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Fusion gene ID: 24513 |
FusionGeneSummary for NMT1_NME1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NMT1_NME1 | Fusion gene ID: 24513 | Hgene | Tgene | Gene symbol | NMT1 | NME1 | Gene ID | 4836 | 6023 |
| Gene name | N-myristoyltransferase 1 | RNA component of mitochondrial RNA processing endoribonuclease | |
| Synonyms | NMT | CHH|NME1|RMRPR|RRP2 | |
| Cytomap | 17q21.31 | 9p13.3 | |
| Type of gene | protein-coding | ncRNA | |
| Description | glycylpeptide N-tetradecanoyltransferase 1alternative, short form NMT-Slong form, NMT-Lmyristoyl-CoA:protein N-myristoyltransferase 1type I N-myristoyltransferase | - | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P30419 | P15531 | |
| Ensembl transtripts involved in fusion gene | ENST00000592782, ENST00000258960, ENST00000590114, | ENST00000393196, ENST00000336097, ENST00000480143, ENST00000511355, ENST00000013034, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NMT1 [Title/Abstract] AND NME1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NMT1 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation | 25255805 |
| Hgene | NMT1 | GO:0042180 | cellular ketone metabolic process | 22865860 |
| Tgene | NME1 | GO:0001172 | transcription, RNA-templated | 19701182 |
| Tgene | NME1 | GO:0030422 | production of siRNA involved in RNA interference | 19701182 |
| Tgene | NME1 | GO:0032774 | RNA biosynthetic process | 19701182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-43-2581-01A | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000592782 | ENST00000393196 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000592782 | ENST00000336097 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000592782 | ENST00000480143 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000592782 | ENST00000511355 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000592782 | ENST00000013034 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000258960 | ENST00000393196 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000258960 | ENST00000336097 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000258960 | ENST00000480143 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000258960 | ENST00000511355 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 5CDS-5UTR | ENST00000258960 | ENST00000013034 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 3UTR-5UTR | ENST00000590114 | ENST00000393196 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 3UTR-5UTR | ENST00000590114 | ENST00000336097 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 3UTR-5UTR | ENST00000590114 | ENST00000480143 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 3UTR-5UTR | ENST00000590114 | ENST00000511355 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
| 3UTR-5UTR | ENST00000590114 | ENST00000013034 | NMT1 | chr17 | 43138828 | + | NME1 | chr17 | 49233012 | + |
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FusionProtFeatures for NMT1_NME1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NMT1 | NME1 |
| Adds a myristoyl group to the N-terminal glycine residueof certain cellular and viral proteins.{ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9353336,ECO:0000269|PubMed:9506952}. | Major role in the synthesis of nucleoside triphosphatesother than ATP. The ATP gamma phosphate is transferred to the NDPbeta phosphate via a ping-pong mechanism, using a phosphorylatedactive-site intermediate. Possesses nucleoside-diphosphate kinase,serine/threonine-specific protein kinase, geranyl and farnesylpyrophosphate kinase, histidine protein kinase and 3'-5'exonuclease activities. Involved in cell proliferation,differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required forneural development including neural patterning and cell fatedetermination. During GZMA-mediated cell death, works in concertwith TREX1. NME1 nicks one strand of DNA and TREX1 removes basesfrom the free 3' end to enhance DNA damage and prevent DNA endreannealing and rapid repair. {ECO:0000269|PubMed:12628186,ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NMT1_NME1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NMT1_NME1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NMT1 | LYN, FYN, CABP2, CABP1, CSNK2A1, HNRNPM, HNRNPU, IARS, IGF2BP3, ILF2, MAP2, MRE11A, ABCF1, C14orf166, RTCB, NELFB, YBX3, DDX1, DHX9, DIMT1, DYNC1LI2, EDC4, EIF2B2, EIF2B3, FKBP3, FLII, PA2G4, POLR1C, QARS, RFC4, RPL19, RPL38, YBX1, PDCD6, RPL23A, NXF1, CAPN1, TP53, CDCA3, FBXO17, ODF3L2, FAM84B, PLCXD1, EID3, RP2, TGFB1, ABLIM1, DTNA, ZNRF1, ACSL4, MARS, NTRK1, AHI1, CEP89, FBF1, SCLT1, DCTN1, CEP19, STIL, VIM, NOP56, FBXW7, MCM2, GPRC5C, NCS1, MARCKSL1, AIFM3, TLDC1, ANGPTL7, MGST3, DEFB1, ANGPTL4, BAG4, RFTN2, TBCE, MLF1, DNAJC13, EDRF1, C1orf168, IRF2BP1 | NME1 | WDYHV1, NME4, POLR1C, GORASP2, NME3, NME1, SET, AURKA, TERF1, ITGB1, RRAD, TIAM1, RAC1, PRUNE, USP18, GATA1, STRAP, NME2, HDAC5, ERG, MIF, SOD1, UROD, FXR2, NIF3L1, CCND3, SMARCD1, SOX30, FBXO6, IDH1, CHRAC1, FDPS, MAPK14, NME1-NME2, OXCT1, SORD, THOP1, RBBP7, WDR1, ASB18, TUBG1, TNPO2, PID1, SREK1IP1, BMI1, CFL1, CRIP1, DYNLL1, FUBP1, GOT1, NQO1, PRDX5, PTEN, FBXO24, KAT2A, FOXP4, MCM2, DUSP19, DUSP2, DUSP22, EYA2, EYA3, DNM1L, SOAT1, FOXA1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NMT1_NME1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NME1 | P15531 | DB01593 | Zinc | Nucleoside diphosphate kinase A | small molecule | approved|investigational |
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RelatedDiseases for NMT1_NME1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NME1 | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
| Tgene | NME1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Tgene | NME1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | NME1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | NME1 | C0242184 | Hypoxia | 1 | CTD_human |
| Tgene | NME1 | C2239176 | Liver carcinoma | 1 | CTD_human |
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