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Fusion gene ID: 24436 |
FusionGeneSummary for NKX3-1_SEC63 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NKX3-1_SEC63 | Fusion gene ID: 24436 | Hgene | Tgene | Gene symbol | NKX3-1 | SEC63 | Gene ID | 4824 | 11231 |
| Gene name | NK3 homeobox 1 | SEC63 homolog, protein translocation regulator | |
| Synonyms | BAPX2|NKX3|NKX3.1|NKX3A | DNAJC23|ERdj2|PCLD2|PRO2507|SEC63L | |
| Cytomap | 8p21.2 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeobox protein Nkx-3.1NK homeobox, family 3, ANK3 transcription factor homolog ANK3 transcription factor related, locus 1homeobox protein NK-3 homolog A | translocation protein SEC63 homologSEC63 protein translocation regulatorSEC63-like protein | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q99801 | Q9UGP8 | |
| Ensembl transtripts involved in fusion gene | ENST00000380871, ENST00000523261, | ENST00000369002, ENST00000460009, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 30 X 6 X 14=2520 |
| # samples | 2 | 33 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(33/2520*10)=-2.93288580414146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NKX3-1 [Title/Abstract] AND SEC63 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NKX3-1 | GO:0001934 | positive regulation of protein phosphorylation | 20395202 |
| Hgene | NKX3-1 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17486276|19266349 |
| Hgene | NKX3-1 | GO:0008285 | negative regulation of cell proliferation | 17486276|19266349 |
| Hgene | NKX3-1 | GO:0010628 | positive regulation of gene expression | 17486276|20599703 |
| Hgene | NKX3-1 | GO:0010629 | negative regulation of gene expression | 17486276 |
| Hgene | NKX3-1 | GO:0010942 | positive regulation of cell death | 19266349 |
| Hgene | NKX3-1 | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 20395202 |
| Hgene | NKX3-1 | GO:0030521 | androgen receptor signaling pathway | 19886863 |
| Hgene | NKX3-1 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 20599703 |
| Hgene | NKX3-1 | GO:0045892 | negative regulation of transcription, DNA-templated | 18794125|19597465 |
| Hgene | NKX3-1 | GO:0045930 | negative regulation of mitotic cell cycle | 19266349 |
| Hgene | NKX3-1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19797053|20855495 |
| Hgene | NKX3-1 | GO:0071383 | cellular response to steroid hormone stimulus | 19886863 |
| Hgene | NKX3-1 | GO:0071456 | cellular response to hypoxia | 21056661 |
| Hgene | NKX3-1 | GO:0071850 | mitotic cell cycle arrest | 19266349 |
| Hgene | NKX3-1 | GO:0071899 | negative regulation of estrogen receptor binding | 18794125 |
| Hgene | NKX3-1 | GO:2000836 | positive regulation of androgen secretion | 19886863 |
| Hgene | NKX3-1 | GO:2001022 | positive regulation of response to DNA damage stimulus | 20395202 |
| Hgene | NKX3-1 | GO:2001235 | positive regulation of apoptotic signaling pathway | 20599703 |
| Hgene | NKX3-1 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 17486276 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5519-01A | NKX3-1 | chr8 | 23536206 | - | SEC63 | chr6 | 108214782 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000380871 | ENST00000369002 | NKX3-1 | chr8 | 23536206 | - | SEC63 | chr6 | 108214782 | - |
| 5CDS-intron | ENST00000380871 | ENST00000460009 | NKX3-1 | chr8 | 23536206 | - | SEC63 | chr6 | 108214782 | - |
| intron-3CDS | ENST00000523261 | ENST00000369002 | NKX3-1 | chr8 | 23536206 | - | SEC63 | chr6 | 108214782 | - |
| intron-intron | ENST00000523261 | ENST00000460009 | NKX3-1 | chr8 | 23536206 | - | SEC63 | chr6 | 108214782 | - |
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FusionProtFeatures for NKX3-1_SEC63 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NKX3-1 | SEC63 |
| Transcription factor, which binds preferentially theconsensus sequence 5'-TAAGT[AG]-3' and can behave as atranscriptional repressor. Plays an important role in normalprostate development, regulating proliferation of glandularepithelium and in the formation of ducts in prostate. Acts as atumor suppressor controlling prostate carcinogenesis, as shown bythe ability to inhibit proliferation and invasion activities ofPC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}. | Required for integral membrane and secreted preproteintranslocation across the endoplasmic reticulum membrane. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NKX3-1_SEC63 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NKX3-1_SEC63 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NKX3-1 | SPDEF, SRF, HDAC1, SP1, SP2, SP3, SP4, SP5, KAT2B, TOPORS, WDR77, TOP1, HNRNPA0, MNAT1, AEN, LMCD1, TEX264, CCT7, RPL37A, FEM1B, CHPF, CKAP4, RABL6, MAN2B1, ND4, HMG20B, PEBP1, PTMS, STRA13, RARG, RPSA, STMN3, HSP90B1, TPT1, FAM136A | SEC63 | GSTK1, IRF1, PMF1, SPA17, GPR183, RFX3, GPRC5D, SKAP1, ACADM, RPS5, ABCC1, DDOST, KPNA4, SEC61A1, NTRK1, TP53, OFD1, TCTN2, TCTN3, NPHP1, RPGRIP1L, EVC2, TCTN1, TMEM17, TMEM216, HSPA5, SENP3, CDKN3, YIPF3, HTR2C, ARFGAP1, BIN3, GPRC5B, TPTE, NR3C1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NKX3-1_SEC63 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NKX3-1_SEC63 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NKX3-1 | C0033578 | Prostatic Neoplasms | 4 | CTD_human |
| Tgene | SEC63 | C0022680 | Polycystic Kidney Diseases | 1 | CTD_human |
| Tgene | SEC63 | C0158683 | Polycystic liver disease | 1 | CTD_human;HPO;ORPHANET |
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