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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 24626

FusionGeneSummary for NOTCH1_NUP214

check button Fusion gene summary
Fusion gene informationFusion gene name: NOTCH1_NUP214
Fusion gene ID: 24626
HgeneTgene
Gene symbol

NOTCH1

NUP214

Gene ID

4851

8021

Gene namenotch 1nucleoporin 214
SynonymsAOS5|AOVD1|TAN1|hN1CAIN|CAN
Cytomap

9q34.3

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionneurogenic locus notch homolog protein 1Notch homolog 1, translocation-associatedtranslocation-associated notch protein TAN-1nuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDa
Modification date2018052720180523
UniProtAcc

P46531

P35658

Ensembl transtripts involved in fusion geneENST00000277541, ENST00000491649, 
ENST00000359428, ENST00000411637, 
ENST00000451030, ENST00000483497, 
ENST00000465486, 
Fusion gene scores* DoF score11 X 9 X 10=9906 X 7 X 4=168
# samples 127
** MAII scorelog2(12/990*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOTCH1 [Title/Abstract] AND NUP214 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOTCH1

GO:0007050

cell cycle arrest

11306509

HgeneNOTCH1

GO:0007219

Notch signaling pathway

11306509

HgeneNOTCH1

GO:0008284

positive regulation of cell proliferation

17849174

HgeneNOTCH1

GO:0008285

negative regulation of cell proliferation

11306509|20616313

HgeneNOTCH1

GO:0010629

negative regulation of gene expression

11306509

HgeneNOTCH1

GO:0010812

negative regulation of cell-substrate adhesion

16501043

HgeneNOTCH1

GO:0035924

cellular response to vascular endothelial growth factor stimulus

20616313

HgeneNOTCH1

GO:0045944

positive regulation of transcription by RNA polymerase II

20616313

HgeneNOTCH1

GO:0045967

negative regulation of growth rate

11306509

HgeneNOTCH1

GO:0046579

positive regulation of Ras protein signal transduction

11306509

HgeneNOTCH1

GO:0070374

positive regulation of ERK1 and ERK2 cascade

11306509

HgeneNOTCH1

GO:0071372

cellular response to follicle-stimulating hormone stimulus

20613903

HgeneNOTCH1

GO:0090051

negative regulation of cell migration involved in sprouting angiogenesis

20616313

HgeneNOTCH1

GO:2001027

negative regulation of endothelial cell chemotaxis

20616313


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1XX000003NOTCH1chr9

139438476

-NUP214chr9

134062675

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000277541ENST00000359428NOTCH1chr9

139438476

-NUP214chr9

134062675

+
In-frameENST00000277541ENST00000411637NOTCH1chr9

139438476

-NUP214chr9

134062675

+
In-frameENST00000277541ENST00000451030NOTCH1chr9

139438476

-NUP214chr9

134062675

+
5CDS-intronENST00000277541ENST00000483497NOTCH1chr9

139438476

-NUP214chr9

134062675

+
5CDS-intronENST00000277541ENST00000465486NOTCH1chr9

139438476

-NUP214chr9

134062675

+
intron-3CDSENST00000491649ENST00000359428NOTCH1chr9

139438476

-NUP214chr9

134062675

+
intron-3CDSENST00000491649ENST00000411637NOTCH1chr9

139438476

-NUP214chr9

134062675

+
intron-3CDSENST00000491649ENST00000451030NOTCH1chr9

139438476

-NUP214chr9

134062675

+
intron-intronENST00000491649ENST00000483497NOTCH1chr9

139438476

-NUP214chr9

134062675

+
intron-intronENST00000491649ENST00000465486NOTCH1chr9

139438476

-NUP214chr9

134062675

+

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FusionProtFeatures for NOTCH1_NUP214


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOTCH1

P46531

NUP214

P35658

Functions as a receptor for membrane-bound ligandsJagged1, Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex withRBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation, proliferation andapoptotic programs. Involved in angiogenesis; negatively regulatesendothelial cell proliferation and migration and angiogenicsprouting. Involved in the maturation of both CD4+ and CD8+ cellsin the thymus. Important for follicular differentiation andpossibly cell fate selection within the follicle. Duringcerebellar development, functions as a receptor for neuronal DNERand is involved in the differentiation of Bergmann glia. Repressesneuronal and myogenic differentiation. May play an essential rolein postimplantation development, probably in some aspect of cellspecification and/or differentiation. May be involved in mesodermdevelopment, somite formation and neurogenesis. May enhance HIF1Afunction by sequestering HIF1AN away from HIF1A. Required for theTHBS4 function in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury. Involved indetermination of left/right symmetry by modulating the balancebetween motile and immotile (sensory) cilia at the left-rightorganiser (LRO). {ECO:0000269|PubMed:20616313}. May serve as a docking site in the receptor-mediatedimport of substrates across the nuclear pore complex.{ECO:0000303|PubMed:8108440}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+23361213_209011392091Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+23361213_209011292081Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+23361213_209011402092Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+23361409_208411392091RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+23361427_208511392091RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+23361409_208411292081RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+23361427_208511292081RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+23361409_208411402092RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+23361427_208511402092RegionNote=11 X 3 AA approximate repeats

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341575_1578462556Compositional biasNote=Poly-Val
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341661_1664462556Compositional biasNote=Poly-Arg
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341728_1731462556Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341740_1743462556Compositional biasNote=Poly-Ala
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341901_1904462556Compositional biasNote=Poly-Glu
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342259_2262462556Compositional biasNote=Poly-Gly
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342403_2406462556Compositional biasNote=Poly-Gln
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342410_2417462556Compositional biasNote=Poly-Pro
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342521_2524462556Compositional biasNote=Poly-Ser
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341021_1057462556DomainEGF-like 27
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234102_139462556DomainEGF-like 3
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341059_1095462556DomainEGF-like 28
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341097_1143462556DomainEGF-like 29
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341145_1181462556DomainEGF-like 30
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341183_1219462556DomainEGF-like 31%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341221_1265462556DomainEGF-like 32%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341267_1305462556DomainEGF-like 33
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341307_1346462556DomainEGF-like 34
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341348_1384462556DomainEGF-like 35
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341387_1426462556DomainEGF-like 36
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234140_176462556DomainEGF-like 4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234178_216462556DomainEGF-like 5%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-23420_58462556DomainEGF-like 1
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234218_255462556DomainEGF-like 6
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234257_293462556DomainEGF-like 7%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234295_333462556DomainEGF-like 8%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234335_371462556DomainEGF-like 9%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234372_410462556DomainEGF-like 10
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234412_450462556DomainEGF-like 11%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234452_488462556DomainEGF-like 12%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234490_526462556DomainEGF-like 13%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234528_564462556DomainEGF-like 14%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234566_601462556DomainEGF-like 15%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-23459_99462556DomainEGF-like 2
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234603_639462556DomainEGF-like 16%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234641_676462556DomainEGF-like 17%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234678_714462556DomainEGF-like 18%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234716_751462556DomainEGF-like 19%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234753_789462556DomainEGF-like 20
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234791_827462556DomainEGF-like 21%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234829_867462556DomainEGF-like 22
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234869_905462556DomainEGF-like 23%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234907_943462556DomainEGF-like 24
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234945_981462556DomainEGF-like 25%3B calcium-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234983_1019462556DomainEGF-like 26
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341947_1955462556RegionHIF1AN-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342014_2022462556RegionHIF1AN-binding
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341449_1489462556RepeatNote=LNR 1
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341490_1531462556RepeatNote=LNR 2
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341532_1571462556RepeatNote=LNR 3
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341928_1960462556RepeatNote=ANK 1
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341961_1994462556RepeatNote=ANK 2
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341995_2027462556RepeatNote=ANK 3
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342028_2060462556RepeatNote=ANK 4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342061_2094462556RepeatNote=ANK 5
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2342095_2122462556RepeatNote=ANK 6
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341757_2555462556Topological domainCytoplasmic
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-23419_1735462556Topological domainExtracellular
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-2341736_1756462556TransmembraneHelical
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336680_120911392091Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336680_120911292081Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336680_120911402092Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+233641_40411392091RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336481_207611392091RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336740_76811392091RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336861_88211392091RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+233641_40411292081RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336481_207611292081RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336740_76811292081RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336861_88211292081RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+233641_40411402092RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336481_207611402092RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336740_76811402092RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336861_88211402092RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336151_19311392091RepeatNote=Blade 3
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336194_23911392091RepeatNote=Blade 4
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336240_30311392091RepeatNote=Blade 5
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336304_35911392091RepeatNote=Blade 6
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+2336360_40411392091RepeatNote=Blade 7
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+233641_9311392091RepeatNote=Blade 1
TgeneNUP214chr9:139438476chr9:134062675ENST00000359428+233694_15011392091RepeatNote=Blade 2
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336151_19311292081RepeatNote=Blade 3
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336194_23911292081RepeatNote=Blade 4
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336240_30311292081RepeatNote=Blade 5
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336304_35911292081RepeatNote=Blade 6
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+2336360_40411292081RepeatNote=Blade 7
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+233641_9311292081RepeatNote=Blade 1
TgeneNUP214chr9:139438476chr9:134062675ENST00000411637+233694_15011292081RepeatNote=Blade 2
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336151_19311402092RepeatNote=Blade 3
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336194_23911402092RepeatNote=Blade 4
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336240_30311402092RepeatNote=Blade 5
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336304_35911402092RepeatNote=Blade 6
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+2336360_40411402092RepeatNote=Blade 7
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+233641_9311402092RepeatNote=Blade 1
TgeneNUP214chr9:139438476chr9:134062675ENST00000451030+233694_15011402092RepeatNote=Blade 2


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FusionGeneSequence for NOTCH1_NUP214


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_NOTCH1_ENST00000277541_chr9_139438476_-_NUP214_ENST00000359428_chr9_134062675_+_4253nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTTTCTTCAGTGCCCTACTCCACAGCCAAAACACCTCACCCAGTGTTGACCCCAGT
GGCTGCTAACCAAGCCAAGCAGGGGTCTCTAATAAATTCCCTTAAGCCATCTGGGCCTACACCAGCATCCGGTCAGTTATCATCTGGTGA
CAAAGCTTCAGGGACAGCCAAGATAGAAACAGCTGTGACTTCAACCCCATCTGCTTCTGGGCAGTTCAGCAAGCCTTTCTCATTTTCTCC
ATCAGGGACTGGCTTTAATTTTGGGATAATCACACCAACACCGTCTTCTAATTTCACTGCTGCACAAGGGGCAACACCCTCCACTAAAGA
GTCAAGCCAGCCGGACGCATTCTCATCTGGTGGGGGAAGCAAACCTTCTTATGAGGCCATTCCTGAAAGCTCACCTCCCTCAGGAATCAC
ATCCGCATCAAACACCACCCCAGGAGAACCTGCCGCATCTAGCAGCAGACCTGTGGCACCTTCTGGAACTGCTCTTTCCACCACCTCTAG
TAAGCTGGAAACCCCACCGTCCAAGCTGGGAGAGCTTCTGTTTCCAAGTTCTTTGGCTGGAGAGACTCTGGGAAGTTTTTCAGGACTGCG
GGTTGGCCAAGCAGATGATTCTACAAAACCAACCAATAAGGCTTCATCCACAAGCCTAACTAGTACCCAGCCAACCAAGACGTCAGGCGT
GCCCTCAGGGTTTAATTTTACTGCCCCCCCGGTGTTAGGGAAGCACACGGAGCCCCCTGTGACATCCTCTGCAACCACCACCTCAGTAGC
ACCACCAGCAGCCACCAGCACTTCCTCAACTGCCGTTTTTGGCAGTCTGCCAGTCACCAGTGCAGGATCCTCTGGGGTCATCAGTTTTGG
TGGGACATCTCTAAGTGCTGGCAAGACTAGTTTTTCATTTGGAAGCCAACAGACCAATAGCACAGTGCCCCCATCTGCCCCACCACCAAC
TACAGCTGCCACTCCCCTTCCAACATCATTCCCCACATTGTCATTTGGTAGCCTCCTGAGTTCAGCAACTACCCCCTCCCTGCCTATGTC
CGCTGGCAGAAGCACAGAAGAGGCCACTTCATCAGCTTTGCCTGAGAAGCCAGGTGACAGTGAGGTCTCAGCATCAGCAGCCTCACTTCT
AGAGGAGCAACAGTCAGCCCAGCTTCCCCAGGCTCCTCCGCAAACTTCTGACTCTGTTAAAAAAGAACCTGTTCTTGCCCAGCCTGCAGT
CAGCAACTCTGGCACTGCAGCATCTAGTACTAGTCTTGTAGCACTTTCTGCAGAGGCTACCCCAGCCACCACGGGGGTCCCTGATGCCAG
GACGGAGGCAGTACCACCTGCTTCCTCCTTTTCTGTGCCTGGGCAGACTGCTGTCACAGCAGCTGCTATCTCAAGTGCAGGCCCTGTGGC
CGTCGAAACATCAAGTACCCCCATAGCCTCCAGCACCACGTCCATTGTTGCTCCCGGCCCATCTGCAGAGGCAGCAGCATTTGGTACCGT
CACTTCTGGCTCATCCGTCTTTGCTCAGCCTCCTGCTGCCAGTTCTAGCTCAGCTTTCAACCAGCTCACCAACAACACAGCCACTGCCCC
CTCTGCCACGCCCGTGTTTGGGCAAGTGGCAGCCAGCACCGCACCAAGTCTGTTTGGGCAGCAGACTGGTAGCACAGCCAGCACAGCAGC
TGCCACACCACAGGTCAGCAGCTCAGGGTTTAGCAGCCCAGCTTTTGGTACCACAGCCCCAGGGGTCTTTGGACAGACAACCTTCGGGCA
GGCCTCAGTCTTTGGGCAGTCGGCGAGCAGTGCTGCAAGTGTCTTTTCCTTCAGTCAGCCTGGGTTCAGTTCCGTGCCTGCCTTCGGTCA
GCCTGCTTCCTCCACTCCCACATCCACCAGTGGAAGTGTCTTTGGTGCCGCCTCAAGTACCAGTAGCTCCAGTTCCTTCTCATTTGGACA
GTCTTCTCCCAACACAGGAGGGGGGCTGTTTGGCCAAAGCAACGCTCCTGCTTTTGGGCAGAGTCCTGGCTTTGGACAGGGAGGCTCTGT
CTTTGGTGGTACCTCAGCTGCCACCACAACAGCAGCAACCTCTGGGTTCAGCTTTTGCCAAGCTTCAGGTTTTGGGTCTAGTAATACTGG
TTCTGTGTTTGGTCAAGCAGCCAGTACTGGTGGAATAGTCTTTGGCCAGCAATCATCCTCTTCCAGTGGTAGCGTGTTTGGGTCTGGAAA
CACTGGAAGAGGGGGAGGTTTCTTCAGTGGCCTTGGAGGAAAACCCAGTCAGGATGCAGCCAACAAAAACCCATTCAGCTCGGCCAGTGG
GGGCTTTGGATCCACAGCTACCTCAAATACCTCTAACCTATTTGGAAACAGTGGGGCCAAGACATTTGGTGGATTTGCCAGCTCGTCGTT
TGGAGAGCAGAAACCCACTGGCACTTTCAGCTCTGGAGGAGGAAGTGTGGCATCCCAAGGCTTTGGGTTTTCCTCTCCAAACAAAACAGG
TGGCTTCGGTGCTGCTCCAGTGTTTGGCAGCCCTCCTACTTTTGGGGGATCCCCTGGGTTTGGAGGGGTGCCAGCATTCGGTTCAGCCCC
AGCCTTTACAAGCCCTCTGGGCTCGACGGGAGGCAAAGTGTTCGGAGAGGGCACTGCAGCTGCCAGCGCAGGAGGATTCGGGTTTGGGAG
CAGCAGCAACACCACATCCTTCGGCACGCTCGCGAGTCAGAATGCCCCCACTTTCGGATCACTGTCCCAACAGACTTCTGGTTTTGGGAC
CCAGAGTAGCGGATTCTCTGGTTTTGGATCAGGCACAGGAGGGTTCAGCTTTGGGTCAAATAACTCGTCTGTCCAGGGTTTTGGTGGCTG
GCGAAGCTGAGGGCGTGTCAGCAGGCCTTTCGATCCCTGGGACCAACCGCATCCTCAGCTTCTTCCCCGAGAAATGCTGGAGCAGGCTGT
TCAGACCGACGTTGCCATCAAAACACATACACCCAGAAAGAAACAACAGAAACCAAAACTCACAAGGCGCATGATTACTTGTTTTATATT
TCATGTTGGGTTTTCCCTCCCACTATTAAACAGTCTGTTTCCGTACAGAACGTATGTGGGTTTTTTCAGATCACAGCCAAGAAGATTGCC
CCGTTTCTGTGGCTCTGAGAAGCCAGCAGAGCCTCCATCAGCCAGAACACTGTGTCTTCAAGGATGGCATCAGAAGTCACCAGCGTCGGG
TGTTGATAAACAGCATCGAATGTGCCGTGGTCTCACTTGGACCTAGCGCCCTCCACATAGGGAAGAGGTTGAATGCTGGTGGGTCATCTT
TTTGAGGCTGAAACTTGGTTATCTCCTCTCCTTGTTCTTTTAGCCATTGTGTATCAGGACCATCCAAGGACGCACTCTGCGATTGAGTGG
AGGCAGAGGAAGCCACTCATGCCAGCAGCAGTTGAGTTTCAGAAGCAGCCATAGCGCTTTTCAGTACAGTACAATAGTAGCCAGCGTGAG
GCAGGACAGTGCTGCGCCTTAGCCGGCCTTGGCTCTCATCTCCATGTGGCTCTTGGGTGCCATGTGTCCTACTCCAGAGAGGAGGGGGCC
GGTCACTTGAGAAGACAGCCTTTATATTCTGTATGTGGCAGTGACATTGGTAGCCACACCTACCCAGTGTCTACTAACCACAGTGCAGAT
AGCCCTTGGGTAGACCCAGGAAGTGTGAAGACAGACACTGCTGTTGCCAGACAACACTAGCAGAACGATGCTGGATTTGACAACAGTGTT
TGCTAGGACGGCCCAGAGCTCATCACTGCAGTTTTATTAGAGTGCTTCTTTATCTTTAATGCAGTATCTTTGAGGCCTGTAACATCCTAG
ATAGTTGCCATCAAACAAGGACCGTCTCGCATTGAAAACAGATGTAAGAATTTCTCTTTCAGGCCCAGAATCTGACAGTGCTTTGGCTTG
GGTCATGAGCAGCGGGGAGTTGGGAAGAGATTTTTTTTTTTAGAGTTTTACATATTGGCAGGTTGTATTTTTTTAATGTTTTAATAAAAG

>In-frame_NOTCH1_ENST00000277541_chr9_139438476_-_NUP214_ENST00000411637_chr9_134062675_+_4246nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTTTCTTCAGTGCCCTACTCCACAGCCAAAACACCTCACCCAGTGTTGACCCCAGT
GGCTGCTAACCAAGCCAAGCAGGGGTCTCTAATAAATTCCCTTAAGCCATCTGGGCCTACACCAGCATCCGGTCAGTTATCATCTGGTGA
CAAAGCTTCAGGGACAGCCAAGATAGAAACAGCTGTGACTTCAACCCCATCTGCTTCTGGGCAGTTCAGCAAGCCTTTCTCATTTTCTCC
ATCAGGGACTGGCTTTAATTTTGGGATAATCACACCAACACCGTCTTCTAATTTCACTGCTGCACAAGGGGCAACACCCTCCACTAAAGA
GTCAAGCCAGCCGGACGCATTCTCATCTGGTGGGGGAAGCAAACCTTCTTATGAGGCCATTCCTGAAAGCTCACCTCCCTCAGGAATCAC
ATCCGCATCAAACACCACCCCAGGAGAACCTGCCGCATCTAGCAGCAGACCTGTGGCACCTTCTGGAACTGCTCTTTCCACCACCTCTAG
TAAGCTGGAAACCCCACCGTCCAAGCTGGGAGAGCTTCTGTTTCCAAGTTCTTTGGCTGGAGAGACTCTGGGAAGTTTTTCAGGACTGCG
GGTTGGCCAAGCAGATGATTCTACAAAACCAACCAATAAGGCTTCATCCACAAGCCTAACTAGTACCCAGCCAACCAAGACGTCAGGCGT
GCCCTCAGGGTTTAATTTTACTGCCCCCCCGGTGTTAGGGAAGCACACGGAGCCCCCTGTGACATCCTCTGCAACCACCACCTCAGTAGC
ACCACCAGCAGCCACCAGCACTTCCTCAACTGCCGTTTTTGGCAGTCTGCCAGTCACCAGTGCAGGATCCTCTGGGGTCATCAGTTTTGG
TGGGACATCTCTAAGTGCTGGCAAGACTAGTTTTTCATTTGGAAGCCAACAGACCAATAGCACAGTGCCCCCATCTGCCCCACCACCAAC
TACAGCTGCCACTCCCCTTCCAACATCATTCCCCACATTGTCATTTGGTAGCCTCCTGAGTTCAGCAACTACCCCCTCCCTGCCTATGTC
CGCTGGCAGAAGCACAGAAGAGGCCACTTCATCAGCTTTGCCTGAGAAGCCAGGTGACAGTGAGGTCTCAGCATCAGCAGCCTCACTTCT
AGAGGAGCAACAGTCAGCCCAGCTTCCCCAGGCTCCTCCGCAAACTTCTGACTCTGTTAAAAAAGAACCTGTTCTTGCCCAGCCTGCAGT
CAGCAACTCTGGCACTGCAGCATCTAGTACTAGTCTTGTAGCACTTTCTGCAGAGGCTACCCCAGCCACCACGGGGGTCCCTGATGCCAG
GACGGAGGCAGTACCACCTGCTTCCTCCTTTTCTGTGCCTGGGCAGACTGCTGTCACAGCAGCTGCTATCTCAAGTGCAGGCCCTGTGGC
CGTCGAAACATCAAGTACCCCCATAGCCTCCAGCACCACGTCCATTGTTGCTCCCGGCCCATCTGCAGAGGCAGCAGCATTTGGTACCGT
CACTTCTGGCTCATCCGTCTTTGCTCAGCCTCCTGCTGCCAGTTCTAGCTCAGCTTTCAACCAGCTCACCAACAACACAGCCACTGCCCC
CTCTGCCACGCCCGTGTTTGGGCAAGTGGCAGCCAGCACCGCACCAAGTCTGTTTGGGCAGCAGACTGGTAGCACAGCCAGCACAGCAGC
TGCCACACCACAGGTCAGCAGCTCAGGGTTTAGCAGCCCAGCTTTTGGTACCACAGCCCCAGGGGTCTTTGGACAGACAACCTTCGGGCA
GGCCTCAGTCTTTGGGCAGTCGGCGAGCAGTGCTGCAAGTGTCTTTTCCTTCAGTCAGCCTGGGTTCAGTTCCGTGCCTGCCTTCGGTCA
GCCTGCTTCCTCCACTCCCACATCCACCAGTGGAAGTGTCTTTGGTGCCGCCTCAAGTACCAGTAGCTCCAGTTCCTTCTCATTTGGACA
GTCTTCTCCCAACACAGGAGGGGGGCTGTTTGGCCAAAGCAACGCTCCTGCTTTTGGGCAGAGTCCTGGCTTTGGACAGGGAGGCTCTGT
CTTTGGTGGTACCTCAGCTGCCACCACAACAGCAGCAACCTCTGGGTTCAGCTTTTGCCAAGCTTCAGGTTTTGGGTCTAGTAATACTGG
TTCTGTGTTTGGTCAAGCAGCCAGTACTGGTGGAATAGTCTTTGGCCAGCAATCATCCTCTTCCAGTGGTAGCGTGTTTGGGTCTGGAAA
CACTGGAAGAGGGGGAGGTTTCTTCAGTGGCCTTGGAGGAAAACCCAGTCAGGATGCAGCCAACAAAAACCCATTCAGCTCGGCCAGTGG
GGGCTTTGGATCCACAGCTACCTCAAATACCTCTAACCTATTTGGAAACAGTGGGGCCAAGACATTTGGTGGATTTGCCAGCTCGTCGTT
TGGAGAGCAGAAACCCACTGGCACTTTCAGCTCTGGAGGAGGAAGTGTGGCATCCCAAGGCTTTGGGTTTTCCTCTCCAAACAAAACAGG
TGGCTTCGGTGCTGCTCCAGTGTTTGGCAGCCCTCCTACTTTTGGGGGATCCCCTGGGTTTGGAGGGGTGCCAGCATTCGGTTCAGCCCC
AGCCTTTACAAGCCCTCTGGGCTCGACGGGAGGCAAAGTGTTCGGAGAGGGCACTGCAGCTGCCAGCGCAGGAGGATTCGGGTTTGGGAG
CAGCAGCAACACCACATCCTTCGGCACGCTCGCGAGTCAGAATGCCCCCACTTTCGGATCACTGTCCCAACAGACTTCTGGTTTTGGGAC
CCAGAGTAGCGGATTCTCTGGTTTTGGATCAGGCACAGGAGGGTTCAGCTTTGGGTCAAATAACTCGTCTGTCCAGGGTTTTGGTGGCTG
GCGAAGCTGAGGGCGTGTCAGCAGGCCTTTCGATCCCTGGGACCAACCGCATCCTCAGCTTCTTCCCCGAGAAATGCTGGAGCAGGCTGT
TCAGACCGACGTTGCCATCAAAACACATACACCCAGAAAGAAACAACAGAAACCAAAACTCACAAGGCGCATGATTACTTGTTTTATATT
TCATGTTGGGTTTTCCCTCCCACTATTAAACAGTCTGTTTCCGTACAGAACGTATGTGGGTTTTTTCAGATCACAGCCAAGAAGATTGCC
CCGTTTCTGTGGCTCTGAGAAGCCAGCAGAGCCTCCATCAGCCAGAACACTGTGTCTTCAAGGATGGCATCAGAAGTCACCAGCGTCGGG
TGTTGATAAACAGCATCGAATGTGCCGTGGTCTCACTTGGACCTAGCGCCCTCCACATAGGGAAGAGGTTGAATGCTGGTGGGTCATCTT
TTTGAGGCTGAAACTTGGTTATCTCCTCTCCTTGTTCTTTTAGCCATTGTGTATCAGGACCATCCAAGGACGCACTCTGCGATTGAGTGG
AGGCAGAGGAAGCCACTCATGCCAGCAGCAGTTGAGTTTCAGAAGCAGCCATAGCGCTTTTCAGTACAGTACAATAGTAGCCAGCGTGAG
GCAGGACAGTGCTGCGCCTTAGCCGGCCTTGGCTCTCATCTCCATGTGGCTCTTGGGTGCCATGTGTCCTACTCCAGAGAGGAGGGGGCC
GGTCACTTGAGAAGACAGCCTTTATATTCTGTATGTGGCAGTGACATTGGTAGCCACACCTACCCAGTGTCTACTAACCACAGTGCAGAT
AGCCCTTGGGTAGACCCAGGAAGTGTGAAGACAGACACTGCTGTTGCCAGACAACACTAGCAGAACGATGCTGGATTTGACAACAGTGTT
TGCTAGGACGGCCCAGAGCTCATCACTGCAGTTTTATTAGAGTGCTTCTTTATCTTTAATGCAGTATCTTTGAGGCCTGTAACATCCTAG
ATAGTTGCCATCAAACAAGGACCGTCTCGCATTGAAAACAGATGTAAGAATTTCTCTTTCAGGCCCAGAATCTGACAGTGCTTTGGCTTG
GGTCATGAGCAGCGGGGAGTTGGGAAGAGATTTTTTTTTTTAGAGTTTTACATATTGGCAGGTTGTATTTTTTTAATGTTTTAATAAAAG

>In-frame_NOTCH1_ENST00000277541_chr9_139438476_-_NUP214_ENST00000451030_chr9_134062675_+_3284nt
GCGCGTGTGCGTCCCAGCCCCGCCGGCCAGCGCAGGAGGCCGCCGCCCGGGCGCAGAGGGCAGCCGGTGGGGAGGCATGCCGCCGCTCCT
GGCGCCCCTGCTCTGCCTGGCGCTGCTGCCCGCGCTCGCCGCACGAGGCCCGCGATGCTCCCAGCCCGGTGAGACCTGCCTGAATGGCGG
GAAGTGTGAAGCGGCCAATGGCACGGAGGCCTGCGTTTCTTCAGTGCCCTACTCCACAGCCAAAACACCTCACCCAGTGTTGACCCCAGT
GGCTGCTAACCAAGCCAAGCAGGGGTCTCTAATAAATTCCCTTAAGCCATCTGGGCCTACACCAGCATCCGGTCAGTTATCATCTGGTGA
CAAAGCTTCAGGGACAGCCAAGATAGAAACAGCTGTGACTTCAACCCCATCTGCTTCTGGGCAGTTCAGCAAGCCTTTCTCATTTTCTCC
ATCAGGGACTGGCTTTAATTTTGGGATAATCACACCAACACCGTCTTCTAATTTCACTGCTGCACAAGGGGCAACACCCTCCACTAAAGA
GTCAAGCCAGCCGGACGCATTCTCATCTGGTGGGGGAAGCAAACCTTCTTATGAGGCCATTCCTGAAAGCTCACCTCCCTCAGGAATCAC
ATCCGCATCAAACACCACCCCAGGAGAACCTGCCGCATCTAGCAGCAGACCTGTGGCACCTTCTGGAACTGCTCTTTCCACCACCTCTAG
TAAGCTGGAAACCCCACCGTCCAAGCTGGGAGAGCTTCTGTTTCCAAGTTCTTTGGCTGGAGAGACTCTGGGAAGTTTTTCAGGACTGCG
GGTTGGCCAAGCAGATGATTCTACAAAACCAACCAATAAGGCTTCATCCACAAGCCTAACTAGTACCCAGCCAACCAAGACGTCAGGCGT
GCCCTCAGGGTTTAATTTTACTGCCCCCCCGGTGTTAGGGAAGCACACGGAGCCCCCTGTGACATCCTCTGCAACCACCACCTCAGTAGC
ACCACCAGCAGCCACCAGCACTTCCTCAACTGCCGTTTTTGGCAGTCTGCCAGTCACCAGTGCAGGATCCTCTGGGGTCATCAGTTTTGG
TGGGACATCTCTAAGTGCTGGCAAGACTAGTTTTTCATTTGGAAGCCAACAGACCAATAGCACAGTGCCCCCATCTGCCCCACCACCAAC
TACAGCTGCCACTCCCCTTCCAACATCATTCCCCACATTGTCATTTGGTAGCCTCCTGAGTTCAGCAACTACCCCCTCCCTGCCTATGTC
CGCTGGCAGAAGCACAGAAGAGGCCACTTCATCAGCTTTGCCTGAGAAGCCAGGTGACAGTGAGGTCTCAGCATCAGCAGCCTCACTTCT
AGAGGAGCAACAGTCAGCCCAGCTTCCCCAGGCTCCTCCGCAAACTTCTGACTCTGTTAAAAAAGAACCTGTTCTTGCCCAGCCTGCAGT
CAGCAACTCTGGCACTGCAGCATCTAGTACTAGTCTTGTAGCACTTTCTGCAGAGGCTACCCCAGCCACCACGGGGGTCCCTGATGCCAG
GACGGAGGCAGTACCACCTGCTTCCTCCTTTTCTGTGCCTGGGCAGACTGCTGTCACAGCAGCTGCTATCTCAAGTGCAGGCCCTGTGGC
CGTCGAAACATCAAGTACCCCCATAGCCTCCAGCACCACGTCCATTGTTGCTCCCGGCCCATCTGCAGAGGCAGCAGCATTTGGTACCGT
CACTTCTGGCTCATCCGTCTTTGCTCAGCCTCCTGCTGCCAGTTCTAGCTCAGCTTTCAACCAGCTCACCAACAACACAGCCACTGCCCC
CTCTGCCACGCCCGTGTTTGGGCAAGTGGCAGCCAGCACCGCACCAAGTCTGTTTGGGCAGCAGACTGGTAGCACAGCCAGCACAGCAGC
TGCCACACCACAGGTCAGCAGCTCAGGGTTTAGCAGCCCAGCTTTTGGTACCACAGCCCCAGGGGTCTTTGGACAGACAACCTTCGGGCA
GGCCTCAGTCTTTGGGCAGTCGGCGAGCAGTGCTGCAAGTGTCTTTTCCTTCAGTCAGCCTGGGTTCAGTTCCGTGCCTGCCTTCGGTCA
GCCTGCTTCCTCCACTCCCACATCCACCAGTGGAAGTGTCTTTGGTGCCGCCTCAAGTACCAGTAGCTCCAGTTCCTTCTCATTTGGACA
GTCTTCTCCCAACACAGGAGGGGGGCTGTTTGGCCAAAGCAACGCTCCTGCTTTTGGGCAGAGTCCTGGCTTTGGACAGGGAGGCTCTGT
CTTTGGTGGTACCTCAGCTGCCACCACAACAGCAGCAACCTCTGGGTTCAGCTTTTGCCAAGCTTCAGGTTTTGGGTCTAGTAATACTGG
TTCTGTGTTTGGTCAAGCAGCCAGTACTGGTGGAATAGTCTTTGGCCAGCAATCATCCTCTTCCAGTGGTAGCGTGTTTGGGTCTGGAAA
CACTGGAAGAGGGGGAGGTTTCTTCAGTGGCCTTGGAGGAAAACCCAGTCAGGATGCAGCCAACAAAAACCCATTCAGCTCGGCCAGTGG
GGGCTTTGGATCCACAGCTACCTCAAATACCTCTAACCTATTTGGAAACAGTGGGGCCAAGACATTTGGTGGATTTGCCAGCTCGTCGTT
TGGAGAGCAGAAACCCACTGGCACTTTCAGCTCTGGAGGAGGAAGTGTGGCATCCCAAGGCTTTGGGTTTTCCTCTCCAAACAAAACAGG
TGGCTTCGGTGCTGCTCCAGTGTTTGGCAGCCCTCCTACTTTTGGGGGATCCCCTGGGTTTGGAGGGGTGCCAGCATTCGGTTCAGCCCC
AGCCTTTACAAGCCCTCTGGGCTCGACGGGAGGCAAAGTGTTCGGAGAGGGCACTGCAGCTGCCAGCGCAGGAGGATTCGGGTTTGGGAG
CAGCAGCAACACCACATCCTTCGGCACGCTCGCGAGTCAGAATGCCCCCACTTTCGGATCACTGTCCCAACAGACTTCTGGTTTTGGGAC
CCAGAGTAGCGGATTCTCTGGTTTTGGATCAGGCACAGGAGGGTTCAGCTTTGGGTCAAATAACTCGTCTGTCCAGGGTTTTGGTGGCTG
GCGAAGCTGAGGGCGTGTCAGCAGGCCTTTCGATCCCTGGGACCAACCGCATCCTCAGCTTCTTCCCCGAGAAATGCTGGAGCAGGCTGT
TCAGACCGACGTTGCCATCAAAACACATACACCCAGAAAGAAACAACAGAAACCAAAACTCACAAGGCGCATGATTACTTGTTTTATATT


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FusionGenePPI for NOTCH1_NUP214


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOTCH1SMAD3, LCK, PIK3CA, CNTN1, YY1, RBPJ, DTX1, SNW1, NOTCH3, XRCC6, RELA, NFKB1, DLL1, JAG1, JAG2, LEF1, NUMB, GSK3B, NOTCH1, MAML1, NOV, PSEN1, FBXW7, MAML2, MAML3, EP300, AKT1, CBL, CTNNB1, CACNA1A, SNAI1, MDM2, RUNX3, HEY1, HEY2, KAT5, APP, APBB1, EIF3F, EPN1, ILK, GFI1B, NOTCH2, PRKAA1, MAPK1, LIMK2, ROCK1, TAB1, MOB1A, HCLS1, RANBP9, RANBP10, VAV1, ARHGEF2, USP7, USP11, USP15, PPP2CA, PPP2R1A, PPP2R2A, PPP6R1, PPP6R3, ARIH1, ARIH2, TRIM32, ANAPC7, ANAPC1, CDC23, CDC27, ANAPC5, STK38, GPS1, CAND1, SLFN5, SLFN11, RLTPR, LRCH1, WDR11, NCKAP1L, ARMC8, ERH, WDR6, C18orf8, PTBP3, CCZ1B, SMARCA4, PBRM1, SMARCC2, SMARCC1, HLTF, SMARCA5, SMC1A, SMC3, PDS5A, MAU2, SMCHD1, TRIM28, WIZ, RB1, PHF8, RNF40, CHD4, RBBP4, GATAD2B, HDAC1, KDM1A, RING1, RNF2, FRYL, HCFC1, C14orf166, ASCC3, SRRT, TBL1XR1, WWTR1, DDX17, HTATSF1, MED23, MED25, BCL11B, IKZF1, IKZF2, IKZF3, TCF12, RUNX1, SMAD9, ZBTB2, ZBED4, RFX1, IFI16, PRKDC, PARP1, TOP2B, MCM3, MCM5, RFC1, RFC4, MMS19, RIF1, PRPF6, PRPF8, PRPF19, RBM10, DHX15, DHX8, SART1, PTBP1, CNOT1, XPO5, NBEA, LRBA, MDN1, TNPO1, KPNB1, IPO5, TRAPPC9, TRAPPC10, CCT3, CCT6A, CCT8, VPS39, VPS11, KIF3A, KIF2A, PPP2CB, CAMK4, XIAP, ITCH, NEDD4L, ARRB1, EGFL7, LATS2, WWP1, TGFBR1, USP12, ANKRD44, PTEN, TMEM17, RND3, PRKCD, RAB5A, RAB7A, LAMP1, HGS, ZMIZ1, MAP1LC3A, SQSTM1, MAP3K1, CDH1, CTDSPL, DLK2, FANCA, FANCC, FANCF, FANCG, MAGEA1, TRIM25, ARL6IP5, B3GALT4, LINC00260, CEP57L1, C9orf62, COL4A6, EXT1, FAM185A, KIAA1191, LNX2, RHOA, GOLGA2, HMGN5, MAGED1, GOPC, POU2AF1, TLE3, DAZAP2, KCTD10, CUL3, DTX4, ADAM10NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, NUPL2, NUP214, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234420_421462556DLL4
HgeneNOTCH1chr9:139438476chr9:134062675ENST00000277541-234448_452462556DLL4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOTCH1_NUP214


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOTCH1_NUP214


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOTCH1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma4CTD_human
HgeneNOTCH1C1458155Mammary Neoplasms2CTD_human
HgeneNOTCH1C0000768Congenital Abnormality1CTD_human
HgeneNOTCH1C0004114Astrocytoma1CTD_human
HgeneNOTCH1C0006663Calcinosis1CTD_human
HgeneNOTCH1C0007621Neoplastic Cell Transformation1CTD_human
HgeneNOTCH1C0007873Uterine Cervical Neoplasm1CTD_human
HgeneNOTCH1C0009375Colonic Neoplasms1CTD_human
HgeneNOTCH1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneNOTCH1C0017636Glioblastoma1CTD_human
HgeneNOTCH1C0018824Heart valve disease1CTD_human
HgeneNOTCH1C0023492Leukemia, T-Cell1CTD_human
HgeneNOTCH1C0024299Lymphoma1CTD_human
HgeneNOTCH1C0027765nervous system disorder1CTD_human
HgeneNOTCH1C0036439Scoliosis, unspecified1CTD_human
HgeneNOTCH1C0038002Splenomegaly1CTD_human
HgeneNOTCH1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneNOTCH1C0376634Craniofacial Abnormalities1CTD_human
HgeneNOTCH1C0428791Aortic valve calcification1CTD_human
HgeneNOTCH1C0887833Carcinoma, Pancreatic Ductal1CTD_human
HgeneNOTCH1C4014970ADAMS-OLIVER SYNDROME 51UNIPROT