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Fusion gene ID: 24588 |
FusionGeneSummary for NOP14_CDK18 |
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Fusion gene information | Fusion gene name: NOP14_CDK18 | Fusion gene ID: 24588 | Hgene | Tgene | Gene symbol | NOP14 | CDK18 | Gene ID | 8602 | 5129 |
Gene name | NOP14 nucleolar protein | cyclin dependent kinase 18 | |
Synonyms | C4orf9|NOL14|RES4-25|RES425|UTP2 | PCTAIRE|PCTAIRE3|PCTK3 | |
Cytomap | 4p16.3 | 1q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleolar protein 14NOP14 nucleolar protein homologprobable nucleolar complex protein 14 | cyclin-dependent kinase 18PCTAIRE protein kinase 3PCTAIRE-motif protein kinase 3cell division protein kinase 18serine/threonine-protein kinase PCTAIRE-3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P78316 | Q07002 | |
Ensembl transtripts involved in fusion gene | ENST00000507120, ENST00000416614, ENST00000314262, ENST00000502735, ENST00000398071, | ENST00000429964, ENST00000506784, ENST00000360066, ENST00000509056, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 2=32 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NOP14 [Title/Abstract] AND CDK18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-KK-A8I5-01A | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000507120 | ENST00000429964 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
intron-5UTR | ENST00000507120 | ENST00000506784 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
intron-5UTR | ENST00000507120 | ENST00000360066 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
intron-intron | ENST00000507120 | ENST00000509056 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000416614 | ENST00000429964 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000416614 | ENST00000506784 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000416614 | ENST00000360066 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-intron | ENST00000416614 | ENST00000509056 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000314262 | ENST00000429964 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000314262 | ENST00000506784 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000314262 | ENST00000360066 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-intron | ENST00000314262 | ENST00000509056 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000502735 | ENST00000429964 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000502735 | ENST00000506784 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000502735 | ENST00000360066 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-intron | ENST00000502735 | ENST00000509056 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000398071 | ENST00000429964 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000398071 | ENST00000506784 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-5UTR | ENST00000398071 | ENST00000360066 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
5CDS-intron | ENST00000398071 | ENST00000509056 | NOP14 | chr4 | 2964852 | - | CDK18 | chr1 | 205492275 | + |
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FusionProtFeatures for NOP14_CDK18 |
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Hgene | Tgene |
NOP14 | CDK18 |
Involved in nucleolar processing of pre-18S ribosomalRNA. Has a role in the nuclear export of 40S pre-ribosomal subunitto the cytoplasm (By similarity). {ECO:0000250}. | May play a role in signal transduction cascades interminally differentiated cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NOP14_CDK18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NOP14_CDK18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NOP14 | SIRT7, PAXIP1, SIRT1, MMS19, TARDBP, MOV10, NXF1, RNF2, BMI1, HIST1H1A, STX7, STX12, BYSL, EZH2, KIAA0368, FOXQ1, FOXS1, CDC14B, ZNF414, SEC31A, GPATCH4, ZNF324B, RPS14, RRP8, HIST1H1E | CDK18 | CCDC85B, CCNK, APP, HSP90AA1, YWHAE, YWHAQ, PPP5C, EEF2, MAGED2, BAG6, PPP2CB, NSRP1, LARP4B, GNB4, MTR, EIF3I, CTSB, UBL4A, STUB1, YWHAB, CDK5, GOLGA2, KIFC3, KRT31, TRIM27, PNMA1, MTUS2, CCNDBP1, TRIM54, CCDC102B, TSGA10, LZTS2, KRT40, MIPOL1, DUSP7, SFXN2, TTC29, CDK16, HSP90AB1, HSP90AA5P, MTA2, FKBP5, CDC37, FGR, CDK15, DNLZ, MASTL, RBM4, RPL37A, TRPS1, FXR1, FUBP3, P3H1, C17orf70, FBXW7, CA4, ACKR2, RAB3IP, CBY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOP14_CDK18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOP14_CDK18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |