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Fusion gene ID: 24265 |
FusionGeneSummary for NFKB1_BANK1 |
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Fusion gene information | Fusion gene name: NFKB1_BANK1 | Fusion gene ID: 24265 | Hgene | Tgene | Gene symbol | NFKB1 | BANK1 | Gene ID | 4790 | 55024 |
Gene name | nuclear factor kappa B subunit 1 | B cell scaffold protein with ankyrin repeats 1 | |
Synonyms | CVID12|EBP-1|KBF1|NF-kB1|NF-kappa-B|NF-kappaB|NFKB-p105|NFKB-p50|NFkappaB|p105|p50 | BANK | |
Cytomap | 4q24 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor NF-kappa-B p105 subunitDNA-binding factor KBF1NF-kappabetanuclear factor NF-kappa-B p50 subunitnuclear factor kappa-B DNA binding subunitnuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | B-cell scaffold protein with ankyrin repeats | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P19838 | Q8NDB2 | |
Ensembl transtripts involved in fusion gene | ENST00000226574, ENST00000394820, ENST00000505458, ENST00000510638, ENST00000600343, | ENST00000504592, ENST00000322953, ENST00000428908, ENST00000508653, ENST00000444316, ENST00000510950, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 3=48 |
# samples | 6 | 4 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: NFKB1 [Title/Abstract] AND BANK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFKB1 | GO:0010629 | negative regulation of gene expression | 26687115 |
Hgene | NFKB1 | GO:0010956 | negative regulation of calcidiol 1-monooxygenase activity | 15243130 |
Hgene | NFKB1 | GO:0045893 | positive regulation of transcription, DNA-templated | 17426251 |
Hgene | NFKB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1406630 |
Hgene | NFKB1 | GO:1900127 | positive regulation of hyaluronan biosynthetic process | 17324121 |
Tgene | BANK1 | GO:0042113 | B cell activation | 11782428 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A8BU-01A | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000226574 | ENST00000504592 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000226574 | ENST00000322953 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000226574 | ENST00000428908 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000226574 | ENST00000508653 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000226574 | ENST00000444316 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
5CDS-intron | ENST00000226574 | ENST00000510950 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000394820 | ENST00000504592 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000394820 | ENST00000322953 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000394820 | ENST00000428908 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000394820 | ENST00000508653 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000394820 | ENST00000444316 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
5CDS-intron | ENST00000394820 | ENST00000510950 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000505458 | ENST00000504592 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000505458 | ENST00000322953 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000505458 | ENST00000428908 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000505458 | ENST00000508653 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000505458 | ENST00000444316 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
5CDS-intron | ENST00000505458 | ENST00000510950 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
intron-3CDS | ENST00000510638 | ENST00000504592 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
intron-3CDS | ENST00000510638 | ENST00000322953 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
intron-3CDS | ENST00000510638 | ENST00000428908 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
intron-3CDS | ENST00000510638 | ENST00000508653 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
intron-3CDS | ENST00000510638 | ENST00000444316 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
intron-intron | ENST00000510638 | ENST00000510950 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000600343 | ENST00000504592 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000600343 | ENST00000322953 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000600343 | ENST00000428908 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000600343 | ENST00000508653 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
Frame-shift | ENST00000600343 | ENST00000444316 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
5CDS-intron | ENST00000600343 | ENST00000510950 | NFKB1 | chr4 | 103516138 | + | BANK1 | chr4 | 102984232 | + |
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FusionProtFeatures for NFKB1_BANK1 |
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Hgene | Tgene |
NFKB1 | BANK1 |
NF-kappa-B is a pleiotropic transcription factor presentin almost all cell types and is the endpoint of a series of signaltransduction events that are initiated by a vast array of stimulirelated to many biological processes such as inflammation,immunity, differentiation, cell growth, tumorigenesis andapoptosis. NF-kappa-B is a homo- or heterodimeric complex formedby the Rel-like domain-containing proteins RELA/p65, RELB,NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimericp65-p50 complex appears to be most abundant one. The dimers bindat kappa-B sites in the DNA of their target genes and theindividual dimers have distinct preferences for different kappa-Bsites that they can bind with distinguishable affinity andspecificity. Different dimer combinations act as transcriptionalactivators or repressors, respectively. NF-kappa-B is controlledby various mechanisms of post-translational modification andsubcellular compartmentalization as well as by interactions withother cofactors or corepressors. NF-kappa-B complexes are held inthe cytoplasm in an inactive state complexed with members of theNF-kappa-B inhibitor (I-kappa-B) family. In a conventionalactivation pathway, I-kappa-B is phosphorylated by I-kappa-Bkinases (IKKs) in response to different activators, subsequentlydegraded thus liberating the active NF-kappa-B complex whichtranslocates to the nucleus. NF-kappa-B heterodimeric p65-p50 andRelB-p50 complexes are transcriptional activators. The NF-kappa-Bp50-p50 homodimer is a transcriptional repressor, but can act as atranscriptional activator when associated with BCL3. NFKB1 appearsto have dual functions such as cytoplasmic retention of attachedNF-kappa-B proteins by p105 and generation of p50 by acotranslational processing. The proteasome-mediated processensures the production of both p50 and p105 and preserves theirindependent function, although processing of NFKB1/p105 alsoappears to occur post-translationally. p50 binds to the kappa-Bconsensus sequence 5'-GGRNNYYCC-3', located in the enhancer regionof genes involved in immune response and acute phase reactions. Ina complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPKsignaling; active MAP3K8 is released by proteasome-dependentdegradation of NFKB1/p105. {ECO:0000269|PubMed:15485931}. | Involved in B-cell receptor (BCR)-induced Ca(2+)mobilization from intracellular stores. Promotes Lyn-mediatedphosphorylation of IP3 receptors 1 and 2.{ECO:0000269|PubMed:11782428}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for NFKB1_BANK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for NFKB1_BANK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NFKB1 | LYL1, MAP3K8, COPB2, REL, SPAG9, NFKB2, RELA, KPNA3, NFKB1, RELB, NCOA6, NCOA1, BCL3, TP53BP1, IKBKG, TBK1, TNIP2, TNIP3, RSF1, UNC5CL, KLF5, HMGA2, HMGB1, NCOR1, TAB2, HDAC1, IKBKB, BTRC, ELF1, MEN1, GSK3B, NOTCH1, ITGB3BP, CHUK, ELF3, RXRA, SP1, NR3C1, NFKBIE, NFKBIA, NFKBIZ, NKRF, STAT6, PPP4C, TXN, TSC22D3, CEBPB, E2F1, MTPN, STAT3, IRF8, IRF2, IRF9, ZFP36, BANP, PCBD1, ZBTB9, BRMS1, EP300, HDAC3, POLR2A, PARP1, ANXA4, NCOR2, RPS3, HMGA1, CARM1, PSMD10, HDAC2, DPF2, CLU, PPME1, SF1, HDAC5, HDAC4, NCOA3, HSPA4, KAT5, CTNNB1, RUVBL2, PSMA4, DPF3, PHF10, DPF1, TNIP1, CUL3, CUL4A, CUL4B, CUL5, COPS5, COPS6, DCUN1D1, STAT5A, COMMD1, COMMD2, COMMD4, COMMD5, COMMD8, COMMD9, COMMD3, COMMD10, COMMD6, SOCS3, FBXW11, RPS6KA5, SRF, TP63, ABCC2, SPPL2A, SERPINA3, GLUL, NR4A1, PML, YY1, RGS14, YWHAQ, MXD3, HIF1AN, PELP1, PLD3, MPP6, ECSIT, PPARG, PPARGC1A, XRCC4, NFKBIB, NOV, AURKA, TRIP4, XPO1, VPS26A, BIRC3, ETS1, HSP90AB1, CD82, HSPA1L, SMAD4, VCP, RNF123, DNMT3L, TFAP2A, CDX2, MTMR2, NFKBID, PADI3, NFYC, CNOT2, CNOT6, CNOT6L, CNOT11, TNKS1BP1, CNOT7, TNFAIP3 | BANK1 | LYN, ITPR1, YWHAQ |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for NFKB1_BANK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | NFKB1 | P19838 | DB01411 | Pranlukast | Nuclear factor NF-kappa-B p105 subunit | small molecule | approved|investigational |
Hgene | NFKB1 | P19838 | DB08814 | Triflusal | Nuclear factor NF-kappa-B p105 subunit | small molecule | approved|investigational |
Hgene | NFKB1 | P19838 | DB01041 | Thalidomide | Nuclear factor NF-kappa-B p105 subunit | small molecule | approved|investigational|withdrawn |
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RelatedDiseases for NFKB1_BANK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NFKB1 | C0001973 | Alcoholic Intoxication, Chronic | 4 | PSYGENET |
Hgene | NFKB1 | C0009375 | Colonic Neoplasms | 2 | CTD_human |
Hgene | NFKB1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | NFKB1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | NFKB1 | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | NFKB1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | NFKB1 | C0018843 | Heat Stroke | 1 | CTD_human |
Hgene | NFKB1 | C0020500 | Hyperoxaluria | 1 | CTD_human |
Hgene | NFKB1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Hgene | NFKB1 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Hgene | NFKB1 | C0023895 | Liver diseases | 1 | CTD_human |
Hgene | NFKB1 | C0029927 | Ovarian Cysts | 1 | CTD_human |
Hgene | NFKB1 | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | BANK1 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |