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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 2441

FusionGeneSummary for ARHGAP32_PRDM10

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP32_PRDM10
Fusion gene ID: 2441
HgeneTgene
Gene symbol

ARHGAP32

PRDM10

Gene ID

9743

56980

Gene nameRho GTPase activating protein 32PR/SET domain 10
SynonymsGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAPPFM7
Cytomap

11q24.3

11q24.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaPR domain zinc finger protein 10PR domain 10PR domain containing 10PR domain-containing protein 10PR-domain family member 7PRDM zinc finger transcription factortristanin
Modification date2018052320180526
UniProtAcc

A7KAX9

Q9NQV6

Ensembl transtripts involved in fusion geneENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
ENST00000358825, ENST00000304538, 
ENST00000360871, ENST00000423662, 
ENST00000528746, ENST00000526082, 
Fusion gene scores* DoF score9 X 7 X 4=2521 X 1 X 1=1
# samples 91
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ARHGAP32 [Title/Abstract] AND PRDM10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YL-A8SK-01BARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000310343ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
In-frameENST00000524655ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-3CDSENST00000392657ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-3CDSENST00000527272ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-

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FusionProtFeatures for ARHGAP32_PRDM10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP32

A7KAX9

PRDM10

Q9NQV6

GTPase-activating protein (GAP) promoting GTP hydrolysison RHOA, CDC42 and RAC1 small GTPases. May be involved in thedifferentiation of neuronal cells during the formation of neuriteextensions. Involved in NMDA receptor activity-dependent actinreorganization in dendritic spines. May mediate cross-talksbetween Ras- and Rho-regulated signaling pathways in cell growthregulation. Isoform 2 has higher GAP activity (By similarity).{ECO:0000250, ECO:0000269|PubMed:12446789,ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901,ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203,ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-0161131_1134-491024Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016866_916-491024Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016918_1031-491024Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-17221131_11349511161Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-16211131_11349471157Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-13181131_11348651062Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318866_9168651062Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318918_10318651062Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-13181131_11348651075Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318866_9168651075Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318918_10318651075Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016208_326-491024DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016355_377-491024Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016530_552-491024Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016560_582-491024Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016588_610-491024Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016616_639-491024Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016644_666-491024Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016672_695-491024Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016727_750-491024Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016772_795-491024Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538-016834_857-491024Zinc fingerC2H2-type 10

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221031_10361632088Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221305_13101632088Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131031_1036-1271739Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131305_1310-1271739Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121031_1036-121739Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121305_1310-121739Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522131_2451632088DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522259_3211632088DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522372_5671632088DomainRho-GAP
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113131_245-1271739DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113259_321-1271739DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113372_567-1271739DomainRho-GAP
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112131_245-121739DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112259_321-121739DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112372_567-121739DomainRho-GAP
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722866_9169511161Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722918_10319511161Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621866_9169471157Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621918_10319471157Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722208_3269511161DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621208_3269471157DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318208_3268651062DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318208_3268651075DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722355_3779511161Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722530_5529511161Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722560_5829511161Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722588_6109511161Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722616_6399511161Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722644_6669511161Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722672_6959511161Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722727_7509511161Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722772_7959511161Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000358825-1722834_8579511161Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621355_3779471157Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621530_5529471157Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621560_5829471157Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621588_6109471157Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621616_6399471157Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621644_6669471157Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621672_6959471157Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621727_7509471157Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621772_7959471157Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000360871-1621834_8579471157Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318355_3778651062Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318530_5528651062Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318560_5828651062Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318588_6108651062Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318616_6398651062Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318644_6668651062Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318672_6958651062Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318727_7508651062Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318772_7958651062Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000423662-1318834_8578651062Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318355_3778651075Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318530_5528651075Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318560_5828651075Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318588_6108651075Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318616_6398651075Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318644_6668651075Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318672_6958651075Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318727_7508651075Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318772_7958651075Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000526082-1318834_8578651075Zinc fingerC2H2-type 10


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FusionGeneSequence for ARHGAP32_PRDM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ARHGAP32_ENST00000310343_chr11_128963516_-_PRDM10_ENST00000358825_chr11_129782120_-_373aa
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQATSPHQSQQSTVDVGQL
HDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFRGY
SSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTN

>In-frame_ARHGAP32_ENST00000524655_chr11_128963516_-_PRDM10_ENST00000358825_chr11_129782120_-_299aa
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQA
TSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSS
VQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ARHGAP32_ENST00000310343_chr11_128963516_-_PRDM10_ENST00000358825_chr11_129782120_-_1119nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGCCACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTC
CATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTACCGCCTCGGCCCCGTCCTCCGCCCAG
GTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAGGGG
CAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTAT
TCATCTGAGATTCAAATGATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTG
AAGGCGGTTACTTCGGGTCATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAG
GTCGAGCCACCTGCACACAGTGACTCCCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAAC

>In-frame_ARHGAP32_ENST00000524655_chr11_128963516_-_PRDM10_ENST00000358825_chr11_129782120_-_897nt
ATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTG
AAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAG
CTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGCC
ACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTCCATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGTGCAG
CACATCCAGGTCAGCGAGCCTACCGCCTCGGCCCCGTCCTCCGCCCAGGTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAG
CAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAGGGGCAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCT
GTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTATTCATCTGAGATTCAAATGATGACGCTTCCTCCGGGTCAGTTT
GTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTGAAGGCGGTTACTTCGGGTCATTATGTGTTATCAGAAAGTCAA
TCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAGGTCGAGCCACCTGCACACAGTGACTCCCTGGACCCCCAGACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ARHGAP32_ENST00000310343_chr11_128963516_-_PRDM10_ENST00000358825_chr11_129782120_-_3726nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGCCACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTC
CATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTACCGCCTCGGCCCCGTCCTCCGCCCAG
GTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAGGGG
CAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTAT
TCATCTGAGATTCAAATGATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTG
AAGGCGGTTACTTCGGGTCATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAG
GTCGAGCCACCTGCACACAGTGACTCCCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAAC
GGGAACGGAAGCAGCGAAGTGCATATCACCAAACCATGACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAA
GTCTGAAAGCTCTGACACGTAGAGCTCTTTTGTAAGATTTATTATTCACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACA
CTGGGGTTTATTTTGCCAAGGTCATCTTTATCAAATTGACTCTTCAAACCCTCGGTTTTTGCCACAGAACAGAGATCTTTCAGGGGAAAG
TAGATTTCGAGGTGGAGAGAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATACTGACGAGCCTTACTTTTCCTTTGTGGAAATATTAA
GTGGCATATTGTGTTCATACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTTCTTATTCCAAGCCATGGCACCAAAGG
AGAAGGGGCATTTTGTGGGTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAAGGGAGCCTGCTGAATA
ACAAAATTAAAATGATGAAACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTTTTAACT
TCCCTATTTTAGAAAACTATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTG
ATAGTTCTTCATTATTTCACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTT
TGCCTCCCATTCTGTGGTTGTGGTGGTGGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAA
GTATTGAAATTTTGTTCTGCCTTGCAGGATCCATTTATCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACT
CTTGCTGACATGTTCAGTGTATTTTATTACTTTTAATGCTGTCTTAAAATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTA
TTTATTAACATTTTTAACTTTAAACATATTGTGACTCATCTAGACCTTTTAATAAGACGGTCAACTTCACACTTAGGGAAAAAATTAAAA
TGTGATGGCCACTTCTAATAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCCAGTCTTTATGAATATACTATTAGTTGGGCATTAAAA
AATCAGTATATATTTTAACTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGTAGAATTTATTACTCCAGAACAGAAAG
ACCTTACTTCATTTCAAATGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAGTAGCTTCTTTATGATA
AAGACAATTTTCTGAAAAGTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGTTCATGT
AGTTGTTCCCCAATGTTTGAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAA
AGATATTCAACAGAAAATATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAG
TGTCCGGTCTAGAAAGACTTTCTAGGAGAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTT
ACGTTCTTTTTAATTTGAACCATAAGGTATCTCCCCTCCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTT
CATTTTATGGCAGTTGTTTTAAGTTTTAAAATACACAGAGGAAAATATTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTT
CTTCTTCTTCTTCTTCTTCTTCTTCTTTGGTCCTTAAGTGAAATAAAGACTCTAAAACTAATTTGTATATTATCAGCCAGAGATGCGGAT
GGCAGTCGAGCCAAATCGCATGGCTTTCAGATCAGGTATTCTGCACATTCATTCCAAGGTCATAGATTTTTAAAAGGACCTGGATTTGAA
GAGATGGCAAATGATGAGCCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGATATTGTGGCCTCTCTCAAGACACATT
GACACTGTAGACTTCATTCAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTGATTTGTACCGACAGAA
ATAGACATTTCATCATGTAAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCCTTTCAA
AAAAACTCTTAAGATATCTAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTAT
TTAAATGTGAACATTTATTGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTT

>In-frame_ARHGAP32_ENST00000524655_chr11_128963516_-_PRDM10_ENST00000358825_chr11_129782120_-_3528nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGCCACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTCCATGATCCTCAGCCCTAC
CCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTACCGCCTCGGCCCCGTCCTCCGCCCAGGTATCTGGGCAGCCGTTG
AGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAGGGGCAGGCTCTGCAGCAGCAG
CAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTATTCATCTGAGATTCAAATG
ATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTGAAGGCGGTTACTTCGGGT
CATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAGGTCGAGCCACCTGCACAC
AGTGACTCCCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAACGGGAACGGAAGCAGCGAA
GTGCATATCACCAAACCATGACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAAGTCTGAAAGCTCTGACAC
GTAGAGCTCTTTTGTAAGATTTATTATTCACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACACTGGGGTTTATTTTGCCA
AGGTCATCTTTATCAAATTGACTCTTCAAACCCTCGGTTTTTGCCACAGAACAGAGATCTTTCAGGGGAAAGTAGATTTCGAGGTGGAGA
GAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATACTGACGAGCCTTACTTTTCCTTTGTGGAAATATTAAGTGGCATATTGTGTTCAT
ACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTTCTTATTCCAAGCCATGGCACCAAAGGAGAAGGGGCATTTTGTGG
GTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAAGGGAGCCTGCTGAATAACAAAATTAAAATGATGA
AACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTTTTAACTTCCCTATTTTAGAAAACT
ATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTGATAGTTCTTCATTATTTC
ACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTTTGCCTCCCATTCTGTGGT
TGTGGTGGTGGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAAGTATTGAAATTTTGTTCT
GCCTTGCAGGATCCATTTATCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACTCTTGCTGACATGTTCAGT
GTATTTTATTACTTTTAATGCTGTCTTAAAATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTATTTATTAACATTTTTAAC
TTTAAACATATTGTGACTCATCTAGACCTTTTAATAAGACGGTCAACTTCACACTTAGGGAAAAAATTAAAATGTGATGGCCACTTCTAA
TAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCCAGTCTTTATGAATATACTATTAGTTGGGCATTAAAAAATCAGTATATATTTTAA
CTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGTAGAATTTATTACTCCAGAACAGAAAGACCTTACTTCATTTCAAA
TGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAGTAGCTTCTTTATGATAAAGACAATTTTCTGAAAA
GTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGTTCATGTAGTTGTTCCCCAATGTTT
GAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAAAGATATTCAACAGAAAAT
ATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAGTGTCCGGTCTAGAAAGAC
TTTCTAGGAGAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTTACGTTCTTTTTAATTTGA
ACCATAAGGTATCTCCCCTCCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTTCATTTTATGGCAGTTGTT
TTAAGTTTTAAAATACACAGAGGAAAATATTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTTCTTCTTCTTCTTCTTCTT
CTTCTTCTTTGGTCCTTAAGTGAAATAAAGACTCTAAAACTAATTTGTATATTATCAGCCAGAGATGCGGATGGCAGTCGAGCCAAATCG
CATGGCTTTCAGATCAGGTATTCTGCACATTCATTCCAAGGTCATAGATTTTTAAAAGGACCTGGATTTGAAGAGATGGCAAATGATGAG
CCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGATATTGTGGCCTCTCTCAAGACACATTGACACTGTAGACTTCATT
CAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTGATTTGTACCGACAGAAATAGACATTTCATCATGT
AAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCCTTTCAAAAAAACTCTTAAGATATC
TAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTATTTAAATGTGAACATTTAT
TGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTTTTTAATAAACATGTTTGT


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FusionGenePPI for ARHGAP32_PRDM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARHGAP32SFN, GRIN2B, RHOA, CDC42, GAB2, GAB1, RAC1, CRK, NCK1, BCAR1, FYN, NTRK1, CRKL, SHC2, SHC3, SRC, PLCG1, PIK3R1, GRB2, ARRB1, NPHP1, ATXN1, FZR1, SMURF1, AES, MDFI, NCK2, DZIP3, ABI2, LZTS2, NXF1, EGFR, SHC1, ZWINT, HNRNPD, SORT1, SYNCRIP, SGTB, CDH1, PTPRK, ASB3, TRIM25PRDM10BAP1, CUL1, REL, TMEFF1, CASQ2, FOXK2, SDC2, PRICKLE3, CD44, SDC1, RAP1GDS1, BHLHA15, PPAN, PRDM5, HIST1H1T


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221685_20871632088FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131685_2087-1271739FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121685_2087-121739FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221391_17111632088GAB2
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131391_1711-1271739GAB2
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121391_1711-121739GAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARHGAP32_PRDM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARHGAP32_PRDM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP32C0036341Schizophrenia1PSYGENET