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Fusion gene ID: 24345 |
FusionGeneSummary for NHS_F11R |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NHS_F11R | Fusion gene ID: 24345 | Hgene | Tgene | Gene symbol | NHS | F11R | Gene ID | 4810 | 50848 |
| Gene name | NHS actin remodeling regulator | F11 receptor | |
| Synonyms | CTRCT40|CXN|SCML1 | CD321|JAM|JAM1|JAMA|JCAM|KAT|PAM-1 | |
| Cytomap | Xp22.2-p22.13 | 1q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Nance-Horan syndrome proteinNance-Horan syndrome (congenital cataracts and dental anomalies)congenital cataracts and dental anomalies protein | junctional adhesion molecule Ajunctional adhesion molecule 1platelet F11 receptorplatelet adhesion molecule 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6T4R5 | Q9Y624 | |
| Ensembl transtripts involved in fusion gene | ENST00000380060, ENST00000398097, ENST00000485305, | ENST00000368026, ENST00000289779, ENST00000537746, ENST00000472573, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 5 X 2=40 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/40*10)=0.584962500721156 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NHS [Title/Abstract] AND F11R [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A240-01A | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000380060 | ENST00000368026 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| 5CDS-3UTR | ENST00000380060 | ENST00000289779 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| 5CDS-3UTR | ENST00000380060 | ENST00000537746 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| 5CDS-intron | ENST00000380060 | ENST00000472573 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-3CDS | ENST00000398097 | ENST00000368026 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-3UTR | ENST00000398097 | ENST00000289779 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-3UTR | ENST00000398097 | ENST00000537746 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-intron | ENST00000398097 | ENST00000472573 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-3CDS | ENST00000485305 | ENST00000368026 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-3UTR | ENST00000485305 | ENST00000289779 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-3UTR | ENST00000485305 | ENST00000537746 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
| intron-intron | ENST00000485305 | ENST00000472573 | NHS | chrX | 17394445 | + | F11R | chr1 | 160971143 | - |
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FusionProtFeatures for NHS_F11R |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NHS | F11R |
| May function in cell morphology by maintaining theintegrity of the circumferential actin ring and controllinglamellipod formation. Involved in the regulation eye, tooth, brainand craniofacial development. {ECO:0000269|PubMed:20332100}. | Seems to play a role in epithelial tight junctionformation. Appears early in primordial forms of cell junctions andrecruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1,thereby preventing tight junction assembly (By similarity). Playsa role in regulating monocyte transmigration involved in integrityof epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration(PubMed:11812992). Involved in platelet activation(PubMed:10753840). {ECO:0000250|UniProtKB:O88792,ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913,ECO:0000269|PubMed:11812992}. (Microbial infection) Acts as a receptor for Mammalianreovirus sigma-1. {ECO:0000269|PubMed:11239401}. (Microbial infection) Acts as a receptor for HumanRotavirus strain Wa. {ECO:0000269|PubMed:25481868}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NHS | chrX:17394445 | chr1:160971143 | ENST00000380060 | + | 1 | 8 | 112_117 | 188 | 1631 | Compositional bias | Note=Poly-Ala |
| Hgene | NHS | chrX:17394445 | chr1:160971143 | ENST00000380060 | + | 1 | 8 | 68_77 | 188 | 1631 | Compositional bias | Note=Poly-Pro |
| Tgene | >F11R | chrX:17394445 | chr1:160971143 | ENST00000368026 | - | 0 | 10 | 135_228 | 21 | 300 | Domain | Note=Ig-like V-type 2 |
| Tgene | >F11R | chrX:17394445 | chr1:160971143 | ENST00000368026 | - | 0 | 10 | 28_125 | 21 | 300 | Domain | Note=Ig-like V-type 1 |
| Tgene | >F11R | chrX:17394445 | chr1:160971143 | ENST00000368026 | - | 0 | 10 | 260_299 | 21 | 300 | Topological domain | Cytoplasmic |
| Tgene | >F11R | chrX:17394445 | chr1:160971143 | ENST00000368026 | - | 0 | 10 | 28_238 | 21 | 300 | Topological domain | Extracellular |
| Tgene | >F11R | chrX:17394445 | chr1:160971143 | ENST00000368026 | - | 0 | 10 | 239_259 | 21 | 300 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >NHS | chrX:17394445 | chr1:160971143 | ENST00000380060 | + | 1 | 8 | 1475_1483 | 188 | 1631 | Compositional bias | Note=Poly-Ser |
| Hgene | >NHS | chrX:17394445 | chr1:160971143 | ENST00000398097 | + | 1 | 9 | 112_117 | -92 | 1475 | Compositional bias | Note=Poly-Ala |
| Hgene | >NHS | chrX:17394445 | chr1:160971143 | ENST00000398097 | + | 1 | 9 | 1475_1483 | -92 | 1475 | Compositional bias | Note=Poly-Ser |
| Hgene | >NHS | chrX:17394445 | chr1:160971143 | ENST00000398097 | + | 1 | 9 | 68_77 | -92 | 1475 | Compositional bias | Note=Poly-Pro |
| Hgene | >NHS | chrX:17394445 | chr1:160971143 | ENST00000380060 | + | 1 | 8 | 1_262 | 188 | 1631 | Region | Note=WAVE homology domain (WHD) |
| Hgene | >NHS | chrX:17394445 | chr1:160971143 | ENST00000398097 | + | 1 | 9 | 1_262 | -92 | 1475 | Region | Note=WAVE homology domain (WHD) |
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FusionGeneSequence for NHS_F11R |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_NHS_ENST00000380060_chrX_17394445_+_F11R_ENST00000368026_chr1_160971143_-_467aa MPFAKRIVEPQWLCRQRRPAPGPAVDASGGSAEPPPPLQPPGRRDLDEVEAPGPEEPARAVPAPSGLPPPPPPLPAPADQTQPPHGEASV AGEESTAGIPEAAPAAGEASSAAAAAAVLLMLDLCAVSNAALARVLRQLSDVARHACSLFQELESDIQLTHRRVWALQGKLGGVQRVLST LDPKQEAVRSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTRED TGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPT TGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_NHS_ENST00000380060_chrX_17394445_+_F11R_ENST00000368026_chr1_160971143_-_1401nt ATGCCTTTCGCCAAGCGGATCGTGGAGCCGCAATGGCTGTGCAGGCAGCGGCGCCCTGCGCCCGGCCCAGCAGTGGACGCGAGCGGAGGC AGCGCTGAGCCGCCGCCGCCCTTGCAGCCGCCGGGCCGGAGGGACCTGGACGAGGTCGAGGCGCCAGGGCCAGAGGAGCCAGCCCGCGCC GTCCCTGCACCTTCAGGGCTGCCACCGCCGCCGCCGCCACTGCCCGCGCCGGCCGACCAGACTCAGCCGCCGCACGGAGAGGCGTCCGTG GCTGGCGAGGAGAGCACGGCGGGGATCCCGGAGGCGGCGCCCGCAGCCGGCGAGGCGTCCTCGGCGGCGGCGGCGGCGGCCGTGCTGCTC ATGCTGGACCTATGCGCGGTCAGCAACGCCGCTCTGGCCCGTGTCCTCCGGCAGCTCTCGGACGTGGCCCGGCACGCTTGCAGCCTCTTC CAGGAGCTCGAGAGCGACATCCAGCTCACCCACCGCCGCGTCTGGGCGCTGCAGGGCAAGCTCGGCGGCGTGCAGCGCGTCCTCAGCACG CTTGACCCTAAGCAGGAGGCAGTGCGCTCCCTGGCATTGGGCAGTGTTACAGTGCACTCTTCTGAACCTGAAGTCAGAATTCCTGAGAAT AATCCTGTGAAGTTGTCCTGTGCCTACTCGGGCTTTTCTTCTCCCCGTGTGGAGTGGAAGTTTGACCAAGGAGACACCACCAGACTCGTT TGCTATAATAACAAGATCACAGCTTCCTATGAGGACCGGGTGACCTTCTTGCCAACTGGTATCACCTTCAAGTCCGTGACACGGGAAGAC ACTGGGACATACACTTGTATGGTCTCTGAGGAAGGCGGCAACAGCTATGGGGAGGTCAAGGTCAAGCTCATCGTGCTTGTGCCTCCATCC AAGCCTACAGTTAACATCCCCTCCTCTGCCACCATTGGGAACCGGGCAGTGCTGACATGCTCAGAACAAGATGGTTCCCCACCTTCTGAA TACACCTGGTTCAAAGATGGGATAGTGATGCCTACGAATCCCAAAAGCACCCGTGCCTTCAGCAACTCTTCCTATGTCCTGAATCCCACA ACAGGAGAGCTGGTCTTTGATCCCCTGTCAGCCTCTGATACTGGAGAATACAGCTGTGAGGCACGGAATGGGTATGGGACACCCATGACT TCAAATGCTGTGCGCATGGAAGCTGTGGAGCGGAATGTGGGGGTCATCGTGGCAGCCGTCCTTGTAACCCTGATTCTCCTGGGAATCTTG GTTTTTGGCATCTGGTTTGCCTATAGCCGAGGCCACTTTGACAGAACAAAGAAAGGGACTTCGAGTAAGAAGGTGATTTACAGCCAGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_NHS_ENST00000380060_chrX_17394445_+_F11R_ENST00000368026_chr1_160971143_-_5399nt GGTGGCGACGGCGAGCACAGAAACGATGGAGTTGAGCCAGTCGACCCTGGTTGGAAGCAAGTGAGAAGAGACCAGGCGCACCCCTAAATT TCTGTGCGGAGCGCTTGTCATCCTCCCCAGGGAACGGTGCACCCAAAGGAGGACTGGCTGGACTGATTTGCTAGGGAGAGGGCGGGGAAG AGGAGGCAAGGTGAGCAGAGAAGCCCCCTGCGTATCCGGACTGCCAGATCGCGCTTTTGCCGGACTCCTGCCCCCTCCCTGCTCAGGTGG GCGCGCCCGGTCTCCAGCTCACAGGGGCGCTTGGAGGAGACCAGAAAGTCGCCGCCTGGCTGCGCGGGATGCCTTTCGCCAAGCGGATCG TGGAGCCGCAATGGCTGTGCAGGCAGCGGCGCCCTGCGCCCGGCCCAGCAGTGGACGCGAGCGGAGGCAGCGCTGAGCCGCCGCCGCCCT TGCAGCCGCCGGGCCGGAGGGACCTGGACGAGGTCGAGGCGCCAGGGCCAGAGGAGCCAGCCCGCGCCGTCCCTGCACCTTCAGGGCTGC CACCGCCGCCGCCGCCACTGCCCGCGCCGGCCGACCAGACTCAGCCGCCGCACGGAGAGGCGTCCGTGGCTGGCGAGGAGAGCACGGCGG GGATCCCGGAGGCGGCGCCCGCAGCCGGCGAGGCGTCCTCGGCGGCGGCGGCGGCGGCCGTGCTGCTCATGCTGGACCTATGCGCGGTCA GCAACGCCGCTCTGGCCCGTGTCCTCCGGCAGCTCTCGGACGTGGCCCGGCACGCTTGCAGCCTCTTCCAGGAGCTCGAGAGCGACATCC AGCTCACCCACCGCCGCGTCTGGGCGCTGCAGGGCAAGCTCGGCGGCGTGCAGCGCGTCCTCAGCACGCTTGACCCTAAGCAGGAGGCAG TGCGCTCCCTGGCATTGGGCAGTGTTACAGTGCACTCTTCTGAACCTGAAGTCAGAATTCCTGAGAATAATCCTGTGAAGTTGTCCTGTG CCTACTCGGGCTTTTCTTCTCCCCGTGTGGAGTGGAAGTTTGACCAAGGAGACACCACCAGACTCGTTTGCTATAATAACAAGATCACAG CTTCCTATGAGGACCGGGTGACCTTCTTGCCAACTGGTATCACCTTCAAGTCCGTGACACGGGAAGACACTGGGACATACACTTGTATGG TCTCTGAGGAAGGCGGCAACAGCTATGGGGAGGTCAAGGTCAAGCTCATCGTGCTTGTGCCTCCATCCAAGCCTACAGTTAACATCCCCT CCTCTGCCACCATTGGGAACCGGGCAGTGCTGACATGCTCAGAACAAGATGGTTCCCCACCTTCTGAATACACCTGGTTCAAAGATGGGA TAGTGATGCCTACGAATCCCAAAAGCACCCGTGCCTTCAGCAACTCTTCCTATGTCCTGAATCCCACAACAGGAGAGCTGGTCTTTGATC CCCTGTCAGCCTCTGATACTGGAGAATACAGCTGTGAGGCACGGAATGGGTATGGGACACCCATGACTTCAAATGCTGTGCGCATGGAAG CTGTGGAGCGGAATGTGGGGGTCATCGTGGCAGCCGTCCTTGTAACCCTGATTCTCCTGGGAATCTTGGTTTTTGGCATCTGGTTTGCCT ATAGCCGAGGCCACTTTGACAGAACAAAGAAAGGGACTTCGAGTAAGAAGGTGATTTACAGCCAGCCTAGTGCCCGAAGTGAAGGAGAAT TCAAACAGACCTCGTCATTCCTGGTGTGAGCCTGGTCGGCTCACCGCCTATCATCTGCATTTGCCTTACTCAGGTGCTACCGGACTCTGG CCCCTGATGTCTGTAGTTTCACAGGATGCCTTATTTGTCTTCTACACCCCACAGGGCCCCCTACTTCTTCGGATGTGTTTTTAATAATGT CAGCTATGTGCCCCATCCTCCTTCATGCCCTCCCTCCCTTTCCTACCACTGCTGAGTGGCCTGGAACTTGTTTAAAGTGTTTATTCCCCA TTTCTTTGAGGGATCAGGAAGGAATCCTGGGTATGCCATTGACTTCCCTTCTAAGTAGACAGCAAAAATGGCGGGGGTCGCAGGAATCTG CACTCAACTGCCCACCTGGCTGGCAGGGATCTTTGAATAGGTATCTTGAGCTTGGTTCTGGGCTCTTTCCTTGTGTACTGACGACCAGGG CCAGCTGTTCTAGAGCGGGAATTAGAGGCTAGAGCGGCTGAAATGGTTGTTTGGTGATGACACTGGGGTCCTTCCATCTCTGGGGCCCAC TCTCTTCTGTCTTCCCATGGGAAGTGCCACTGGGATCCCTCTGCCCTGTCCTCCTGAATACAAGCTGACTGACATTGACTGTGTCTGTGG AAAATGGGAGCTCTTGTTGTGGAGAGCATAGTAAATTTTCAGAGAACTTGAAGCCAAAAGGATTTAAAACCGCTGCTCTAAAGAAAAGAA AACTGGAGGCTGGGCGCAGTGGCTCACGCCTATAATCCCAGAGGCTGAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGATCAGCCTG ACCAACATGGAGAAACCCTACTAAAAATACAAAGTTAGCCAGGCATAGTGGTGCATGCCTGTAATCCCAGCTGCTCAGGAGCCTGGCAAC AAGAGCAAAACTCCAGCTCAAAAAAAAAAAGAAAGAAAAGAAAGCTGGAGCTGGTGGCTTAGGCCATCACCCTTCCCTTGGCTGGAACTA CTGGACAGACCCTTTTGAGATGTGCCTGTGGTGCTGTGGAGATGTGTGTAGTGGTCTTAGCTCTTTGTTGAGCTTGTGTGTGTGTTGTGT AGTCTTAGCTGTATGCTGAAATTGGGCGTGTGTTGGAGGGCTTCTTAGCTCTTTGGTGAGATTGTATTTCTATGTGTTTGTATCAGCTGA ATGTTGCTGGAAATAAAACCTTGGTTTGTCAAGGCTCTTTTTTGTGGGAAGTAAGTAGGGGAAAAGGTCTTTGAGGGTTCCTAGGCTCCT TTGTACAACAGGAAAATGCCTCAAAGCCTTGCTTCCCAGCAACCTGGGGCTGGTTCCCAGTGCCTGGTCCTGCCCCTTCCTGGTTCTTAT CTCAAGGCAGAGCTTCTGAATTTCAGGCCTTCATTCCAGAGCCCTCTTGTGGCCAGGCCTTCCTTTGCTGGAGGAAGGTACACAGGGTGA AGCTGATGCTGTACTTGGGGGATCTCCTTGGCCTGTTCCACCAAGTGAGAGAAGGTACTTACTCTTGTACCTCCTGTTCAGCCAGGTGCA TTAACAGACCTCCCTACAGCTGTAGGAACTACTGTCCCAGAGCTGAGGCAAGGGGATTTCTCAGGTCATTTGGAGAACAAGTGCTTTAGT AGTAGTTTAAAGTAGTAACTGCTACTGTATTTAGTGGGGTGGAATTCAGAAGAAATTTGAAGACCAGATCATGGGTGGTCTGCATGTGAA TGAACAGGAATGAGCCGGACAGCCTGGCTGTCATTGCTTTCTTCCTCCCCATTTGGACCCTTCTCTGCCCTTACATTTTTGTTTCTCCAT CTACCACCATCCACCAGTCTATTTATTAACTTAGCAAGAGGACAAGTAAAGGGCCCTCTTGGCTTGATTTTGCTTCTTTCTTTCTGTGGA GGATATACTAAGTGCGACTTTGCCCTATCCTATTTGGAAATCCCTAACAGAATTGAGTTTTCTATTAAGGATCCAAAAAGAAAAACAAAA TGCTAATGAAGCCATCAGTCAAGGGTCACATGCCAATAAACAATAAATTTTCCAGAAGAAATGAAATCCAACTAGACAAATAAAGTAGAG CTTATGAAATGGTTCAGTAAAGATGAGTTTGTTGTTTTTTGTTTTGTTTTGTTTTGTTTTTTTAAAGACGGAGTCTCGCTCTGTCACCCA GGCTGGAGTGCAGTGGTATGATCTTGGCTCACTGTAACCTCCGCCTCCCGGGTTCAAGCCATTCTCCTGCCTCAGTCTCCTGAGTAGCTG GGATTACGGGTGCGTGCCACCATGCCTGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCGGGCTGGTCTCAAAC TCCTGACCTCTTGATCCGCCTGCCTTGGCCTCCCAAAGTGATGGGATTACAGATGTGAGCCACCGTGCCTAGCCAAGGATGAGATTTTTA AAGTATGTTTCAGTTCTGTGTCATGGTTGGAAGACAGAGTAGGAAGGATATGGAAAAGGTCATGGGGAAGCAGAGGTGATTCATGGCTCT GTGAATTTGAGGTGAATGGTTCCTTATTGTCTAGGCCACTTGTGAAGAATATGAGTCAGTTATTGCCAGCCTTGGAATTTACTTCTCTAG CTTACAATGGACCTTTTGAACTGGAAAACACCTTGTCTGCATTCACTTTAAAATGTCAAAACTAATTTTTATAATAAATGTTTATTTTCA CATTGAGTTTGTTTAAATCCTGAAGTTCTTACCTTAAGAGAATTGGGACTCCTAGAGTGATTGGACATTCAAAATATTCCTGATAGTCTT GTTAATTAAGAGATTAGGATATCTTTCCATTACCTTGATAATTACGTTTTAATTTAGCTTTTTTCATTGGCCTGTGTTTAAATGCAAATA ACCCCACAATGGACATTTCCTATGTTAAAGTGACATTTAGGGGATAAAAAATGAGAGCAGTTCCATGGATTTTGGTGTTTCCCCTGAGAC ATGAACTCAGCATAATCTGGGATAAAATGATTGAGTGTTAAGGATGTGTTTGTTGTTCCTGTCGTTTTTTTATTTTCTTCAAAGTATACA ACATGGTTTGATATGCACATACATTTGTGTAATGATTGCCATGGTCAATTAACACATCACCATTTTTGTGTGTGTGTGTGTGTGTGTGTG TGAGGGAGTCTTGCTCCGTTGCCAGGCTGGAGTGCAATGGTACAACCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTC TTGCCTCAGCCTCCTAAGTAGCTGGGACTATAGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACC ATGTTGGCCAGGATGATCTCGATCCCTTGACCTCATGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACTGC ACCCGGCCACATCACCTCCCATGTTCTATCTTACGTATTCAGAACTTGTTCATCTTGTAACTGAAAGCGTGTACCCTTTGACCAACACTG TTTTTCCTGTCTTAACAGGATCTACAGATCAAGGACAGGGGAGGGGATAGTGGAGGAAAACGGAGTTAGTCTGTTTCTAAATGAGGGGAC |
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FusionGenePPI for NHS_F11R |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| NHS | CFTR, RPN1, HNRNPD, KIF5B, KIFC3, SORT1, YWHAH, ABI1, SYNCRIP, SGTB, USP43, BAG6, CENPU, CDH1, PTPRU | F11R | TJP1, SGTA, PARD3, CASK, MLLT4, ELAVL1, PEX19, BDNF, CCDC8, PICK1, TMEM216, PRKCZ, CDH1, IL12A, MBLAC2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NHS_F11R |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NHS_F11R |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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