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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24588

FusionGeneSummary for NOP14_CDK18

check button Fusion gene summary
Fusion gene informationFusion gene name: NOP14_CDK18
Fusion gene ID: 24588
HgeneTgene
Gene symbol

NOP14

CDK18

Gene ID

8602

5129

Gene nameNOP14 nucleolar proteincyclin dependent kinase 18
SynonymsC4orf9|NOL14|RES4-25|RES425|UTP2PCTAIRE|PCTAIRE3|PCTK3
Cytomap

4p16.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein 14NOP14 nucleolar protein homologprobable nucleolar complex protein 14cyclin-dependent kinase 18PCTAIRE protein kinase 3PCTAIRE-motif protein kinase 3cell division protein kinase 18serine/threonine-protein kinase PCTAIRE-3
Modification date2018052320180523
UniProtAcc

P78316

Q07002

Ensembl transtripts involved in fusion geneENST00000507120, ENST00000416614, 
ENST00000314262, ENST00000502735, 
ENST00000398071, 
ENST00000429964, 
ENST00000506784, ENST00000360066, 
ENST00000509056, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 2=32
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NOP14 [Title/Abstract] AND CDK18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A8I5-01ANOP14chr4

2964852

-CDK18chr1

205492275

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000507120ENST00000429964NOP14chr4

2964852

-CDK18chr1

205492275

+
intron-5UTRENST00000507120ENST00000506784NOP14chr4

2964852

-CDK18chr1

205492275

+
intron-5UTRENST00000507120ENST00000360066NOP14chr4

2964852

-CDK18chr1

205492275

+
intron-intronENST00000507120ENST00000509056NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000416614ENST00000429964NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000416614ENST00000506784NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000416614ENST00000360066NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-intronENST00000416614ENST00000509056NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000314262ENST00000429964NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000314262ENST00000506784NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000314262ENST00000360066NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-intronENST00000314262ENST00000509056NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000502735ENST00000429964NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000502735ENST00000506784NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000502735ENST00000360066NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-intronENST00000502735ENST00000509056NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000398071ENST00000429964NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000398071ENST00000506784NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-5UTRENST00000398071ENST00000360066NOP14chr4

2964852

-CDK18chr1

205492275

+
5CDS-intronENST00000398071ENST00000509056NOP14chr4

2964852

-CDK18chr1

205492275

+

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FusionProtFeatures for NOP14_CDK18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NOP14

P78316

CDK18

Q07002

Involved in nucleolar processing of pre-18S ribosomalRNA. Has a role in the nuclear export of 40S pre-ribosomal subunitto the cytoplasm (By similarity). {ECO:0000250}. May play a role in signal transduction cascades interminally differentiated cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NOP14_CDK18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NOP14_CDK18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NOP14SIRT7, PAXIP1, SIRT1, MMS19, TARDBP, MOV10, NXF1, RNF2, BMI1, HIST1H1A, STX7, STX12, BYSL, EZH2, KIAA0368, FOXQ1, FOXS1, CDC14B, ZNF414, SEC31A, GPATCH4, ZNF324B, RPS14, RRP8, HIST1H1ECDK18CCDC85B, CCNK, APP, HSP90AA1, YWHAE, YWHAQ, PPP5C, EEF2, MAGED2, BAG6, PPP2CB, NSRP1, LARP4B, GNB4, MTR, EIF3I, CTSB, UBL4A, STUB1, YWHAB, CDK5, GOLGA2, KIFC3, KRT31, TRIM27, PNMA1, MTUS2, CCNDBP1, TRIM54, CCDC102B, TSGA10, LZTS2, KRT40, MIPOL1, DUSP7, SFXN2, TTC29, CDK16, HSP90AB1, HSP90AA5P, MTA2, FKBP5, CDC37, FGR, CDK15, DNLZ, MASTL, RBM4, RPL37A, TRPS1, FXR1, FUBP3, P3H1, C17orf70, FBXW7, CA4, ACKR2, RAB3IP, CBY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NOP14_CDK18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NOP14_CDK18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource