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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24405

FusionGeneSummary for NISCH_DNAH1

check button Fusion gene summary
Fusion gene informationFusion gene name: NISCH_DNAH1
Fusion gene ID: 24405
HgeneTgene
Gene symbol

NISCH

DNAH1

Gene ID

11188

25981

Gene namenischarindynein axonemal heavy chain 1
SynonymsI-1|IR1|IRAS|hIRASCILD37|DNAHC1|HDHC7|HL-11|HL11|HSRF-1|SPGF18|XLHSRF-1
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
DescriptionnischarinI-1 receptor candidate proteinI1R candidate proteinimidazoline receptor 1imidazoline receptor antisera selecteddynein heavy chain 1, axonemalaxonemal beta dynein heavy chain 1ciliary dynein heavy chain 1dynein, axonemal, heavy polypeptide 1heat shock regulated protein 1testicular tissue protein Li 60
Modification date2018052320180523
UniProtAcc

Q9Y2I1

Q9P2D7

Ensembl transtripts involved in fusion geneENST00000479054, ENST00000345716, 
ENST00000488380, ENST00000420808, 
ENST00000464280, 		ENST00000420323, 
ENST00000466628, 
Fusion gene scores* DoF score6 X 6 X 4=1445 X 5 X 5=125
# samples 65
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NISCH [Title/Abstract] AND DNAH1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNAH1

GO:0036159

inner dynein arm assembly

24360805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A8NI-01ANISCHchr3

52492860

+DNAH1chr3

52413921

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000479054ENST00000420323NISCHchr3

52492860

+DNAH1chr3

52413921

+
5CDS-intronENST00000479054ENST00000466628NISCHchr3

52492860

+DNAH1chr3

52413921

+
In-frameENST00000345716ENST00000420323NISCHchr3

52492860

+DNAH1chr3

52413921

+
5CDS-intronENST00000345716ENST00000466628NISCHchr3

52492860

+DNAH1chr3

52413921

+
In-frameENST00000488380ENST00000420323NISCHchr3

52492860

+DNAH1chr3

52413921

+
5CDS-intronENST00000488380ENST00000466628NISCHchr3

52492860

+DNAH1chr3

52413921

+
In-frameENST00000420808ENST00000420323NISCHchr3

52492860

+DNAH1chr3

52413921

+
5CDS-intronENST00000420808ENST00000466628NISCHchr3

52492860

+DNAH1chr3

52413921

+
intron-3CDSENST00000464280ENST00000420323NISCHchr3

52492860

+DNAH1chr3

52413921

+
intron-intronENST00000464280ENST00000466628NISCHchr3

52492860

+DNAH1chr3

52413921

+

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FusionProtFeatures for NISCH_DNAH1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NISCH

Q9Y2I1

DNAH1

Q9P2D7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+32111_1211201505DomainPX
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+31411_121120516DomainPX
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+42211_1211201505DomainPX
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782836_291724594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46783062_312324594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46783185_321124594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46783433_350024594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46784095_411524594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782586_259324594266Nucleotide bindingATP
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782547_279924594266RegionAAA 4
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782814_311224594266RegionStalk
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46783262_349224594266RegionAAA 5
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46783705_392424594266RegionAAA 6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321634_6951201505Coiled coilOntology_term=ECO:0000255
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314634_695120516Coiled coilOntology_term=ECO:0000255
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422634_6951201505Coiled coilOntology_term=ECO:0000255
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+3211048_11041201505Compositional biasNote=Ala/Pro-rich
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321629_6911201505Compositional biasNote=Glu-rich
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+3141048_1104120516Compositional biasNote=Ala/Pro-rich
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314629_691120516Compositional biasNote=Glu-rich
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+4221048_11041201505Compositional biasNote=Ala/Pro-rich
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422629_6911201505Compositional biasNote=Glu-rich
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321120_6951201505RegionNote=Necessary for homooligomerization and targeting to endosomes
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+3212_1331201505RegionNote=Necessary for binding to phosphoinositide-3-P%3B not sufficient for targeting to endosomes
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314120_695120516RegionNote=Necessary for homooligomerization and targeting to endosomes
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+3142_133120516RegionNote=Necessary for binding to phosphoinositide-3-P%3B not sufficient for targeting to endosomes
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422120_6951201505RegionNote=Necessary for homooligomerization and targeting to endosomes
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+4222_1331201505RegionNote=Necessary for binding to phosphoinositide-3-P%3B not sufficient for targeting to endosomes
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321288_3091201505RepeatNote=LRR 1
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321311_3321201505RepeatNote=LRR 2
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321333_3541201505RepeatNote=LRR 3
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321356_3771201505RepeatNote=LRR 4
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321378_3991201505RepeatNote=LRR 5
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321403_4241201505RepeatNote=LRR 6
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314288_309120516RepeatNote=LRR 1
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314311_332120516RepeatNote=LRR 2
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314333_354120516RepeatNote=LRR 3
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314356_377120516RepeatNote=LRR 4
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314378_399120516RepeatNote=LRR 5
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314403_424120516RepeatNote=LRR 6
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422288_3091201505RepeatNote=LRR 1
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422311_3321201505RepeatNote=LRR 2
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422333_3541201505RepeatNote=LRR 3
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422356_3771201505RepeatNote=LRR 4
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422378_3991201505RepeatNote=LRR 5
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422403_4241201505RepeatNote=LRR 6
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781216_123924594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+4678968_99824594266Coiled coilOntology_term=ECO:0000255
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782167_217224594266Compositional biasNote=Poly-Glu
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781581_158824594266MotifNote=GPAGTGKT motif
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781631_163724594266MotifNote=CFDEFNR motif
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781862_186924594266Nucleotide bindingATP
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782227_223424594266Nucleotide bindingATP
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781543_176424594266RegionAAA 1
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781824_205724594266RegionAAA 2
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46781_154224594266RegionStem
TgeneDNAH1chr3:52492860chr3:52413921ENST00000420323+46782189_244924594266RegionAAA 3


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FusionGeneSequence for NISCH_DNAH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NISCH_DNAH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NISCHIRS4, IRS1, IRS2, CUL3, GRB2, LGR4, FOXH1, HAVCR2, PIK3R3, CNKSR3, UBE2M, CSNK1G2, ODAM, UNC119, MANSC1, KIAA0430, HELZ, PCGF5, SOWAHA, CTBP1, PAN2, EIF4ENIF1, KIAA1671, PIK3R1, CREBBP, ARID3A, PCGF3, ERF, POM121C, NUP50, UBE2ADNAH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321709_8071201505ITGA5
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314709_807120516ITGA5
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422709_8071201505ITGA5
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321660_8691201505LIMK
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314660_869120516LIMK
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422660_8691201505LIMK
HgeneNISCHchr3:52492860chr3:52413921ENST00000345716+321245_8691201505PAK1
HgeneNISCHchr3:52492860chr3:52413921ENST00000420808+314245_869120516PAK1
HgeneNISCHchr3:52492860chr3:52413921ENST00000479054+422245_8691201505PAK1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NISCH_DNAH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneNISCHQ9Y2I1DB00697TizanidineNischarinsmall moleculeapproved|investigational
HgeneNISCHQ9Y2I1DB09242MoxonidineNischarinsmall moleculeapproved|investigational

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RelatedDiseases for NISCH_DNAH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNISCHC0020649Hypotension2CTD_human
HgeneNISCHC0428977Bradycardia1CTD_human