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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24496

FusionGeneSummary for NME7_ASH1L

check button Fusion gene summary
Fusion gene informationFusion gene name: NME7_ASH1L
Fusion gene ID: 24496
HgeneTgene
Gene symbol

NME7

ASH1L

Gene ID

29922

55870

Gene nameNME/NM23 family member 7ASH1 like histone lysine methyltransferase
SynonymsCFAP67|MN23H7|NDK 7|NDK7|nm23-H7ASH1|ASH1L1|KMT2H|MRD52
Cytomap

1q24.2

1q22

Type of geneprotein-codingprotein-coding
Descriptionnucleoside diphosphate kinase 7NDP kinase 7cilia and flagella associated protein 67non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L
Modification date2018052220180519
UniProtAcc

Q9Y5B8

Q9NR48

Ensembl transtripts involved in fusion geneENST00000472647, ENST00000367811, 
ENST00000469474, 
ENST00000368346, 
ENST00000392403, ENST00000548830, 
Fusion gene scores* DoF score5 X 3 X 3=459 X 8 X 5=360
# samples 59
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NME7 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASH1L

GO:0097676

histone H3-K36 dimethylation

26002201


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5518-01ANME7chr1

169292355

-ASH1Lchr1

155491409

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000472647ENST00000368346NME7chr1

169292355

-ASH1Lchr1

155491409

-
5CDS-5UTRENST00000472647ENST00000392403NME7chr1

169292355

-ASH1Lchr1

155491409

-
5CDS-5UTRENST00000472647ENST00000548830NME7chr1

169292355

-ASH1Lchr1

155491409

-
5CDS-5UTRENST00000367811ENST00000368346NME7chr1

169292355

-ASH1Lchr1

155491409

-
5CDS-5UTRENST00000367811ENST00000392403NME7chr1

169292355

-ASH1Lchr1

155491409

-
5CDS-5UTRENST00000367811ENST00000548830NME7chr1

169292355

-ASH1Lchr1

155491409

-
5UTR-5UTRENST00000469474ENST00000368346NME7chr1

169292355

-ASH1Lchr1

155491409

-
5UTR-5UTRENST00000469474ENST00000392403NME7chr1

169292355

-ASH1Lchr1

155491409

-
5UTR-5UTRENST00000469474ENST00000548830NME7chr1

169292355

-ASH1Lchr1

155491409

-

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FusionProtFeatures for NME7_ASH1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NME7

Q9Y5B8

ASH1L

Q9NR48

Major role in the synthesis of nucleoside triphosphatesother than ATP. The ATP gamma phosphate is transferred to the NDPbeta phosphate via a ping-pong mechanism, using a phosphorylatedactive-site intermediate. Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NME7_ASH1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NME7_ASH1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NME7FKBP6, NT5C2, TCHP, KRT18, ZNF263, CDK5RAP2, TUFT1, DDX1, OFD1, MAP4K4, TNIP1, YWHAQ, LATS2, TUBG1, TUBGCP2, TUBGCP3, GOLGA2, ZBTB48, NAB2, NEFL, REL, TRIM27, TCF4, FOSL1, MYOT, CDC42EP2, CCHCR1, CEP72, KIAA1598, LNX1, SYCE1, C1orf189, CSPP1, MZT2B, WNT2, GLUL, LPPR2, PCED1B, BTRC, SSX2IP, PCM1, CEP170, KIAA0753, CEP104, CEP162, CEP290, CNTROB, CEP128, CEP135, CEP63, CEP89, CNTRL, NINL, NIN, ODF2, RPGRIP1L, STIL, LGALS3BP, SCAF11, TUBGCP4, TUBGCP5, NEDD1, MZT1, TXNDC12, TUBG2, PRICKLE3, KIAA1683, AMPD2ASH1LHIST1H3A, H3F3A, SMAD7, THAP7, MORF4L1, PARD6A, SIKE1, MORF4L2, NXF2, CDX1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NME7_ASH1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NME7_ASH1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNME7C0236969Substance-Related Disorders1CTD_human
TgeneASH1LC0023903Liver neoplasms1CTD_human