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Fusion gene ID: 24496 |
FusionGeneSummary for NME7_ASH1L |
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Fusion gene information | Fusion gene name: NME7_ASH1L | Fusion gene ID: 24496 | Hgene | Tgene | Gene symbol | NME7 | ASH1L | Gene ID | 29922 | 55870 |
Gene name | NME/NM23 family member 7 | ASH1 like histone lysine methyltransferase | |
Synonyms | CFAP67|MN23H7|NDK 7|NDK7|nm23-H7 | ASH1|ASH1L1|KMT2H|MRD52 | |
Cytomap | 1q24.2 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleoside diphosphate kinase 7NDP kinase 7cilia and flagella associated protein 67non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9Y5B8 | Q9NR48 | |
Ensembl transtripts involved in fusion gene | ENST00000472647, ENST00000367811, ENST00000469474, | ENST00000368346, ENST00000392403, ENST00000548830, | |
Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 9 X 8 X 5=360 |
# samples | 5 | 9 | |
** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NME7 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-5518-01A | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000472647 | ENST00000368346 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5CDS-5UTR | ENST00000472647 | ENST00000392403 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5CDS-5UTR | ENST00000472647 | ENST00000548830 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5CDS-5UTR | ENST00000367811 | ENST00000368346 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5CDS-5UTR | ENST00000367811 | ENST00000392403 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5CDS-5UTR | ENST00000367811 | ENST00000548830 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5UTR-5UTR | ENST00000469474 | ENST00000368346 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5UTR-5UTR | ENST00000469474 | ENST00000392403 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
5UTR-5UTR | ENST00000469474 | ENST00000548830 | NME7 | chr1 | 169292355 | - | ASH1L | chr1 | 155491409 | - |
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FusionProtFeatures for NME7_ASH1L |
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Hgene | Tgene |
NME7 | ASH1L |
Major role in the synthesis of nucleoside triphosphatesother than ATP. The ATP gamma phosphate is transferred to the NDPbeta phosphate via a ping-pong mechanism, using a phosphorylatedactive-site intermediate. | Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NME7_ASH1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NME7_ASH1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NME7 | FKBP6, NT5C2, TCHP, KRT18, ZNF263, CDK5RAP2, TUFT1, DDX1, OFD1, MAP4K4, TNIP1, YWHAQ, LATS2, TUBG1, TUBGCP2, TUBGCP3, GOLGA2, ZBTB48, NAB2, NEFL, REL, TRIM27, TCF4, FOSL1, MYOT, CDC42EP2, CCHCR1, CEP72, KIAA1598, LNX1, SYCE1, C1orf189, CSPP1, MZT2B, WNT2, GLUL, LPPR2, PCED1B, BTRC, SSX2IP, PCM1, CEP170, KIAA0753, CEP104, CEP162, CEP290, CNTROB, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, STIL, LGALS3BP, SCAF11, TUBGCP4, TUBGCP5, NEDD1, MZT1, TXNDC12, TUBG2, PRICKLE3, KIAA1683, AMPD2 | ASH1L | HIST1H3A, H3F3A, SMAD7, THAP7, MORF4L1, PARD6A, SIKE1, MORF4L2, NXF2, CDX1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NME7_ASH1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NME7_ASH1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NME7 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Tgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |