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Fusion gene ID: 24524 |
FusionGeneSummary for NOA1_PPP3CA |
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Fusion gene information | Fusion gene name: NOA1_PPP3CA | Fusion gene ID: 24524 | Hgene | Tgene | Gene symbol | NOA1 | PPP3CA | Gene ID | 84273 | 5530 |
Gene name | nitric oxide associated 1 | protein phosphatase 3 catalytic subunit alpha | |
Synonyms | C4orf14|MTG3|hAtNOS1|hNOA1|mAtNOS1 | CALN|CALNA|CALNA1|CCN1|CNA1|IECEE|IECEE1|PPP2B | |
Cytomap | 4q12 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | nitric oxide-associated protein 1mitochondrial GTPase 3 homolognitric oxide synthase, mitochondrial (putative)putative ortholog of Arabidopsis mitochondrial nitric oxide synthase | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformCAM-PRP catalytic subunitcalcineurin A alphacalmodulin-dependent calcineurin A subunit alpha isoformprotein phosphatase 2B, catalytic subunit, alpha isoformprotein phosphatase 3 ( | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q8NC60 | Q08209 | |
Ensembl transtripts involved in fusion gene | ENST00000264230, | ENST00000512215, ENST00000394854, ENST00000323055, ENST00000394853, ENST00000507176, ENST00000523694, ENST00000510292, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 5 X 3=120 |
# samples | 3 | 8 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NOA1 [Title/Abstract] AND PPP3CA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP3CA | GO:0006470 | protein dephosphorylation | 18815128|19154138 |
Tgene | PPP3CA | GO:0033173 | calcineurin-NFAT signaling cascade | 19154138|22688515 |
Tgene | PPP3CA | GO:0035690 | cellular response to drug | 11005320 |
Tgene | PPP3CA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
Tgene | PPP3CA | GO:0051592 | response to calcium ion | 18815128 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A12D-01A | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264230 | ENST00000512215 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
Frame-shift | ENST00000264230 | ENST00000394854 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
Frame-shift | ENST00000264230 | ENST00000323055 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
Frame-shift | ENST00000264230 | ENST00000394853 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
5CDS-intron | ENST00000264230 | ENST00000507176 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
5CDS-intron | ENST00000264230 | ENST00000523694 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
5CDS-intron | ENST00000264230 | ENST00000510292 | NOA1 | chr4 | 57832786 | - | PPP3CA | chr4 | 102117273 | - |
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FusionProtFeatures for NOA1_PPP3CA |
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Hgene | Tgene |
NOA1 | PPP3CA |
Involved in regulation of mitochondrial proteintranslation and respiration. Plays a role in mitochondria-mediatedcell death. May act as a scaffolding protein or stabilizer ofrespiratory chain supercomplexes. Binds GTP.{ECO:0000269|PubMed:19103604}. | Calcium-dependent, calmodulin-stimulated proteinphosphatase which plays an essential role in the transduction ofintracellular Ca(2+)-mediated signals (PubMed:15671020,PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of thesubstrates contain a PxIxIT motif and/or a LxVP motif(PubMed:17498738, PubMed:17502104, PubMed:23468591,PubMed:27974827, PubMed:22343722). In response to increased Ca(2+)levels, dephosphorylates and activates phosphatase SSH1 whichresults in cofilin dephosphorylation (PubMed:15671020). Inresponse to increased Ca(2+) levels following mitochondrialdepolarization, dephosphorylates DNM1L inducing DNM1Ltranslocation to the mitochondrion (PubMed:18838687).Dephosphorylates heat shock protein HSPB1 (By similarity).Dephosphorylates and activates transcription factor NFATC1(PubMed:19154138). In response to increased Ca(2+) levels,regulates NFAT-mediated transcription probably bydephosphorylating NFAT and promoting its nuclear translocation(PubMed:26248042). Dephosphorylates and inactivates transcriptionfactor ELK1 (PubMed:19154138). Dephosphorylates DARPP32(PubMed:19154138). {ECO:0000250|UniProtKB:P48452,ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738,ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:18838687,ECO:0000269|PubMed:19154138, ECO:0000269|PubMed:22343722,ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042,ECO:0000269|PubMed:27974827}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NOA1_PPP3CA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NOA1_PPP3CA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NOA1 | ARF1, COL9A2, HSPA8, MPP3, ICT1, GRB10, BOK, LIN28A, ZNF346, TRA2A, TRMT10B, MRPS11, MRPS27, MRPS34, AURKAIP1, FGF8, MRPS15, KLHL22, CCDC59 | PPP3CA | C16orf74, PPIA, RCAN1, ADRB2, RCAN2, AKAP5, BCL2, CABIN1, MYOZ2, MYOZ1, IRF2, GRB2, AKT1, PHLPP2, PTEN, PSMA6, PDE4D, KCNIP3, TRAF3, PPP3R1, MRI1, RHOC, MAPK7, HNRNPH1, P3H1, SETSIP, MAT2B, NASP, NRD1, PDIA6, PFDN5, PPP2R2A, TNPO3, TNPO1, TSN, VBP1, XPO5, MARCH7, CEP76, TP53, VCP, JUN, FAM122A, RASSF2, PDHB, RCAN3, NFATC4, SIK3, ARFIP1, C6orf211, PSMD9, CRTC2, LBH, NCAPG, TUBA1B, DEFA1, TMEM200A, SMPD3, NFATC1, KLRG2, AATK, FGFR4, RYK, PTK7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NOA1_PPP3CA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOA1_PPP3CA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PPP3CA | C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
Tgene | PPP3CA | C0030305 | Pancreatitis | 1 | CTD_human |
Tgene | PPP3CA | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | PPP3CA | C0039584 | Testicular Diseases | 1 | CTD_human |
Tgene | PPP3CA | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
Tgene | PPP3CA | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |