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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 24602

FusionGeneSummary for NOS1AP_ATF6

check button Fusion gene summary
Fusion gene informationFusion gene name: NOS1AP_ATF6
Fusion gene ID: 24602
HgeneTgene
Gene symbol

NOS1AP

ATF6

Gene ID

9722

22926

Gene namenitric oxide synthase 1 adaptor proteinactivating transcription factor 6
Synonyms6330408P19Rik|CAPONACHM7|ATF6A
Cytomap

1q23.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptioncarboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinC-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)C-terminal PDZ ligand of neuronal nitric oxide synthase proteinligand of neuronal nitric oxide synthase with carcyclic AMP-dependent transcription factor ATF-6 alphacAMP-dependent transcription factor ATF-6 alpha
Modification date2018051920180522
UniProtAcc

O75052

P18850

Ensembl transtripts involved in fusion geneENST00000530878, ENST00000361897, 
ENST00000493151, ENST00000454693, 
ENST00000367942, ENST00000476437, 
Fusion gene scores* DoF score12 X 8 X 7=6728 X 7 X 7=392
# samples 1411
** MAII scorelog2(14/672*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/392*10)=-1.83335013059055
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOS1AP [Title/Abstract] AND ATF6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATF6

GO:0043065

positive regulation of apoptotic process

14752510

TgeneATF6

GO:0045944

positive regulation of transcription by RNA polymerase II

14973138

TgeneATF6

GO:1903893

positive regulation of ATF6-mediated unfolded protein response

9837962

TgeneATF6

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

11163209|11256944|16469704


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-NJ-A4YF-01ANOS1APchr1

162040072

+ATF6chr1

161928236

+
TCGARVUCECTCGA-FI-A3PX-01ANOS1APchr1

162257226

+ATF6chr1

161789423

+
TCGARVUCECTCGA-DF-A2KR-01ANOS1APchr1

162040072

+ATF6chr1

161928236

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000530878ENST00000367942NOS1APchr1

162040072

+ATF6chr1

161928236

+
5CDS-intronENST00000530878ENST00000476437NOS1APchr1

162040072

+ATF6chr1

161928236

+
Frame-shiftENST00000361897ENST00000367942NOS1APchr1

162040072

+ATF6chr1

161928236

+
5CDS-intronENST00000361897ENST00000476437NOS1APchr1

162040072

+ATF6chr1

161928236

+
intron-3CDSENST00000493151ENST00000367942NOS1APchr1

162040072

+ATF6chr1

161928236

+
intron-intronENST00000493151ENST00000476437NOS1APchr1

162040072

+ATF6chr1

161928236

+
intron-3CDSENST00000454693ENST00000367942NOS1APchr1

162040072

+ATF6chr1

161928236

+
intron-intronENST00000454693ENST00000476437NOS1APchr1

162040072

+ATF6chr1

161928236

+
In-frameENST00000530878ENST00000367942NOS1APchr1

162257226

+ATF6chr1

161789423

+
5CDS-intronENST00000530878ENST00000476437NOS1APchr1

162257226

+ATF6chr1

161789423

+
In-frameENST00000361897ENST00000367942NOS1APchr1

162257226

+ATF6chr1

161789423

+
5CDS-intronENST00000361897ENST00000476437NOS1APchr1

162257226

+ATF6chr1

161789423

+
intron-3CDSENST00000493151ENST00000367942NOS1APchr1

162257226

+ATF6chr1

161789423

+
intron-intronENST00000493151ENST00000476437NOS1APchr1

162257226

+ATF6chr1

161789423

+
intron-3CDSENST00000454693ENST00000367942NOS1APchr1

162257226

+ATF6chr1

161789423

+
intron-intronENST00000454693ENST00000476437NOS1APchr1

162257226

+ATF6chr1

161789423

+

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FusionProtFeatures for NOS1AP_ATF6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOS1AP

O75052

ATF6

P18850

Adapter protein involved in neuronal nitric-oxide (NO)synthesis regulation via its association with nNOS/NOS1. Thecomplex formed with NOS1 and synapsins is necessary for specificNO and synapsin functions at a presynaptic level. Mediates anindirect interaction between NOS1 and RASD1 leading to enhance theability of NOS1 to activate RASD1. Competes with DLG4 forinteraction with NOS1, possibly affecting NOS1 activity byregulating the interaction between NOS1 and DLG4 (By similarity).{ECO:0000250}. Transmembrane glycoprotein of the endoplasmic reticulumthat functions as a transcription activator and initiates theunfolded protein response (UPR) during endoplasmic reticulumstress. Cleaved upon ER stress, the N-terminal processed cyclicAMP-dependent transcription factor ATF-6 alpha translocates to thenucleus where it activates transcription of genes involved in theUPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress responseelement (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y toERSE. Could also be involved in activation of transcription by theserum response factor. May play a role in foveal development andcone function in the retina. {ECO:0000269|PubMed:10564271,ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464,ECO:0000269|PubMed:26029869}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616325_328303671Compositional biasNote=Poly-Lys
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616463_466303671Compositional biasNote=Poly-Pro
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616306_369303671DomainbZIP
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616308_339303671RegionNote=Basic motif
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616348_355303671RegionNote=Leucine-zipper
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616399_670303671Topological domainLumenal
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616378_398303671TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNOS1APchr1:162257226chr1:161789423ENST00000361897+310322_36390507Coiled coilOntology_term=ECO:0000255
HgeneNOS1APchr1:162257226chr1:161789423ENST00000493151+12322_363-789212Coiled coilOntology_term=ECO:0000255
HgeneNOS1APchr1:162257226chr1:161789423ENST00000530878+310322_36390502Coiled coilOntology_term=ECO:0000255
HgeneNOS1APchr1:162257226chr1:161789423ENST00000361897+310301_30890507Compositional biasNote=Poly-Gln
HgeneNOS1APchr1:162257226chr1:161789423ENST00000493151+12301_308-789212Compositional biasNote=Poly-Gln
HgeneNOS1APchr1:162257226chr1:161789423ENST00000530878+310301_30890502Compositional biasNote=Poly-Gln
HgeneNOS1APchr1:162257226chr1:161789423ENST00000361897+31026_19690507DomainPID
HgeneNOS1APchr1:162257226chr1:161789423ENST00000493151+1226_196-789212DomainPID
HgeneNOS1APchr1:162257226chr1:161789423ENST00000530878+31026_19690502DomainPID
HgeneNOS1APchr1:162257226chr1:161789423ENST00000361897+310504_50690507MotifPDZ-binding
HgeneNOS1APchr1:162257226chr1:161789423ENST00000493151+12504_506-789212MotifPDZ-binding
HgeneNOS1APchr1:162257226chr1:161789423ENST00000530878+310504_50690502MotifPDZ-binding
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616124_127303671Compositional biasNote=Poly-Ser
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+6161_150303671RegionNote=Transcription activation
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+6161_377303671Topological domainCytoplasmic


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FusionGeneSequence for NOS1AP_ATF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NOS1AP_ENST00000530878_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_458aa
MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKK
IAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYG
PMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHEL
RGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRR
DHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVS

>In-frame_NOS1AP_ENST00000361897_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_458aa
MPSKTKYNLVDDGHDLRIPLHNEDAFQHGICFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKK
IAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYG
PMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHEL
RGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRR
DHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NOS1AP_ENST00000530878_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_1374nt
ATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATC
TGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTAT
GAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAG
ATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAATCCGCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGG
TTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGAAGAAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTG
TCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTGTCTGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGA
CCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTGTGAGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCT
AAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCTACAGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTG
CTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGCCCCTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTT
CGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAAGAATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCT
CTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAGAAACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAA
GTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCATCCGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGG
GATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGACCAAAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAAT
GTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTCAGGTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTT
CCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCTTTGGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGC

>In-frame_NOS1AP_ENST00000361897_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_1374nt
ATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATC
TGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTAT
GAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAG
ATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAATCCGCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGG
TTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGAAGAAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTG
TCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTGTCTGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGA
CCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTGTGAGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCT
AAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCTACAGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTG
CTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGCCCCTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTT
CGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAAGAATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCT
CTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAGAAACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAA
GTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCATCCGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGG
GATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGACCAAAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAAT
GTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTCAGGTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTT
CCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCTTTGGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NOS1AP_ENST00000530878_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_7194nt
ACCGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCC
ACCGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGC
GACCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCA
GGGCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTC
CTGCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACC
TGCGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCA
ACAGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGG
TTTCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAAT
CCGCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGGTTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGA
AGAAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTGTCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTG
TCTGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGACCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTG
TGAGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCTAAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCT
ACAGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTGCTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGC
CCCTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTTCGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAA
GAATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCTCTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAG
AAACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAAGTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCA
TCCGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGGGATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGAC
CAAAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAATGTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTC
AGGTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTTCCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCT
TTGGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGCACCATCCCTGAGTCATTACAATAGCACCCTGCAGCTATGCTGGAAA
ACTGAGCGTGGGACCCTGCCAGACTGAAGAGCAGGTGAGCAAAATGCTGCTTTCTGCCTTGGTGGCAGGCAGAGAACTGTCTCGTACTAG
AATTCAAGGAGGAAAGAAGAAGAAATAAAAGAAGCTGCTCCATTTTTCATCATCTACCCATCTATTTGGAAAGCACTGGAATTCAGATGC
AAGAGAACAATGTTTCTTCAGTGGCAAATGTAGCCCTGCATCCTCCAGTGTTACCTGGTGTAGATTTTTTTTTCTGTACCTTTCTAAACC
TCTCTTCCCTCTGTGATGGTTTTGTGTTTAAACAGTCATCTTCTTTTAAATAATATCCACCTCTCCTTTTTGCCATTTCACTTATTGATT
CATAAAGTGAATTTTATTTAAAGCTATGCCACACATGCATGTTCAAATGGTTTCCACTGATTCGATTTTTCATTCATTTAATGCAAACCC
ATTCTGGATATTGTGCTTATTTGAGAAAACACATTTCAAAACCAGAAAAGCCAAAAACACTCCAAAAACAAGCAAAACAATTTGGAGCTT
TAGATAAAAGGAAAAACTCCCAGTTGGTAAAGTTTATCTTTACTTAGGATTTGTGGCTCACACCTAAACAAAGGGGGTCAGGGAGTGGGT
ACAAATTTGAGAAAATAGAAGGGTAAGGGAAGGGCCAGTGGTGGGGTTTGGAGAGAGGAGATAGCTCCATTAATACACATGTTTAAAAGA
TGGAAAGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCAAGACCATCCCGGCTAAAAC
GGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGACGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCA
GGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGT
CTCAAAAAAAAAAAAAAAAAAAAAAAAAGATGGAAAGTTCGATGTGACTGCAGTATGAGATTAAAGCCACAACTATTGTTTATTTTGGGG
ACTCTAGGCCACCAAGTATTAGCACACATACTTATGTTTTCTCTACTAATCTGGTCCAGGTCCTCATGGACCACAGGACAAAGCTTTCAT
TTTCATTCATTCTTCTATTGAAATTATACCAAATTCAGCTGAGGAATATGGAAGTAACTTTAGACTTAAACAAGACAAAAGTTTTTTCAC
TGAAGAATTGACAAGTATTTGCTCCTTAAAACAACGCAGATTAGTGAACGTGGATTCCTGCTGAGGGAGTGCATCCCATAATATGGCAAT
AATTTTCAGTTTCTCCAACGAAAAGATAGTGAAGGAATTAAATCTTTTGTCCTCCCATGGTTAAAAAAAAAAAAAAAGCTGTGTTCATTT
TTACTGTACTATGCCTCTTTTTTCACCATAGTAGACAATTATGTTTCATTTGATGAATTCATAGAACTGGATCTCATACAGCGATGTCCT
CTCTAATGTTCTACCTTTCAGTTTCTAAAGTGAGTCTTCCTCCCTCTCCTACAAAACTTTTCAATTTTTTGATGTAACTCATCTACAAAT
ACTGTTTCTTACCCCAGTTGACTTGCCTTTGTCAGATTTCTTCTTGTTCCACACTATAGCAATCAATTTCTCTTCTTCCTTACAAGAAAG
GGAACGAGAAATTGTAGCAACCTCTCAAGGATTATATGCAGCTAGTTAGTTTTCTGCCTGTGAAATTAGGTCTGGCTCCTAAATAATTTT
AAAGAACCATCAGCACTTCTAACTCTCTGGACAGGTGCCTCTTTGTCCAAGCTAGTTAAATGCTTTCCAAGGAAATCAGTTCAACTTTTG
TGAGCGGGGAAAAGCAGGGCTTTATTGTTGTGTTACCTGGGAGTCTGGAGTTTGAAAAGTGCTAATTAACCTTCCTCTTTTTCCACATTA
CAAACCTTTTTAAGCAGCGCAGCACTCCCCTTAGATTTGGCTATCCTGGGTGATTTTCAGACAAGAACCATTTTCTCTGGGGACCATTCT
TCTGCTGGGTGCCAAGGAATATAAGGCAAATGCCCAGAAGACCTTCAGGTGACTGGGCAGTCTTATCATGGGATATTTCTTCTGGCCCTG
CCCCTTCCCATTCTGTAATGTGAATTAGCCACACCAGAGGCTGTGACCATGGCTAGTAGACAGTGGCAACATAGTCATCCCCAAGATGCT
AATCTTCTGCTGGAACTGTCATACGTTATCATGGTCAATGTAAACCTGGTTTGTGTGGGGTGATTATAAATAGAGTTTCCCTCCTCTCTG
TGACAGAATCACAGGAGAAGGACCCATCTCGTGGCCTTCTTGTTCTTAGCGCTTCACTTTTACTTCATCCCTCGATTCCCAGCTTTTTCT
ATCATCATTTTGCCAACTCCTCAGATGCAAGACTTTGGTTATGTCATACTCACCAACGTTAGTCCCTCTCTTCCAGGTGAAAAGGTGGGT
AGCGGTTGGGAGGGAGTCTCCACTGAAGAGCAGGAAGGTGGTAGCAGGGCCGGCAGCTCTGCCACAGAGCTAGGGGTGCCTGTAAGGTGC
CGCCTAGAGCAGCCTGGGAGCTTTGCCTTCTTTTGTCTCTCACTAGCCCTTCTACTCTTTGTCATTGCCTGTTCTTGAGTGGATCTTTGA
AATGAGGGGACAGGATTCTCCTAAGGGTAGAGTTTCAGGAAATGAGTGAAAGGCAATTGACAAATGCAAAGAAGTAGTCACTTTTTAAAT
TGCTGGCAAAGCTATAATTAATCCCTAGGCACAATTGTAGTTTTTATTTTAATGTTTGTATGCACAAGGCCCTTTAGGAAATGAGAAGTT
GCCATGCCAGATTAATTTTTTTTTTTTTTTTTGGTGGGATTGCCTTTTGGGGGTTGCAGCCAGAAATTGTGGGTAATGTGTGTATTTTTT
TATTTATTAAATTTTAAACAGGATTGTGCAAGCTTATGAGACAATTAGATAAACTCATGGAGGAGGCAGGTCCTCCTGTTATTAGATGAT
TTTGTGCTCTTGGGGCTGACAATAATACACTCTTGGGAAGTGATGGTAGAGACTGATGGGAATAGTCTTTCTGCCTGGTTGCAAGTCCCA
AATTTTTAAGGGTTAATGGAAGTAAGTGGATGTTTCCTCATGTTAACTACTGAATCAGATGTTAGGAGCTTGTCCCTTTGGGGTTGACTT
ATGCCCAGCAGTACAGGGACACAGCTTCATTAGAGTGTTAGTGTAAACTAACTCCAAAGTTAGGAGTTAATGTGAAAGGATCATCCTTGA
AACAAATCTGCTGTTTGCCATGCTTGTAGTACAGAAACTTCACATGGAGTTTTGGGTGGGATTTGTGTTTTCACAAGTAAAAAATCCCTC
ACGATTATAAAACTCAGAGCATCATCTAATTTTTTTTTTTAATGACTACAAGTTCCAGCACAAAACTGGCATTTCTTTGCCATTTCTTGC
CAGTAAGAAGTTGACACGGAGGTATTTGAAAGCAATGTTATGTGAGTCATTCTTAAGTGTTCCAAGTAAGTTTAGAAACAGAAAAGGAAC
TTGGGATTCAAATTGATTTTTCAAATCATTTTTAAAGAGACATCATCCTGACTAAATCTTAGCCTGAACCTTCCTCCCCTGTGTGTATTC
CCCGGTAGTCACCGCAGCGAGATGCTGGTGAGACTGCCGTGGTGGCATTTAGCATCGTTAAAACTGGAAAACTCTCAAGCTCTTTGCCAC
TTTCCTACTATTTTTTGATTCTTGCCATTTTACCAAGCTTAGGTTGTGAAACTTGACAGAAATGTATTACAGGAAAAACTTATAATTGTA
TTTGACTTTCTAACACATTGCAAAGTTTCAAAGTGACTTTCACTTTCAACAACATATTAGAAGTAACCACTTTTGCTTTCACAGCCTGAA
GAGTTAGAGCCTGATCTGATGCCCCCTTTCACTCTGAAGTCATGGGAAATTTTCCAGCCATGAAAGCCCTCTTTCCACTGCATACTGATG
GGCTGACTCAGCTTCCTTCAGCCGACTGAGATCTTTTCATACTATTGGCTATTTCATACCAATTAACCTCTTAAATAAGATTGTGAATTG
CCAAAATTGATAGACACTTATTACCACCTGTGGACTCCATATTCCTTACCACAAATGTTATTTTCATCAGTCCTGAGTCATTTTAACTTA
CAGAAATTAGGATTGTTGCTGCTAATATGAATACCAATTATAACTTTTAGAAACAAGAATAAAGCCTAAAAGAGAATGAAATATAAGAAA
TGTTCGTTCCCACCCCTAATAACATTTGGAAGTGAATATTCCCATTTTCTTCCACCCACAGGGATTGGGATTGATTTTTAATTTCCTAGG
AAACAATACTAGACTACCCAAAAAGATGTTGCCAGAATCCAAAAGGAACTATGCTCGTAAAAGAAATGCAGTTTTCTCCTACCTAAAAAA
AAGAAAGTAAAGTGTGTTCTGTTCTTATCTTTTTAATGACTAAGCTTTAAACAGTTTATTTTGGGTAAGACTAGAACTTTCGGCCATTTG
TTCTAATATGTGTGTTATTAGATGCAATAGAATTTATGAAAAGAAGAATGACAAAGGTATCTGATTAGAAAATTTGATCTTACGCATGAA
TCCATGTCATGGCCAGCCACTGTCACATAGTGGGTGCCATTCTCAACATATTGGTTTGCTAACTTTAAGCATTAGGGATTTAGCACACTA
AAATACTTTTAATTATATTAGGTTTGGTAACTAAGGAGTAAATAAATCATAATTTATCATTTGCCAAGGCCAACAAACAACACTATTGTG
CTGTTTGCTCTCAATGAAGTTGAATAAACCAGGAGGCTTGGCATATCCCCTTTATGTTAATCCCAGCTAGAGATTAGTAGGTTGACTTTC
ACAGCAATTGTATATTGATCCATTTTAACTCATCCTTGCCATAATTTCCAGGCCAGTCACCAGGACAGAGGAGATGATGGGGAAACAGAG
CTTTAGATGAAAACTACTATGCACTACTAGCCTTAGAGGCACTGGTTTCCTGTTACCACTTTGGCAAGTATGGATGGTCTAAGTCCAGTA
GGGCTTCATCCATGGAGCCATTAGAACTGAGGGGGGAGTGTTAGAGATGCCATTTCACCAGGATCTTTTTGCTCAGGTTGTACCCATGCC
AATTGAAGAACGTGTTAAAGATGAGGAGGAGAGATGTACCATTCTCTCCCTTAATAATGATGTTGGTTTGCAAAACCTAAAGAAATAATA

>In-frame_NOS1AP_ENST00000361897_chr1_162257226_+_ATF6_ENST00000367942_chr1_161789423_+_7192nt
CGTCGCCTTTTCTTCTTCGTCCCGGGCGGTGCGTTCCACTGCTCTGGGGCCGGCGCCGCGCCCAGTCCCGCTTCGGGCCGCAAGCCCCAC
CGCTCCCCTCCCCGGGCAGGGGCGCCGCGCAGCCCGCTCCCGCCGCCACCTCCTCCCCTGCCGCCCTCCTAGCCGGCAGGAATTGCGCGA
CCACAGCGCCGCTCGCGTCGCCCGCATCAGCTCAGCCCGCTGCCGCTCGGCCCTCGGCACCGCTCCGGGTCCGGCCGCCGCGCGGCCAGG
GCTCCCCCTGCCCAGCGCTCCCAGGCCCCGCCACGCGTCGCCGCGCCCAGCTCCAGTCTCCCCTCCCCGGGGTCTCGCCAGCCCCTTCCT
GCAGCCGCCGCCTCCGAAGGAGCGGGTCCGCCGCGGGTAACCATGCCTAGCAAAACCAAGTACAACCTTGTGGACGATGGGCACGACCTG
CGGATCCCCTTGCACAACGAGGACGCCTTCCAGCACGGCATCTGCTTTGAGGCCAAGTACGTAGGAAGCCTGGACGTGCCAAGGCCCAAC
AGCAGGGTGGAGATCGTGGCTGCCATGCGCCGGATACGGTATGAGTTTAAAGCCAAGAACATCAAGAAGAAGAAAGTGAGCATTATGGTT
TCAGTGGATGGAGTGAAAGTGATTCTGAAGAAGAAGAAAAAGATTGCTGTGCTAAGGAGACAGCAACGTATGATAAAAAATCGAGAATCC
GCTTGTCAGTCTCGCAAGAAGAAGAAAGAATATATGCTAGGGTTAGAGGCGAGATTAAAGGCTGCCCTCTCAGAAAACGAGCAACTGAAG
AAAGAAAATGGAACACTGAAGCGGCAGCTGGATGAAGTTGTGTCAGAGAACCAGAGGCTTAAAGTCCCTAGTCCAAAGCGAAGAGTTGTC
TGTGTGATGATAGTATTGGCATTTATAATACTGAACTATGGACCTATGAGCATGTTGGAACAGGATTCCAGGAGAATGAACCCTAGTGTG
AGCCCTGCAAATCAAAGGAGGCACCTTCTAGGATTTTCTGCTAAAGAGGCACAGGACACATCAGATGGTATTATCCAGAAAAACAGCTAC
AGATATGATCATTCTGTTTCAAATGACAAAGCCCTGATGGTGCTAACTGAAGAACCATTGCTTTACATTCCTCCACCTCCTTGTCAGCCC
CTAATTAACACAACAGAGTCTCTCAGGTTAAATCATGAACTTCGAGGATGGGTTCATAGACATGAAGTAGAAAGGACCAAGTCAAGAAGA
ATGACAAATAATCAACAGAAAACCCGTATTCTTCAGGGTGCTCTGGAACAGGGCTCAAATTCTCAGCTGATGGCTGTTCAATACACAGAA
ACCACTAGTAGTATCAGCAGGAACTCAGGGAGTGAGCTACAAGTGTATTATGCTTCACCCAGAAGTTATCAAGACTTTTTTGAAGCCATC
CGCAGAAGGGGAGACACATTTTATGTTGTGTCATTTCGAAGGGATCACCTGCTGTTACCAGCTACCACCCATAACAAGACCACAAGACCA
AAAATGTCAATTGTGTTACCAGCAATAAACATAAATGAGAATGTGATCAATGGGCAGGACTACGAAGTGATGATGCAGATTGACTGTCAG
GTGATGGACACCAGGATCCTCCATATCAAAAGTTCGTCAGTTCCTCCTTACCTCCGAGATCAGCAGAGGAATCAAACCAACACCTTCTTT
GGCTCCCCTCCCGCAGCCACAGAGGCAACCCACGTTGTCAGCACCATCCCTGAGTCATTACAATAGCACCCTGCAGCTATGCTGGAAAAC
TGAGCGTGGGACCCTGCCAGACTGAAGAGCAGGTGAGCAAAATGCTGCTTTCTGCCTTGGTGGCAGGCAGAGAACTGTCTCGTACTAGAA
TTCAAGGAGGAAAGAAGAAGAAATAAAAGAAGCTGCTCCATTTTTCATCATCTACCCATCTATTTGGAAAGCACTGGAATTCAGATGCAA
GAGAACAATGTTTCTTCAGTGGCAAATGTAGCCCTGCATCCTCCAGTGTTACCTGGTGTAGATTTTTTTTTCTGTACCTTTCTAAACCTC
TCTTCCCTCTGTGATGGTTTTGTGTTTAAACAGTCATCTTCTTTTAAATAATATCCACCTCTCCTTTTTGCCATTTCACTTATTGATTCA
TAAAGTGAATTTTATTTAAAGCTATGCCACACATGCATGTTCAAATGGTTTCCACTGATTCGATTTTTCATTCATTTAATGCAAACCCAT
TCTGGATATTGTGCTTATTTGAGAAAACACATTTCAAAACCAGAAAAGCCAAAAACACTCCAAAAACAAGCAAAACAATTTGGAGCTTTA
GATAAAAGGAAAAACTCCCAGTTGGTAAAGTTTATCTTTACTTAGGATTTGTGGCTCACACCTAAACAAAGGGGGTCAGGGAGTGGGTAC
AAATTTGAGAAAATAGAAGGGTAAGGGAAGGGCCAGTGGTGGGGTTTGGAGAGAGGAGATAGCTCCATTAATACACATGTTTAAAAGATG
GAAAGTTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCAAGACCATCCCGGCTAAAACGG
TGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGACGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGG
AGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCCCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCT
CAAAAAAAAAAAAAAAAAAAAAAAAAGATGGAAAGTTCGATGTGACTGCAGTATGAGATTAAAGCCACAACTATTGTTTATTTTGGGGAC
TCTAGGCCACCAAGTATTAGCACACATACTTATGTTTTCTCTACTAATCTGGTCCAGGTCCTCATGGACCACAGGACAAAGCTTTCATTT
TCATTCATTCTTCTATTGAAATTATACCAAATTCAGCTGAGGAATATGGAAGTAACTTTAGACTTAAACAAGACAAAAGTTTTTTCACTG
AAGAATTGACAAGTATTTGCTCCTTAAAACAACGCAGATTAGTGAACGTGGATTCCTGCTGAGGGAGTGCATCCCATAATATGGCAATAA
TTTTCAGTTTCTCCAACGAAAAGATAGTGAAGGAATTAAATCTTTTGTCCTCCCATGGTTAAAAAAAAAAAAAAAGCTGTGTTCATTTTT
ACTGTACTATGCCTCTTTTTTCACCATAGTAGACAATTATGTTTCATTTGATGAATTCATAGAACTGGATCTCATACAGCGATGTCCTCT
CTAATGTTCTACCTTTCAGTTTCTAAAGTGAGTCTTCCTCCCTCTCCTACAAAACTTTTCAATTTTTTGATGTAACTCATCTACAAATAC
TGTTTCTTACCCCAGTTGACTTGCCTTTGTCAGATTTCTTCTTGTTCCACACTATAGCAATCAATTTCTCTTCTTCCTTACAAGAAAGGG
AACGAGAAATTGTAGCAACCTCTCAAGGATTATATGCAGCTAGTTAGTTTTCTGCCTGTGAAATTAGGTCTGGCTCCTAAATAATTTTAA
AGAACCATCAGCACTTCTAACTCTCTGGACAGGTGCCTCTTTGTCCAAGCTAGTTAAATGCTTTCCAAGGAAATCAGTTCAACTTTTGTG
AGCGGGGAAAAGCAGGGCTTTATTGTTGTGTTACCTGGGAGTCTGGAGTTTGAAAAGTGCTAATTAACCTTCCTCTTTTTCCACATTACA
AACCTTTTTAAGCAGCGCAGCACTCCCCTTAGATTTGGCTATCCTGGGTGATTTTCAGACAAGAACCATTTTCTCTGGGGACCATTCTTC
TGCTGGGTGCCAAGGAATATAAGGCAAATGCCCAGAAGACCTTCAGGTGACTGGGCAGTCTTATCATGGGATATTTCTTCTGGCCCTGCC
CCTTCCCATTCTGTAATGTGAATTAGCCACACCAGAGGCTGTGACCATGGCTAGTAGACAGTGGCAACATAGTCATCCCCAAGATGCTAA
TCTTCTGCTGGAACTGTCATACGTTATCATGGTCAATGTAAACCTGGTTTGTGTGGGGTGATTATAAATAGAGTTTCCCTCCTCTCTGTG
ACAGAATCACAGGAGAAGGACCCATCTCGTGGCCTTCTTGTTCTTAGCGCTTCACTTTTACTTCATCCCTCGATTCCCAGCTTTTTCTAT
CATCATTTTGCCAACTCCTCAGATGCAAGACTTTGGTTATGTCATACTCACCAACGTTAGTCCCTCTCTTCCAGGTGAAAAGGTGGGTAG
CGGTTGGGAGGGAGTCTCCACTGAAGAGCAGGAAGGTGGTAGCAGGGCCGGCAGCTCTGCCACAGAGCTAGGGGTGCCTGTAAGGTGCCG
CCTAGAGCAGCCTGGGAGCTTTGCCTTCTTTTGTCTCTCACTAGCCCTTCTACTCTTTGTCATTGCCTGTTCTTGAGTGGATCTTTGAAA
TGAGGGGACAGGATTCTCCTAAGGGTAGAGTTTCAGGAAATGAGTGAAAGGCAATTGACAAATGCAAAGAAGTAGTCACTTTTTAAATTG
CTGGCAAAGCTATAATTAATCCCTAGGCACAATTGTAGTTTTTATTTTAATGTTTGTATGCACAAGGCCCTTTAGGAAATGAGAAGTTGC
CATGCCAGATTAATTTTTTTTTTTTTTTTTGGTGGGATTGCCTTTTGGGGGTTGCAGCCAGAAATTGTGGGTAATGTGTGTATTTTTTTA
TTTATTAAATTTTAAACAGGATTGTGCAAGCTTATGAGACAATTAGATAAACTCATGGAGGAGGCAGGTCCTCCTGTTATTAGATGATTT
TGTGCTCTTGGGGCTGACAATAATACACTCTTGGGAAGTGATGGTAGAGACTGATGGGAATAGTCTTTCTGCCTGGTTGCAAGTCCCAAA
TTTTTAAGGGTTAATGGAAGTAAGTGGATGTTTCCTCATGTTAACTACTGAATCAGATGTTAGGAGCTTGTCCCTTTGGGGTTGACTTAT
GCCCAGCAGTACAGGGACACAGCTTCATTAGAGTGTTAGTGTAAACTAACTCCAAAGTTAGGAGTTAATGTGAAAGGATCATCCTTGAAA
CAAATCTGCTGTTTGCCATGCTTGTAGTACAGAAACTTCACATGGAGTTTTGGGTGGGATTTGTGTTTTCACAAGTAAAAAATCCCTCAC
GATTATAAAACTCAGAGCATCATCTAATTTTTTTTTTTAATGACTACAAGTTCCAGCACAAAACTGGCATTTCTTTGCCATTTCTTGCCA
GTAAGAAGTTGACACGGAGGTATTTGAAAGCAATGTTATGTGAGTCATTCTTAAGTGTTCCAAGTAAGTTTAGAAACAGAAAAGGAACTT
GGGATTCAAATTGATTTTTCAAATCATTTTTAAAGAGACATCATCCTGACTAAATCTTAGCCTGAACCTTCCTCCCCTGTGTGTATTCCC
CGGTAGTCACCGCAGCGAGATGCTGGTGAGACTGCCGTGGTGGCATTTAGCATCGTTAAAACTGGAAAACTCTCAAGCTCTTTGCCACTT
TCCTACTATTTTTTGATTCTTGCCATTTTACCAAGCTTAGGTTGTGAAACTTGACAGAAATGTATTACAGGAAAAACTTATAATTGTATT
TGACTTTCTAACACATTGCAAAGTTTCAAAGTGACTTTCACTTTCAACAACATATTAGAAGTAACCACTTTTGCTTTCACAGCCTGAAGA
GTTAGAGCCTGATCTGATGCCCCCTTTCACTCTGAAGTCATGGGAAATTTTCCAGCCATGAAAGCCCTCTTTCCACTGCATACTGATGGG
CTGACTCAGCTTCCTTCAGCCGACTGAGATCTTTTCATACTATTGGCTATTTCATACCAATTAACCTCTTAAATAAGATTGTGAATTGCC
AAAATTGATAGACACTTATTACCACCTGTGGACTCCATATTCCTTACCACAAATGTTATTTTCATCAGTCCTGAGTCATTTTAACTTACA
GAAATTAGGATTGTTGCTGCTAATATGAATACCAATTATAACTTTTAGAAACAAGAATAAAGCCTAAAAGAGAATGAAATATAAGAAATG
TTCGTTCCCACCCCTAATAACATTTGGAAGTGAATATTCCCATTTTCTTCCACCCACAGGGATTGGGATTGATTTTTAATTTCCTAGGAA
ACAATACTAGACTACCCAAAAAGATGTTGCCAGAATCCAAAAGGAACTATGCTCGTAAAAGAAATGCAGTTTTCTCCTACCTAAAAAAAA
GAAAGTAAAGTGTGTTCTGTTCTTATCTTTTTAATGACTAAGCTTTAAACAGTTTATTTTGGGTAAGACTAGAACTTTCGGCCATTTGTT
CTAATATGTGTGTTATTAGATGCAATAGAATTTATGAAAAGAAGAATGACAAAGGTATCTGATTAGAAAATTTGATCTTACGCATGAATC
CATGTCATGGCCAGCCACTGTCACATAGTGGGTGCCATTCTCAACATATTGGTTTGCTAACTTTAAGCATTAGGGATTTAGCACACTAAA
ATACTTTTAATTATATTAGGTTTGGTAACTAAGGAGTAAATAAATCATAATTTATCATTTGCCAAGGCCAACAAACAACACTATTGTGCT
GTTTGCTCTCAATGAAGTTGAATAAACCAGGAGGCTTGGCATATCCCCTTTATGTTAATCCCAGCTAGAGATTAGTAGGTTGACTTTCAC
AGCAATTGTATATTGATCCATTTTAACTCATCCTTGCCATAATTTCCAGGCCAGTCACCAGGACAGAGGAGATGATGGGGAAACAGAGCT
TTAGATGAAAACTACTATGCACTACTAGCCTTAGAGGCACTGGTTTCCTGTTACCACTTTGGCAAGTATGGATGGTCTAAGTCCAGTAGG
GCTTCATCCATGGAGCCATTAGAACTGAGGGGGGAGTGTTAGAGATGCCATTTCACCAGGATCTTTTTGCTCAGGTTGTACCCATGCCAA
TTGAAGAACGTGTTAAAGATGAGGAGGAGAGATGTACCATTCTCTCCCTTAATAATGATGTTGGTTTGCAAAACCTAAAGAAATAATAAC


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FusionGenePPI for NOS1AP_ATF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOS1APLRP2, LRP1, LRP8, RASD1, SYN1, SYN2, SYN3, NOS1, APP, TRAF4, FAM133A, EAF1, AP2M1, AKNAD1, NHP2, NKAP, CT45A5, RYBP, CKM, FYN, HSPD1, PLAGL2, PNP, BTRC, XPO1, PCNA, RAB5C, RALA, SNCA, YWHAH, PRPF4, TOMM40, RNPS1, NAF1, KLC3, PTPRH, PTPRJ, C11orf57, ZCCHC17, DDX41, MDK, PLK1, SREK1IP1, GPR156, C1orf186, AKAP17A, PNN, PIP4K2A, OIP5, CAMKV, TRPC4APATF6GTF2I, YY1, ATF6, ATF6B, NFYA, NFYC, SRF, CREB1, SREBF2, WFS1, SYVN1, UBC, SP1, APP, XBP1, BPGM, DDC, NNMT, TNFRSF1A, FBXO6, MAPK14, HLA-E, ERLEC1, APOD, SH3TC1, RFWD2, STK40, ACLY, PARG, PCDH20, CDH5, PCDHAC1, PCDHB11, GABRD, CLEC3A, CLEC2D, CD300E, OS9, MGAT4C, PCDHB16, LRRN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneATF6chr1:162257226chr1:161789423ENST00000367942+616468_589303671THBS4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNOS1APchr1:162257226chr1:161789423ENST00000361897+310494_50690507NOS1
HgeneNOS1APchr1:162257226chr1:161789423ENST00000493151+12494_506-789212NOS1
HgeneNOS1APchr1:162257226chr1:161789423ENST00000530878+310494_50690502NOS1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOS1AP_ATF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOS1AP_ATF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNOS1APC0036341Schizophrenia2PSYGENET
TgeneATF6C0003949Asbestosis1CTD_human
TgeneATF6C0009398Color vision defect1CTD_human
TgeneATF6C0022336Creutzfeldt-Jakob disease1CTD_human
TgeneATF6C0035334Retinitis Pigmentosa1CTD_human
TgeneATF6C0036457Scrapie1CTD_human
TgeneATF6C0085636Photophobia1CTD_human;HPO
TgeneATF6C0700501Congenital nystagmus1CTD_human
TgeneATF6C4225297ACHROMATOPSIA 71UNIPROT