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Fusion gene ID: 24572 |
FusionGeneSummary for NOLC1_SHROOM3 |
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Fusion gene information | Fusion gene name: NOLC1_SHROOM3 | Fusion gene ID: 24572 | Hgene | Tgene | Gene symbol | NOLC1 | SHROOM3 | Gene ID | 9221 | 57619 |
Gene name | nucleolar and coiled-body phosphoprotein 1 | shroom family member 3 | |
Synonyms | NOPP130|NOPP140|NS5ATP13|P130 | APXL3|MSTP013|SHRM|ShrmL | |
Cytomap | 10q24.32 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleolar and coiled-body phosphoprotein 1140 kDa nucleolar phosphoproteinHCV NS5A trans-regulated protein 13HCV NS5A-transactivated protein 13hepatitis C virus NS5A-transactivated protein 13nucleolar 130 kDa proteinnucleolar and coiled-body phosphp | protein Shroom3F-actin-binding proteinshroom-related protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14978 | Q8TF72 | |
Ensembl transtripts involved in fusion gene | ENST00000605788, ENST00000405356, ENST00000603742, ENST00000488254, ENST00000477977, | ENST00000296043, ENST00000473602, | |
Fusion gene scores | * DoF score | 7 X 7 X 2=98 | 6 X 3 X 4=72 |
# samples | 8 | 7 | |
** MAII score | log2(8/98*10)=-0.292781749227846 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NOLC1 [Title/Abstract] AND SHROOM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW206361 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - | ||
ChiTaRS3.1 | AA643680 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000605788 | ENST00000296043 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
5CDS-intron | ENST00000605788 | ENST00000473602 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
Frame-shift | ENST00000405356 | ENST00000296043 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
5CDS-intron | ENST00000405356 | ENST00000473602 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
Frame-shift | ENST00000603742 | ENST00000296043 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
5CDS-intron | ENST00000603742 | ENST00000473602 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
Frame-shift | ENST00000488254 | ENST00000296043 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
5CDS-intron | ENST00000488254 | ENST00000473602 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
3UTR-3CDS | ENST00000477977 | ENST00000296043 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
3UTR-intron | ENST00000477977 | ENST00000473602 | NOLC1 | chr10 | 103920514 | - | SHROOM3 | chr4 | 77676077 | - |
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FusionProtFeatures for NOLC1_SHROOM3 |
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Hgene | Tgene |
NOLC1 | SHROOM3 |
Nucleolar protein that acts as a regulator of RNApolymerase I by connecting RNA polymerase I with enzymesresponsible for ribosomal processing and modification(PubMed:10567578, PubMed:26399832). Required for neural crestspecification: following monoubiquitination by the BCR(KBTBD8)complex, associates with TCOF1 and acts as a platform to connectRNA polymerase I with enzymes responsible for ribosomal processingand modification, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). Involved in nucleologenesis, possibly byplaying a role in the maintenance of the fundamental structure ofthe fibrillar center and dense fibrillar component in thenucleolus (PubMed:9016786). It has intrinsic GTPase and ATPaseactivities (PubMed:9016786). {ECO:0000269|PubMed:10567578,ECO:0000269|PubMed:26399832, ECO:0000269|PubMed:9016786}. | Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NOLC1_SHROOM3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NOLC1_SHROOM3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOLC1_SHROOM3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NOLC1 | Q14978 | DB00997 | Doxorubicin | Nucleolar and coiled-body phosphoprotein 1 {ECO:0000305} | small molecule | approved|investigational |
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RelatedDiseases for NOLC1_SHROOM3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |