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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 24222

FusionGeneSummary for NFIB_HEATR5B

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIB_HEATR5B
Fusion gene ID: 24222
HgeneTgene
Gene symbol

NFIB

HEATR5B

Gene ID

4781

54497

Gene namenuclear factor I BHEAT repeat containing 5B
SynonymsCTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3-
Cytomap

9p23-p22.3

2p22.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/BHEAT repeat-containing protein 5B
Modification date2018052320180523
UniProtAcc

O00712

Q9P2D3

Ensembl transtripts involved in fusion geneENST00000380934, ENST00000380959, 
ENST00000380953, ENST00000397575, 
ENST00000397581, ENST00000397579, 
ENST00000543693, ENST00000380924, 
ENST00000380921, 
ENST00000233099, 
ENST00000354531, 
Fusion gene scores* DoF score8 X 8 X 4=2562 X 3 X 4=24
# samples 84
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIB [Title/Abstract] AND HEATR5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIB

GO:0045944

positive regulation of transcription by RNA polymerase II

9099724|19540848


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A1-A0SB-01ANFIBchr9

14313481

-HEATR5Bchr2

37208937

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000380934ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
intron-3CDSENST00000380934ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000380959ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000380959ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000380953ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000380953ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000397575ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000397575ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000397581ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000397581ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000397579ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000397579ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
intron-3CDSENST00000543693ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
intron-3CDSENST00000543693ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
intron-3CDSENST00000380924ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
intron-3CDSENST00000380924ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000380921ENST00000233099NFIBchr9

14313481

-HEATR5Bchr2

37208937

-
Frame-shiftENST00000380921ENST00000354531NFIBchr9

14313481

-HEATR5Bchr2

37208937

-

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FusionProtFeatures for NFIB_HEATR5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIB

O00712

HEATR5B

Q9P2D3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for NFIB_HEATR5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for NFIB_HEATR5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
NFIBRFX1, NFIC, NFIX, SOX2, ELAVL1, GRK5, EED, UNK, XRCC5, SASS6, NFIAHEATR5BELAVL1, CCDC8, MLF1, AP1M2, VAPB, AURKA, NTRK1, XPO1, AP1S2, VAPA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for NFIB_HEATR5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NFIB_HEATR5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNFIBC0010606Adenoid Cystic Carcinoma1CTD_human