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Fusion gene ID: 24355 |
FusionGeneSummary for NINJ1_TET2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NINJ1_TET2 | Fusion gene ID: 24355 | Hgene | Tgene | Gene symbol | NINJ1 | TET2 | Gene ID | 4814 | 54790 |
| Gene name | ninjurin 1 | tet methylcytosine dioxygenase 2 | |
| Synonyms | NIN1|NINJURIN | KIAA1546|MDS | |
| Cytomap | 9q22.31 | 4q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ninjurin-1nerve injury-induced protein-1 | methylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q92982 | Q6N021 | |
| Ensembl transtripts involved in fusion gene | ENST00000375446, ENST00000489274, | ENST00000545826, ENST00000513237, ENST00000540549, ENST00000380013, ENST00000305737, ENST00000394764, ENST00000504042, ENST00000413648, | |
| Fusion gene scores | * DoF score | 4 X 3 X 1=12 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NINJ1 [Title/Abstract] AND TET2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TET2 | GO:0006211 | 5-methylcytosine catabolic process | 24315485 |
| Tgene | TET2 | GO:0006493 | protein O-linked glycosylation | 23222540 |
| Tgene | TET2 | GO:0080111 | DNA demethylation | 24315485 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB243858 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000375446 | ENST00000545826 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000513237 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000540549 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000380013 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000305737 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000394764 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000504042 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000375446 | ENST00000413648 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000545826 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000513237 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000540549 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000380013 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000305737 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000394764 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000504042 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
| intron-intron | ENST00000489274 | ENST00000413648 | NINJ1 | chr9 | 95883840 | + | TET2 | chr4 | 106074016 | + |
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FusionProtFeatures for NINJ1_TET2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NINJ1 | TET2 |
| Homophilic cell adhesion molecule that promotes axonalgrowth. May play a role in nerve regeneration and in the formationand function of other tissues. Cell adhesion requires divalentcations. | Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Has a preference for 5-hydroxymethylcytosine in CpGmotifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, also involved in the recruitment of the O-GlcNActransferase OGT to CpG-rich transcription start sites of activegenes, thereby promoting histone H2B GlcNAcylation by OGT.{ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493,ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540,ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NINJ1_TET2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NINJ1_TET2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NINJ1_TET2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NINJ1_TET2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | NINJ1 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| Tgene | TET2 | C0079774 | Peripheral T-Cell Lymphoma | 2 | CTD_human |
| Tgene | TET2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | TET2 | C0020981 | Angioimmunoblastic Lymphadenopathy | 1 | CTD_human |
| Tgene | TET2 | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| Tgene | TET2 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Tgene | TET2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | TET2 | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | TET2 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human;HPO |
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