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Fusion gene ID: 24584 |
FusionGeneSummary for NOP10_NOP10 |
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Fusion gene information | Fusion gene name: NOP10_NOP10 | Fusion gene ID: 24584 | Hgene | Tgene | Gene symbol | NOP10 | NOP10 | Gene ID | 55505 | 55505 |
Gene name | NOP10 ribonucleoprotein | NOP10 ribonucleoprotein | |
Synonyms | DKCB1|NOLA3|NOP10P | DKCB1|NOLA3|NOP10P | |
Cytomap | 15q14 | 15q14 | |
Type of gene | protein-coding | protein-coding | |
Description | H/ACA ribonucleoprotein complex subunit 3NOP10 ribonucleoprotein homologhomolog of yeast Nop10pnucleolar protein 10nucleolar protein family A member 3nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)snoRNP protein NOP10 | H/ACA ribonucleoprotein complex subunit 3NOP10 ribonucleoprotein homologhomolog of yeast Nop10pnucleolar protein 10nucleolar protein family A member 3nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)snoRNP protein NOP10 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NPE3 | Q9NPE3 | |
Ensembl transtripts involved in fusion gene | ENST00000328848, ENST00000557912, | ENST00000328848, ENST00000557912, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: NOP10 [Title/Abstract] AND NOP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI934278 | NOP10 | chr15 | 34633995 | + | NOP10 | chr15 | 34634167 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000328848 | ENST00000328848 | NOP10 | chr15 | 34633995 | + | NOP10 | chr15 | 34634167 | - |
intron-3UTR | ENST00000328848 | ENST00000557912 | NOP10 | chr15 | 34633995 | + | NOP10 | chr15 | 34634167 | - |
intron-3UTR | ENST00000557912 | ENST00000328848 | NOP10 | chr15 | 34633995 | + | NOP10 | chr15 | 34634167 | - |
intron-3UTR | ENST00000557912 | ENST00000557912 | NOP10 | chr15 | 34633995 | + | NOP10 | chr15 | 34634167 | - |
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FusionProtFeatures for NOP10_NOP10 |
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Hgene | Tgene |
NOP10 | NOP10 |
Required for ribosome biogenesis and telomeremaintenance. Part of the H/ACA small nucleolar ribonucleoprotein(H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.This involves the isomerization of uridine such that the ribose issubsequently attached to C5, instead of the normal N1. Each rRNAcan contain up to 100 pseudouridine ("psi") residues, which mayserve to stabilize the conformation of rRNAs. May also be requiredfor correct processing or intranuclear trafficking of TERC, theRNA component of the telomerase reverse transcriptase (TERT)holoenzyme. {ECO:0000269|PubMed:15044956}. | Required for ribosome biogenesis and telomeremaintenance. Part of the H/ACA small nucleolar ribonucleoprotein(H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA.This involves the isomerization of uridine such that the ribose issubsequently attached to C5, instead of the normal N1. Each rRNAcan contain up to 100 pseudouridine ("psi") residues, which mayserve to stabilize the conformation of rRNAs. May also be requiredfor correct processing or intranuclear trafficking of TERC, theRNA component of the telomerase reverse transcriptase (TERT)holoenzyme. {ECO:0000269|PubMed:15044956}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NOP10_NOP10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NOP10_NOP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOP10_NOP10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOP10_NOP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NOP10 | C1857144 | DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1 | 1 | UNIPROT |
Tgene | NOP10 | C1857144 | DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1 | 1 | UNIPROT |