|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 24602 |
FusionGeneSummary for NOS1AP_ATF6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NOS1AP_ATF6 | Fusion gene ID: 24602 | Hgene | Tgene | Gene symbol | NOS1AP | ATF6 | Gene ID | 9722 | 22926 |
| Gene name | nitric oxide synthase 1 adaptor protein | activating transcription factor 6 | |
| Synonyms | 6330408P19Rik|CAPON | ACHM7|ATF6A | |
| Cytomap | 1q23.3 | 1q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with car | cyclic AMP-dependent transcription factor ATF-6 alphacAMP-dependent transcription factor ATF-6 alpha | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | O75052 | P18850 | |
| Ensembl transtripts involved in fusion gene | ENST00000530878, ENST00000361897, ENST00000493151, ENST00000454693, | ENST00000367942, ENST00000476437, | |
| Fusion gene scores | * DoF score | 12 X 8 X 7=672 | 8 X 7 X 7=392 |
| # samples | 14 | 11 | |
| ** MAII score | log2(14/672*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/392*10)=-1.83335013059055 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NOS1AP [Title/Abstract] AND ATF6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATF6 | GO:0043065 | positive regulation of apoptotic process | 14752510 |
| Tgene | ATF6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14973138 |
| Tgene | ATF6 | GO:1903893 | positive regulation of ATF6-mediated unfolded protein response | 9837962 |
| Tgene | ATF6 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 11163209|11256944|16469704 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-NJ-A4YF-01A | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| TCGA | RV | UCEC | TCGA-FI-A3PX-01A | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| TCGA | RV | UCEC | TCGA-DF-A2KR-01A | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000530878 | ENST00000367942 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| 5CDS-intron | ENST00000530878 | ENST00000476437 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| Frame-shift | ENST00000361897 | ENST00000367942 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| 5CDS-intron | ENST00000361897 | ENST00000476437 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| intron-3CDS | ENST00000493151 | ENST00000367942 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| intron-intron | ENST00000493151 | ENST00000476437 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| intron-3CDS | ENST00000454693 | ENST00000367942 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| intron-intron | ENST00000454693 | ENST00000476437 | NOS1AP | chr1 | 162040072 | + | ATF6 | chr1 | 161928236 | + |
| In-frame | ENST00000530878 | ENST00000367942 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| 5CDS-intron | ENST00000530878 | ENST00000476437 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| In-frame | ENST00000361897 | ENST00000367942 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| 5CDS-intron | ENST00000361897 | ENST00000476437 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| intron-3CDS | ENST00000493151 | ENST00000367942 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| intron-intron | ENST00000493151 | ENST00000476437 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| intron-3CDS | ENST00000454693 | ENST00000367942 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
| intron-intron | ENST00000454693 | ENST00000476437 | NOS1AP | chr1 | 162257226 | + | ATF6 | chr1 | 161789423 | + |
Top |
FusionProtFeatures for NOS1AP_ATF6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NOS1AP | ATF6 |
| Adapter protein involved in neuronal nitric-oxide (NO)synthesis regulation via its association with nNOS/NOS1. Thecomplex formed with NOS1 and synapsins is necessary for specificNO and synapsin functions at a presynaptic level. Mediates anindirect interaction between NOS1 and RASD1 leading to enhance theability of NOS1 to activate RASD1. Competes with DLG4 forinteraction with NOS1, possibly affecting NOS1 activity byregulating the interaction between NOS1 and DLG4 (By similarity).{ECO:0000250}. | Transmembrane glycoprotein of the endoplasmic reticulumthat functions as a transcription activator and initiates theunfolded protein response (UPR) during endoplasmic reticulumstress. Cleaved upon ER stress, the N-terminal processed cyclicAMP-dependent transcription factor ATF-6 alpha translocates to thenucleus where it activates transcription of genes involved in theUPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress responseelement (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y toERSE. Could also be involved in activation of transcription by theserum response factor. May play a role in foveal development andcone function in the retina. {ECO:0000269|PubMed:10564271,ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464,ECO:0000269|PubMed:26029869}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 325_328 | 303 | 671 | Compositional bias | Note=Poly-Lys |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 463_466 | 303 | 671 | Compositional bias | Note=Poly-Pro |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 306_369 | 303 | 671 | Domain | bZIP |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 308_339 | 303 | 671 | Region | Note=Basic motif |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 348_355 | 303 | 671 | Region | Note=Leucine-zipper |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 399_670 | 303 | 671 | Topological domain | Lumenal |
| Tgene | >ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 378_398 | 303 | 671 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000361897 | + | 3 | 10 | 322_363 | 90 | 507 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000493151 | + | 1 | 2 | 322_363 | -789 | 212 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000530878 | + | 3 | 10 | 322_363 | 90 | 502 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000361897 | + | 3 | 10 | 301_308 | 90 | 507 | Compositional bias | Note=Poly-Gln |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000493151 | + | 1 | 2 | 301_308 | -789 | 212 | Compositional bias | Note=Poly-Gln |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000530878 | + | 3 | 10 | 301_308 | 90 | 502 | Compositional bias | Note=Poly-Gln |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000361897 | + | 3 | 10 | 26_196 | 90 | 507 | Domain | PID |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000493151 | + | 1 | 2 | 26_196 | -789 | 212 | Domain | PID |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000530878 | + | 3 | 10 | 26_196 | 90 | 502 | Domain | PID |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000361897 | + | 3 | 10 | 504_506 | 90 | 507 | Motif | PDZ-binding |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000493151 | + | 1 | 2 | 504_506 | -789 | 212 | Motif | PDZ-binding |
| Hgene | >NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000530878 | + | 3 | 10 | 504_506 | 90 | 502 | Motif | PDZ-binding |
| Tgene | ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 124_127 | 303 | 671 | Compositional bias | Note=Poly-Ser |
| Tgene | ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 1_150 | 303 | 671 | Region | Note=Transcription activation |
| Tgene | ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 1_377 | 303 | 671 | Topological domain | Cytoplasmic |
Top |
FusionGeneSequence for NOS1AP_ATF6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NOS1AP_ENST00000530878_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_458aa MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKK IAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYG PMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHEL RGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRR DHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVS >In-frame_NOS1AP_ENST00000361897_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_458aa MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKK IAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYG PMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHEL RGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRR DHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NOS1AP_ENST00000530878_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_1374nt ATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATC TGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTAT GAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAG ATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAATCCGCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGG TTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGAAGAAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTG TCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTGTCTGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGA CCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTGTGAGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCT AAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCTACAGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTG CTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGCCCCTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTT CGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAAGAATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCT CTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAGAAACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAA GTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCATCCGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGG GATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGACCAAAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAAT GTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTCAGGTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTT CCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCTTTGGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGC >In-frame_NOS1AP_ENST00000361897_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_1374nt ATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATC TGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTAT GAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAG ATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAATCCGCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGG TTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGAAGAAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTG TCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTGTCTGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGA CCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTGTGAGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCT AAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCTACAGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTG CTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGCCCCTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTT CGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAAGAATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCT CTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAGAAACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAA GTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCATCCGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGG GATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGACCAAAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAAT GTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTCAGGTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTT CCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCTTTGGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NOS1AP_ENST00000530878_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_7194nt ACCGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCC ACCGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGC GACCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCA GGGCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTC CTGCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACC TGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCA ACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGG TTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAAT CCGCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGGTTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGA AGAAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTGTCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTG TCTGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGACCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTG TGAGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCTAAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCT ACAGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTGCTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGC CCCTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTTCGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAA GAATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCTCTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAG AAACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAAGTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCA TCCGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGGGATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGAC CAAAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAATGTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTC AGGTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTTCCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCT TTGGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGCACCATCCCTGAGTCATTACAATAGCACCCTGCAGCTATGCTGGAAA ACTGAGCGTGGGACCCTGCCAGACTGAAGAGCAGGTGAGCAAAATGCTGCTTTCTGCCTTGGTGGCAGGCAGAGAACTGTCTCGTACTAG AATTCAAGGAGGAAAGAAGAAGAAATAAAAGAAGCTGCTCCATTTTTCATCATCTACCCATCTATTTGGAAAGCACTGGAATTCAGATGC AAGAGAACAATGTTTCTTCAGTGGCAAATGTAGCCCTGCATCCTCCAGTGTTACCTGGTGTAGATTTTTTTTTCTGTACCTTTCTAAACC TCTCTTCCCTCTGTGATGGTTTTGTGTTTAAACAGTCATCTTCTTTTAAATAATATCCACCTCTCCTTTTTGCCATTTCACTTATTGATT CATAAAGTGAATTTTATTTAAAGCTATGCCACACATGCATGTTCAAATGGTTTCCACTGATTCGATTTTTCATTCATTTAATGCAAACCC ATTCTGGATATTGTGCTTATTTGAGAAAACACATTTCAAAACCAGAAAAGCCAAAAACACTCCAAAAACAAGCAAAACAATTTGGAGCTT TAGATAAAAGGAAAAACTCCCAGTTGGTAAAGTTTATCTTTACTTAGGATTTGTGGCTCACACCTAAACAAAGGGGGTCAGGGAGTGGGT ACAAATTTGAGAAAATAGAAGGGTAAGGGAAGGGCCAGTGGTGGGGTTTGGAGAGAGGAGATAGCTCCATTAATACACATGTTTAAAAGA TGGAAAGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCAAGACCATCCCGGCTAAAAC GGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGACGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCA GGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGT CTCAAAAAAAAAAAAAAAAAAAAAAAAAGATGGAAAGTTCGATGTGACTGCAGTATGAGATTAAAGCCACAACTATTGTTTATTTTGGGG ACTCTAGGCCACCAAGTATTAGCACACATACTTATGTTTTCTCTACTAATCTGGTCCAGGTCCTCATGGACCACAGGACAAAGCTTTCAT TTTCATTCATTCTTCTATTGAAATTATACCAAATTCAGCTGAGGAATATGGAAGTAACTTTAGACTTAAACAAGACAAAAGTTTTTTCAC TGAAGAATTGACAAGTATTTGCTCCTTAAAACAACGCAGATTAGTGAACGTGGATTCCTGCTGAGGGAGTGCATCCCATAATATGGCAAT AATTTTCAGTTTCTCCAACGAAAAGATAGTGAAGGAATTAAATCTTTTGTCCTCCCATGGTTAAAAAAAAAAAAAAAGCTGTGTTCATTT TTACTGTACTATGCCTCTTTTTTCACCATAGTAGACAATTATGTTTCATTTGATGAATTCATAGAACTGGATCTCATACAGCGATGTCCT CTCTAATGTTCTACCTTTCAGTTTCTAAAGTGAGTCTTCCTCCCTCTCCTACAAAACTTTTCAATTTTTTGATGTAACTCATCTACAAAT ACTGTTTCTTACCCCAGTTGACTTGCCTTTGTCAGATTTCTTCTTGTTCCACACTATAGCAATCAATTTCTCTTCTTCCTTACAAGAAAG GGAACGAGAAATTGTAGCAACCTCTCAAGGATTATATGCAGCTAGTTAGTTTTCTGCCTGTGAAATTAGGTCTGGCTCCTAAATAATTTT AAAGAACCATCAGCACTTCTAACTCTCTGGACAGGTGCCTCTTTGTCCAAGCTAGTTAAATGCTTTCCAAGGAAATCAGTTCAACTTTTG TGAGCGGGGAAAAGCAGGGCTTTATTGTTGTGTTACCTGGGAGTCTGGAGTTTGAAAAGTGCTAATTAACCTTCCTCTTTTTCCACATTA CAAACCTTTTTAAGCAGCGCAGCACTCCCCTTAGATTTGGCTATCCTGGGTGATTTTCAGACAAGAACCATTTTCTCTGGGGACCATTCT TCTGCTGGGTGCCAAGGAATATAAGGCAAATGCCCAGAAGACCTTCAGGTGACTGGGCAGTCTTATCATGGGATATTTCTTCTGGCCCTG CCCCTTCCCATTCTGTAATGTGAATTAGCCACACCAGAGGCTGTGACCATGGCTAGTAGACAGTGGCAACATAGTCATCCCCAAGATGCT AATCTTCTGCTGGAACTGTCATACGTTATCATGGTCAATGTAAACCTGGTTTGTGTGGGGTGATTATAAATAGAGTTTCCCTCCTCTCTG TGACAGAATCACAGGAGAAGGACCCATCTCGTGGCCTTCTTGTTCTTAGCGCTTCACTTTTACTTCATCCCTCGATTCCCAGCTTTTTCT ATCATCATTTTGCCAACTCCTCAGATGCAAGACTTTGGTTATGTCATACTCACCAACGTTAGTCCCTCTCTTCCAGGTGAAAAGGTGGGT AGCGGTTGGGAGGGAGTCTCCACTGAAGAGCAGGAAGGTGGTAGCAGGGCCGGCAGCTCTGCCACAGAGCTAGGGGTGCCTGTAAGGTGC CGCCTAGAGCAGCCTGGGAGCTTTGCCTTCTTTTGTCTCTCACTAGCCCTTCTACTCTTTGTCATTGCCTGTTCTTGAGTGGATCTTTGA AATGAGGGGACAGGATTCTCCTAAGGGTAGAGTTTCAGGAAATGAGTGAAAGGCAATTGACAAATGCAAAGAAGTAGTCACTTTTTAAAT TGCTGGCAAAGCTATAATTAATCCCTAGGCACAATTGTAGTTTTTATTTTAATGTTTGTATGCACAAGGCCCTTTAGGAAATGAGAAGTT GCCATGCCAGATTAATTTTTTTTTTTTTTTTTGGTGGGATTGCCTTTTGGGGGTTGCAGCCAGAAATTGTGGGTAATGTGTGTATTTTTT TATTTATTAAATTTTAAACAGGATTGTGCAAGCTTATGAGACAATTAGATAAACTCATGGAGGAGGCAGGTCCTCCTGTTATTAGATGAT TTTGTGCTCTTGGGGCTGACAATAATACACTCTTGGGAAGTGATGGTAGAGACTGATGGGAATAGTCTTTCTGCCTGGTTGCAAGTCCCA AATTTTTAAGGGTTAATGGAAGTAAGTGGATGTTTCCTCATGTTAACTACTGAATCAGATGTTAGGAGCTTGTCCCTTTGGGGTTGACTT ATGCCCAGCAGTACAGGGACACAGCTTCATTAGAGTGTTAGTGTAAACTAACTCCAAAGTTAGGAGTTAATGTGAAAGGATCATCCTTGA AACAAATCTGCTGTTTGCCATGCTTGTAGTACAGAAACTTCACATGGAGTTTTGGGTGGGATTTGTGTTTTCACAAGTAAAAAATCCCTC ACGATTATAAAACTCAGAGCATCATCTAATTTTTTTTTTTAATGACTACAAGTTCCAGCACAAAACTGGCATTTCTTTGCCATTTCTTGC CAGTAAGAAGTTGACACGGAGGTATTTGAAAGCAATGTTATGTGAGTCATTCTTAAGTGTTCCAAGTAAGTTTAGAAACAGAAAAGGAAC TTGGGATTCAAATTGATTTTTCAAATCATTTTTAAAGAGACATCATCCTGACTAAATCTTAGCCTGAACCTTCCTCCCCTGTGTGTATTC CCCGGTAGTCACCGCAGCGAGATGCTGGTGAGACTGCCGTGGTGGCATTTAGCATCGTTAAAACTGGAAAACTCTCAAGCTCTTTGCCAC TTTCCTACTATTTTTTGATTCTTGCCATTTTACCAAGCTTAGGTTGTGAAACTTGACAGAAATGTATTACAGGAAAAACTTATAATTGTA TTTGACTTTCTAACACATTGCAAAGTTTCAAAGTGACTTTCACTTTCAACAACATATTAGAAGTAACCACTTTTGCTTTCACAGCCTGAA GAGTTAGAGCCTGATCTGATGCCCCCTTTCACTCTGAAGTCATGGGAAATTTTCCAGCCATGAAAGCCCTCTTTCCACTGCATACTGATG GGCTGACTCAGCTTCCTTCAGCCGACTGAGATCTTTTCATACTATTGGCTATTTCATACCAATTAACCTCTTAAATAAGATTGTGAATTG CCAAAATTGATAGACACTTATTACCACCTGTGGACTCCATATTCCTTACCACAAATGTTATTTTCATCAGTCCTGAGTCATTTTAACTTA CAGAAATTAGGATTGTTGCTGCTAATATGAATACCAATTATAACTTTTAGAAACAAGAATAAAGCCTAAAAGAGAATGAAATATAAGAAA TGTTCGTTCCCACCCCTAATAACATTTGGAAGTGAATATTCCCATTTTCTTCCACCCACAGGGATTGGGATTGATTTTTAATTTCCTAGG AAACAATACTAGACTACCCAAAAAGATGTTGCCAGAATCCAAAAGGAACTATGCTCGTAAAAGAAATGCAGTTTTCTCCTACCTAAAAAA AAGAAAGTAAAGTGTGTTCTGTTCTTATCTTTTTAATGACTAAGCTTTAAACAGTTTATTTTGGGTAAGACTAGAACTTTCGGCCATTTG TTCTAATATGTGTGTTATTAGATGCAATAGAATTTATGAAAAGAAGAATGACAAAGGTATCTGATTAGAAAATTTGATCTTACGCATGAA TCCATGTCATGGCCAGCCACTGTCACATAGTGGGTGCCATTCTCAACATATTGGTTTGCTAACTTTAAGCATTAGGGATTTAGCACACTA AAATACTTTTAATTATATTAGGTTTGGTAACTAAGGAGTAAATAAATCATAATTTATCATTTGCCAAGGCCAACAAACAACACTATTGTG CTGTTTGCTCTCAATGAAGTTGAATAAACCAGGAGGCTTGGCATATCCCCTTTATGTTAATCCCAGCTAGAGATTAGTAGGTTGACTTTC ACAGCAATTGTATATTGATCCATTTTAACTCATCCTTGCCATAATTTCCAGGCCAGTCACCAGGACAGAGGAGATGATGGGGAAACAGAG CTTTAGATGAAAACTACTATGCACTACTAGCCTTAGAGGCACTGGTTTCCTGTTACCACTTTGGCAAGTATGGATGGTCTAAGTCCAGTA GGGCTTCATCCATGGAGCCATTAGAACTGAGGGGGGAGTGTTAGAGATGCCATTTCACCAGGATCTTTTTGCTCAGGTTGTACCCATGCC AATTGAAGAACGTGTTAAAGATGAGGAGGAGAGATGTACCATTCTCTCCCTTAATAATGATGTTGGTTTGCAAAACCTAAAGAAATAATA >In-frame_NOS1AP_ENST00000361897_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_7192nt CGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCCAC CGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGCGA CCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCAGG GCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTCCT GCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTG CGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAAC AGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTT TCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAATCC GCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGGTTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGAAG AAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTGTCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTGTC TGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGACCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTGTG AGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCTAAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCTAC AGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTGCTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGCCC CTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTTCGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAAGA ATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCTCTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAGAA ACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAAGTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCATC CGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGGGATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGACCA AAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAATGTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTCAG GTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTTCCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCTTT GGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGCACCATCCCTGAGTCATTACAATAGCACCCTGCAGCTATGCTGGAAAAC TGAGCGTGGGACCCTGCCAGACTGAAGAGCAGGTGAGCAAAATGCTGCTTTCTGCCTTGGTGGCAGGCAGAGAACTGTCTCGTACTAGAA TTCAAGGAGGAAAGAAGAAGAAATAAAAGAAGCTGCTCCATTTTTCATCATCTACCCATCTATTTGGAAAGCACTGGAATTCAGATGCAA GAGAACAATGTTTCTTCAGTGGCAAATGTAGCCCTGCATCCTCCAGTGTTACCTGGTGTAGATTTTTTTTTCTGTACCTTTCTAAACCTC TCTTCCCTCTGTGATGGTTTTGTGTTTAAACAGTCATCTTCTTTTAAATAATATCCACCTCTCCTTTTTGCCATTTCACTTATTGATTCA TAAAGTGAATTTTATTTAAAGCTATGCCACACATGCATGTTCAAATGGTTTCCACTGATTCGATTTTTCATTCATTTAATGCAAACCCAT TCTGGATATTGTGCTTATTTGAGAAAACACATTTCAAAACCAGAAAAGCCAAAAACACTCCAAAAACAAGCAAAACAATTTGGAGCTTTA GATAAAAGGAAAAACTCCCAGTTGGTAAAGTTTATCTTTACTTAGGATTTGTGGCTCACACCTAAACAAAGGGGGTCAGGGAGTGGGTAC AAATTTGAGAAAATAGAAGGGTAAGGGAAGGGCCAGTGGTGGGGTTTGGAGAGAGGAGATAGCTCCATTAATACACATGTTTAAAAGATG GAAAGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCAAGACCATCCCGGCTAAAACGG TGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGACGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGG AGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCT CAAAAAAAAAAAAAAAAAAAAAAAAAGATGGAAAGTTCGATGTGACTGCAGTATGAGATTAAAGCCACAACTATTGTTTATTTTGGGGAC TCTAGGCCACCAAGTATTAGCACACATACTTATGTTTTCTCTACTAATCTGGTCCAGGTCCTCATGGACCACAGGACAAAGCTTTCATTT TCATTCATTCTTCTATTGAAATTATACCAAATTCAGCTGAGGAATATGGAAGTAACTTTAGACTTAAACAAGACAAAAGTTTTTTCACTG AAGAATTGACAAGTATTTGCTCCTTAAAACAACGCAGATTAGTGAACGTGGATTCCTGCTGAGGGAGTGCATCCCATAATATGGCAATAA TTTTCAGTTTCTCCAACGAAAAGATAGTGAAGGAATTAAATCTTTTGTCCTCCCATGGTTAAAAAAAAAAAAAAAGCTGTGTTCATTTTT ACTGTACTATGCCTCTTTTTTCACCATAGTAGACAATTATGTTTCATTTGATGAATTCATAGAACTGGATCTCATACAGCGATGTCCTCT CTAATGTTCTACCTTTCAGTTTCTAAAGTGAGTCTTCCTCCCTCTCCTACAAAACTTTTCAATTTTTTGATGTAACTCATCTACAAATAC TGTTTCTTACCCCAGTTGACTTGCCTTTGTCAGATTTCTTCTTGTTCCACACTATAGCAATCAATTTCTCTTCTTCCTTACAAGAAAGGG AACGAGAAATTGTAGCAACCTCTCAAGGATTATATGCAGCTAGTTAGTTTTCTGCCTGTGAAATTAGGTCTGGCTCCTAAATAATTTTAA AGAACCATCAGCACTTCTAACTCTCTGGACAGGTGCCTCTTTGTCCAAGCTAGTTAAATGCTTTCCAAGGAAATCAGTTCAACTTTTGTG AGCGGGGAAAAGCAGGGCTTTATTGTTGTGTTACCTGGGAGTCTGGAGTTTGAAAAGTGCTAATTAACCTTCCTCTTTTTCCACATTACA AACCTTTTTAAGCAGCGCAGCACTCCCCTTAGATTTGGCTATCCTGGGTGATTTTCAGACAAGAACCATTTTCTCTGGGGACCATTCTTC TGCTGGGTGCCAAGGAATATAAGGCAAATGCCCAGAAGACCTTCAGGTGACTGGGCAGTCTTATCATGGGATATTTCTTCTGGCCCTGCC CCTTCCCATTCTGTAATGTGAATTAGCCACACCAGAGGCTGTGACCATGGCTAGTAGACAGTGGCAACATAGTCATCCCCAAGATGCTAA TCTTCTGCTGGAACTGTCATACGTTATCATGGTCAATGTAAACCTGGTTTGTGTGGGGTGATTATAAATAGAGTTTCCCTCCTCTCTGTG ACAGAATCACAGGAGAAGGACCCATCTCGTGGCCTTCTTGTTCTTAGCGCTTCACTTTTACTTCATCCCTCGATTCCCAGCTTTTTCTAT CATCATTTTGCCAACTCCTCAGATGCAAGACTTTGGTTATGTCATACTCACCAACGTTAGTCCCTCTCTTCCAGGTGAAAAGGTGGGTAG CGGTTGGGAGGGAGTCTCCACTGAAGAGCAGGAAGGTGGTAGCAGGGCCGGCAGCTCTGCCACAGAGCTAGGGGTGCCTGTAAGGTGCCG CCTAGAGCAGCCTGGGAGCTTTGCCTTCTTTTGTCTCTCACTAGCCCTTCTACTCTTTGTCATTGCCTGTTCTTGAGTGGATCTTTGAAA TGAGGGGACAGGATTCTCCTAAGGGTAGAGTTTCAGGAAATGAGTGAAAGGCAATTGACAAATGCAAAGAAGTAGTCACTTTTTAAATTG CTGGCAAAGCTATAATTAATCCCTAGGCACAATTGTAGTTTTTATTTTAATGTTTGTATGCACAAGGCCCTTTAGGAAATGAGAAGTTGC CATGCCAGATTAATTTTTTTTTTTTTTTTTGGTGGGATTGCCTTTTGGGGGTTGCAGCCAGAAATTGTGGGTAATGTGTGTATTTTTTTA TTTATTAAATTTTAAACAGGATTGTGCAAGCTTATGAGACAATTAGATAAACTCATGGAGGAGGCAGGTCCTCCTGTTATTAGATGATTT TGTGCTCTTGGGGCTGACAATAATACACTCTTGGGAAGTGATGGTAGAGACTGATGGGAATAGTCTTTCTGCCTGGTTGCAAGTCCCAAA TTTTTAAGGGTTAATGGAAGTAAGTGGATGTTTCCTCATGTTAACTACTGAATCAGATGTTAGGAGCTTGTCCCTTTGGGGTTGACTTAT GCCCAGCAGTACAGGGACACAGCTTCATTAGAGTGTTAGTGTAAACTAACTCCAAAGTTAGGAGTTAATGTGAAAGGATCATCCTTGAAA CAAATCTGCTGTTTGCCATGCTTGTAGTACAGAAACTTCACATGGAGTTTTGGGTGGGATTTGTGTTTTCACAAGTAAAAAATCCCTCAC GATTATAAAACTCAGAGCATCATCTAATTTTTTTTTTTAATGACTACAAGTTCCAGCACAAAACTGGCATTTCTTTGCCATTTCTTGCCA GTAAGAAGTTGACACGGAGGTATTTGAAAGCAATGTTATGTGAGTCATTCTTAAGTGTTCCAAGTAAGTTTAGAAACAGAAAAGGAACTT GGGATTCAAATTGATTTTTCAAATCATTTTTAAAGAGACATCATCCTGACTAAATCTTAGCCTGAACCTTCCTCCCCTGTGTGTATTCCC CGGTAGTCACCGCAGCGAGATGCTGGTGAGACTGCCGTGGTGGCATTTAGCATCGTTAAAACTGGAAAACTCTCAAGCTCTTTGCCACTT TCCTACTATTTTTTGATTCTTGCCATTTTACCAAGCTTAGGTTGTGAAACTTGACAGAAATGTATTACAGGAAAAACTTATAATTGTATT TGACTTTCTAACACATTGCAAAGTTTCAAAGTGACTTTCACTTTCAACAACATATTAGAAGTAACCACTTTTGCTTTCACAGCCTGAAGA GTTAGAGCCTGATCTGATGCCCCCTTTCACTCTGAAGTCATGGGAAATTTTCCAGCCATGAAAGCCCTCTTTCCACTGCATACTGATGGG CTGACTCAGCTTCCTTCAGCCGACTGAGATCTTTTCATACTATTGGCTATTTCATACCAATTAACCTCTTAAATAAGATTGTGAATTGCC AAAATTGATAGACACTTATTACCACCTGTGGACTCCATATTCCTTACCACAAATGTTATTTTCATCAGTCCTGAGTCATTTTAACTTACA GAAATTAGGATTGTTGCTGCTAATATGAATACCAATTATAACTTTTAGAAACAAGAATAAAGCCTAAAAGAGAATGAAATATAAGAAATG TTCGTTCCCACCCCTAATAACATTTGGAAGTGAATATTCCCATTTTCTTCCACCCACAGGGATTGGGATTGATTTTTAATTTCCTAGGAA ACAATACTAGACTACCCAAAAAGATGTTGCCAGAATCCAAAAGGAACTATGCTCGTAAAAGAAATGCAGTTTTCTCCTACCTAAAAAAAA GAAAGTAAAGTGTGTTCTGTTCTTATCTTTTTAATGACTAAGCTTTAAACAGTTTATTTTGGGTAAGACTAGAACTTTCGGCCATTTGTT CTAATATGTGTGTTATTAGATGCAATAGAATTTATGAAAAGAAGAATGACAAAGGTATCTGATTAGAAAATTTGATCTTACGCATGAATC CATGTCATGGCCAGCCACTGTCACATAGTGGGTGCCATTCTCAACATATTGGTTTGCTAACTTTAAGCATTAGGGATTTAGCACACTAAA ATACTTTTAATTATATTAGGTTTGGTAACTAAGGAGTAAATAAATCATAATTTATCATTTGCCAAGGCCAACAAACAACACTATTGTGCT GTTTGCTCTCAATGAAGTTGAATAAACCAGGAGGCTTGGCATATCCCCTTTATGTTAATCCCAGCTAGAGATTAGTAGGTTGACTTTCAC AGCAATTGTATATTGATCCATTTTAACTCATCCTTGCCATAATTTCCAGGCCAGTCACCAGGACAGAGGAGATGATGGGGAAACAGAGCT TTAGATGAAAACTACTATGCACTACTAGCCTTAGAGGCACTGGTTTCCTGTTACCACTTTGGCAAGTATGGATGGTCTAAGTCCAGTAGG GCTTCATCCATGGAGCCATTAGAACTGAGGGGGGAGTGTTAGAGATGCCATTTCACCAGGATCTTTTTGCTCAGGTTGTACCCATGCCAA TTGAAGAACGTGTTAAAGATGAGGAGGAGAGATGTACCATTCTCTCCCTTAATAATGATGTTGGTTTGCAAAACCTAAAGAAATAATAAC |
Top |
FusionGenePPI for NOS1AP_ATF6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NOS1AP | LRP2, LRP1, LRP8, RASD1, SYN1, SYN2, SYN3, NOS1, APP, TRAF4, FAM133A, EAF1, AP2M1, AKNAD1, NHP2, NKAP, CT45A5, RYBP, CKM, FYN, HSPD1, PLAGL2, PNP, BTRC, XPO1, PCNA, RAB5C, RALA, SNCA, YWHAH, PRPF4, TOMM40, RNPS1, NAF1, KLC3, PTPRH, PTPRJ, C11orf57, ZCCHC17, DDX41, MDK, PLK1, SREK1IP1, GPR156, C1orf186, AKAP17A, PNN, PIP4K2A, OIP5, CAMKV, TRPC4AP | ATF6 | GTF2I, YY1, ATF6, ATF6B, NFYA, NFYC, SRF, CREB1, SREBF2, WFS1, SYVN1, UBC, SP1, APP, XBP1, BPGM, DDC, NNMT, TNFRSF1A, FBXO6, MAPK14, HLA-E, ERLEC1, APOD, SH3TC1, RFWD2, STK40, ACLY, PARG, PCDH20, CDH5, PCDHAC1, PCDHB11, GABRD, CLEC3A, CLEC2D, CD300E, OS9, MGAT4C, PCDHB16, LRRN2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ATF6 | chr1:162257226 | chr1:161789423 | ENST00000367942 | + | 6 | 16 | 468_589 | 303 | 671 | THBS4 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000361897 | + | 3 | 10 | 494_506 | 90 | 507 | NOS1 |
| Hgene | NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000493151 | + | 1 | 2 | 494_506 | -789 | 212 | NOS1 |
| Hgene | NOS1AP | chr1:162257226 | chr1:161789423 | ENST00000530878 | + | 3 | 10 | 494_506 | 90 | 502 | NOS1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NOS1AP_ATF6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NOS1AP_ATF6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NOS1AP | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | ATF6 | C0003949 | Asbestosis | 1 | CTD_human |
| Tgene | ATF6 | C0009398 | Color vision defect | 1 | CTD_human |
| Tgene | ATF6 | C0022336 | Creutzfeldt-Jakob disease | 1 | CTD_human |
| Tgene | ATF6 | C0035334 | Retinitis Pigmentosa | 1 | CTD_human |
| Tgene | ATF6 | C0036457 | Scrapie | 1 | CTD_human |
| Tgene | ATF6 | C0085636 | Photophobia | 1 | CTD_human;HPO |
| Tgene | ATF6 | C0700501 | Congenital nystagmus | 1 | CTD_human |
| Tgene | ATF6 | C4225297 | ACHROMATOPSIA 7 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|