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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24616

FusionGeneSummary for NOS2_MYO18A

check button Fusion gene summary
Fusion gene informationFusion gene name: NOS2_MYO18A
Fusion gene ID: 24616
HgeneTgene
Gene symbol

NOS2

MYO18A

Gene ID

4843

399687

Gene namenitric oxide synthase 2myosin XVIIIA
SynonymsHEP-NOS|INOS|NOS|NOS2AMAJN|MYSPDZ|SP-R210|SPR210
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionnitric oxide synthase, inducibleNOS, type IIhepatocyte NOSinducible NO synthaseinducible NOSnitric oxide synthase 2, induciblenitric oxide synthase 2A (inducible, hepatocytes)nitric oxide synthase, macrophagepeptidyl-cysteine S-nitrosylase NOS2unconventional myosin-XVIIIaSP-A receptor subunit SP-R210 alphaSmolecule associated with JAK3 N-terminusmyosin 18Amyosin containing PDZ domainmyosin containing a PDZ domainsurfactant protein receptor SP-R210
Modification date2018052720180519
UniProtAcc

P35228

Q92614

Ensembl transtripts involved in fusion geneENST00000313735, ENST00000354329, 
ENST00000529578, ENST00000533112, 
ENST00000531253, ENST00000527372, 
Fusion gene scores* DoF score3 X 3 X 3=2715 X 13 X 10=1950
# samples 320
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(20/1950*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOS2 [Title/Abstract] AND MYO18A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNOS2

GO:0006527

arginine catabolic process

7504305

HgeneNOS2

GO:0006809

nitric oxide biosynthetic process

7504305|7682706

HgeneNOS2

GO:0032310

prostaglandin secretion

19688109

HgeneNOS2

GO:0072604

interleukin-6 secretion

19688109

HgeneNOS2

GO:0072606

interleukin-8 secretion

19688109

HgeneNOS2

GO:1900015

regulation of cytokine production involved in inflammatory response

19688109


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A4OH-01ANOS2chr17

26125726

-MYO18Achr17

27449271

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313735ENST00000354329NOS2chr17

26125726

-MYO18Achr17

27449271

-
5CDS-intronENST00000313735ENST00000529578NOS2chr17

26125726

-MYO18Achr17

27449271

-
5CDS-intronENST00000313735ENST00000533112NOS2chr17

26125726

-MYO18Achr17

27449271

-
5CDS-intronENST00000313735ENST00000531253NOS2chr17

26125726

-MYO18Achr17

27449271

-
5CDS-intronENST00000313735ENST00000527372NOS2chr17

26125726

-MYO18Achr17

27449271

-

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FusionProtFeatures for NOS2_MYO18A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOS2

P35228

MYO18A

Q92614

May link Golgi membranes to the cytoskeleton andparticipate in the tensile force required for vesicle budding fromthe Golgi. Thereby, may play a role in Golgi membrane traffickingand could indirectly give its flattened shape to the Golgiapparatus (PubMed:19837035, PubMed:23345592). Alternatively, inconcert with LURAP1 and CDC42BPA/CDC42BPB, has been involved inmodulating lamellar actomyosin retrograde flow that is crucial tocell protrusion and migration (PubMed:18854160). May be involvedin the maintenance of the stromal cell architectures required forcell to cell contact (By similarity). Regulates trafficking,expression, and activation of innate immune receptors onmacrophages. Plays a role to suppress inflammatory responsivenessof macrophages via a mechanism that modulates CD14 trafficking(PubMed:25965346). Acts as a receptor of surfactant-associatedprotein A (SFTPA1/SP-A) and plays an important role ininternalization and clearance of SFTPA1-opsonized S.aureus byalveolar macrophages (PubMed:16087679, PubMed:21123169). Stronglyenhances natural killer cell cytotoxicity (PubMed:27467939).{ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679,ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035,ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592,ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOS2_MYO18A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOS2_MYO18A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOS2CAV1, SLC9A3R1, RAC2, RAC1, SPSB1, SPSB4, SPSB2, TCEB1, CUL5, UCHL5, STUB1, CALM1, PEX5, YWHAE, YWHAG, YWHAQ, YWHAZ, PPP2R1A, SLC3A2, SLC25A5, AIFM1, AKR1B10, ALDH1A1, ASPH, ATP2A2, C1QBP, HSPD1, DDX3X, DNAJA1, DNAJA2, DNAJC7, EMD, FASN, HSPA9, HSPA5, HKDC1, HNRNPF, HSPH1, HSP90AA1, HSP90AB1, HSPA2, HSPA4, HSPB1, HUWE1, KPNB1, KRT18, SLC7A5, SLC25A3, NAP1L1, NPM1, PCBP1, PRKDC, PSMC6, PSMC1, PSMC3, PSMC4, PSMC2, PSMC5, PSMA1, PSMA2, PSMA3, PSMA5, PSMA6, PSMA7, PSMB7, PSMD11, PSMD12, PSMD13, PSMD7, PSMD2, PSMD3, PSMD6, PSMD8, CAD, RCN1, RPL23, RPL31, RPL5, RPL7, HNRNPA1, RPS17, RPS18, RPS3A, RPS3, RPS4X, SNRPB, RUVBL2, SKP1, SQRDL, SSBP1, SSR4, STIP1, TCP1, CCT2, CCT4, CCT5, CCT3, CCT7, CCT8, CCT6A, VCP, TIMM50, YBX1, CALU, TCEB2, FAT1, HERC1, CLNS1A, MYCBP2, QPCTL, ALDH3B1, BAG2, CDIPT, DICER1, DNAJA3, LGALS3BP, PARP4, PPM1B, PPP6C, PSMD14, PSMD4, RCN2, TUBB6, TNFAIP2, COPRS, FBXO45, HSPA6, ICAM1, ZSWIM8, KRT8, KRT81, NOS2, SERPINE1, AGR2, XRCC5, NME2, PCBP2, PLEC, PSMA4, PTPLAD1, PTBP1, TRIM21, SNRPD3, SMN1, STRAP, PTGES3MYO18AGRB2, ARAF, MARK4, CUL4B, ATXN1, PAN2, ENO1, SHMT2, MOV10, NXF1, YIF1B, DDRGK1, LIMS1, LRFN4, PYCR2, UPK3B, RCN1, SEPT1, SP6, CDKL4, FIG4, SLC30A6, SPC25, UQCRB, YEATS4, DDX46, DIEXF, PUF60, SMARCA4, ACTA1, ACTB, ACTG1, ACTN4, AP2A1, ANXA2, DST, CALM1, CAPZA1, CAPZA2, CAPZB, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CSNK1A1, DAB2, DAPK3, DBN1, DSG2, CTTN, FLII, FLNA, FLNB, FYN, GSN, HMGB2, ABLIM1, LMO7, MYO1B, MYH9, MYL6, MYO1C, MYO1E, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, PIK3C2A, PLEC, PPP1CA, PPP1CB, TWF1, RANGAP1, SPTAN1, SPTBN1, SPTBN2, SSFA2, ST5, SVIL, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, PICALM, SORBS2, LRRFIP2, TJP2, CDC42BPB, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, BASP1, DCTN2, MYL12A, DSTN, TRIOBP, AKAP2, SYNPO, CEP162, LIMCH1, SIPA1L3, MPRIP, COBL, SPECC1L, FBXO46, CORO1C, CCRN4L, PLEKHG3, RAI14, TES, TMOD3, LIMA1, BMP2K, MYO5C, CORO1B, KIAA1211, CGN, MICAL3, ARHGAP21, AFAP1, INF2, EFHD2, CYBRD1, MYO19, ARPC5L, KCTD10, LZTS2, STON2, SSH2, PHLDB2, NEXN, SPECC1, MISP, MYL6B, PPP1R18, TPRN, DDX51, CDK2, IQGAP1, PLK2, ANLN, GAN, MYL3, RPL15, PATL1, HBZ, NOX4, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOS2_MYO18A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNOS2P35228DB08814TriflusalNitric oxide synthase, induciblesmall moleculeapproved|investigational
HgeneNOS2P35228DB01110MiconazoleNitric oxide synthase, induciblesmall moleculeapproved|investigational|vet_approved
HgeneNOS2P35228DB01234DexamethasoneNitric oxide synthase, induciblesmall moleculeapproved|investigational|vet_approved
HgeneNOS2P35228DB00125L-ArginineNitric oxide synthase, induciblesmall moleculeapproved|nutraceutical

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RelatedDiseases for NOS2_MYO18A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOS2C0011570Mental Depression5PSYGENET
HgeneNOS2C0011581Depressive disorder5PSYGENET
HgeneNOS2C0027055Myocardial Reperfusion Injury5CTD_human
HgeneNOS2C0035126Reperfusion Injury4CTD_human
HgeneNOS2C0020538Hypertensive disease3CTD_human
HgeneNOS2C0038358Gastric ulcer3CTD_human
HgeneNOS2C0007786Brain Ischemia2CTD_human
HgeneNOS2C0008370Cholestasis2CTD_human
HgeneNOS2C0009319Colitis2CTD_human
HgeneNOS2C0009375Colonic Neoplasms2CTD_human
HgeneNOS2C0011853Diabetes Mellitus, Experimental2CTD_human
HgeneNOS2C0013295Duodenal Ulcer2CTD_human
HgeneNOS2C0020429Hyperalgesia2CTD_human
HgeneNOS2C0021368Inflammation2CTD_human
HgeneNOS2C0024121Lung Neoplasms2CTD_human
HgeneNOS2C0027051Myocardial Infarction2CTD_human
HgeneNOS2C0027540Necrosis2CTD_human
HgeneNOS2C0243026Sepsis2CTD_human
HgeneNOS2C0677050Manganese Poisoning2CTD_human
HgeneNOS2C0003872Arthritis, Psoriatic1CTD_human
HgeneNOS2C0003949Asbestosis1CTD_human
HgeneNOS2C0004096Asthma1CTD_human
HgeneNOS2C0004153Atherosclerosis1CTD_human
HgeneNOS2C0004352Autistic Disorder1CTD_human
HgeneNOS2C0006261Bronchial Diseases1CTD_human
HgeneNOS2C0007621Neoplastic Cell Transformation1CTD_human
HgeneNOS2C0008313Cholangitis, Sclerosing1CTD_human
HgeneNOS2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneNOS2C0013990Pathological accumulation of air in tissues1CTD_human
HgeneNOS2C0014859Esophageal Neoplasms1CTD_human
HgeneNOS2C0017668Focal glomerulosclerosis1CTD_human
HgeneNOS2C0018801Heart failure1CTD_human
HgeneNOS2C0020452Hyperemia1CTD_human
HgeneNOS2C0020672Hypothermia, natural1CTD_human
HgeneNOS2C0021831Intestinal Diseases1CTD_human
HgeneNOS2C0022658Kidney Diseases1CTD_human
HgeneNOS2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneNOS2C0023895Liver diseases1CTD_human
HgeneNOS2C0024117Chronic Obstructive Airway Disease1CTD_human
HgeneNOS2C0024796Marfan Syndrome1CTD_human
HgeneNOS2C0026936Mycoplasma Infections1CTD_human
HgeneNOS2C0032290Aspiration Pneumonia1CTD_human
HgeneNOS2C0033860Psoriasis1CTD_human
HgeneNOS2C0035309Retinal Diseases1CTD_human
HgeneNOS2C0036330Schistosomiasis mansoni1CTD_human
HgeneNOS2C0036572Seizures1CTD_human
HgeneNOS2C0036983Septic Shock1CTD_human
HgeneNOS2C0037116Silicosis1CTD_human
HgeneNOS2C0038220Status Epilepticus1CTD_human
HgeneNOS2C0038325Stevens-Johnson Syndrome1CTD_human
HgeneNOS2C0038454Cerebrovascular accident1CTD_human
HgeneNOS2C0038525Subarachnoid Hemorrhage1CTD_human
HgeneNOS2C0038587Substance Withdrawal Syndrome1CTD_human
HgeneNOS2C0039263Takayasu Arteritis1CTD_human
HgeneNOS2C0041408Turner Syndrome1CTD_human
HgeneNOS2C0042029Urinary tract infection1CTD_human
HgeneNOS2C0206146Myocardial Stunning1CTD_human
HgeneNOS2C0206698Cholangiocarcinoma1CTD_human
HgeneNOS2C0243050Cardiovascular Abnormalities1CTD_human
HgeneNOS2C0376618Endotoxemia1CTD_human
HgeneNOS2C0520459Necrotizing Enterocolitis1CTD_human
HgeneNOS2C0751651Mitochondrial Diseases1CTD_human
HgeneNOS2C0752308Hypoxia-Ischemia, Brain1CTD_human
HgeneNOS2C1458155Mammary Neoplasms1CTD_human
HgeneNOS2C1527311Brain Edema1CTD_human
HgeneNOS2C2609414Acute kidney injury1CTD_human