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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 24367

FusionGeneSummary for NIN_PDGFRB

check button Fusion gene summary
Fusion gene informationFusion gene name: NIN_PDGFRB
Fusion gene ID: 24367
HgeneTgene
Gene symbol

NIN

PDGFRB

Gene ID

51199

5159

Gene namenineinplatelet derived growth factor receptor beta
SynonymsSCKL7CD140B|IBGC4|IMF1|JTK12|KOGS|PDGFR|PDGFR-1|PDGFR1|PENTT
Cytomap

14q22.1

5q32

Type of geneprotein-codingprotein-coding
Descriptionnineinglycogen synthase kinase 3 beta-interacting proteinhNineinninein (GSK3B interacting protein)ninein centrosomal proteinplatelet-derived growth factor receptor betaActivated tyrosine kinase PDGFRBCD140 antigen-like family member BNDEL1-PDGFRBPDGF-R-betaPDGFR-betabeta-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 1platelet-deriv
Modification date2018052320180523
UniProtAcc

Q8N4C6

P09619

Ensembl transtripts involved in fusion geneENST00000245441, ENST00000389868, 
ENST00000530997, ENST00000382043, 
ENST00000382041, ENST00000324330, 
ENST00000453196, ENST00000486200, 
ENST00000261799, ENST00000523456, 
Fusion gene scores* DoF score9 X 9 X 5=4056 X 7 X 3=126
# samples 107
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NIN [Title/Abstract] AND PDGFRB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDGFRB

GO:0007165

signal transduction

10821867

TgenePDGFRB

GO:0010863

positive regulation of phospholipase C activity

1653029

TgenePDGFRB

GO:0018108

peptidyl-tyrosine phosphorylation

1653029|2536956|2850496

TgenePDGFRB

GO:0030335

positive regulation of cell migration

17470632

TgenePDGFRB

GO:0032516

positive regulation of phosphoprotein phosphatase activity

7691811

TgenePDGFRB

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgenePDGFRB

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

1314164

TgenePDGFRB

GO:0046777

protein autophosphorylation

1314164|2536956|2850496

TgenePDGFRB

GO:0048008

platelet-derived growth factor receptor signaling pathway

1314164|2536956

TgenePDGFRB

GO:0060326

cell chemotaxis

2554309|17991872


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY764156NINchr14

51192671

-PDGFRBchr5

149505140

-
ChiTaRS3.1AY764157NINchr14

51190639

-PDGFRBchr5

149505576

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000245441ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
5CDS-intronENST00000245441ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
3UTR-3CDSENST00000389868ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
3UTR-intronENST00000389868ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
In-frameENST00000530997ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
5CDS-intronENST00000530997ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-3CDSENST00000382043ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-intronENST00000382043ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-3CDSENST00000382041ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-intronENST00000382041ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-3CDSENST00000324330ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-intronENST00000324330ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-3CDSENST00000453196ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-intronENST00000453196ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-3CDSENST00000486200ENST00000261799NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-intronENST00000486200ENST00000523456NINchr14

51192671

-PDGFRBchr5

149505140

-
intron-intronENST00000245441ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000245441ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000389868ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000389868ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000530997ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000530997ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000382043ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000382043ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000382041ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000382041ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000324330ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000324330ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000453196ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000453196ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000486200ENST00000261799NINchr14

51190639

-PDGFRBchr5

149505576

-
intron-intronENST00000486200ENST00000523456NINchr14

51190639

-PDGFRBchr5

149505576

-

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FusionProtFeatures for NIN_PDGFRB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NIN

Q8N4C6

PDGFRB

P09619

Tyrosine-protein kinase that acts as cell-surfacereceptor for homodimeric PDGFB and PDGFD and for heterodimersformed by PDGFA and PDGFB, and plays an essential role in theregulation of embryonic development, cell proliferation, survival,differentiation, chemotaxis and migration. Plays an essential rolein blood vessel development by promoting proliferation, migrationand recruitment of pericytes and smooth muscle cells toendothelial cells. Plays a role in the migration of vascularsmooth muscle cells and the formation of neointima at vascularinjury sites. Required for normal development of thecardiovascular system. Required for normal recruitment ofpericytes (mesangial cells) in the kidney glomerulus, and fornormal formation of a branched network of capillaries in kidneyglomeruli. Promotes rearrangement of the actin cytoskeleton andthe formation of membrane ruffles. Binding of its cognate ligands- homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB orhomodimeric PDGFD -leads to the activation of several signalingcascades; the response depends on the nature of the bound ligandand is modulated by the formation of heterodimers between PDGFRAand PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL,SHC1 and NCK1. Activation of PLCG1 leads to the production of thecellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activationof protein kinase C. Phosphorylation of PIK3R1, the regulatorysubunit of phosphatidylinositol 3-kinase, leads to the activationof the AKT1 signaling pathway. Phosphorylation of SHC1, or of theC-terminus of PTPN11, creates a binding site for GRB2, resultingin the activation of HRAS, RAF1 and down-stream MAP kinases,including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylationand activation of SRC family kinases. Promotes phosphorylation ofPDCD6IP/ALIX and STAM. Receptor signaling is down-regulated byprotein phosphatases that dephosphorylate the receptor and itsdown-stream effectors, and by rapid internalization of theactivated receptor. {ECO:0000269|PubMed:11297552,ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164,ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029,ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866,ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858,ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854,ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309,ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772,ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273,ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233,ECO:0000269|PubMed:8195171}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311068_109920642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311181_134120642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311441_181620642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311854_188520642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30311922_206720642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031357_57020642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031625_102720642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291068_109920642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291181_134120642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291441_181620642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291854_188520642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28291922_206720642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829357_57020642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829625_102720642134Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031182_21720642134DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031219_25220642134DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031317_35220642134DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000245441-303142_7720642134DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000245441-30318_4320642134DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829182_21720642134DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829219_25220642134DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829317_35220642134DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000530997-282942_7720642134DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000530997-28298_4320642134DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031245_25220642134Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031300_30420642134Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000245441-3031420_42320642134Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829245_25220642134Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829300_30420642134Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000530997-2829420_42320642134Nucleotide bindingGTP
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023600_9625581107DomainProtein kinase
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023606_6145581107Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301068_1099-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301181_1341-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301441_1816-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301854_1885-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1301922_2067-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130357_570-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130625_1027-642091Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281068_1099-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281181_1341-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281441_1816-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281854_1885-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1281922_2067-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128357_570-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128625_1027-131378Coiled coilOntology_term=ECO:0000255
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130182_217-642091DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130219_252-642091DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130317_352-642091DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000382041-13042_77-642091DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000382041-1308_43-642091DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128182_217-131378DomainEF-hand 3
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128219_252-131378DomainEF-hand 4
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128317_352-131378DomainEF-hand 5
HgeneNINchr14:51192671chr5:149505140ENST00000382043-12842_77-131378DomainEF-hand 2
HgeneNINchr14:51192671chr5:149505140ENST00000382043-1288_43-131378DomainEF-hand 1
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130245_252-642091Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130300_304-642091Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382041-130420_423-642091Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128245_252-131378Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128300_304-131378Nucleotide bindingGTP
HgeneNINchr14:51192671chr5:149505140ENST00000382043-128420_423-131378Nucleotide bindingGTP
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023129_2105581107DomainNote=Ig-like C2-type 2
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023214_3095581107DomainNote=Ig-like C2-type 3
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023331_4035581107DomainNote=Ig-like C2-type 4
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-102333_1205581107DomainNote=Ig-like C2-type 1
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023416_5245581107DomainNote=Ig-like C2-type 5
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-102333_5325581107Topological domainExtracellular
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023554_11065581107Topological domainCytoplasmic
TgenePDGFRBchr14:51192671chr5:149505140ENST00000261799-1023533_5535581107TransmembraneHelical


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FusionGeneSequence for NIN_PDGFRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_NIN_ENST00000245441_chr14_51192671_-_PDGFRB_ENST00000261799_chr5_149505140_-_600aa
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKSAGGGLPAVRALRRDRQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPR
DQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYG
DLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDN
YVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPL
KWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLL
LERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASS

>In-frame_NIN_ENST00000530997_chr14_51192671_-_PDGFRB_ENST00000261799_chr5_149505140_-_549aa
KPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQAL
MSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDG
GYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLA
ARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIK
RGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVL
YTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_NIN_ENST00000245441_chr14_51192671_-_PDGFRB_ENST00000261799_chr5_149505140_-_1800nt
ATGGGGAGCTTGAAGGAGGAGCTGCTCAAAGCCATCTGGCACGCCTTCACCGCACTCGACCAGGACCACAGCGGCAAGGTCTCCAAGTCC
CAGCTCAAGAGCGCTGGAGGCGGGCTGCCGGCTGTGCGGGCGCTCCGGAGAGACCGACAGAAGAAGCCACGTTACGAGATCCGATGGAAG
GTGATTGAGTCTGTGAGCTCTGACGGCCATGAGTACATCTACGTGGACCCCATGCAGCTGCCCTATGACTCCACGTGGGAGCTGCCGCGG
GACCAGCTTGTGCTGGGACGCACCCTCGGCTCTGGGGCCTTTGGGCAGGTGGTGGAGGCCACGGCTCATGGCCTGAGCCATTCTCAGGCC
ACGATGAAAGTGGCCGTCAAGATGCTTAAATCCACAGCCCGCAGCAGTGAGAAGCAAGCCCTTATGTCGGAGCTGAAGATCATGAGTCAC
CTTGGGCCCCACCTGAACGTGGTCAACCTGTTGGGGGCCTGCACCAAAGGAGGACCCATCTATATCATCACTGAGTACTGCCGCTACGGA
GACCTGGTGGACTACCTGCACCGCAACAAACACACCTTCCTGCAGCACCACTCCGACAAGCGCCGCCCGCCCAGCGCGGAGCTCTACAGC
AATGCTCTGCCCGTTGGGCTCCCCCTGCCCAGCCATGTGTCCTTGACCGGGGAGAGCGACGGTGGCTACATGGACATGAGCAAGGACGAG
TCGGTGGACTATGTGCCCATGCTGGACATGAAAGGAGACGTCAAATATGCAGACATCGAGTCCTCCAACTACATGGCCCCTTACGATAAC
TACGTTCCCTCTGCCCCTGAGAGGACCTGCCGAGCAACTTTGATCAACGAGTCTCCAGTGCTAAGCTACATGGACCTCGTGGGCTTCAGC
TACCAGGTGGCCAATGGCATGGAGTTTCTGGCCTCCAAGAACTGCGTCCACAGAGACCTGGCGGCTAGGAACGTGCTCATCTGTGAAGGC
AAGCTGGTCAAGATCTGTGACTTTGGCCTGGCTCGAGACATCATGCGGGACTCGAATTACATCTCCAAAGGCAGCACCTTTTTGCCTTTA
AAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTACACCACCCTGAGCGACGTGTGGTCCTTCGGGATCCTGCTCTGGGAGATCTTC
ACCTTGGGTGGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTACAATGCCATCAAACGGGGTTACCGCATGGCCCAGCCTGCC
CATGCCTCCGACGAGATCTATGAGATCATGCAGAAGTGCTGGGAAGAGAAGTTTGAGATTCGGCCCCCCTTCTCCCAGCTGGTGCTGCTT
CTCGAGAGACTGTTGGGCGAAGGTTACAAAAAGAAGTACCAGCAGGTGGATGAGGAGTTTCTGAGGAGTGACCACCCAGCCATCCTTCGG
TCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCTCCCCTGGACACCAGCTCCGTCCTCTATACTGCCGTGCAGCCCAATGAGGGT
GACAACGACTATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGACGAGGGCCCACTGGAGGGTTCCCCCAGCCTAGCCAGCTCC
ACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGTGACAGCCCCCTGGAGCCCCAGGACGAACCAGAGCCAGAGCCCCAGCTTGAG
CTCCAGGTGGAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTGCCCTGCGCCTCGGGCGGAAGCAGAGGATAGCTTCCTGTAG

>In-frame_NIN_ENST00000530997_chr14_51192671_-_PDGFRB_ENST00000261799_chr5_149505140_-_1647nt
AAGCCACGTTACGAGATCCGATGGAAGGTGATTGAGTCTGTGAGCTCTGACGGCCATGAGTACATCTACGTGGACCCCATGCAGCTGCCC
TATGACTCCACGTGGGAGCTGCCGCGGGACCAGCTTGTGCTGGGACGCACCCTCGGCTCTGGGGCCTTTGGGCAGGTGGTGGAGGCCACG
GCTCATGGCCTGAGCCATTCTCAGGCCACGATGAAAGTGGCCGTCAAGATGCTTAAATCCACAGCCCGCAGCAGTGAGAAGCAAGCCCTT
ATGTCGGAGCTGAAGATCATGAGTCACCTTGGGCCCCACCTGAACGTGGTCAACCTGTTGGGGGCCTGCACCAAAGGAGGACCCATCTAT
ATCATCACTGAGTACTGCCGCTACGGAGACCTGGTGGACTACCTGCACCGCAACAAACACACCTTCCTGCAGCACCACTCCGACAAGCGC
CGCCCGCCCAGCGCGGAGCTCTACAGCAATGCTCTGCCCGTTGGGCTCCCCCTGCCCAGCCATGTGTCCTTGACCGGGGAGAGCGACGGT
GGCTACATGGACATGAGCAAGGACGAGTCGGTGGACTATGTGCCCATGCTGGACATGAAAGGAGACGTCAAATATGCAGACATCGAGTCC
TCCAACTACATGGCCCCTTACGATAACTACGTTCCCTCTGCCCCTGAGAGGACCTGCCGAGCAACTTTGATCAACGAGTCTCCAGTGCTA
AGCTACATGGACCTCGTGGGCTTCAGCTACCAGGTGGCCAATGGCATGGAGTTTCTGGCCTCCAAGAACTGCGTCCACAGAGACCTGGCG
GCTAGGAACGTGCTCATCTGTGAAGGCAAGCTGGTCAAGATCTGTGACTTTGGCCTGGCTCGAGACATCATGCGGGACTCGAATTACATC
TCCAAAGGCAGCACCTTTTTGCCTTTAAAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTACACCACCCTGAGCGACGTGTGGTCC
TTCGGGATCCTGCTCTGGGAGATCTTCACCTTGGGTGGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTACAATGCCATCAAA
CGGGGTTACCGCATGGCCCAGCCTGCCCATGCCTCCGACGAGATCTATGAGATCATGCAGAAGTGCTGGGAAGAGAAGTTTGAGATTCGG
CCCCCCTTCTCCCAGCTGGTGCTGCTTCTCGAGAGACTGTTGGGCGAAGGTTACAAAAAGAAGTACCAGCAGGTGGATGAGGAGTTTCTG
AGGAGTGACCACCCAGCCATCCTTCGGTCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCTCCCCTGGACACCAGCTCCGTCCTC
TATACTGCCGTGCAGCCCAATGAGGGTGACAACGACTATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGACGAGGGCCCACTG
GAGGGTTCCCCCAGCCTAGCCAGCTCCACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGTGACAGCCCCCTGGAGCCCCAGGAC
GAACCAGAGCCAGAGCCCCAGCTTGAGCTCCAGGTGGAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTGCCCTGCGCCTCGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_NIN_ENST00000245441_chr14_51192671_-_PDGFRB_ENST00000261799_chr5_149505140_-_9956nt
CCGAGCCGGGAGCCGAGCGCGCTGGGCGCGGCCGTCCCGCTGCCGCCGCCAAGCCCGGAGTGCGCCAGCGGCCATGGTTCCCGCGGCGGC
GCCGGGCGCCTGAGCCCCGGGACGCAAGCGCTGGAGGCGGGCTGCCGGCTGTGCGGGCGCTCCGGAGAGACCGACAGAAGGTGAGCACTG
TGGGCTATGGGATGGATGAGGTGGAGCAGGACCAGCATGAGGCCCGACTCAAGGAGCTGTTTGACAGTTTTGACACGACGGGCACAGGGT
CCCTGGGGCAGGAGGAACTCACCGACCTTTGCCACATGTTGAGCTTGGAGGAGGTGGCCCCAGTGCTGCAGCAGACATTACTTCAGGACA
ACCTCTTGGGCAGGGTACATTTTGACCAATTTAAAGAAGCATTAATACTCATCTTGTCCAGAACTCTGTCAAATGAAGAACACTTTCAAG
AACCAGACTGCTCACTAGAAGCTCAGCCCAAATATGTTAGAGGTGGGAAGCGTTACGGACGAAGGTCCTTGCCCGAGTTCCAAGAGTCCG
TGGAGGAGTTTCCTGAAGTGACGGTGATTGAGCCACTGGATGAAGAAGCGCGGCCTTCACACATCCCAGCCGGTGACTGCAGTGAGCACT
GGAAGACGCAACGCAGTGAGGAGTATGAAGCGGAAGGCCAGTTAAGGTTTTGGAACCCAGATGACTTGAATGCTTCACAGAGTGGATCTT
CCCCTCCCCAAGACTGGATAGAAGAGAAACTGCAAGAAGTTTGTGAAGATTTGGGGATCACCCGTGATGGTCACCTGAACCGGAAGAAGC
TGGTCTCCATCTGTGAGCAGTATGGTTTACAGAATGTGGATGGAGAGATGCTCGAGGAAGTATTCCATAATCTTGATCCTGACGGTACAA
TGAGTGTAGAAGATTTTTTCTATGGTTTGTTTAAAAATGGAAAATCTCTTACACCATCAGCATCTACTCCATATAGACAACTAAAAAGGC
ACCTTTCCATGCAGTCTTTCGATGAGAGTGGACGACGTACCACAACCTCATCAGCAATGACAAGTACCATTGGCTTTCGGGTCTTCTCCT
GCCTGGATGATGGGATGGGCCATGCATCTGTGGAGAGAATACTGGACACCTGGCAGGAAGAGGGCATTGAGAACAGCCAGGAGATCCTGA
AGGCCTTGGATTTCAGCCTCGATGGAAACATCAATTTGACAGAATTAACACTGGCCCTTGAAAATGAACTTTTGGTTACCAAGAACAGCA
TTCACCAGGCGGCTCTGGCCAGCTTTAAGGCTGAAATCCGGCATTTGTTGGAACGAGTTGATCAGGTGGTCAGAGAAAAAGAGAAGCTAC
GGTCAGATCTGGACAAGGCCGAGAAGCTCAAGTCTTTAATGGCCTCGGAGGTGGATGATCACCATGCGGCCATAGAGCGGCGGAATGAGT
ACAACCTCAGGAAACTGGATGAAGAGTACAAGGAGCGAATAGCAGCCTTAAAAAATGAACTCCGAAAAGAGAGAGAGCAGATCCTGCAGC
AGGCAGGCAAGCAGCGTTTAGAACTTGAACAGGAAATTGAAAAGGCAAAAACAGAAGAGAACTATATCCGGGACCGCCTTGCCCTCTCTT
TAAAGGAAAACAGTCGTCTGGAAAATGAGCTTCTAGAAAATGCAGAGAAGTTGGCAGAATATGAGAATCTGACAAACAAACTTCAGAGAA
ATTTGGAAAATGTGTTAGCAGAAAAGTTTGGTGACCTCGATCCTAGCAGTGCTGAGTTCTTCCTGCAAGAAGAGAGACTGACACAGATGA
GAAATGAATATGAGCGGCAGTGCAGGGTACTACAAGACCAAGTAGATGAACTCCAGTCTGAGCTGGAAGAATATCGTGCACAAGGCAGAG
TGCTCAGGCTTCCGTTGAAGAACTCACCGTCAGAAGAAGTTGAGGCTAACAGCGGTGGCATTGAGCCCGAACACGGGCTCGGTTCTGAAG
AATGCAATCCATTGAATATGAGCATTGAGGCAGAGCTGGTCATTGAACAGATGAAAGAACAACATCACAGGGACATATGTTGCCTCAGAC
TGGAGCTCGAAGATAAAGTGCGCCATTATGAAAAGCAGCTGGACGAAACCGTGGTCAGCTGCAAGAAGGCACAGGAGAACATGAAGCAAA
GGCATGAGAACGAAACGCACACCTTAGAAAAACAAATAAGTGACCTTAAAAATGAAATTGCTGAACTTCAGGGGCAAGCAGCAGTGCTCA
AGGAGGCACATCATGAGGCCACTTGCAGGCATGAGGAGGAGAAAAAACAACTGCAAGTGAAGCTTGAGGAGGAAAAGACTCACCTGCAGG
AGAAGCTGAGGCTGCAACATGAGATGGAGCTCAAGGCTAGACTGACACAGGCTCAAGCAAGCTTTGAGCGGGAGAGGGAAGGCCTTCAGA
GTAGCGCCTGGACAGAAGAGAAGGTGAGAGGCTTGACTCAGGAACTAGAGCAGTTTCACCAGGAGCAGCTGACAAGCCTGGTGGAGAAAC
ACACTCTTGAGAAAGAGGAGTTAAGAAAAGAGCTCTTGGAAAAGCACCAAAGGGAGCTTCAGGAGGGAAGGGAAAAAATGGAAACAGAGT
GTAATAGAAGAACCTCTCAAATAGAAGCCCAGTTTCAGTCTGATTGTCAGAAAGTCACTGAGAGGTGTGAAAGCGCTCTGCAAAGCCTGG
AGGGGCGCTACCGCCAAGAGCTGAAGGACCTCCAGGAACAGCAGCGTGAGGAGAAATCCCAGTGGGAATTTGAGAAGGACGAGCTCACCC
AGGAGTGTGCGGAAGCCCAGGAGCTGCTGAAAGAGACTCTTAAGAGAGAGAAAACAACTTCTCTGGTCCTGACCCAGGAGAGAGAGATGC
TGGAGAAAACATACAAAGAACATTTGAACAGCATGGTCGTCGAGAGACAGCAGCTACTCCAAGACCTGGAAGACCTAAGAAATGTATCTG
AAACCCAGCAAAGCCTGCTGTCTGACCAGATACTTGAGCTGAAGAGCAGTCACAAAAGGGAACTGAGGGAGCGTGAGGAGGTCCTGTGCC
AGGCAGGGGCTTCGGAGCAGCTGGCCAGCCAGCGGCTGGAAAGACTAGAAATGGAACATGACCAGGAAAGGCAGGAAATGATGTCCAAGC
TTCTAGCCATGGAGAACATTCACAAAGCGACCTGTGAGACAGCAGATCGAGAAAGAGCCGAGATGAGCACAGAAATCTCCAGACTTCAGA
GTAAAATAAAGGAAATGCAGCAGGCAACATCTCCTCTCTCAATGCTTCAGAGTGGTTGCCAGGTGATAGGAGAGGAGGAGGTGGAAGGAG
ATGGAGCCCTGTCCCTGCTTCAGCAAGGGGAGCAGCTGTTGGAAGAAAATGGGGACGTCCTCTTAAGCCTGCAGAGAGCTCATGAACAGG
CAGTGAAGGAAAATGTGAAAATGGCTACTGAAATTTCTAGATTGCAACAGAGGCTACAAAAGTTAGAGCCAGGGTTAGTAATGTCTTCTT
GTTTGGATGAGCCAGCTACTGAGTTTTTTGGAAATACTGCGGAACAAACAGAGCAGTTTTTACAGCAAAACCGAACGAAGCAAGTAGAAG
GTGTGACCAGGCGGCATGTCCTAAGTGACCTGGAAGATGATGAGGTCCGGGACCTGGGAAGTACAGGGACGAGCTCTGTTCAGAGACAGG
AAGTCAAAATAGAGGAGTCTGAAGCTTCAGTAGAGGGTTTTTCTGAGCTTGAAAACAGTGAAGAGACCAGGACTGAATCCTGGGAGCTGA
AGAATCAGATTAGTCAGCTTCAGGAACAGCTAATGATGTTATGTGCGGACTGTGATCGAGCTTCTGAAAAGAAACAGGACCTACTTTTTG
ATGTTTCTGTGCTAAAAAAGAAACTGAAGATGCTTGAGAGAATCCCTGAGGCTTCTCCCAAATATAAGCTGTTGTATGAAGATGTGAGCC
GAGAAAATGACTGCCTTCAGGAAGAGCTGAGAATGATGGAGACACGCTACGATGAGGCACTAGAAAATAACAAAGAACTCACTGCAGAGG
TTTTCAGGTTGCAGGATGAGCTGAAGAAAATGGAGGAAGTCACTGAAACATTCCTCAGCCTGGAAAAGAGTTACGATGAGGTCAAAATAG
AAAATGAGGGGCTGAATGTTCTGGTTTTGAGACTTCAAGGCAAGATTGAGAAGCTTCAGGAAAGCGTGGTCCAGCGGTGTGACTGCTGCT
TATGGGAAGCCAGTTTAGAGAACCTGGAAATCGAACCTGATGGAAATATACTCCAGCTCAATCAGACACTGGAAGAGTGTGTGCCCAGGG
TTAGGAGTGTACATCATGTCATAGAGGAATGTAAGCAAGAAAACCAGTACCTTGAGGGGAACACACAGCTCTTGGAAAAAGTAAAAGCAC
ATGAAATTGCCTGGTTACATGGAACAATTCAGACACATCAAGAAAGGCCAAGAGTACAGAATCAAGTTATACTGGAGGAAAACACTACTC
TCCTAGGCTTTCAAGACAAACATTTTCAGCATCAGGCCACCATAGCAGAGTTAGAACTGGAGAAAACAAAGTTACAGGAGCTGACTAGGA
AGTTGAAGGAGAGAGTCACTATTTTAGTTAAGCAAAAAGATGTACTTTCTCACGGAGAAAAGGAGGAAGAGCTGAAGGCAATGATGCATG
ACTTGCAGATCACGTGCAGTGAGATGCAGCAAAAAGTTGAACTTCTGAGATATGAATCTGAAAAGCTTCAACAGGAAAATTCTATTTTGA
GAAATGAAATTACTACTTTAAATGAAGAAGATAGCATTTCTAACCTGAAATTAGGGACATTAAATGGATCTCAGGAAGAAATGTGGCAAA
AAACGGAAACTGTAAAACAAGAAAATGCTGCAGTTCAGAAGATGGTTGAAAATTTAAAGAAACAGATTTCAGAATTAAAAATCAAAAACC
AACAATTGGATTTGGAAAATACAGAACTTAGCCAAAAGAACTCTCAAAACCAGGAAAAACTGCAAGAACTTAATCAACGTCTAACAGAAA
TGCTATGCCAGAAGGAAAAAGAGCCAGGAAACAGTGCATTGGAGGAACGGGAACAAGAGAAGTTTAATCTGAAAGAAGAACTGGAACGTT
GTAAAGTGCAGTCCTCCACTTTAGTGTCTTCTCTGGAGGCGGAGCTCTCTGAAGTTAAAATACAGACCCATATTGTGCAACAGGAAAACC
ACCTTCTCAAAGATGAACTGGAGAAAATGAAACAGCTGCACAGATGTCCCGATCTCTCTGACTTCCAGCAAAAAATCTCTAGTGTTCTAA
GCTACAACGAAAAACTGCTGAAAGAAAAGGAAGCTCTGAGTGAGGAATTAAATAGCTGTGTCGATAAGTTGGCAAAATCAAGTCTTTTAG
AGCATAGAATTGCGACGATGAAGCAGGAACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAGCTGGTGGCTTCTCAGGAAA
AGGTTCAGAATTTAGAAGACACCGTGCAGAATGTAAACCTGCAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAGG
AGGCTTTAAAACAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCTGGTGGCAAGAGCTGGGCCCCAGAGATAGCTACTCATCCAT
CAGGGCTCCATAACCAGCAGAAAAGGCTGTCCTGGGACAAGTTGGATCATCTGATGAATGAGGAACAGCAGCTGCTTTGGCAAGAGAATG
AGAGGCTCCAGACCATGGTACAGAACACCAAAGCCGAACTCACGCACTCCCGGGAGAAGGTCCGTCAGTTGGAATCCAATCTTCTTCCCA
AGCACCAAAAACATCTAAACCCATCAGGTACCATGAATCCCACAGAGCAAGAAAAATTGAGCTTAAAGAGAGAGTGTGATCAGTTTCAGA
AAGAACAATCTCCTGCTAACAGGAAGGTCAGTCAGATGAATTCCCTTGAACAAGAATTAGAAACAATTCATTTGGAAAATGAAGGCCTGA
AAAAGAAACAAGTAAAACTGGATGAGCAGCTCATGGAGATGCAGCACCTGAGGTCCACTGCGACGCCTAGCCCGTCCCCTCATGCTTGGG
ATTTGCAGCTGCTCCAGCAGCAAGCCTGTCCGATGGTGCCCAGGGAGCAGTTTCTGCAGCTTCAACGCCAGCTGCTGCAGGCAGAAAGGA
TAAACCAGCACCTGCAGGAGGAACTTGAAAACAGGACCTCCGAAACCAACACACCACAGGGAAACCAGGAACAACTGGTAACTGTCATGG
AGGAACGAATGATAGAAGTTGAACAGAAACTGAAACTAGTGAAAAGGCTTCTTCAAGAGAAAGTGAATCAGCTCAAAGAACAAAAGCCAC
GTTACGAGATCCGATGGAAGGTGATTGAGTCTGTGAGCTCTGACGGCCATGAGTACATCTACGTGGACCCCATGCAGCTGCCCTATGACT
CCACGTGGGAGCTGCCGCGGGACCAGCTTGTGCTGGGACGCACCCTCGGCTCTGGGGCCTTTGGGCAGGTGGTGGAGGCCACGGCTCATG
GCCTGAGCCATTCTCAGGCCACGATGAAAGTGGCCGTCAAGATGCTTAAATCCACAGCCCGCAGCAGTGAGAAGCAAGCCCTTATGTCGG
AGCTGAAGATCATGAGTCACCTTGGGCCCCACCTGAACGTGGTCAACCTGTTGGGGGCCTGCACCAAAGGAGGACCCATCTATATCATCA
CTGAGTACTGCCGCTACGGAGACCTGGTGGACTACCTGCACCGCAACAAACACACCTTCCTGCAGCACCACTCCGACAAGCGCCGCCCGC
CCAGCGCGGAGCTCTACAGCAATGCTCTGCCCGTTGGGCTCCCCCTGCCCAGCCATGTGTCCTTGACCGGGGAGAGCGACGGTGGCTACA
TGGACATGAGCAAGGACGAGTCGGTGGACTATGTGCCCATGCTGGACATGAAAGGAGACGTCAAATATGCAGACATCGAGTCCTCCAACT
ACATGGCCCCTTACGATAACTACGTTCCCTCTGCCCCTGAGAGGACCTGCCGAGCAACTTTGATCAACGAGTCTCCAGTGCTAAGCTACA
TGGACCTCGTGGGCTTCAGCTACCAGGTGGCCAATGGCATGGAGTTTCTGGCCTCCAAGAACTGCGTCCACAGAGACCTGGCGGCTAGGA
ACGTGCTCATCTGTGAAGGCAAGCTGGTCAAGATCTGTGACTTTGGCCTGGCTCGAGACATCATGCGGGACTCGAATTACATCTCCAAAG
GCAGCACCTTTTTGCCTTTAAAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTACACCACCCTGAGCGACGTGTGGTCCTTCGGGA
TCCTGCTCTGGGAGATCTTCACCTTGGGTGGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTACAATGCCATCAAACGGGGTT
ACCGCATGGCCCAGCCTGCCCATGCCTCCGACGAGATCTATGAGATCATGCAGAAGTGCTGGGAAGAGAAGTTTGAGATTCGGCCCCCCT
TCTCCCAGCTGGTGCTGCTTCTCGAGAGACTGTTGGGCGAAGGTTACAAAAAGAAGTACCAGCAGGTGGATGAGGAGTTTCTGAGGAGTG
ACCACCCAGCCATCCTTCGGTCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCTCCCCTGGACACCAGCTCCGTCCTCTATACTG
CCGTGCAGCCCAATGAGGGTGACAACGACTATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGACGAGGGCCCACTGGAGGGTT
CCCCCAGCCTAGCCAGCTCCACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGTGACAGCCCCCTGGAGCCCCAGGACGAACCAG
AGCCAGAGCCCCAGCTTGAGCTCCAGGTGGAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTGCCCTGCGCCTCGGGCGGAAG
CAGAGGATAGCTTCCTGTAGGGGGCTGGCCCCTACCCTGCCCTGCCTGAAGCTCCCCCCCTGCCAGCACCCAGCATCTCCTGGCCTGGCC
TGACCGGGCTTCCTGTCAGCCAGGCTGCCCTTATCAGCTGTCCCCTTCTGGAAGCTTTCTGCTCCTGACGTGTTGTGCCCCAAACCCTGG
GGCTGGCTTAGGAGGCAAGAAAACTGCAGGGGCCGTGACCAGCCCTCTGCCTCCAGGGAGGCCAACTGACTCTGAGCCAGGGTTCCCCCA
GGGAACTCAGTTTTCCCATATGTAAAATGGGAAAGTTAGGCTTGATGACCCAGAATCTAGGATTCTCTCCCTGGCTGACAGGTGGGGAGA
CCGAATCCCTCCCTGGGAAGATTCTTGGAGTTACTGAGGTGGTAAATTAACTTTTTTCTGTTCAGCCAGCTACCCCTCAAGGAATCATAG
CTCTCTCCTCGCACTTTTATCCACCCAGGAGCTAGGGAAGAGACCCTAGCCTCCCTGGCTGCTGGCTGAGCTAGGGCCTAGCCTTGAGCA
GTGTTGCCTCATCCAGAAGAAAGCCAGTCTCCTCCCTATGATGCCAGTCCCTGCGTTCCCTGGCCCGAGCTGGTCTGGGGCCATTAGGCA
GCCTAATTAATGCTGGAGGCTGAGCCAAGTACAGGACACCCCCAGCCTGCAGCCCTTGCCCAGGGCACTTGGAGCACACGCAGCCATAGC
AAGTGCCTGTGTCCCTGTCCTTCAGGCCCATCAGTCCTGGGGCTTTTTCTTTATCACCCTCAGTCTTAATCCATCCACCAGAGTCTAGAA
GGCCAGACGGGCCCCGCATCTGTGATGAGAATGTAAATGTGCCAGTGTGGAGTGGCCACGTGTGTGTGCCAGTATATGGCCCTGGCTCTG
CATTGGACCTGCTATGAGGCTTTGGAGGAATCCCTCACCCTCTCTGGGCCTCAGTTTCCCCTTCAAAAAATGAATAAGTCGGACTTATTA
ACTCTGAGTGCCTTGCCAGCACTAACATTCTAGAGTATTCCAGGTGGTTGCACATTTGTCCAGATGAAGCAAGGCCATATACCCTAAACT
TCCATCCTGGGGGTCAGCTGGGCTCCTGGGAGATTCCAGATCACACATCACACTCTGGGGACTCAGGAACCATGCCCCTTCCCCAGGCCC
CCAGCAAGTCTCAAGAACACAGCTGCACAGGCCTTGACTTAGAGTGACAGCCGGTGTCCTGGAAAGCCCCCAGCAGCTGCCCCAGGGACA
TGGGAAGACCACGGGACCTCTTTCACTACCCACGATGACCTCCGGGGGTATCCTGGGCAAAAGGGACAAAGAGGGCAAATGAGATCACCT
CCTGCAGCCCACCACTCCAGCACCTGTGCCGAGGTCTGCGTCGAAGACAGAATGGACAGTGAGGACAGTTATGTCTTGTAAAAGACAAGA
AGCTTCAGATGGGTACCCCAAGAAGGATGTGAGAGGTGGGCGCTTTGGAGGTTTGCCCCTCACCCACCAGCTGCCCCATCCCTGAGGCAG
CGCTCCATGGGGGTATGGTTTTGTCACTGCCCAGACCTAGCAGTGACATCTCATTGTCCCCAGCCCAGTGGGCATTGGAGGTGCCAGGGG
AGTCAGGGTTGTAGCCAAGACGCCCCCGCACGGGGAGGGTTGGGAAGGGGGTGCAGGAAGCTCAACCCCTCTGGGCACCAACCCTGCATT
GCAGGTTGGCACCTTACTTCCCTGGGATCCCCAGAGTTGGTCCAAGGAGGGAGAGTGGGTTCTCAATACGGTACCAAAGATATAATCACC
TAGGTTTACAAATATTTTTAGGACTCACGTTAACTCACATTTATACAGCAGAAATGCTATTTTGTATGCTGTTGAGTTTTTCTATCTGTG

>In-frame_NIN_ENST00000530997_chr14_51192671_-_PDGFRB_ENST00000261799_chr5_149505140_-_9765nt
ATGGATGAGGTGGAGCAGGACCAGCATGAGGCCCGACTCAAGGAGCTGTTTGACAGTTTTGACACGACGGGCACAGGGTCCCTGGGGCAG
GAGGAACTCACCGACCTTTGCCACATGTTGAGCTTGGAGGAGGTGGCCCCAGTGCTGCAGCAGACATTACTTCAGGACAACCTCTTGGGC
AGGGTACATTTTGACCAATTTAAAGAAGCATTAATACTCATCTTGTCCAGAACTCTGTCAAATGAAGAACACTTTCAAGAACCAGACTGC
TCACTAGAAGCTCAGCCCAAATATGTTAGAGGTGGGAAGCGTTACGGACGAAGGTCCTTGCCCGAGTTCCAAGAGTCCGTGGAGGAGTTT
CCTGAAGTGACGGTGATTGAGCCACTGGATGAAGAAGCGCGGCCTTCACACATCCCAGCCGGTGACTGCAGTGAGCACTGGAAGACGCAA
CGCAGTGAGGAGTATGAAGCGGAAGGCCAGTTAAGGTTTTGGAACCCAGATGACTTGAATGCTTCACAGAGTGGATCTTCCCCTCCCCAA
GACTGGATAGAAGAGAAACTGCAAGAAGTTTGTGAAGATTTGGGGATCACCCGTGATGGTCACCTGAACCGGAAGAAGCTGGTCTCCATC
TGTGAGCAGTATGGTTTACAGAATGTGGATGGAGAGATGCTCGAGGAAGTATTCCATAATCTTGATCCTGACGGTACAATGAGTGTAGAA
GATTTTTTCTATGGTTTGTTTAAAAATGGAAAATCTCTTACACCATCAGCATCTACTCCATATAGACAACTAAAAAGGCACCTTTCCATG
CAGTCTTTCGATGAGAGTGGACGACGTACCACAACCTCATCAGCAATGACAAGTACCATTGGCTTTCGGGTCTTCTCCTGCCTGGATGAT
GGGATGGGCCATGCATCTGTGGAGAGAATACTGGACACCTGGCAGGAAGAGGGCATTGAGAACAGCCAGGAGATCCTGAAGGCCTTGGAT
TTCAGCCTCGATGGAAACATCAATTTGACAGAATTAACACTGGCCCTTGAAAATGAACTTTTGGTTACCAAGAACAGCATTCACCAGGCG
GCTCTGGCCAGCTTTAAGGCTGAAATCCGGCATTTGTTGGAACGAGTTGATCAGGTGGTCAGAGAAAAAGAGAAGCTACGGTCAGATCTG
GACAAGGCCGAGAAGCTCAAGTCTTTAATGGCCTCGGAGGTGGATGATCACCATGCGGCCATAGAGCGGCGGAATGAGTACAACCTCAGG
AAACTGGATGAAGAGTACAAGGAGCGAATAGCAGCCTTAAAAAATGAACTCCGAAAAGAGAGAGAGCAGATCCTGCAGCAGGCAGGCAAG
CAGCGTTTAGAACTTGAACAGGAAATTGAAAAGGCAAAAACAGAAGAGAACTATATCCGGGACCGCCTTGCCCTCTCTTTAAAGGAAAAC
AGTCGTCTGGAAAATGAGCTTCTAGAAAATGCAGAGAAGTTGGCAGAATATGAGAATCTGACAAACAAACTTCAGAGAAATTTGGAAAAT
GTGTTAGCAGAAAAGTTTGGTGACCTCGATCCTAGCAGTGCTGAGTTCTTCCTGCAAGAAGAGAGACTGACACAGATGAGAAATGAATAT
GAGCGGCAGTGCAGGGTACTACAAGACCAAGTAGATGAACTCCAGTCTGAGCTGGAAGAATATCGTGCACAAGGCAGAGTGCTCAGGCTT
CCGTTGAAGAACTCACCGTCAGAAGAAGTTGAGGCTAACAGCGGTGGCATTGAGCCCGAACACGGGCTCGGTTCTGAAGAATGCAATCCA
TTGAATATGAGCATTGAGGCAGAGCTGGTCATTGAACAGATGAAAGAACAACATCACAGGGACATATGTTGCCTCAGACTGGAGCTCGAA
GATAAAGTGCGCCATTATGAAAAGCAGCTGGACGAAACCGTGGTCAGCTGCAAGAAGGCACAGGAGAACATGAAGCAAAGGCATGAGAAC
GAAACGCACACCTTAGAAAAACAAATAAGTGACCTTAAAAATGAAATTGCTGAACTTCAGGGGCAAGCAGCAGTGCTCAAGGAGGCACAT
CATGAGGCCACTTGCAGGCATGAGGAGGAGAAAAAACAACTGCAAGTGAAGCTTGAGGAGGAAAAGACTCACCTGCAGGAGAAGCTGAGG
CTGCAACATGAGATGGAGCTCAAGGCTAGACTGACACAGGCTCAAGCAAGCTTTGAGCGGGAGAGGGAAGGCCTTCAGAGTAGCGCCTGG
ACAGAAGAGAAGGTGAGAGGCTTGACTCAGGAACTAGAGCAGTTTCACCAGGAGCAGCTGACAAGCCTGGTGGAGAAACACACTCTTGAG
AAAGAGGAGTTAAGAAAAGAGCTCTTGGAAAAGCACCAAAGGGAGCTTCAGGAGGGAAGGGAAAAAATGGAAACAGAGTGTAATAGAAGA
ACCTCTCAAATAGAAGCCCAGTTTCAGTCTGATTGTCAGAAAGTCACTGAGAGGTGTGAAAGCGCTCTGCAAAGCCTGGAGGGGCGCTAC
CGCCAAGAGCTGAAGGACCTCCAGGAACAGCAGCGTGAGGAGAAATCCCAGTGGGAATTTGAGAAGGACGAGCTCACCCAGGAGTGTGCG
GAAGCCCAGGAGCTGCTGAAAGAGACTCTTAAGAGAGAGAAAACAACTTCTCTGGTCCTGACCCAGGAGAGAGAGATGCTGGAGAAAACA
TACAAAGAACATTTGAACAGCATGGTCGTCGAGAGACAGCAGCTACTCCAAGACCTGGAAGACCTAAGAAATGTATCTGAAACCCAGCAA
AGCCTGCTGTCTGACCAGATACTTGAGCTGAAGAGCAGTCACAAAAGGGAACTGAGGGAGCGTGAGGAGGTCCTGTGCCAGGCAGGGGCT
TCGGAGCAGCTGGCCAGCCAGCGGCTGGAAAGACTAGAAATGGAACATGACCAGGAAAGGCAGGAAATGATGTCCAAGCTTCTAGCCATG
GAGAACATTCACAAAGCGACCTGTGAGACAGCAGATCGAGAAAGAGCCGAGATGAGCACAGAAATCTCCAGACTTCAGAGTAAAATAAAG
GAAATGCAGCAGGCAACATCTCCTCTCTCAATGCTTCAGAGTGGTTGCCAGGTGATAGGAGAGGAGGAGGTGGAAGGAGATGGAGCCCTG
TCCCTGCTTCAGCAAGGGGAGCAGCTGTTGGAAGAAAATGGGGACGTCCTCTTAAGCCTGCAGAGAGCTCATGAACAGGCAGTGAAGGAA
AATGTGAAAATGGCTACTGAAATTTCTAGATTGCAACAGAGGCTACAAAAGTTAGAGCCAGGGTTAGTAATGTCTTCTTGTTTGGATGAG
CCAGCTACTGAGTTTTTTGGAAATACTGCGGAACAAACAGAGCAGTTTTTACAGCAAAACCGAACGAAGCAAGTAGAAGGTGTGACCAGG
CGGCATGTCCTAAGTGACCTGGAAGATGATGAGGTCCGGGACCTGGGAAGTACAGGGACGAGCTCTGTTCAGAGACAGGAAGTCAAAATA
GAGGAGTCTGAAGCTTCAGTAGAGGGTTTTTCTGAGCTTGAAAACAGTGAAGAGACCAGGACTGAATCCTGGGAGCTGAAGAATCAGATT
AGTCAGCTTCAGGAACAGCTAATGATGTTATGTGCGGACTGTGATCGAGCTTCTGAAAAGAAACAGGACCTACTTTTTGATGTTTCTGTG
CTAAAAAAGAAACTGAAGATGCTTGAGAGAATCCCTGAGGCTTCTCCCAAATATAAGCTGTTGTATGAAGATGTGAGCCGAGAAAATGAC
TGCCTTCAGGAAGAGCTGAGAATGATGGAGACACGCTACGATGAGGCACTAGAAAATAACAAAGAACTCACTGCAGAGGTTTTCAGGTTG
CAGGATGAGCTGAAGAAAATGGAGGAAGTCACTGAAACATTCCTCAGCCTGGAAAAGAGTTACGATGAGGTCAAAATAGAAAATGAGGGG
CTGAATGTTCTGGTTTTGAGACTTCAAGGCAAGATTGAGAAGCTTCAGGAAAGCGTGGTCCAGCGGTGTGACTGCTGCTTATGGGAAGCC
AGTTTAGAGAACCTGGAAATCGAACCTGATGGAAATATACTCCAGCTCAATCAGACACTGGAAGAGTGTGTGCCCAGGGTTAGGAGTGTA
CATCATGTCATAGAGGAATGTAAGCAAGAAAACCAGTACCTTGAGGGGAACACACAGCTCTTGGAAAAAGTAAAAGCACATGAAATTGCC
TGGTTACATGGAACAATTCAGACACATCAAGAAAGGCCAAGAGTACAGAATCAAGTTATACTGGAGGAAAACACTACTCTCCTAGGCTTT
CAAGACAAACATTTTCAGCATCAGGCCACCATAGCAGAGTTAGAACTGGAGAAAACAAAGTTACAGGAGCTGACTAGGAAGTTGAAGGAG
AGAGTCACTATTTTAGTTAAGCAAAAAGATGTACTTTCTCACGGAGAAAAGGAGGAAGAGCTGAAGGCAATGATGCATGACTTGCAGATC
ACGTGCAGTGAGATGCAGCAAAAAGTTGAACTTCTGAGATATGAATCTGAAAAGCTTCAACAGGAAAATTCTATTTTGAGAAATGAAATT
ACTACTTTAAATGAAGAAGATAGCATTTCTAACCTGAAATTAGGGACATTAAATGGATCTCAGGAAGAAATGTGGCAAAAAACGGAAACT
GTAAAACAAGAAAATGCTGCAGTTCAGAAGATGGTTGAAAATTTAAAGAAACAGATTTCAGAATTAAAAATCAAAAACCAACAATTGGAT
TTGGAAAATACAGAACTTAGCCAAAAGAACTCTCAAAACCAGGAAAAACTGCAAGAACTTAATCAACGTCTAACAGAAATGCTATGCCAG
AAGGAAAAAGAGCCAGGAAACAGTGCATTGGAGGAACGGGAACAAGAGAAGTTTAATCTGAAAGAAGAACTGGAACGTTGTAAAGTGCAG
TCCTCCACTTTAGTGTCTTCTCTGGAGGCGGAGCTCTCTGAAGTTAAAATACAGACCCATATTGTGCAACAGGAAAACCACCTTCTCAAA
GATGAACTGGAGAAAATGAAACAGCTGCACAGATGTCCCGATCTCTCTGACTTCCAGCAAAAAATCTCTAGTGTTCTAAGCTACAACGAA
AAACTGCTGAAAGAAAAGGAAGCTCTGAGTGAGGAATTAAATAGCTGTGTCGATAAGTTGGCAAAATCAAGTCTTTTAGAGCATAGAATT
GCGACGATGAAGCAGGAACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAGCTGGTGGCTTCTCAGGAAAAGGTTCAGAAT
TTAGAAGACACCGTGCAGAATGTAAACCTGCAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAGGAGGCTTTAAAA
CAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCTGGTGGCAAGAGCTGGGCCCCAGAGATAGCTACTCATCCATCAGGGCTCCAT
AACCAGCAGAAAAGGCTGTCCTGGGACAAGTTGGATCATCTGATGAATGAGGAACAGCAGCTGCTTTGGCAAGAGAATGAGAGGCTCCAG
ACCATGGTACAGAACACCAAAGCCGAACTCACGCACTCCCGGGAGAAGGTCCGTCAGTTGGAATCCAATCTTCTTCCCAAGCACCAAAAA
CATCTAAACCCATCAGGTACCATGAATCCCACAGAGCAAGAAAAATTGAGCTTAAAGAGAGAGTGTGATCAGTTTCAGAAAGAACAATCT
CCTGCTAACAGGAAGGTCAGTCAGATGAATTCCCTTGAACAAGAATTAGAAACAATTCATTTGGAAAATGAAGGCCTGAAAAAGAAACAA
GTAAAACTGGATGAGCAGCTCATGGAGATGCAGCACCTGAGGTCCACTGCGACGCCTAGCCCGTCCCCTCATGCTTGGGATTTGCAGCTG
CTCCAGCAGCAAGCCTGTCCGATGGTGCCCAGGGAGCAGTTTCTGCAGCTTCAACGCCAGCTGCTGCAGGCAGAAAGGATAAACCAGCAC
CTGCAGGAGGAACTTGAAAACAGGACCTCCGAAACCAACACACCACAGGGAAACCAGGAACAACTGGTAACTGTCATGGAGGAACGAATG
ATAGAAGTTGAACAGAAACTGAAACTAGTGAAAAGGCTTCTTCAAGAGAAAGTGAATCAGCTCAAAGAACAAAAGCCACGTTACGAGATC
CGATGGAAGGTGATTGAGTCTGTGAGCTCTGACGGCCATGAGTACATCTACGTGGACCCCATGCAGCTGCCCTATGACTCCACGTGGGAG
CTGCCGCGGGACCAGCTTGTGCTGGGACGCACCCTCGGCTCTGGGGCCTTTGGGCAGGTGGTGGAGGCCACGGCTCATGGCCTGAGCCAT
TCTCAGGCCACGATGAAAGTGGCCGTCAAGATGCTTAAATCCACAGCCCGCAGCAGTGAGAAGCAAGCCCTTATGTCGGAGCTGAAGATC
ATGAGTCACCTTGGGCCCCACCTGAACGTGGTCAACCTGTTGGGGGCCTGCACCAAAGGAGGACCCATCTATATCATCACTGAGTACTGC
CGCTACGGAGACCTGGTGGACTACCTGCACCGCAACAAACACACCTTCCTGCAGCACCACTCCGACAAGCGCCGCCCGCCCAGCGCGGAG
CTCTACAGCAATGCTCTGCCCGTTGGGCTCCCCCTGCCCAGCCATGTGTCCTTGACCGGGGAGAGCGACGGTGGCTACATGGACATGAGC
AAGGACGAGTCGGTGGACTATGTGCCCATGCTGGACATGAAAGGAGACGTCAAATATGCAGACATCGAGTCCTCCAACTACATGGCCCCT
TACGATAACTACGTTCCCTCTGCCCCTGAGAGGACCTGCCGAGCAACTTTGATCAACGAGTCTCCAGTGCTAAGCTACATGGACCTCGTG
GGCTTCAGCTACCAGGTGGCCAATGGCATGGAGTTTCTGGCCTCCAAGAACTGCGTCCACAGAGACCTGGCGGCTAGGAACGTGCTCATC
TGTGAAGGCAAGCTGGTCAAGATCTGTGACTTTGGCCTGGCTCGAGACATCATGCGGGACTCGAATTACATCTCCAAAGGCAGCACCTTT
TTGCCTTTAAAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTACACCACCCTGAGCGACGTGTGGTCCTTCGGGATCCTGCTCTGG
GAGATCTTCACCTTGGGTGGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTACAATGCCATCAAACGGGGTTACCGCATGGCC
CAGCCTGCCCATGCCTCCGACGAGATCTATGAGATCATGCAGAAGTGCTGGGAAGAGAAGTTTGAGATTCGGCCCCCCTTCTCCCAGCTG
GTGCTGCTTCTCGAGAGACTGTTGGGCGAAGGTTACAAAAAGAAGTACCAGCAGGTGGATGAGGAGTTTCTGAGGAGTGACCACCCAGCC
ATCCTTCGGTCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCTCCCCTGGACACCAGCTCCGTCCTCTATACTGCCGTGCAGCCC
AATGAGGGTGACAACGACTATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGACGAGGGCCCACTGGAGGGTTCCCCCAGCCTA
GCCAGCTCCACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGTGACAGCCCCCTGGAGCCCCAGGACGAACCAGAGCCAGAGCCC
CAGCTTGAGCTCCAGGTGGAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTGCCCTGCGCCTCGGGCGGAAGCAGAGGATAGC
TTCCTGTAGGGGGCTGGCCCCTACCCTGCCCTGCCTGAAGCTCCCCCCCTGCCAGCACCCAGCATCTCCTGGCCTGGCCTGACCGGGCTT
CCTGTCAGCCAGGCTGCCCTTATCAGCTGTCCCCTTCTGGAAGCTTTCTGCTCCTGACGTGTTGTGCCCCAAACCCTGGGGCTGGCTTAG
GAGGCAAGAAAACTGCAGGGGCCGTGACCAGCCCTCTGCCTCCAGGGAGGCCAACTGACTCTGAGCCAGGGTTCCCCCAGGGAACTCAGT
TTTCCCATATGTAAAATGGGAAAGTTAGGCTTGATGACCCAGAATCTAGGATTCTCTCCCTGGCTGACAGGTGGGGAGACCGAATCCCTC
CCTGGGAAGATTCTTGGAGTTACTGAGGTGGTAAATTAACTTTTTTCTGTTCAGCCAGCTACCCCTCAAGGAATCATAGCTCTCTCCTCG
CACTTTTATCCACCCAGGAGCTAGGGAAGAGACCCTAGCCTCCCTGGCTGCTGGCTGAGCTAGGGCCTAGCCTTGAGCAGTGTTGCCTCA
TCCAGAAGAAAGCCAGTCTCCTCCCTATGATGCCAGTCCCTGCGTTCCCTGGCCCGAGCTGGTCTGGGGCCATTAGGCAGCCTAATTAAT
GCTGGAGGCTGAGCCAAGTACAGGACACCCCCAGCCTGCAGCCCTTGCCCAGGGCACTTGGAGCACACGCAGCCATAGCAAGTGCCTGTG
TCCCTGTCCTTCAGGCCCATCAGTCCTGGGGCTTTTTCTTTATCACCCTCAGTCTTAATCCATCCACCAGAGTCTAGAAGGCCAGACGGG
CCCCGCATCTGTGATGAGAATGTAAATGTGCCAGTGTGGAGTGGCCACGTGTGTGTGCCAGTATATGGCCCTGGCTCTGCATTGGACCTG
CTATGAGGCTTTGGAGGAATCCCTCACCCTCTCTGGGCCTCAGTTTCCCCTTCAAAAAATGAATAAGTCGGACTTATTAACTCTGAGTGC
CTTGCCAGCACTAACATTCTAGAGTATTCCAGGTGGTTGCACATTTGTCCAGATGAAGCAAGGCCATATACCCTAAACTTCCATCCTGGG
GGTCAGCTGGGCTCCTGGGAGATTCCAGATCACACATCACACTCTGGGGACTCAGGAACCATGCCCCTTCCCCAGGCCCCCAGCAAGTCT
CAAGAACACAGCTGCACAGGCCTTGACTTAGAGTGACAGCCGGTGTCCTGGAAAGCCCCCAGCAGCTGCCCCAGGGACATGGGAAGACCA
CGGGACCTCTTTCACTACCCACGATGACCTCCGGGGGTATCCTGGGCAAAAGGGACAAAGAGGGCAAATGAGATCACCTCCTGCAGCCCA
CCACTCCAGCACCTGTGCCGAGGTCTGCGTCGAAGACAGAATGGACAGTGAGGACAGTTATGTCTTGTAAAAGACAAGAAGCTTCAGATG
GGTACCCCAAGAAGGATGTGAGAGGTGGGCGCTTTGGAGGTTTGCCCCTCACCCACCAGCTGCCCCATCCCTGAGGCAGCGCTCCATGGG
GGTATGGTTTTGTCACTGCCCAGACCTAGCAGTGACATCTCATTGTCCCCAGCCCAGTGGGCATTGGAGGTGCCAGGGGAGTCAGGGTTG
TAGCCAAGACGCCCCCGCACGGGGAGGGTTGGGAAGGGGGTGCAGGAAGCTCAACCCCTCTGGGCACCAACCCTGCATTGCAGGTTGGCA
CCTTACTTCCCTGGGATCCCCAGAGTTGGTCCAAGGAGGGAGAGTGGGTTCTCAATACGGTACCAAAGATATAATCACCTAGGTTTACAA
ATATTTTTAGGACTCACGTTAACTCACATTTATACAGCAGAAATGCTATTTTGTATGCTGTTGAGTTTTTCTATCTGTGTACTTTTTTTT


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FusionGenePPI for NIN_PDGFRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NINNIN, PRKACA, AURKA, GSK3B, AMOT, ELAVL1, LATS2, CEP170, CCDC68, TMOD1, CASQ2, C17orf59, CEP63, MED4, HERC2, OFD1, CEP128, CNTRL, ACTR1A, ANLN, AP3D1, CEP131, BAIAP2, CAMK2D, CC2D1A, CCDC138, CCNB1, CCNB2, CENPE, CEP164, CEP350, CKAP2, CLASP1, CLASP2, CSPP1, DBT, DCTN1, DCTN2, DHX35, DIAPH3, DYNC1H1, DYNC1I2, DYNC1LI1, DYNC1LI2, ECH1, EIF4ENIF1, ERC1, FAM83B, FGFR1OP, GPATCH1, HAUS1, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7, HAUS8, HECTD1, HMMR, IQCB1, KIAA1671, KIF14, LUZP1, MAP7D3, MGA, NCKAP5L, NEDD1, NME7, PALLD, PCM1, PLK1, RASSF8, RLTPR, SAMD4B, SDCCAG3, SPC24, SVIL, TJP1, TNRC6B, TP53, TP53BP2, TTC28, TTF2, TTK, TXLNA, UNC45A, UPF1, WDR83, ACTR2, AHCY, ARPC3, CEP192, CSNK1A1, HMGN3, ISOC1, PIBF1, PMPCB, RAB2A, SSX2IP, TCHP, YWHAH, POC5, KIAA1244, NHP2L1, BAX, MYH13, DOT1L, CDC14A, SYCE3, TCP10L, ZNF331, COG5PDGFRBKRTAP4-12, GRB2, PTPN11, PDGFRA, PDGFRB, VAV1, VAV2, VAV3, PLCG1, COPA, NCK2, CRK, GRB14, NCK1, RAF1, SLC9A3R1, SH3KBP1, ITGB3, SHC1, S1PR1, CAV1, CAV3, EIF2AK2, SNX1, SNX2, SNX4, EGFR, PIK3R1, RASA1, PDCD6IP, SRC, ADRBK1, MFGE8, NEDD4, ETV6, IRF8, SLA, SH2B2, TNK2, ERRFI1, HSP90AA1, TRIP6, KLHL12, PDGFB, NTRK1, MYO1E, BCLAF1, ZZEF1, FGD6, FOXK1, PIK3R3, PTEN, STAT5A, STAT3, CBLB, DEPDC1, ATR, FOXK2, ANKLE2, ACVR2B, UBB, ABCD4, NOP9, FNDC3A, HUS1, TYW1, CGRRF1, HELLS, PDE3B, BMPR1A, CTDNEP1, LACC1, PPM1L, TPTE


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NIN_PDGFRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDGFRBP09619DB00619ImatinibPlatelet-derived growth factor receptor betasmall moleculeapproved
TgenePDGFRBP09619DB06589PazopanibPlatelet-derived growth factor receptor betasmall moleculeapproved
TgenePDGFRBP09619DB08896RegorafenibPlatelet-derived growth factor receptor betasmall moleculeapproved
TgenePDGFRBP09619DB00102BecaplerminPlatelet-derived growth factor receptor betabiotechapproved|investigational
TgenePDGFRBP09619DB00398SorafenibPlatelet-derived growth factor receptor betasmall moleculeapproved|investigational
TgenePDGFRBP09619DB01254DasatinibPlatelet-derived growth factor receptor betasmall moleculeapproved|investigational
TgenePDGFRBP09619DB01268SunitinibPlatelet-derived growth factor receptor betasmall moleculeapproved|investigational

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RelatedDiseases for NIN_PDGFRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDGFRBC3554321BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 43UNIPROT
TgenePDGFRBC0023893Liver Cirrhosis, Experimental2CTD_human
TgenePDGFRBC0036341Schizophrenia2PSYGENET
TgenePDGFRBC0432284Infantile myofibromatosis2ORPHANET;UNIPROT
TgenePDGFRBC0004782Basal Ganglia Diseases1CTD_human
TgenePDGFRBC0006663Calcinosis1CTD_human
TgenePDGFRBC0036337Schizoaffective Disorder1PSYGENET
TgenePDGFRBC1866182Penttinen-Aula syndrome1ORPHANET;UNIPROT
TgenePDGFRBC4225270KOSAKI OVERGROWTH SYNDROME1UNIPROT