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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24318

FusionGeneSummary for NFYC_SLC4A4

check button Fusion gene summary
Fusion gene informationFusion gene name: NFYC_SLC4A4
Fusion gene ID: 24318
HgeneTgene
Gene symbol

NFYC

SLC4A4

Gene ID

4802

8671

Gene namenuclear transcription factor Y subunit gammasolute carrier family 4 member 4
SynonymsCBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YCHNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBC
Cytomap

1p34.2

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cnelectrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransporter
Modification date2018052320180523
UniProtAcc

Q13952

Q9Y6R1

Ensembl transtripts involved in fusion geneENST00000427410, ENST00000447388, 
ENST00000425457, ENST00000456393, 
ENST00000372654, ENST00000372653, 
ENST00000372652, ENST00000372651, 
ENST00000440226, ENST00000308733, 
ENST00000483091, 		ENST00000264485, 
ENST00000425175, ENST00000351898, 
ENST00000340595, ENST00000514331, 
ENST00000512686, 
Fusion gene scores* DoF score11 X 5 X 8=44010 X 8 X 5=400
# samples 1111
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFYC [Title/Abstract] AND SLC4A4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFYC

GO:0006355

regulation of transcription, DNA-templated

15243141

TgeneSLC4A4

GO:0006814

sodium ion transport

16769890


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-8262-01ANFYCchr1

41157539

+SLC4A4chr4

72102293

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000427410ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000427410ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000427410ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000427410ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000427410ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000427410ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000447388ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000447388ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000447388ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000447388ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000447388ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000447388ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000425457ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000425457ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000425457ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000425457ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000425457ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000425457ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000456393ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000456393ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000456393ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000456393ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000456393ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000456393ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000372654ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000372654ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-5UTRENST00000372654ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000372654ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000372654ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
5UTR-intronENST00000372654ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372653ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372653ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372653ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372653ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372653ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372653ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372652ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372652ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372652ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372652ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372652ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372652ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372651ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372651ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000372651ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372651ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372651ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000372651ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000440226ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000440226ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000440226ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000440226ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000440226ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000440226ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000308733ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000308733ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000308733ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000308733ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000308733ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000308733ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000483091ENST00000264485NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000483091ENST00000425175NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-5UTRENST00000483091ENST00000351898NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000483091ENST00000340595NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000483091ENST00000514331NFYCchr1

41157539

+SLC4A4chr4

72102293

+
intron-intronENST00000483091ENST00000512686NFYCchr1

41157539

+SLC4A4chr4

72102293

+

Top

FusionProtFeatures for NFYC_SLC4A4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFYC

Q13952

SLC4A4

Q9Y6R1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for NFYC_SLC4A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFYC_SLC4A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFYCMYC, SMAD3, SMAD2, TBP, ATF6, ATF6B, TP73, DST, CSN2, DR1, NFYA, NFYB, SP1, SREBF2, LMO4, ADNP2, POGZ, CIC, ZDHHC17, GLTSCR1L, GLTSCR1, ARID2, KIAA2018, TRIM27, TBPL2, HDAC1, TAF12, TAF11, TAF6, KAT2B, GAPDH, ELAVL1, CDK2, SNX2, FCGR2A, CORO1B, CORO1C, FOXJ2, FOXK2, NFATC2, PON1, ENDOG, PON3, NFKB1, COMMD1, PRR20ESLC4A4SREBF2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for NFYC_SLC4A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for NFYC_SLC4A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC4A4C1970309Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation3CTD_human;ORPHANET;UNIPROT
TgeneSLC4A4C0001126Renal tubular acidosis1CTD_human
TgeneSLC4A4C0008073Developmental Disabilities1CTD_human
TgeneSLC4A4C0010038Corneal Opacity1CTD_human
TgeneSLC4A4C0017601Glaucoma1CTD_human;HPO
TgeneSLC4A4C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSLC4A4C0086543Cataract1CTD_human;HPO