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Fusion gene ID: 24502 |
FusionGeneSummary for NMI_SLC9A4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NMI_SLC9A4 | Fusion gene ID: 24502 | Hgene | Tgene | Gene symbol | NMI | SLC9A4 | Gene ID | 9111 | 389015 |
| Gene name | N-myc and STAT interactor | solute carrier family 9 member A4 | |
| Synonyms | - | NHE4 | |
| Cytomap | 2q23.3 | 2q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-myc-interactor | sodium/hydrogen exchanger 4NHE-4Na(+)/H(+) exchanger 4solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9 (sodium/hydrogen exchanger), member 4solute carrier family 9 member 4solute carrier family 9, subfamily A (NHE4, cation | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q13287 | Q6AI14 | |
| Ensembl transtripts involved in fusion gene | ENST00000243346, | ENST00000295269, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NMI [Title/Abstract] AND SLC9A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-KP-A3W1-01A | NMI | chr2 | 152138462 | - | SLC9A4 | chr2 | 103125306 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000243346 | ENST00000295269 | NMI | chr2 | 152138462 | - | SLC9A4 | chr2 | 103125306 | + |
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FusionProtFeatures for NMI_SLC9A4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NMI | SLC9A4 |
| May be involved in augmenting coactivator proteinrecruitment to a group of sequence-specific transcription factors.Augments cytokine-mediated STAT transcription. Enhances CBP/p300coactivator protein recruitment to STAT1 and STAT5. | Involved in pH regulation to eliminate acids generatedby active metabolism or to counter adverse environmentalconditions. Major proton extruding system driven by the inwardsodium ion chemical gradient. Plays an important role in signaltransduction. May play a specialized role in the kidney inrectifying cell volume in response to extreme fluctuations ofhyperosmolar-stimulated cell shrinkage. Is relatively amilorideand ethylisopropylamiloride (EIPA) insensitive. Can be activatedunder conditions of hyperosmolar-induced cell shrinkage in asustained intracellular acidification-dependence manner. Activatedby 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in asustained intracellular acidification-dependence manner. Affectspotassium/proton exchange as well as sodium/proton andlithium/proton exchange. In basolateral cell membrane,participates in homeostatic control of intracellular pH, and mayplay a role in proton extrusion in order to achievetransepithelial HCO3(-) secretion. In apical cell membrane may beinvolved in mediating sodium absorption. Requires for normallevels of gastric acid secretion, secretory membrane development,parietal cell maturation and/or differentiation and at leastsecondarily for chief cell differentiation (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NMI_SLC9A4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NMI_SLC9A4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NMI | IFI35, HGS, PSMA1, GCSH, HDDC3, HHLA3, EMILIN1, SNAPC5, NECAP2, TUBA3C, BRCA1, MYC, STAT5A, STAT1, STAT3, STAT5B, HOXC9, KAT5, BRMS1, CDKN2A, TRIP12, DSTN, SOX10, MYCN, IRF7, CYP2E1, LSM4, KDM1A, APEH, CYHR1, EXOSC4, H1FX, HIST1H1B, ME1, NAA10, PSMG3, TBCD, TOLLIP, VPS26A, OXR1, HSPA8, TRAF5, SCEL, MTMR6, NMI, MAD2L1BP, POMZP3, COPS7B, MTMR9, TUBA3E, SFR1, C1orf216, LCA5L, CNKSR3, TXLNB, TXLNA, C9orf72, GOLGA8EP, CNP, TARSL2, ASRGL1, MOCS3, DCTN3, FAM60A, UBE2I, JAK3, TRIM21, MCPH1 | SLC9A4 | CHP2, CHP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NMI_SLC9A4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NMI_SLC9A4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NMI | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | SLC9A4 | C0001122 | Acidosis | 1 | CTD_human |
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