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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24224

FusionGeneSummary for NFIB_NFIB

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIB_NFIB
Fusion gene ID: 24224
HgeneTgene
Gene symbol

NFIB

NFIB

Gene ID

4781

4781

Gene namenuclear factor I Bnuclear factor I B
SynonymsCTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3CTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3
Cytomap

9p23-p22.3

9p23-p22.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/Bnuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/B
Modification date2018052320180523
UniProtAcc

O00712

O00712

Ensembl transtripts involved in fusion geneENST00000380934, ENST00000380959, 
ENST00000380953, ENST00000397575, 
ENST00000397581, ENST00000397579, 
ENST00000543693, ENST00000380924, 
ENST00000380921, 
ENST00000380934, 
ENST00000380959, ENST00000380953, 
ENST00000397575, ENST00000397581, 
ENST00000397579, ENST00000543693, 
ENST00000380924, ENST00000380921, 
Fusion gene scores* DoF score8 X 8 X 4=2563 X 7 X 2=42
# samples 87
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIB [Title/Abstract] AND NFIB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIB

GO:0045944

positive regulation of transcription by RNA polymerase II

9099724|19540848

TgeneNFIB

GO:0045944

positive regulation of transcription by RNA polymerase II

9099724|19540848


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW383911NFIBchr9

14088064

-NFIBchr9

14146809

-
ChiTaRS3.1BI495276NFIBchr9

14087230

+NFIBchr9

14087156

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380934ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380934ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000380934ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380959ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000380959ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380953ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000380953ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397575ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000397575ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397581ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000397581ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000397579ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000397579ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000543693ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000543693ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380924ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000380924ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000380934NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000380959NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000380953NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000397575NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000397581NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000397579NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000543693NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3CDSENST00000380921ENST00000380924NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-intronENST00000380921ENST00000380921NFIBchr9

14088064

-NFIBchr9

14146809

-
intron-3UTRENST00000380934ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380934ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380934ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380959ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380959ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380959ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380953ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380953ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380953ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000397575ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000397575ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397575ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000397581ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000397581ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397581ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000397579ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000397579ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000397579ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000543693ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000543693ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000543693ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380924ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380924ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380924ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380921ENST00000380934NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-3UTRENST00000380921ENST00000380959NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000380953NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000397575NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000397581NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000397579NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000543693NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000380924NFIBchr9

14087230

+NFIBchr9

14087156

-
intron-intronENST00000380921ENST00000380921NFIBchr9

14087230

+NFIBchr9

14087156

-

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FusionProtFeatures for NFIB_NFIB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIB

O00712

NFIB

O00712


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFIB_NFIB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFIB_NFIB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFIB_NFIB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFIB_NFIB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIBC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneNFIBC0010606Adenoid Cystic Carcinoma1CTD_human