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Fusion gene ID: 24463 |
FusionGeneSummary for NLK_KSR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NLK_KSR1 | Fusion gene ID: 24463 | Hgene | Tgene | Gene symbol | NLK | KSR1 | Gene ID | 51701 | 8844 |
| Gene name | nemo like kinase | kinase suppressor of ras 1 | |
| Synonyms | - | KSR|RSU2 | |
| Cytomap | 17q11.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase NLK | kinase suppressor of Ras 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UBE8 | Q8IVT5 | |
| Ensembl transtripts involved in fusion gene | ENST00000407008, ENST00000583517, ENST00000582037, | ENST00000509603, ENST00000319524, ENST00000268763, ENST00000398988, ENST00000581975, ENST00000582410, ENST00000578981, | |
| Fusion gene scores | * DoF score | 13 X 7 X 8=728 | 10 X 7 X 5=350 |
| # samples | 15 | 9 | |
| ** MAII score | log2(15/728*10)=-2.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/350*10)=-1.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NLK [Title/Abstract] AND KSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NLK | GO:0050821 | protein stabilization | 25512613 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-4357-01A | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000407008 | ENST00000509603 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| In-frame | ENST00000407008 | ENST00000319524 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| 5CDS-5UTR | ENST00000407008 | ENST00000268763 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| 5CDS-5UTR | ENST00000407008 | ENST00000398988 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| 5CDS-intron | ENST00000407008 | ENST00000581975 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| 5CDS-intron | ENST00000407008 | ENST00000582410 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| 5CDS-intron | ENST00000407008 | ENST00000578981 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-3CDS | ENST00000583517 | ENST00000509603 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-3CDS | ENST00000583517 | ENST00000319524 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-5UTR | ENST00000583517 | ENST00000268763 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-5UTR | ENST00000583517 | ENST00000398988 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-intron | ENST00000583517 | ENST00000581975 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-intron | ENST00000583517 | ENST00000582410 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-intron | ENST00000583517 | ENST00000578981 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-3CDS | ENST00000582037 | ENST00000509603 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-3CDS | ENST00000582037 | ENST00000319524 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-5UTR | ENST00000582037 | ENST00000268763 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-5UTR | ENST00000582037 | ENST00000398988 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-intron | ENST00000582037 | ENST00000581975 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-intron | ENST00000582037 | ENST00000582410 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
| intron-intron | ENST00000582037 | ENST00000578981 | NLK | chr17 | 26512291 | + | KSR1 | chr17 | 25904518 | + |
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FusionProtFeatures for NLK_KSR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NLK | KSR1 |
| Serine/threonine-protein kinase that regulates a numberof transcription factors with key roles in cell fatedetermination. Positive effector of the non-canonical Wntsignaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 andHIPK2. Activation of this pathway causes binding to andphosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading tomethylation of PPARG target promoters at histone H3K9 andtranscriptional silencing. The resulting loss of PPARG target genetranscription inhibits adipogenesis and promotesosteoblastogenesis in mesenchymal stem cells (MSCs). Negativeregulator of the canonical Wnt/beta-catenin signaling pathway.Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting thedissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, aswell as the ubiquitination and subsequent proteolysis of LEF1.Together these effects inhibit the transcriptional activation ofcanonical Wnt/beta-catenin target genes. Negative regulator of theNotch signaling pathway. Binds to and phosphorylates NOTCH1,thereby preventing the formation of a transcriptionally activeternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negativeregulator of the MYB family of transcription factors.Phosphorylation of MYB leads to its subsequent proteolysis whilephosphorylation of MYBL1 and MYBL2 inhibits their interaction withthe coactivator CREBBP. Other transcription factors may also beinhibited by direct phosphorylation of CREBBP itself. Actsdownstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which isin turn required for activation of NLK by MAP3K7/TAK1. Upon IL1Bstimulus, cooperates with ATF5 to activate the transactivationactivity of C/EBP subfamily members. Phosphorylates ATF5 but alsostabilizes ATF5 protein levels in a kinase-independent manner(PubMed:25512613). {ECO:0000250|UniProtKB:O54949,ECO:0000269|PubMed:12482967, ECO:0000269|PubMed:14960582,ECO:0000269|PubMed:15004007, ECO:0000269|PubMed:15764709,ECO:0000269|PubMed:17952062, ECO:0000269|PubMed:20061393,ECO:0000269|PubMed:20118921, ECO:0000269|PubMed:20874444,ECO:0000269|PubMed:21454679, ECO:0000269|PubMed:25512613}. | Scaffolding protein that is part of a multiproteinsignaling complex. Promotes phosphorylation of Raf family membersand activation of downstream MAP kinases. Promotes activation ofMAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does nothave kinase activity by itself. {ECO:0000250|UniProtKB:Q61097}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 106_111 | 412 | 528 | Compositional bias | Note=Poly-Ala |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 115_119 | 412 | 528 | Compositional bias | Note=Poly-Ala |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 22_25 | 412 | 528 | Compositional bias | Note=Poly-Ala |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 27_34 | 412 | 528 | Compositional bias | Note=Poly-His |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 42_48 | 412 | 528 | Compositional bias | Note=Poly-His |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 71_83 | 412 | 528 | Compositional bias | Note=Poly-Ala |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 298_300 | 412 | 528 | Motif | Note=TQE |
| Hgene | NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 144_152 | 412 | 528 | Nucleotide binding | ATP |
| Tgene | >KSR1 | chr17:26512291 | chr17:25904518 | ENST00000268763 | + | 2 | 22 | 17_21 | -13 | 787 | Compositional bias | Note=Poly-Gly |
| Tgene | >KSR1 | chr17:26512291 | chr17:25904518 | ENST00000268763 | + | 2 | 22 | 289_292 | -13 | 787 | Compositional bias | Note=Poly-Pro |
| Tgene | >KSR1 | chr17:26512291 | chr17:25904518 | ENST00000268763 | + | 2 | 22 | 613_883 | -13 | 787 | Domain | Protein kinase |
| Tgene | >KSR1 | chr17:26512291 | chr17:25904518 | ENST00000268763 | + | 2 | 22 | 1_172 | -13 | 787 | Region | Mediates association with membranes |
| Tgene | >KSR1 | chr17:26512291 | chr17:25904518 | ENST00000268763 | + | 2 | 22 | 347_391 | -13 | 787 | Zinc finger | Phorbol-ester/DAG-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 138_427 | 412 | 528 | Domain | Protein kinase |
| Hgene | >NLK | chr17:26512291 | chr17:25904518 | ENST00000407008 | + | 8 | 11 | 428_527 | 412 | 528 | Region | Required for homodimerization and kinase activation and localization to the nucleus |
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FusionGeneSequence for NLK_KSR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000509603_chr17_25904518_+_1165aa MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNL LVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQY ALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCI PLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDI GLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTK KEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPDISAFAHAAPLPEAADGTR LDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHG EVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYL HAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYEL >In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000319524_chr17_25904518_+_1212aa MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQ QPYFPSPAPGQAPGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNL LVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQY ALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCI PLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDI GLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTK KEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKE NAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQ VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPK TSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKD EDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000509603_chr17_25904518_+_3495nt ATGTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCAC CATCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCT GTACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAA CAGCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACA GTTAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGT GTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAA AGGGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGAC TATTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCAT GTCAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTC CTTGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAA GTTGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATC TTTGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCA TCACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTAT ACCCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTG GATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTAT GCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGT GGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCC CAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATT CCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAG CTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCAT GAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATC GGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAG TGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGG AGGACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAG AAGGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTC CCGACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTAC TTCATTCATCATAGACAGCAGTTTATCTTTCCAGACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGG CTCGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGAT GAGGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAG GAGTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGC GAGGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACG CGGCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTG CACTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTT CATGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTT GGGATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTA CGCGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTG CAAGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACT TCTGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATG >In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000319524_chr17_25904518_+_3636nt ATGTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCAC CATCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCT GTACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAA CAGCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACA GTTAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGT GTTGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAA AGGGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGAC TATTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCAT GTCAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTC CTTGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAA GTTGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATC TTTGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCA TCACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTAT ACCCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTG GATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTAT GCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGT GGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCC CAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATT CCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAG CTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCAT GAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATC GGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAG TGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGG AGGACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAG AAGGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTC CCGACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTAC TTCATTCATCATAGACAGCAGTTTATCTTTCCAGTGCCATCTGCTGGCCATTGCTGGAAATGCCTCCTTATTGCAGAAAGTTTAAAGGAA AACGCTTTCAACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGAT GTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCG AGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAG GTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAG ATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTC ATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAG ACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAA GATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAG GGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGAC GAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAG AACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTC AGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAG CTGAACCGGCGGCTCTCCCACCCTGGACACTTCTGGAAGTCAGCTGACATTAACAGCAGCAAAGTTGTACCCCGGTTTGAAAGGTTTGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000509603_chr17_25904518_+_4213nt CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGACTA TTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCATGT CAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTCCT TGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAAGT TGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATCTT TGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCATC ACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTATAC CCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTGGA TGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGC CCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGG CTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCA GGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCC CCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCT GAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGA GTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGG GCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTG CAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAG GACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAA GGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCC GACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTT CATTCATCATAGACAGCAGTTTATCTTTCCAGACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCT CGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGA GGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGA GTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGA GGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCG GCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCA CTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCA TGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGG GATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACG CGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCA AGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTC TGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGA >In-frame_NLK_ENST00000407008_chr17_26512291_+_KSR1_ENST00000319524_chr17_25904518_+_4653nt CCCCGGCTCTCTTTCTCCTCTCTGTCCTGCTGTCGCCTCCTCTCCTCACTCCAGCCTCCTTCCCTGGCTTATTCTGCCCAGGAAAGTTTG GAACCCCCGCCCCCCCTCCCCAATCAGGTCAACCTGACTAGGAGTAGGGGGAGATGTAGGAAGGCCTGAGAGTTCGGGGGGGGGGAAGCT GGAAGCTGGTTTCCCAGAAAATTTCCCCCCATCTTCTCCATTTAGGGTGGTGGGAATTTTTTTTAATCCTGTTTTTGAGGAGGTGGTAGG TGTTTAGAAAAGGATGTGGGAATGGAAGGGGTAGATGAGTCAACCCTCTTTCAAGATTCCAAGGGTGGTGTGTTACCTGATCCTTTTCGT GTGTGGAGTTCAGGGGGTCGGGAGGTTTGGCCTTTATTCCCACATTCAAAGTTGGAACCTCCCCCAAATTAAGAATGGAGTTTTAGTACC CACTTGTGGCAGGAATCCTGGGGGGAAGGGGTCCTTTTTTCCTTTTTCTTTTCTTTTTTCCCTTTTTTTTCCTTTTGGCAACCCACACCC TTCCACACACGCTCACCCCAAAATTAAACACCAAGATCCTCTAACTTGTTTGGATTGACTGATGAAGACATAAAGCTCTATGTTTTTTGA GGTGGAGTGAGTGGTTTTTCTTCATTTTTAAATGGCCAAATGACAGCTTGACCCAGTTTGCTTTCCAATCAAAGGGCATTTATTTTGAAT GTCTCTTTGTGGCGCAAGAGCCAACGCAAAAATGATGGCGGCTTACAATGGCGGTACATCTGCAGCAGCAGCAGGTCACCACCACCACCA TCACCACCACCTTCCACACCTCCCTCCTCCTCACCTGCACCACCACCACCACCCTCAACACCATCTTCATCCGGGGTCGGCTGCCGCTGT ACACCCTGTACAGCAGCACACCTCTTCGGCAGCTGCGGCAGCCGCAGCAGCGGCTGCAGCTGCAGCCATGTTAAACCCTGGGCAACAACA GCCATATTTCCCATCACCGGCACCGGGGCAGGCTCCTGGACCAGCTGCAGCAGCCCCAGCTCAGGTACAGGCTGCCGCAGCTGCTACAGT TAAGGCGCACCATCATCAGCACTCGCATCATCCACAGCAGCAGCTGGATATTGAGCCGGATAGACCTATTGGATATGGAGCCTTTGGTGT TGTCTGGTCAGTAACAGATCCAAGAGATGGAAAGAGAGTAGCGCTCAAAAAGATGCCCAACGTCTTCCAGAATCTGGTCTCTTGCAAAAG GGTCTTCCGGGAATTGAAGATGTTGTGTTTTTTTAAGCATGATAATGTACTCTCTGCCCTTGACATACTCCAACCTCCACACATTGACTA TTTTGAAGAAATATATGTTGTCACAGAATTGATGCAGAGTGACCTACATAAAATTATCGTCTCTCCTCAACCACTCAGCTCAGATCATGT CAAAGTTTTTCTTTATCAGATTTTGCGAGGTTTGAAATATCTCCATTCAGCTGGCATTTTACATCGAGACATTAAGCCAGGGAATCTCCT TGTGAACAGCAACTGTGTTCTAAAGATTTGTGATTTTGGATTGGCCAGAGTGGAAGAATTAGATGAATCCCGTCATATGACTCAGGAAGT TGTTACTCAGTATTATCGGGCTCCAGAAATCCTGATGGGCAGCCGTCATTACAGCAATGCTATTGACATCTGGTCTGTGGGATGTATCTT TGCAGAACTACTAGGACGAAGAATATTGTTTCAGGCACAGAGTCCCATTCAGCAGTTGGATTTGATCACGGATCTGTTGGGCACACCATC ACTGGAAGCAATGAGGACAGCTTGTGAAGGCGCTAAGGCACATATACTCAGGGGTCCTCATAAACAGCCATCTCTTCCTGTACTCTATAC CCTGTCTAGCCAGGCTACACATGAAGCTGTTCATCTCCTTTGCAGGATGTTGGTCTTTGATCCAGAGATCCCCCGAGACCTCACGCTGGA TGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGC CCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGG CTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCA GGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCC CCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCT GAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGA GTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGG GCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTG CAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAG GACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAA GGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCC GACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTT CATTCATCATAGACAGCAGTTTATCTTTCCAGTGCCATCTGCTGGCCATTGCTGGAAATGCCTCCTTATTGCAGAAAGTTTAAAGGAAAA CGCTTTCAACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGATGT GTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCGAG CTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAGGT AGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAGAT GGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTCAT GGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAGAC GTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAAGA TCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAGGG ACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGACGA GGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAGAA CCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTCAG TGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAGCT GAACCGGCGGCTCTCCCACCCTGGACACTTCTGGAAGTCAGCTGACATTAACAGCAGCAAAGTTGTACCCCGGTTTGAAAGGTTTGGCTT GGGCGTCCTGGAGTCCAGTAATCCAAAGATGTAGCCAGCCATATGGTTTTTCGCTGCTGATCTCTTTCTTTTTAAAATGTGTTTCTGAAA CATCCCAACAACCACCACGACAAAAAAACACTGCCTGCCCAGCGCTGCAAACCAGGAGCACACGTCCTAGATTCAGACTGTTGGCCATAA ACCCCACTCGGGAGATGGAGCTGCACCTGCTATTTCTTAAAATGACACCACCAACAACCAAACCTGTCATGACAGACAGCAAATGTTTAC |
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FusionGenePPI for NLK_KSR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NLK | LEF1, CTNNB1, TCF7L2, FBXW4, FBXW5, SKP2, CUL1, MYB, HIPK2, MYBL1, MYBL2, CREBBP, FOXO4, FOXO1, FOXO3, ASGR1, ELAVL1, USP4, ATXN1, TAB2, MAP3K7, NLK, SMAD4, RCHY1, SDR16C5, KPNB1, RANBP2, C2orf44, FAM222B, FAM222A, RNF219, TNKS1BP1, SKI, RANGAP1, TLE3, CEP97, PASK, CNOT2, CCP110, UBAP2L, TRPS1, CNOT11, BACH1, CNOT3, SHANK2, PKM, TP53, MDM2, GRN, KRTAP5-9, ZHX3, QRICH1, KRTAP4-2, KRTAP10-3, KRTAP5-6, STAT5A | KSR1 | MAP2K1, BRAF, BRAP, KSR1, MARK3, RAF1, LSP1, HSP90AA1, YWHAE, YWHAB, SDF4, SKAP1, PRMT2, XPO1, VPRBP, NF2, PJA2, KCTD3, KIF13B, ZBTB21, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, DENND4C, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LPIN3, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, MAPKAP1, NF1, HDAC4, CBY1, SH3RF3, SRSF12, CDC25C, SYDE1, AGAP1, NADK, GIGYF2, CDC25B, CDK16, TANC2, CAMSAP2, PTPN13, RALGPS2, FAM110B, USP21, KIAA1804, RASAL2, TIAM1, ANKRD34A, FAM53C, PHLDB2, RPTOR, PLEKHA7, OSBPL6, KIF1C, MELK, NAV1, DENND4A, FAM110A, GAB2, STARD13, PTPN14, DEPDC1B, HDAC7, CWC25, INPP5E, LARP1, RAB11FIP2, PLEKHA5, MTFR1L, MLLT4, CHEK1, KIF1B, CSNK1A1, TBC1D25, EDC3, HDAC5, TBC1D1, DACT3, PANK2, REEP3, CRTC2, CRTC3, MICALL1, SH3BP4, BAIAP2, FGD6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NLK_KSR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NLK_KSR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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