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Fusion gene ID: 24289 |
FusionGeneSummary for NFU1_LYZ |
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Fusion gene information | Fusion gene name: NFU1_LYZ | Fusion gene ID: 24289 | Hgene | Tgene | Gene symbol | NFU1 | LYZ | Gene ID | 27247 | 4069 |
Gene name | NFU1 iron-sulfur cluster scaffold | lysozyme | |
Synonyms | CGI-33|HIRIP|HIRIP5|MMDS1|NIFUC|Nfu|NifU | LYZF1|LZM | |
Cytomap | 2p13.3 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | NFU1 iron-sulfur cluster scaffold homolog, mitochondrialHIRA-interacting protein 5NifU-like C-terminal domain containingiron-sulfur cluster scaffold protein | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UMS0 | P61626 | |
Ensembl transtripts involved in fusion gene | ENST00000410022, ENST00000471185, ENST00000303698, ENST00000394305, ENST00000462320, | ENST00000261267, ENST00000549690, ENST00000548839, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 26 X 11 X 9=2574 |
# samples | 1 | 30 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(30/2574*10)=-3.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NFU1 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFU1 | GO:0016226 | iron-sulfur cluster assembly | 12886008|28906594 |
Tgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
Tgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
Tgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE720550 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000410022 | ENST00000261267 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000410022 | ENST00000549690 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000410022 | ENST00000548839 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-3UTR | ENST00000471185 | ENST00000261267 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000471185 | ENST00000549690 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000471185 | ENST00000548839 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-3UTR | ENST00000303698 | ENST00000261267 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000303698 | ENST00000549690 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000303698 | ENST00000548839 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-3UTR | ENST00000394305 | ENST00000261267 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000394305 | ENST00000549690 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000394305 | ENST00000548839 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-3UTR | ENST00000462320 | ENST00000261267 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000462320 | ENST00000549690 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
intron-intron | ENST00000462320 | ENST00000548839 | NFU1 | chr2 | 69661580 | - | LYZ | chr12 | 69747539 | + |
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FusionProtFeatures for NFU1_LYZ |
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Hgene | Tgene |
NFU1 | LYZ |
Iron-sulfur cluster scaffold protein which can assemble[4Fe-2S] clusters and deliver them to target proteins.{ECO:0000269|PubMed:12886008, ECO:0000269|PubMed:27818104,ECO:0000269|PubMed:28906594}. | Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFU1_LYZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFU1_LYZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFU1_LYZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFU1_LYZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NFU1 | C3276432 | MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 1 | 1 | ORPHANET;UNIPROT |
Tgene | LYZ | C0268389 | Amyloidosis, familial visceral | 1 | CTD_human;UNIPROT |