![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 24222 |
FusionGeneSummary for NFIB_HEATR5B |
![]() |
Fusion gene information | Fusion gene name: NFIB_HEATR5B | Fusion gene ID: 24222 | Hgene | Tgene | Gene symbol | NFIB | HEATR5B | Gene ID | 4781 | 54497 |
Gene name | nuclear factor I B | HEAT repeat containing 5B | |
Synonyms | CTF|HMGIC/NFIB|NF-I/B|NF1-B|NFI-B|NFI-RED|NFIB2|NFIB3 | - | |
Cytomap | 9p23-p22.3 | 2p22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/B | HEAT repeat-containing protein 5B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O00712 | Q9P2D3 | |
Ensembl transtripts involved in fusion gene | ENST00000380934, ENST00000380959, ENST00000380953, ENST00000397575, ENST00000397581, ENST00000397579, ENST00000543693, ENST00000380924, ENST00000380921, | ENST00000233099, ENST00000354531, | |
Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 2 X 3 X 4=24 |
# samples | 8 | 4 | |
** MAII score | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: NFIB [Title/Abstract] AND HEATR5B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | NFIB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9099724|19540848 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A1-A0SB-01A | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000380934 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
intron-3CDS | ENST00000380934 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000380959 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000380959 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000380953 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000380953 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000397575 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000397575 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000397581 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000397581 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000397579 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000397579 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
intron-3CDS | ENST00000543693 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
intron-3CDS | ENST00000543693 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
intron-3CDS | ENST00000380924 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
intron-3CDS | ENST00000380924 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000380921 | ENST00000233099 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Frame-shift | ENST00000380921 | ENST00000354531 | NFIB | chr9 | 14313481 | - | HEATR5B | chr2 | 37208937 | - |
Top |
FusionProtFeatures for NFIB_HEATR5B |
![]() |
Hgene | Tgene |
NFIB | HEATR5B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for NFIB_HEATR5B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for NFIB_HEATR5B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
NFIB | RFX1, NFIC, NFIX, SOX2, ELAVL1, GRK5, EED, UNK, XRCC5, SASS6, NFIA | HEATR5B | ELAVL1, CCDC8, MLF1, AP1M2, VAPB, AURKA, NTRK1, XPO1, AP1S2, VAPA |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for NFIB_HEATR5B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for NFIB_HEATR5B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | NFIB | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |