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Fusion gene ID: 24609 |
FusionGeneSummary for NOS1AP_MROH9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOS1AP_MROH9 | Fusion gene ID: 24609 | Hgene | Tgene | Gene symbol | NOS1AP | MROH9 | Gene ID | 9722 | 80133 |
| Gene name | nitric oxide synthase 1 adaptor protein | maestro heat like repeat family member 9 | |
| Synonyms | 6330408P19Rik|CAPON | ARMC11|C1orf129 | |
| Cytomap | 1q23.3 | 1q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with car | maestro heat-like repeat-containing protein family member 9armadillo repeat containing 11 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | O75052 | Q5TGP6 | |
| Ensembl transtripts involved in fusion gene | ENST00000530878, ENST00000361897, ENST00000493151, ENST00000454693, | ENST00000367759, ENST00000367758, | |
| Fusion gene scores | * DoF score | 12 X 8 X 7=672 | 2 X 2 X 2=8 |
| # samples | 14 | 2 | |
| ** MAII score | log2(14/672*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NOS1AP [Title/Abstract] AND MROH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A0YG-01A | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000530878 | ENST00000367759 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| 5CDS-intron | ENST00000530878 | ENST00000367758 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| In-frame | ENST00000361897 | ENST00000367759 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| 5CDS-intron | ENST00000361897 | ENST00000367758 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| intron-3CDS | ENST00000493151 | ENST00000367759 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| intron-intron | ENST00000493151 | ENST00000367758 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| intron-3CDS | ENST00000454693 | ENST00000367759 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
| intron-intron | ENST00000454693 | ENST00000367758 | NOS1AP | chr1 | 162302915 | + | MROH9 | chr1 | 170983258 | + |
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FusionProtFeatures for NOS1AP_MROH9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOS1AP | MROH9 |
| Adapter protein involved in neuronal nitric-oxide (NO)synthesis regulation via its association with nNOS/NOS1. Thecomplex formed with NOS1 and synapsins is necessary for specificNO and synapsin functions at a presynaptic level. Mediates anindirect interaction between NOS1 and RASD1 leading to enhance theability of NOS1 to activate RASD1. Competes with DLG4 forinteraction with NOS1, possibly affecting NOS1 activity byregulating the interaction between NOS1 and DLG4 (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367758 | + | 0 | 15 | 118_155 | -33 | 574 | Repeat | Note=HEAT 1 |
| Tgene | >MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367758 | + | 0 | 15 | 252_289 | -33 | 574 | Repeat | Note=HEAT 2 |
| Tgene | >MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367758 | + | 0 | 15 | 292_328 | -33 | 574 | Repeat | Note=HEAT 3 |
| Tgene | >MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367758 | + | 0 | 15 | 357_394 | -33 | 574 | Repeat | Note=HEAT 4 |
| Tgene | >MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367758 | + | 0 | 15 | 418_458 | -33 | 574 | Repeat | Note=HEAT 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000361897 | + | 5 | 10 | 322_363 | 151 | 507 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000493151 | + | 1 | 2 | 322_363 | -789 | 212 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000530878 | + | 5 | 10 | 322_363 | 146 | 502 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000361897 | + | 5 | 10 | 301_308 | 151 | 507 | Compositional bias | Note=Poly-Gln |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000493151 | + | 1 | 2 | 301_308 | -789 | 212 | Compositional bias | Note=Poly-Gln |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000530878 | + | 5 | 10 | 301_308 | 146 | 502 | Compositional bias | Note=Poly-Gln |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000361897 | + | 5 | 10 | 26_196 | 151 | 507 | Domain | PID |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000493151 | + | 1 | 2 | 26_196 | -789 | 212 | Domain | PID |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000530878 | + | 5 | 10 | 26_196 | 146 | 502 | Domain | PID |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000361897 | + | 5 | 10 | 504_506 | 151 | 507 | Motif | PDZ-binding |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000493151 | + | 1 | 2 | 504_506 | -789 | 212 | Motif | PDZ-binding |
| Hgene | >NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000530878 | + | 5 | 10 | 504_506 | 146 | 502 | Motif | PDZ-binding |
| Tgene | MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367759 | + | 14 | 22 | 118_155 | 532 | 862 | Repeat | Note=HEAT 1 |
| Tgene | MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367759 | + | 14 | 22 | 252_289 | 532 | 862 | Repeat | Note=HEAT 2 |
| Tgene | MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367759 | + | 14 | 22 | 292_328 | 532 | 862 | Repeat | Note=HEAT 3 |
| Tgene | MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367759 | + | 14 | 22 | 357_394 | 532 | 862 | Repeat | Note=HEAT 4 |
| Tgene | MROH9 | chr1:162302915 | chr1:170983258 | ENST00000367759 | + | 14 | 22 | 418_458 | 532 | 862 | Repeat | Note=HEAT 5 |
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FusionGeneSequence for NOS1AP_MROH9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NOS1AP_ENST00000530878_chr1_162302915_+_MROH9_ENST00000367759_chr1_170983258_+_476aa MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKK KKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKLLNNFFKDPLPEEFLVLFINWINDSNPVVSRLIL HRIVHMSPIINKTENVSSILIAILDAFLSKDDNVVLQALLTLRRLLNELDKVTYSLGTRIGSSYCTLMDHINGGIRSMAIRHFGQLVRDM RQYTWMVNDVVLEGLVPLILFLEDDDKRVAEACKYTLKICTSQLKWSTSRLLKDENYSFEMVVLNICNNLIISHRNYITDLTSDTLRFLW SPRTYLKRASVILIGYLAKSGGHLLLRDEIEVMLDVIERLLRDEDPMIKQLAEITYDIFKKKAHKLTSAPLKQNFQKLLKLFYIKKLKPL >In-frame_NOS1AP_ENST00000361897_chr1_162302915_+_MROH9_ENST00000367759_chr1_170983258_+_481aa MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKK LLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKLLNNFFKDPLPEEFLVLFINWINDSNPVV SRLILHRIVHMSPIINKTENVSSILIAILDAFLSKDDNVVLQALLTLRRLLNELDKVTYSLGTRIGSSYCTLMDHINGGIRSMAIRHFGQ LVRDMRQYTWMVNDVVLEGLVPLILFLEDDDKRVAEACKYTLKICTSQLKWSTSRLLKDENYSFEMVVLNICNNLIISHRNYITDLTSDT LRFLWSPRTYLKRASVILIGYLAKSGGHLLLRDEIEVMLDVIERLLRDEDPMIKQLAEITYDIFKKKAHKLTSAPLKQNFQKLLKLFYIK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NOS1AP_ENST00000530878_chr1_162302915_+_MROH9_ENST00000367759_chr1_170983258_+_1428nt ATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATC TGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTAT GAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAG AAAAAGGAATGGACGTGGGATGAGAGCAAGATGCTGGTGATGCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGAC TTGAAGATCTTCAGCTATATCGCTCGAGATGGTGCCAGCAATATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGCTTCTGAATAAC TTCTTCAAGGACCCTTTACCAGAAGAATTTTTGGTCCTCTTCATAAACTGGATCAATGATTCCAATCCTGTAGTTAGCAGACTGATCCTT CATAGAATTGTCCACATGTCACCAATTATCAATAAGACAGAAAATGTCAGCAGTATATTAATAGCCATCCTGGATGCCTTCCTTTCCAAA GACGATAATGTTGTACTTCAGGCCTTGCTCACCCTTAGAAGGCTTTTAAACGAACTGGACAAAGTGACCTACTCTTTGGGTACCAGAATT GGTTCCAGCTACTGTACTCTGATGGATCATATTAATGGAGGCATTCGAAGTATGGCAATTCGACACTTTGGTCAATTAGTTAGGGATATG AGACAGTACACATGGATGGTGAATGATGTGGTTCTAGAAGGCTTGGTGCCCCTAATCCTATTTTTGGAGGATGATGATAAAAGAGTAGCT GAAGCATGTAAATATACATTAAAAATCTGTACCTCACAATTAAAGTGGTCAACATCACGTTTGCTCAAAGATGAAAATTACAGTTTTGAG ATGGTGGTGCTCAATATCTGTAACAATCTTATTATTTCTCATAGGAACTACATTACAGATTTGACATCTGATACCTTACGATTCCTGTGG AGCCCCAGAACATATCTTAAGAGGGCATCGGTTATTTTGATAGGATATTTGGCAAAATCAGGTGGTCATTTACTGCTTAGAGATGAAATC GAAGTCATGCTTGATGTTATTGAACGACTGCTCCGAGATGAAGACCCTATGATCAAACAGTTGGCTGAAATAACCTATGATATTTTTAAG AAAAAAGCCCATAAACTGACCTCTGCACCTCTTAAACAAAACTTCCAAAAATTGCTTAAATTATTCTACATCAAAAAATTGAAGCCTCTT >In-frame_NOS1AP_ENST00000361897_chr1_162302915_+_MROH9_ENST00000367759_chr1_170983258_+_1443nt ATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATC TGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTAT GAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAG CTTCTTTTATTGCAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATGCTGGTGATGCAGGACCCCATCTACAGGATCTTCTATGTCTCT CATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGTGCCAGCAATATCTTCAGGTGTAACGTCTTTAAATCCAAGAAG AAGCTTCTGAATAACTTCTTCAAGGACCCTTTACCAGAAGAATTTTTGGTCCTCTTCATAAACTGGATCAATGATTCCAATCCTGTAGTT AGCAGACTGATCCTTCATAGAATTGTCCACATGTCACCAATTATCAATAAGACAGAAAATGTCAGCAGTATATTAATAGCCATCCTGGAT GCCTTCCTTTCCAAAGACGATAATGTTGTACTTCAGGCCTTGCTCACCCTTAGAAGGCTTTTAAACGAACTGGACAAAGTGACCTACTCT TTGGGTACCAGAATTGGTTCCAGCTACTGTACTCTGATGGATCATATTAATGGAGGCATTCGAAGTATGGCAATTCGACACTTTGGTCAA TTAGTTAGGGATATGAGACAGTACACATGGATGGTGAATGATGTGGTTCTAGAAGGCTTGGTGCCCCTAATCCTATTTTTGGAGGATGAT GATAAAAGAGTAGCTGAAGCATGTAAATATACATTAAAAATCTGTACCTCACAATTAAAGTGGTCAACATCACGTTTGCTCAAAGATGAA AATTACAGTTTTGAGATGGTGGTGCTCAATATCTGTAACAATCTTATTATTTCTCATAGGAACTACATTACAGATTTGACATCTGATACC TTACGATTCCTGTGGAGCCCCAGAACATATCTTAAGAGGGCATCGGTTATTTTGATAGGATATTTGGCAAAATCAGGTGGTCATTTACTG CTTAGAGATGAAATCGAAGTCATGCTTGATGTTATTGAACGACTGCTCCGAGATGAAGACCCTATGATCAAACAGTTGGCTGAAATAACC TATGATATTTTTAAGAAAAAAGCCCATAAACTGACCTCTGCACCTCTTAAACAAAACTTCCAAAAATTGCTTAAATTATTCTACATCAAA AAATTGAAGCCTCTTTACAATTATAACTCACCCAATGGCCAGATAGACAGTCCTACAGACAGTAAAGATGTCAAGAATGATAAGGCCTTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NOS1AP_ENST00000530878_chr1_162302915_+_MROH9_ENST00000367759_chr1_170983258_+_2257nt ACCGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCC ACCGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGC GACCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCA GGGCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTC CTGCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACC TGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCA ACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGG TTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATGCTGGTGATGCAGG ACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGTGCCAGCAATATCT TCAGGTGTAACGTCTTTAAATCCAAGAAGAAGCTTCTGAATAACTTCTTCAAGGACCCTTTACCAGAAGAATTTTTGGTCCTCTTCATAA ACTGGATCAATGATTCCAATCCTGTAGTTAGCAGACTGATCCTTCATAGAATTGTCCACATGTCACCAATTATCAATAAGACAGAAAATG TCAGCAGTATATTAATAGCCATCCTGGATGCCTTCCTTTCCAAAGACGATAATGTTGTACTTCAGGCCTTGCTCACCCTTAGAAGGCTTT TAAACGAACTGGACAAAGTGACCTACTCTTTGGGTACCAGAATTGGTTCCAGCTACTGTACTCTGATGGATCATATTAATGGAGGCATTC GAAGTATGGCAATTCGACACTTTGGTCAATTAGTTAGGGATATGAGACAGTACACATGGATGGTGAATGATGTGGTTCTAGAAGGCTTGG TGCCCCTAATCCTATTTTTGGAGGATGATGATAAAAGAGTAGCTGAAGCATGTAAATATACATTAAAAATCTGTACCTCACAATTAAAGT GGTCAACATCACGTTTGCTCAAAGATGAAAATTACAGTTTTGAGATGGTGGTGCTCAATATCTGTAACAATCTTATTATTTCTCATAGGA ACTACATTACAGATTTGACATCTGATACCTTACGATTCCTGTGGAGCCCCAGAACATATCTTAAGAGGGCATCGGTTATTTTGATAGGAT ATTTGGCAAAATCAGGTGGTCATTTACTGCTTAGAGATGAAATCGAAGTCATGCTTGATGTTATTGAACGACTGCTCCGAGATGAAGACC CTATGATCAAACAGTTGGCTGAAATAACCTATGATATTTTTAAGAAAAAAGCCCATAAACTGACCTCTGCACCTCTTAAACAAAACTTCC AAAAATTGCTTAAATTATTCTACATCAAAAAATTGAAGCCTCTTTACAATTATAACTCACCCAATGGCCAGATAGACAGTCCTACAGACA GTAAAGATGTCAAGAATGATAAGGCCTTATAGAAGAGAATGATGATGACATTCATCATTCATAAACAATGGGAAGTCCAACAATGTCTTG GAGCTGACCTTAGAAGAAGAATGATTTTTCTTTCCCTCCTGACAACTTGAGTCTGTTTGTAGATGCTTTTCTGAAAAATTCTGGAAGCTT TTACTGTTACTTCTTAATTCTCTATTCAAATATAGAAATCTGAGAGAACTAGTGCCTCTGTATGTCTGACAGTGATCAGAAGCCCTATTT CATCAAAACCACTAAGACAATTGAAAATAACATAAGCAAAGTGTTTGATGAGAAGCTCTGGGAACTTGATTCAGTCCGGAAGCTCTACTG AGCACCTTCTAAGTGCCAGATACTGTGTTAGGCAGTGGGGACATTTGGATGATATAGACAAGGTTCCTGATCTCAGGATGGGCACAGTCT >In-frame_NOS1AP_ENST00000361897_chr1_162302915_+_MROH9_ENST00000367759_chr1_170983258_+_2270nt CGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCCAC CGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGCGA CCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCAGG GCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTCCT GCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTG CGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAAC AGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTT TCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGCTTCTTTTATTGCAGAAAAAGGAATGGACGTGGGATGAGAGCAAGATG CTGGTGATGCAGGACCCCATCTACAGGATCTTCTATGTCTCTCATGATTCCCAAGACTTGAAGATCTTCAGCTATATCGCTCGAGATGGT GCCAGCAATATCTTCAGGTGTAACGTCTTTAAATCCAAGAAGAAGCTTCTGAATAACTTCTTCAAGGACCCTTTACCAGAAGAATTTTTG GTCCTCTTCATAAACTGGATCAATGATTCCAATCCTGTAGTTAGCAGACTGATCCTTCATAGAATTGTCCACATGTCACCAATTATCAAT AAGACAGAAAATGTCAGCAGTATATTAATAGCCATCCTGGATGCCTTCCTTTCCAAAGACGATAATGTTGTACTTCAGGCCTTGCTCACC CTTAGAAGGCTTTTAAACGAACTGGACAAAGTGACCTACTCTTTGGGTACCAGAATTGGTTCCAGCTACTGTACTCTGATGGATCATATT AATGGAGGCATTCGAAGTATGGCAATTCGACACTTTGGTCAATTAGTTAGGGATATGAGACAGTACACATGGATGGTGAATGATGTGGTT CTAGAAGGCTTGGTGCCCCTAATCCTATTTTTGGAGGATGATGATAAAAGAGTAGCTGAAGCATGTAAATATACATTAAAAATCTGTACC TCACAATTAAAGTGGTCAACATCACGTTTGCTCAAAGATGAAAATTACAGTTTTGAGATGGTGGTGCTCAATATCTGTAACAATCTTATT ATTTCTCATAGGAACTACATTACAGATTTGACATCTGATACCTTACGATTCCTGTGGAGCCCCAGAACATATCTTAAGAGGGCATCGGTT ATTTTGATAGGATATTTGGCAAAATCAGGTGGTCATTTACTGCTTAGAGATGAAATCGAAGTCATGCTTGATGTTATTGAACGACTGCTC CGAGATGAAGACCCTATGATCAAACAGTTGGCTGAAATAACCTATGATATTTTTAAGAAAAAAGCCCATAAACTGACCTCTGCACCTCTT AAACAAAACTTCCAAAAATTGCTTAAATTATTCTACATCAAAAAATTGAAGCCTCTTTACAATTATAACTCACCCAATGGCCAGATAGAC AGTCCTACAGACAGTAAAGATGTCAAGAATGATAAGGCCTTATAGAAGAGAATGATGATGACATTCATCATTCATAAACAATGGGAAGTC CAACAATGTCTTGGAGCTGACCTTAGAAGAAGAATGATTTTTCTTTCCCTCCTGACAACTTGAGTCTGTTTGTAGATGCTTTTCTGAAAA ATTCTGGAAGCTTTTACTGTTACTTCTTAATTCTCTATTCAAATATAGAAATCTGAGAGAACTAGTGCCTCTGTATGTCTGACAGTGATC AGAAGCCCTATTTCATCAAAACCACTAAGACAATTGAAAATAACATAAGCAAAGTGTTTGATGAGAAGCTCTGGGAACTTGATTCAGTCC GGAAGCTCTACTGAGCACCTTCTAAGTGCCAGATACTGTGTTAGGCAGTGGGGACATTTGGATGATATAGACAAGGTTCCTGATCTCAGG |
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FusionGenePPI for NOS1AP_MROH9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NOS1AP | LRP2, LRP1, LRP8, RASD1, SYN1, SYN2, SYN3, NOS1, APP, TRAF4, FAM133A, EAF1, AP2M1, AKNAD1, NHP2, NKAP, CT45A5, RYBP, CKM, FYN, HSPD1, PLAGL2, PNP, BTRC, XPO1, PCNA, RAB5C, RALA, SNCA, YWHAH, PRPF4, TOMM40, RNPS1, NAF1, KLC3, PTPRH, PTPRJ, C11orf57, ZCCHC17, DDX41, MDK, PLK1, SREK1IP1, GPR156, C1orf186, AKAP17A, PNN, PIP4K2A, OIP5, CAMKV, TRPC4AP | MROH9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000361897 | + | 5 | 10 | 494_506 | 151 | 507 | NOS1 |
| Hgene | NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000493151 | + | 1 | 2 | 494_506 | -789 | 212 | NOS1 |
| Hgene | NOS1AP | chr1:162302915 | chr1:170983258 | ENST00000530878 | + | 5 | 10 | 494_506 | 146 | 502 | NOS1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOS1AP_MROH9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOS1AP_MROH9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NOS1AP | C0036341 | Schizophrenia | 2 | PSYGENET |
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