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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24355

FusionGeneSummary for NINJ1_TET2

check button Fusion gene summary
Fusion gene informationFusion gene name: NINJ1_TET2
Fusion gene ID: 24355
HgeneTgene
Gene symbol

NINJ1

TET2

Gene ID

4814

54790

Gene nameninjurin 1tet methylcytosine dioxygenase 2
SynonymsNIN1|NINJURINKIAA1546|MDS
Cytomap

9q22.31

4q24

Type of geneprotein-codingprotein-coding
Descriptionninjurin-1nerve injury-induced protein-1methylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2
Modification date2018051920180523
UniProtAcc

Q92982

Q6N021

Ensembl transtripts involved in fusion geneENST00000375446, ENST00000489274, 
ENST00000545826, ENST00000513237, 
ENST00000540549, ENST00000380013, 
ENST00000305737, ENST00000394764, 
ENST00000504042, ENST00000413648, 
Fusion gene scores* DoF score4 X 3 X 1=121 X 1 X 1=1
# samples 41
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: NINJ1 [Title/Abstract] AND TET2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTET2

GO:0006211

5-methylcytosine catabolic process

24315485

TgeneTET2

GO:0006493

protein O-linked glycosylation

23222540

TgeneTET2

GO:0080111

DNA demethylation

24315485


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB243858NINJ1chr9

95883840

+TET2chr4

106074016

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000375446ENST00000545826NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000513237NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000540549NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000380013NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000305737NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000394764NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000504042NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000375446ENST00000413648NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000545826NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000513237NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000540549NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000380013NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000305737NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000394764NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000504042NINJ1chr9

95883840

+TET2chr4

106074016

+
intron-intronENST00000489274ENST00000413648NINJ1chr9

95883840

+TET2chr4

106074016

+

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FusionProtFeatures for NINJ1_TET2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NINJ1

Q92982

TET2

Q6N021

Homophilic cell adhesion molecule that promotes axonalgrowth. May play a role in nerve regeneration and in the formationand function of other tissues. Cell adhesion requires divalentcations. Dioxygenase that catalyzes the conversion of themodified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNAdemethylation. Has a preference for 5-hydroxymethylcytosine in CpGmotifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine(5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probablyconstitutes the first step in cytosine demethylation. Methylationat the C5 position of cytosine bases is an epigenetic modificationof the mammalian genome which plays an important role intranscriptional regulation. In addition to its role in DNAdemethylation, also involved in the recruitment of the O-GlcNActransferase OGT to CpG-rich transcription start sites of activegenes, thereby promoting histone H2B GlcNAcylation by OGT.{ECO:0000269|PubMed:19483684, ECO:0000269|PubMed:21057493,ECO:0000269|PubMed:21817016, ECO:0000269|PubMed:23222540,ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24315485}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NINJ1_TET2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NINJ1_TET2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NINJ1_TET2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NINJ1_TET2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNINJ1C0162820Dermatitis, Allergic Contact1CTD_human
TgeneTET2C0079774Peripheral T-Cell Lymphoma2CTD_human
TgeneTET2C0007134Renal Cell Carcinoma1CTD_human
TgeneTET2C0020981Angioimmunoblastic Lymphadenopathy1CTD_human
TgeneTET2C0023487Acute Promyelocytic Leukemia1CTD_human
TgeneTET2C0027643Neoplasm Recurrence, Local1CTD_human
TgeneTET2C0033578Prostatic Neoplasms1CTD_human
TgeneTET2C0036920Sezary Syndrome1CTD_human
TgeneTET2C3463824MYELODYSPLASTIC SYNDROME1CTD_human;HPO