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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 24463

FusionGeneSummary for NLK_KSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: NLK_KSR1
Fusion gene ID: 24463
HgeneTgene
Gene symbol

NLK

KSR1

Gene ID

51701

8844

Gene namenemo like kinasekinase suppressor of ras 1
Synonyms-KSR|RSU2
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase NLKkinase suppressor of Ras 1
Modification date2018052320180523
UniProtAcc

Q9UBE8

Q8IVT5

Ensembl transtripts involved in fusion geneENST00000407008, ENST00000583517, 
ENST00000582037, 
ENST00000509603, 
ENST00000319524, ENST00000268763, 
ENST00000398988, ENST00000581975, 
ENST00000582410, ENST00000578981, 
Fusion gene scores* DoF score13 X 7 X 8=72810 X 7 X 5=350
# samples 159
** MAII scorelog2(15/728*10)=-2.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/350*10)=-1.95935801550265
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NLK [Title/Abstract] AND KSR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNLK

GO:0050821

protein stabilization

25512613


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-4357-01ANLKchr17

26512291

+KSR1chr17

25904518

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000407008ENST00000509603NLKchr17

26512291

+KSR1chr17

25904518

+
In-frameENST00000407008ENST00000319524NLKchr17

26512291

+KSR1chr17

25904518

+
5CDS-5UTRENST00000407008ENST00000268763NLKchr17

26512291

+KSR1chr17

25904518

+
5CDS-5UTRENST00000407008ENST00000398988NLKchr17

26512291

+KSR1chr17

25904518

+
5CDS-intronENST00000407008ENST00000581975NLKchr17

26512291

+KSR1chr17

25904518

+
5CDS-intronENST00000407008ENST00000582410NLKchr17

26512291

+KSR1chr17

25904518

+
5CDS-intronENST00000407008ENST00000578981NLKchr17

26512291

+KSR1chr17

25904518

+
intron-3CDSENST00000583517ENST00000509603NLKchr17

26512291

+KSR1chr17

25904518

+
intron-3CDSENST00000583517ENST00000319524NLKchr17

26512291

+KSR1chr17

25904518

+
intron-5UTRENST00000583517ENST00000268763NLKchr17

26512291

+KSR1chr17

25904518

+
intron-5UTRENST00000583517ENST00000398988NLKchr17

26512291

+KSR1chr17

25904518

+
intron-intronENST00000583517ENST00000581975NLKchr17

26512291

+KSR1chr17

25904518

+
intron-intronENST00000583517ENST00000582410NLKchr17

26512291

+KSR1chr17

25904518

+
intron-intronENST00000583517ENST00000578981NLKchr17

26512291

+KSR1chr17

25904518

+
intron-3CDSENST00000582037ENST00000509603NLKchr17

26512291

+KSR1chr17

25904518

+
intron-3CDSENST00000582037ENST00000319524NLKchr17

26512291

+KSR1chr17

25904518

+
intron-5UTRENST00000582037ENST00000268763NLKchr17

26512291

+KSR1chr17

25904518

+
intron-5UTRENST00000582037ENST00000398988NLKchr17

26512291

+KSR1chr17

25904518

+
intron-intronENST00000582037ENST00000581975NLKchr17

26512291

+KSR1chr17

25904518

+
intron-intronENST00000582037ENST00000582410NLKchr17

26512291

+KSR1chr17

25904518

+
intron-intronENST00000582037ENST00000578981NLKchr17

26512291

+KSR1chr17

25904518

+

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FusionProtFeatures for NLK_KSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NLK

Q9UBE8

KSR1

Q8IVT5

Serine/threonine-protein kinase that regulates a numberof transcription factors with key roles in cell fatedetermination. Positive effector of the non-canonical Wntsignaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 andHIPK2. Activation of this pathway causes binding to andphosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading tomethylation of PPARG target promoters at histone H3K9 andtranscriptional silencing. The resulting loss of PPARG target genetranscription inhibits adipogenesis and promotesosteoblastogenesis in mesenchymal stem cells (MSCs). Negativeregulator of the canonical Wnt/beta-catenin signaling pathway.Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting thedissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, aswell as the ubiquitination and subsequent proteolysis of LEF1.Together these effects inhibit the transcriptional activation ofcanonical Wnt/beta-catenin target genes. Negative regulator of theNotch signaling pathway. Binds to and phosphorylates NOTCH1,thereby preventing the formation of a transcriptionally activeternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negativeregulator of the MYB family of transcription factors.Phosphorylation of MYB leads to its subsequent proteolysis whilephosphorylation of MYBL1 and MYBL2 inhibits their interaction withthe coactivator CREBBP. Other transcription factors may also beinhibited by direct phosphorylation of CREBBP itself. Actsdownstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which isin turn required for activation of NLK by MAP3K7/TAK1. Upon IL1Bstimulus, cooperates with ATF5 to activate the transactivationactivity of C/EBP subfamily members. Phosphorylates ATF5 but alsostabilizes ATF5 protein levels in a kinase-independent manner(PubMed:25512613). {ECO:0000250|UniProtKB:O54949,ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582,ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15764709,ECO:0000269|PubMed:17952062, ECO:0000269|PubMed:20061393,ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444,ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613}. Scaffolding protein that is part of a multiproteinsignaling complex. Promotes phosphorylation of Raf family membersand activation of downstream MAP kinases. Promotes activation ofMAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does nothave kinase activity by itself. {ECO:0000250|UniProtKB:Q61097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+811106_111412528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+811115_119412528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+81122_25412528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+81127_34412528Compositional biasNote=Poly-His
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+81142_48412528Compositional biasNote=Poly-His
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+81171_83412528Compositional biasNote=Poly-Ala
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+811298_300412528MotifNote=TQE
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+811144_152412528Nucleotide bindingATP
TgeneKSR1chr17:26512291chr17:25904518ENST00000268763+22217_21-13787Compositional biasNote=Poly-Gly
TgeneKSR1chr17:26512291chr17:25904518ENST00000268763+222289_292-13787Compositional biasNote=Poly-Pro
TgeneKSR1chr17:26512291chr17:25904518ENST00000268763+222613_883-13787DomainProtein kinase
TgeneKSR1chr17:26512291chr17:25904518ENST00000268763+2221_172-13787RegionMediates association with membranes
TgeneKSR1chr17:26512291chr17:25904518ENST00000268763+222347_391-13787Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+811138_427412528DomainProtein kinase
HgeneNLKchr17:26512291chr17:25904518ENST00000407008+811428_527412528RegionRequired for homodimerization and kinase activation and localization to the nucleus


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FusionGeneSequence for NLK_KSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000509603_chr17_25904518_+_1165aa
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ
QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNL
LVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQY
ALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCI
PLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDI
GLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTK
KEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPDISAFAHAAPLPEAADGTR
LDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG
EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYL
HAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL

>In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000319524_chr17_25904518_+_1212aa
MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ
QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNL
LVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQY
ALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCI
PLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDI
GLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTK
KEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKE
NAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQ
VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK
TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKD
EDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000509603_chr17_25904518_+_3495nt
ATGTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCAC
CATCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCT
GTACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAA
CAGCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACA
GTTAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGT
GTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAA
AGGGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGAC
TATTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCAT
GTCAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTC
CTTGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAA
GTTGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATC
TTTGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCA
TCACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTAT
ACCCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTG
GATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTAT
GCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGT
GGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCC
CAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATT
CCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAG
CTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCAT
GAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATC
GGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAG
TGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGG
AGGACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAG
AAGGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTC
CCGACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTAC
TTCATTCATCATAGACAGCAGTTTATCTTTCCAGACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGG
CTCGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGAT
GAGGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAG
GAGTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGC
GAGGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACG
CGGCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTG
CACTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTT
CATGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTT
GGGATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTA
CGCGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTG
CAAGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACT
TCTGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATG

>In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000319524_chr17_25904518_+_3636nt
ATGTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCAC
CATCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCT
GTACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAA
CAGCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACA
GTTAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGT
GTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAA
AGGGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGAC
TATTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCAT
GTCAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTC
CTTGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAA
GTTGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATC
TTTGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCA
TCACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTAT
ACCCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTG
GATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTAT
GCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGT
GGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCC
CAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATT
CCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAG
CTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCAT
GAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATC
GGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAG
TGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGG
AGGACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAG
AAGGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTC
CCGACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTAC
TTCATTCATCATAGACAGCAGTTTATCTTTCCAGTGCCATCTGCTGGCCATTGCTGGAAATGCCTCCTTATTGCAGAAAGTTTAAAGGAA
AACGCTTTCAACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGAT
GTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCG
AGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAG
GTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAG
ATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTC
ATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAG
ACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAA
GATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAG
GGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGAC
GAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAG
AACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTC
AGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAG
CTGAACCGGCGGCTCTCCCACCCTGGACACTTCTGGAAGTCAGCTGACATTAACAGCAGCAAAGTTGTACCCCGGTTTGAAAGGTTTGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000509603_chr17_25904518_+_4213nt
CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG
GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT
GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG
TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT
GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC
CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC
TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA
GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT
GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA
TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT
ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA
GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT
TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT
TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG
GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGACTA
TTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCATGT
CAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTCCT
TGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAAGT
TGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATCTT
TGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCATC
ACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTATAC
CCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTGGA
TGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGC
CCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGG
CTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCA
GGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCC
CCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCT
GAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGA
GTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGG
GCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTG
CAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAG
GACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAA
GGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCC
GACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTT
CATTCATCATAGACAGCAGTTTATCTTTCCAGACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCT
CGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGA
GGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGA
GTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGA
GGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCG
GCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCA
CTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCA
TGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGG
GATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACG
CGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCA
AGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTC
TGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGA

>In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000319524_chr17_25904518_+_4653nt
CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG
GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT
GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG
TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT
GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC
CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC
TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA
GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT
GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA
TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT
ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA
GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT
TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT
TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG
GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGACTA
TTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCATGT
CAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTCCT
TGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAAGT
TGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATCTT
TGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCATC
ACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTATAC
CCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTGGA
TGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGC
CCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGG
CTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCA
GGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCC
CCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCT
GAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGA
GTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGG
GCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTG
CAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAG
GACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAA
GGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCC
GACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTT
CATTCATCATAGACAGCAGTTTATCTTTCCAGTGCCATCTGCTGGCCATTGCTGGAAATGCCTCCTTATTGCAGAAAGTTTAAAGGAAAA
CGCTTTCAACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGATGT
GTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCGAG
CTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAGGT
AGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAGAT
GGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTCAT
GGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAGAC
GTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAAGA
TCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAGGG
ACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGACGA
GGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAGAA
CCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTCAG
TGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAGCT
GAACCGGCGGCTCTCCCACCCTGGACACTTCTGGAAGTCAGCTGACATTAACAGCAGCAAAGTTGTACCCCGGTTTGAAAGGTTTGGCTT
GGGCGTCCTGGAGTCCAGTAATCCAAAGATGTAGCCAGCCATATGGTTTTTCGCTGCTGATCTCTTTCTTTTTAAAATGTGTTTCTGAAA
CATCCCAACAACCACCACGACAAAAAAACACTGCCTGCCCAGCGCTGCAAACCAGGAGCACACGTCCTAGATTCAGACTGTTGGCCATAA
ACCCCACTCGGGAGATGGAGCTGCACCTGCTATTTCTTAAAATGACACCACCAACAACCAAACCTGTCATGACAGACAGCAAATGTTTAC


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FusionGenePPI for NLK_KSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NLKLEF1, CTNNB1, TCF7L2, FBXW4, FBXW5, SKP2, CUL1, MYB, HIPK2, MYBL1, MYBL2, CREBBP, FOXO4, FOXO1, FOXO3, ASGR1, ELAVL1, USP4, ATXN1, TAB2, MAP3K7, NLK, SMAD4, RCHY1, SDR16C5, KPNB1, RANBP2, C2orf44, FAM222B, FAM222A, RNF219, TNKS1BP1, SKI, RANGAP1, TLE3, CEP97, PASK, CNOT2, CCP110, UBAP2L, TRPS1, CNOT11, BACH1, CNOT3, SHANK2, PKM, TP53, MDM2, GRN, KRTAP5-9, ZHX3, QRICH1, KRTAP4-2, KRTAP10-3, KRTAP5-6, STAT5AKSR1MAP2K1, BRAF, BRAP, KSR1, MARK3, RAF1, LSP1, HSP90AA1, YWHAE, YWHAB, SDF4, SKAP1, PRMT2, XPO1, VPRBP, NF2, PJA2, KCTD3, KIF13B, ZBTB21, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, DENND4C, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LPIN3, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, MAPKAP1, NF1, HDAC4, CBY1, SH3RF3, SRSF12, CDC25C, SYDE1, AGAP1, NADK, GIGYF2, CDC25B, CDK16, TANC2, CAMSAP2, PTPN13, RALGPS2, FAM110B, USP21, KIAA1804, RASAL2, TIAM1, ANKRD34A, FAM53C, PHLDB2, RPTOR, PLEKHA7, OSBPL6, KIF1C, MELK, NAV1, DENND4A, FAM110A, GAB2, STARD13, PTPN14, DEPDC1B, HDAC7, CWC25, INPP5E, LARP1, RAB11FIP2, PLEKHA5, MTFR1L, MLLT4, CHEK1, KIF1B, CSNK1A1, TBC1D25, EDC3, HDAC5, TBC1D1, DACT3, PANK2, REEP3, CRTC2, CRTC3, MICALL1, SH3BP4, BAIAP2, FGD6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NLK_KSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NLK_KSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource