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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24589

FusionGeneSummary for NOP14_LYAR

check button Fusion gene summary
Fusion gene informationFusion gene name: NOP14_LYAR
Fusion gene ID: 24589
HgeneTgene
Gene symbol

NOP14

LYAR

Gene ID

8602

55646

Gene nameNOP14 nucleolar proteinLy1 antibody reactive
SynonymsC4orf9|NOL14|RES4-25|RES425|UTP2ZC2HC2|ZLYAR
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 14NOP14 nucleolar protein homologprobable nucleolar complex protein 14cell growth-regulating nucleolar proteinLy1 antibody reactive homolog
Modification date2018052320180519
UniProtAcc

P78316

Q9NX58

Ensembl transtripts involved in fusion geneENST00000507120, ENST00000416614, 
ENST00000314262, ENST00000502735, 
ENST00000398071, 
ENST00000343470, 
ENST00000452476, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 4=120
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NOP14 [Title/Abstract] AND LYAR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-EP-A2KA-01ANOP14chr4

2951661

-LYARchr4

4288299

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000507120ENST00000343470NOP14chr4

2951661

-LYARchr4

4288299

-
intron-5UTRENST00000507120ENST00000452476NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000416614ENST00000343470NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000416614ENST00000452476NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000314262ENST00000343470NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000314262ENST00000452476NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000502735ENST00000343470NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000502735ENST00000452476NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000398071ENST00000343470NOP14chr4

2951661

-LYARchr4

4288299

-
5CDS-5UTRENST00000398071ENST00000452476NOP14chr4

2951661

-LYARchr4

4288299

-

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FusionProtFeatures for NOP14_LYAR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOP14

P78316

LYAR

Q9NX58

Involved in nucleolar processing of pre-18S ribosomalRNA. Has a role in the nuclear export of 40S pre-ribosomal subunitto the cytoplasm (By similarity). {ECO:0000250}. Plays a role in the maintenance of the appropriateprocessing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and theirsubsequent processing to produce 18S and 28S rRNAs(PubMed:24495227). Also acts at the level of transcriptionregulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2)promoter and represses its expression (PubMed:25092918). Inneuroblastoma cells, may also repress the expression of oxidativestress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41that encodes a small nucleolar RNA (PubMed:28686580).Preferentially binds to a DNA motif containing 5'-GGTTAT-3'(PubMed:25092918). Stimulates phagocytosis of photoreceptor outersegments by retinal pigment epithelial cells (By similarity).Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stemcells (ESCs), which in turn is essential for ESC self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q08288,ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918,ECO:0000269|PubMed:28686580}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOP14_LYAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOP14_LYAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOP14SIRT7, PAXIP1, SIRT1, MMS19, TARDBP, MOV10, NXF1, RNF2, BMI1, HIST1H1A, STX7, STX12, BYSL, EZH2, KIAA0368, FOXQ1, FOXS1, CDC14B, ZNF414, SEC31A, GPATCH4, ZNF324B, RPS14, RRP8, HIST1H1ELYARRPL23A, MYBBP1A, TWF2, KRT85, DHX57, RPL3, TSR1, BRIX1, KRT31, RPS9, GTPBP4, RPL18A, DHX9, RPS3A, RPL21, NAT10, NPM1, GNL2, DDX27, EIF3I, KRT82, EBNA1BP2, RPL31, KPNA1, SRP14, DDX21, ZHX1, ZBTB16, NOP56, OAS3, EIF2AK2, HDGF, TERF1, TERF2, CUL3, CUL1, COPS5, CAND1, GRK5, ESR1, MDC1, PAXIP1, VCP, FGF18, CD2, PHF20L1, ADSSL1, PRKRA, SDCBP2, BEND7, PHF6, RNF2, PRR11, ILF2, EPB41L3, ERCC4, IFI16, CEP152, HNRNPU, NCBP1, RPL10, RFWD3, FAM83H, RNF138, ZNF746, RPL37A, MAGEB10, RPL30, NCL, BRD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOP14_LYAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOP14_LYAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource