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Fusion gene ID: 24525 |
FusionGeneSummary for NOA1_SPINK2 |
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Fusion gene information | Fusion gene name: NOA1_SPINK2 | Fusion gene ID: 24525 | Hgene | Tgene | Gene symbol | NOA1 | SPINK2 | Gene ID | 84273 | 6691 |
Gene name | nitric oxide associated 1 | serine peptidase inhibitor, Kazal type 2 | |
Synonyms | C4orf14|MTG3|hAtNOS1|hNOA1|mAtNOS1 | HUSI-II | |
Cytomap | 4q12 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | nitric oxide-associated protein 1mitochondrial GTPase 3 homolognitric oxide synthase, mitochondrial (putative)putative ortholog of Arabidopsis mitochondrial nitric oxide synthase | serine protease inhibitor Kazal-type 2epididymis tissue protein Li 172serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8NC60 | P20155 | |
Ensembl transtripts involved in fusion gene | ENST00000264230, | ENST00000248701, ENST00000506738, ENST00000504762, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 3 X 5=75 |
# samples | 3 | 5 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NOA1 [Title/Abstract] AND SPINK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A18U-01A | NOA1 | chr4 | 57839314 | - | SPINK2 | chr4 | 57686745 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264230 | ENST00000248701 | NOA1 | chr4 | 57839314 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000264230 | ENST00000506738 | NOA1 | chr4 | 57839314 | - | SPINK2 | chr4 | 57686745 | - |
Frame-shift | ENST00000264230 | ENST00000504762 | NOA1 | chr4 | 57839314 | - | SPINK2 | chr4 | 57686745 | - |
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FusionProtFeatures for NOA1_SPINK2 |
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Hgene | Tgene |
NOA1 | SPINK2 |
Involved in regulation of mitochondrial proteintranslation and respiration. Plays a role in mitochondria-mediatedcell death. May act as a scaffolding protein or stabilizer ofrespiratory chain supercomplexes. Binds GTP.{ECO:0000269|PubMed:19103604}. | Strong inhibitor of acrosin in male and/or femalegenital tract. Also inhibits trypsin.{ECO:0000269|PubMed:19422058}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NOA1_SPINK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NOA1_SPINK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NOA1 | ARF1, COL9A2, HSPA8, MPP3, ICT1, GRB10, BOK, LIN28A, ZNF346, TRA2A, TRMT10B, MRPS11, MRPS27, MRPS34, AURKAIP1, FGF8, MRPS15, KLHL22, CCDC59 | SPINK2 | KRTAP5-9, ADAMTSL4, KRTAP10-3, NOTCH2NL, MAPK8IP2, GCHFR, ATP5S, NUDT8, MIPEP, DCAF15, CTTNBP2NL, PRTFDC1, UBR2, PDP2, IDE, PMPCB, RSPRY1, PMPCA, MOB4, STRIP1, IKBIP, STRN, UBR1, STRN3, STRN4, ATP6V1D |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOA1_SPINK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOA1_SPINK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |