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Fusion gene ID: 24271 |
FusionGeneSummary for NFKBIA_NFKBIA |
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Fusion gene information | Fusion gene name: NFKBIA_NFKBIA | Fusion gene ID: 24271 | Hgene | Tgene | Gene symbol | NFKBIA | NFKBIA | Gene ID | 4792 | 4792 |
Gene name | NFKB inhibitor alpha | NFKB inhibitor alpha | |
Synonyms | IKBA|MAD-3|NFKBI | IKBA|MAD-3|NFKBI | |
Cytomap | 14q13.2 | 14q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | NF-kappa-B inhibitor alphaI-kappa-B-alphaIkappaBalphaikB-alphamajor histocompatibility complex enhancer-binding protein MAD3nuclear factor of kappa light chain gene enhancer in B-cellsnuclear factor of kappa light polypeptide gene enhancer in B-cell | NF-kappa-B inhibitor alphaI-kappa-B-alphaIkappaBalphaikB-alphamajor histocompatibility complex enhancer-binding protein MAD3nuclear factor of kappa light chain gene enhancer in B-cellsnuclear factor of kappa light polypeptide gene enhancer in B-cell | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P25963 | P25963 | |
Ensembl transtripts involved in fusion gene | ENST00000216797, ENST00000557140, ENST00000557389, ENST00000557100, | ENST00000216797, ENST00000557140, ENST00000557389, ENST00000557100, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NFKBIA [Title/Abstract] AND NFKBIA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFKBIA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 25038658 |
Hgene | NFKBIA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11931770 |
Hgene | NFKBIA | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 25038658 |
Hgene | NFKBIA | GO:0042994 | cytoplasmic sequestering of transcription factor | 1493333 |
Hgene | NFKBIA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19245366 |
Hgene | NFKBIA | GO:0050729 | positive regulation of inflammatory response | 25038658 |
Tgene | NFKBIA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 25038658 |
Tgene | NFKBIA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 11931770 |
Tgene | NFKBIA | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 25038658 |
Tgene | NFKBIA | GO:0042994 | cytoplasmic sequestering of transcription factor | 1493333 |
Tgene | NFKBIA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19245366 |
Tgene | NFKBIA | GO:0050729 | positive regulation of inflammatory response | 25038658 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB241819 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000216797 | ENST00000216797 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000216797 | ENST00000557140 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000216797 | ENST00000557389 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-intron | ENST00000216797 | ENST00000557100 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557140 | ENST00000216797 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557140 | ENST00000557140 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557140 | ENST00000557389 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-intron | ENST00000557140 | ENST00000557100 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557389 | ENST00000216797 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557389 | ENST00000557140 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557389 | ENST00000557389 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-intron | ENST00000557389 | ENST00000557100 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557100 | ENST00000216797 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557100 | ENST00000557140 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-3UTR | ENST00000557100 | ENST00000557389 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
intron-intron | ENST00000557100 | ENST00000557100 | NFKBIA | chr14 | 35870827 | + | NFKBIA | chr14 | 35871073 | - |
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FusionProtFeatures for NFKBIA_NFKBIA |
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Hgene | Tgene |
NFKBIA | NFKBIA |
Inhibits the activity of dimeric NF-kappa-B/RELcomplexes by trapping REL dimers in the cytoplasm through maskingof their nuclear localization signals. On cellular stimulation byimmune and proinflammatory responses, becomes phosphorylatedpromoting ubiquitination and degradation, enabling the dimericRELA to translocate to the nucleus and activate transcription.{ECO:0000269|PubMed:7479976}. | Inhibits the activity of dimeric NF-kappa-B/RELcomplexes by trapping REL dimers in the cytoplasm through maskingof their nuclear localization signals. On cellular stimulation byimmune and proinflammatory responses, becomes phosphorylatedpromoting ubiquitination and degradation, enabling the dimericRELA to translocate to the nucleus and activate transcription.{ECO:0000269|PubMed:7479976}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFKBIA_NFKBIA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFKBIA_NFKBIA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFKBIA_NFKBIA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NFKBIA | P25963 | DB00945 | Acetylsalicylic acid | NF-kappa-B inhibitor alpha | small molecule | approved|vet_approved |
Tgene | NFKBIA | P25963 | DB00945 | Acetylsalicylic acid | NF-kappa-B inhibitor alpha | small molecule | approved|vet_approved |
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RelatedDiseases for NFKBIA_NFKBIA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NFKBIA | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | NFKBIA | C0019829 | Hodgkin Disease | 1 | CTD_human |
Hgene | NFKBIA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | NFKBIA | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Hgene | NFKBIA | C0033860 | Psoriasis | 1 | CTD_human |
Hgene | NFKBIA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | NFKBIA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | NFKBIA | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | NFKBIA | C2677481 | Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant | 1 | CTD_human;UNIPROT |
Tgene | NFKBIA | C0007786 | Brain Ischemia | 1 | CTD_human |
Tgene | NFKBIA | C0019829 | Hodgkin Disease | 1 | CTD_human |
Tgene | NFKBIA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | NFKBIA | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Tgene | NFKBIA | C0033860 | Psoriasis | 1 | CTD_human |
Tgene | NFKBIA | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | NFKBIA | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | NFKBIA | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | NFKBIA | C2677481 | Ectodermal Dysplasia, Anhidrotic, With T-Cell Immunodeficiency, Autosomal Dominant | 1 | CTD_human;UNIPROT |