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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24418

FusionGeneSummary for NKAIN2_NEK1

check button Fusion gene summary
Fusion gene informationFusion gene name: NKAIN2_NEK1
Fusion gene ID: 24418
HgeneTgene
Gene symbol

NKAIN2

NEK1

Gene ID

154215

4750

Gene namesodium/potassium transporting ATPase interacting 2NIMA related kinase 1
SynonymsFAM77B|NKAIP2|TCBA|TCBA1ALS24|NY-REN-55|SRPS2|SRPS2A|SRTD6
Cytomap

6q22.31

4q33

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit beta-1-interacting protein 2Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2Na+/K+ transporting ATPase interacting 2T-cell lymphoma breakpoint-associated target protein 1serine/threonine-protein kinase Nek1NIMA (never in mitosis gene a)-related kinase 1never in mitosis A-related kinase 1nimA-related protein kinase 1protein-serine/threonine kinaserenal carcinoma antigen NY-REN-55
Modification date2018052320180523
UniProtAcc

Q5VXU1

Q96PY6

Ensembl transtripts involved in fusion geneENST00000368416, ENST00000368417, 
ENST00000546092, ENST00000545433, 
ENST00000476571, 		ENST00000439128, 
ENST00000511633, ENST00000510533, 
ENST00000507142, ENST00000512193, 
Fusion gene scores* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 42
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NKAIN2 [Title/Abstract] AND NEK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEK1

GO:0006468

protein phosphorylation

19158487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW813844NKAIN2chr6

124812714

+NEK1chr4

170407936

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000368416ENST00000439128NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368416ENST00000511633NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368416ENST00000510533NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368416ENST00000507142NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368416ENST00000512193NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368417ENST00000439128NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368417ENST00000511633NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368417ENST00000510533NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368417ENST00000507142NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000368417ENST00000512193NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000546092ENST00000439128NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000546092ENST00000511633NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000546092ENST00000510533NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000546092ENST00000507142NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000546092ENST00000512193NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000545433ENST00000439128NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000545433ENST00000511633NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000545433ENST00000510533NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000545433ENST00000507142NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000545433ENST00000512193NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000476571ENST00000439128NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000476571ENST00000511633NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000476571ENST00000510533NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000476571ENST00000507142NKAIN2chr6

124812714

+NEK1chr4

170407936

+
intron-intronENST00000476571ENST00000512193NKAIN2chr6

124812714

+NEK1chr4

170407936

+

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FusionProtFeatures for NKAIN2_NEK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NKAIN2

Q5VXU1

NEK1

Q96PY6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NKAIN2_NEK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NKAIN2_NEK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NKAIN2_NEK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NKAIN2_NEK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNKAIN2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNEK1C0002736Amyotrophic Lateral Sclerosis2CTD_human
TgeneNEK1C0036996Short Rib-Polydactyly Syndrome2CTD_human
TgeneNEK1C0024507Majewski Syndrome1ORPHANET;UNIPROT