTTAGTCTTTCCTTTTGTATATGTAAGGTTTACGTAGTGTTA
GGTAAAAATATGAACAATGCCACAACGGTGCTCAACATGCTTTTTCTAGGATTCATTGTTTTCTATTTGTATTATAATACACGTGCCTAC
TGTATACTCAACAGTCCTCTAGAGATTGCTTTTCACAATTGCACAAGCTATTACTGACTTTACAGCATAGTGGAAGATTAGCTGATGACC
CATGTATCTGATGTTCAACCATAGTGGTGCCTTGAGACATTAAACTGTTTTTAACTGTACCAGAAATGAAGTGTGGAACAGTTACCTAAC
CTATTTCACATGGGCGTTTTGTATACAACTATTTTGATCTACACTTGATGTCTGAGCAGAAAACAGAAATAGCTAAATGTGACTCAGGAA
GTATCTCTTGGTTTCTTATTCAGCAGCAGAGTTGGTGACTTTGACAACTGGACTGCAGAGAAACATGGTGATCACCTTTTAATTTTTATT
GGCTGTCTGCCAAATATAAATACAGATGCAAAATTCAGTAATAGGAGATCCATAACCCAACATGGGTCACTACTCGTGAAATGTGACTTT
CTCCCACCAGTAATTGAAATGAGGTGATGATACCTAATTATGTTTTCCTAATTAAAGATAAATTGCTACTTGATTAAAAATCCTGCCCTT
CACCTTTGGGAACAAAGGTTAAGAGACACAGTTGGGCGAACTCTCAAATTTATTGGCATTTACACAAAGTCCCAGACAACCAAGGAACTG
AAGTTTTCATCATATGAGAGCAGCACATCCCACCATTTACAATATTCGTATATCTTTCTGCAAATATGGCTCTGGATAGTGAAAATTGAA
AAACATATGCCAACCCTGAGCAAGGGAACTCCTCAAAAAATCATGCAGCGGAACCTTGTCAGGTAGAGAAGCCGTGCATGAAAGAATTTG

>In-frame_NOTCH1_ENST00000277541_chr9_139407473_-_TMEM117_ENST00000266534_chr12_44338013_+_4897nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTCTGTGGCGGGGCCTTCGTGGGCCCGCGATGCCAGGACCCCAACCCGTGCCTCAG
CACCCCCTGCAAGAACGCCGGGACATGCCACGTGGTGGACCGCAGAGGCGTGGCAGACTATGCCTGCAGCTGTGCCCTGGGCTTCTCTGG
GCCCCTCTGCCTGACACCCCTGGACAATGCCTGCCTCACCAACCCCTGCCGCAACGGGGGCACCTGCGACCTGCTCACGCTGACGGAGTA
CAAGTGCCGCTGCCCGCCCGGCTGGTCAGGGAAATCGTGCCAGCAGGCTGACCCGTGCGCCTCCAACCCCTGCGCCAACGGTGGCCAGTG
CCTGCCCTTCGAGGCCTCCTACATCTGCCACTGCCCACCCAGCTTCCATGGCCCCACCTGCCGGCAGGATGTCAACGAGTGTGGCCAGAA
GCCCGGGCTTTGCCGCCACGGAGGCACCTGCCACAACGAGGTCGGCTCCTACCGCTGCGTCTGCCGCGCCACCCACACTGGCCCCAACTG
CGAGCGGCCCTACGTGCCCTGCAGCCCCTCGCCCTGCCAGAACGGGGGCACCTGCCGCCCCACGGGCGACGTCACCCACGAGTGTGCCTG
CCTGCCAGGCTTCACCGGCCAGAACTGTGAGGAAAATATCGACGATTGTCCAGGAAACAACTGCAAGAACGGGGGTGCCTGTGTGGACGG
CGTGAACACCTACAACTGCCGCTGCCCGCCAGAGTGGACAGGTCAGTACTGTACCGAGGATGTGGACGAGTGCCAGCTGATGCCAAATGC
CTGCCAGAACGGCGGGACCTGCCACAACACCCACGGTGGCTACAACTGCGTGTGTGTCAACGGCTGGACTGGTGAGGACTGCAGCGAGAA
CATTGATGACTGTGCCAGCGCCGCCTGCTTCCACGGCGCCACCTGCCATGACCGTGTGGCCTCCTTCTACTGCGAGTGTCCCCATGGCCG
CACAGGTCTGCTGTGCCACCTCAACGACGCATGCATCAGCAACCCCTGTAACGAGGGCTCCAACTGCGACACCAACCCTGTCAATGGCAA
GGCCATCTGCACCTGCCCCTCGGGGTACACGGGCCCGGCCTGCAGCCAGGACGTGGATGAGTGCTCGCTGGGTGCCAACCCCTGCGAGCA
TGCGGGCAAGTGCATCAACACGCTGGGCTCCTTCGAGTGCCAGTGTCTGCAGGGCTACACGGGCCCCCGATGCGAGATCGACGTCAACGA
GTGCGTCTCGAACCCGTGCCAGAACGACGCCACCTGCCTGGACCAGATTGGGGAGTTCCAGTGCATCTGCATGCCCGGCTACGAGGGTGT
GCACTGCGAGGTCAACACAGACGAGTGTGCCAGCAGCCCCTGCCTGCACAATGGCCGCTGCCTGGACAAGATCAATGAGTTCCAGTGCGA
GTGCCCCACGGGCTTCACTGGGCATCTGTGCCAGTACGATGTGGACGAGTGTGCCAGCACCCCCTGCAAGAATGGTGCCAAGTGCCTGGA
CGGACCCAACACTTACACCTGTGTGTGCACGGAAGGGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTG
CCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAA
CGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGG
ACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGC
CTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGA
CGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTG
CGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAA
TGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGG
TCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTG
CAACTGCCTGCTGCCCTACACAGGTCAGTTGCTCCGATTAAAAATGTTTCGAGAAGATCATGGGTCGTGGATGACAATGTTCTTCAGCAC
AATTCTCTTTCTCTTCATATTTTCTCACATATACAACACGATTCTTCTAATGGATGGGAACATGGGAGCATATATCATTACAGACTATAT
GGGCATCCGAAATGAAAGTTTCATGAAATTAGCTGCAGTAGGGACCTGGATGGGGGACTTTGTCACAGCTTGGATGGTCACTGATATGAT
GCTTCAGGACAAACCCTATCCTGACTGGGGAAAATCAGCAAGAGCTTTCTGGAAGAAAGGAAATGTTAGGATCACTTTATTCTGGACAGT
TCTTTTTACTCTGACGTCTGTGGTTGTACTTGTGATTACAACGGACTGGATCAGCTGGGACAAGCTGAATCGGGGATTTTTGCCCAGTGA
TGAAGTTTCCAGAGCATTCCTTGCTTCTTTTATCTTGGTCTTTGACCTTCTTATTGTGATGCAGGACTGGGAATTCCCACATTTCATGGG
AGATGTTGATGTAAATCTCCCTGGTTTGCACACCCCTCACATGCAGTTCAAGATTCCTTTCTTCCAGAAAATCTTCAAGGAGGAATATCG
TATTCACATAACAGGCAAATGGTTTAACTATGGAATTATCTTCCTCGTCTTGATTTTGGATCTTAATATGTGGAAGAACCAAATATTTTA
TAAACCTCATGAATATGGGCAATATATCGGCCCGGGGCAGAAGATATATACAGTGAAAGACTCAGAAAGTTTAAAAGATTTGAACAGAAC
CAAGCTATCCTGGGAATGGAGGTCCAATCACACTAACCCTCGGACTAATAAAACATATGTTGAGGGAGACATGTTCTTACACAGCAGGTT
CATAGGAGCCAGTCTTGATGTCAAGTGTCTGGCCTTTGTTCCAAGCCTGATAGCCTTTGTGTGGTTTGGATTCTTTATTTGGTTCTTTGG
ACGATTTTTGAAAAATGAGCCACGCATGGAGAATCAAGACAAAACTTACACTCGCATGAAAAGAAAATCTCCATCAGAACATAGCAAAGA
CATGGGAATCACTCGAGAAAACACCCAGGCTTCAGTAGAAGACCCCTTGAATGACCCTTCTTTGGTTTGCATCAGGTCTGACTTCAATGA
GATCGTCTACAAGTCTTCCCACCTAACCTCGGAAAACTTGAGCTCACAGTTGAACGAATCTACTAGTGCAACAGAAGCTGATCAAGACCC
AACGACTTCTAAAAGTACACCTACGAACTAGACTCGGAGATAGACTTGGAGATAACACAAAAAGCAACCTTGAGTGTAACTTTAAAAATT
TAGTCTTTCCTTTTGTATATGTAAGGTTTACGTAGTGTTAGGTAAAAATATGAACAATGCCACAACGGTGCTCAACATGCTTTTTCTAGG
ATTCATTGTTTTCTATTTGTATTATAATACACGTGCCTACTGTATACTCAACAGTCCTCTAGAGATTGCTTTTCACAATTGCACAAGCTA
TTACTGACTTTACAGCATAGTGGAAGATTAGCTGATGACCCATGTATCTGATGTTCAACCATAGTGGTGCCTTGAGACATTAAACTGTTT
TTAACTGTACCAGAAATGAAGTGTGGAACAGTTACCTAACCTATTTCACATGGGCGTTTTGTATACAACTATTTTGATCTACACTTGATG
TCTGAGCAGAAAACAGAAATAGCTAAATGTGACTCAGGAAGTATCTCTTGGTTTCTTATTCAGCAGCAGAGTTGGTGACTTTGACAACTG
GACTGCAGAGAAACATGGTGATCACCTTTTAATTTTTATTGGCTGTCTGCCAAATATAAATACAGATGCAAAATTCAGTAATAGGAGATC
CATAACCCAACATGGGTCACTACTCGTGAAATGTGACTTTCTCCCACCAGTAATTGAAATGAGGTGATGATACCTAATTATGTTTTCCTA
ATTAAAGATAAATTGCTACTTGATTAAAAATCCTGCCCTTCACCTTTGGGAACAAAGGTTAAGAGACACAGTTGGGCGAACTCTCAAATT
TATTGGCATTTACACAAAGTCCCAGACAACCAAGGAACTGAAGTTTTCATCATATGAGAGCAGCACATCCCACCATTTACAATATTCGTA
TATCTTTCTGCAAATATGGCTCTGGATAGTGAAAATTGAAAAACATATGCCAACCCTGAGCAAGGGAACTCCTCAAAAAATCATGCAGCG
GAACCTTGTCAGGTAGAGAAGCCGTGCATGAAAGAATTTGTTTAATGTCTTGTTTTGCGTATGTGTTTTTTGTTTTTGTTTTTTAAGAAC


Top

FusionGenePPI for NOTCH1_TMEM117


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOTCH1SMAD3, LCK, PIK3CA, CNTN1, YY1, RBPJ, DTX1, SNW1, NOTCH3, XRCC6, RELA, NFKB1, DLL1, JAG1, JAG2, LEF1, NUMB, GSK3B, NOTCH1, MAML1, NOV, PSEN1, FBXW7, MAML2, MAML3, EP300, AKT1, CBL, CTNNB1, CACNA1A, SNAI1, MDM2, RUNX3, HEY1, HEY2, KAT5, APP, APBB1, EIF3F, EPN1, ILK, GFI1B, NOTCH2, PRKAA1, MAPK1, LIMK2, ROCK1, TAB1, MOB1A, HCLS1, RANBP9, RANBP10, VAV1, ARHGEF2, USP7, USP11, USP15, PPP2CA, PPP2R1A, PPP2R2A, PPP6R1, PPP6R3, ARIH1, ARIH2, TRIM32, ANAPC7, ANAPC1, CDC23, CDC27, ANAPC5, STK38, GPS1, CAND1, SLFN5, SLFN11, RLTPR, LRCH1, WDR11, NCKAP1L, ARMC8, ERH, WDR6, C18orf8, PTBP3, CCZ1B, SMARCA4, PBRM1, SMARCC2, SMARCC1, HLTF, SMARCA5, SMC1A, SMC3, PDS5A, MAU2, SMCHD1, TRIM28, WIZ, RB1, PHF8, RNF40, CHD4, RBBP4, GATAD2B, HDAC1, KDM1A, RING1, RNF2, FRYL, HCFC1, C14orf166, ASCC3, SRRT, TBL1XR1, WWTR1, DDX17, HTATSF1, MED23, MED25, BCL11B, IKZF1, IKZF2, IKZF3, TCF12, RUNX1, SMAD9, ZBTB2, ZBED4, RFX1, IFI16, PRKDC, PARP1, TOP2B, MCM3, MCM5, RFC1, RFC4, MMS19, RIF1, PRPF6, PRPF8, PRPF19, RBM10, DHX15, DHX8, SART1, PTBP1, CNOT1, XPO5, NBEA, LRBA, MDN1, TNPO1, KPNB1, IPO5, TRAPPC9, TRAPPC10, CCT3, CCT6A, CCT8, VPS39, VPS11, KIF3A, KIF2A, PPP2CB, CAMK4, XIAP, ITCH, NEDD4L, ARRB1, EGFL7, LATS2, WWP1, TGFBR1, USP12, ANKRD44, PTEN, TMEM17, RND3, PRKCD, RAB5A, RAB7A, LAMP1, HGS, ZMIZ1, MAP1LC3A, SQSTM1, MAP3K1, CDH1, CTDSPL, DLK2, FANCA, FANCC, FANCF, FANCG, MAGEA1, TRIM25, ARL6IP5, B3GALT4, LINC00260, CEP57L1, C9orf62, COL4A6, EXT1, FAM185A, KIAA1191, LNX2, RHOA, GOLGA2, HMGN5, MAGED1, GOPC, POU2AF1, TLE3, DAZAP2, KCTD10, CUL3, DTX4, ADAM10TMEM117


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534420_4218222556DLL4
HgeneNOTCH1chr9:139407473chr12:44338013ENST00000277541-1534448_4528222556DLL4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NOTCH1_TMEM117


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NOTCH1_TMEM117


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOTCH1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma4CTD_human
HgeneNOTCH1C1458155Mammary Neoplasms2CTD_human
HgeneNOTCH1C0000768Congenital Abnormality1CTD_human
HgeneNOTCH1C0004114Astrocytoma1CTD_human
HgeneNOTCH1C0006663Calcinosis1CTD_human
HgeneNOTCH1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNOTCH1C0007873Uterine Cervical Neoplasm1CTD_human
HgeneNOTCH1C0009375Colonic Neoplasms1CTD_human
HgeneNOTCH1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneNOTCH1C0017636Glioblastoma1CTD_human
HgeneNOTCH1C0018824Heart valve disease1CTD_human
HgeneNOTCH1C0023492Leukemia, T-Cell1CTD_human
HgeneNOTCH1C0024299Lymphoma1CTD_human
HgeneNOTCH1C0027765nervous system disorder1CTD_human
HgeneNOTCH1C0036439Scoliosis, unspecified1CTD_human
HgeneNOTCH1C0038002Splenomegaly1CTD_human
HgeneNOTCH1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneNOTCH1C0376634Craniofacial Abnormalities1CTD_human
HgeneNOTCH1C0428791Aortic valve calcification1CTD_human
HgeneNOTCH1C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneNOTCH1C4014970ADAMS-OLIVER SYNDROME 51UNIPROT
TgeneTMEM117C0008370Cholestasis1CTD_human
TgeneTMEM117C4277682Chemical and Drug Induced Liver Injury1CTD_human