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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24223

FusionGeneSummary for NFIB_KIF13B

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIB_KIF13B
Fusion gene ID: 24223
HgeneTgene
Gene symbol

NFIB

KIF13B

Gene ID

4781

23303

Gene namenuclear factor I Bkinesin family member 13B
SynonymsCTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3GAKIN
Cytomap

9p23-p22.3

8p12

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/Bkinesin-like protein KIF13Bguanylate kinase associated kinesinkinesin 13Bkinesin-like protein GAKIN
Modification date2018052320180523
UniProtAcc

O00712

Q9NQT8

Ensembl transtripts involved in fusion geneENST00000380934, ENST00000380959, 
ENST00000380953, ENST00000397575, 
ENST00000397581, ENST00000397579, 
ENST00000543693, ENST00000380924, 
ENST00000380921, 
ENST00000524189, 
ENST00000521515, ENST00000404075, 
Fusion gene scores* DoF score8 X 8 X 4=2563 X 3 X 2=18
# samples 83
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIB [Title/Abstract] AND KIF13B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIB

GO:0045944

positive regulation of transcription by RNA polymerase II

9099724|19540848

TgeneKIF13B

GO:0050770

regulation of axonogenesis

20194617


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB383011NFIBchr9

14082130

+KIF13Bchr8

28988123

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380934ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380934ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380934ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000380959ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380959ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380959ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000380953ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380953ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380953ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000397575ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000397575ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000397575ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000397581ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000397581ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000397581ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000397579ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000397579ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000397579ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000543693ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000543693ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000543693ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000380924ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380924ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380924ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-3CDSENST00000380921ENST00000524189NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380921ENST00000521515NFIBchr9

14082130

+KIF13Bchr8

28988123

+
intron-intronENST00000380921ENST00000404075NFIBchr9

14082130

+KIF13Bchr8

28988123

+

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FusionProtFeatures for NFIB_KIF13B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIB

O00712

KIF13B

Q9NQT8

Involved in reorganization of the cortical cytoskeleton.Regulates axon formation by promoting the formation of extraaxons. May be functionally important for the intracellulartrafficking of MAGUKs and associated protein complexes.{ECO:0000269|PubMed:20194617}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFIB_KIF13B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFIB_KIF13B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFIB_KIF13B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFIB_KIF13B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIBC0010606Adenoid Cystic Carcinoma1CTD_human